1-[2(R)-(2-amino-2-methylpropionyl-amino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): A potent, orally bioavailable, and short-duration growth hormone secretagogue [1]

Journal of Medicinal Chemistry

Volumn 41, Issue 14, 1998, Pages 2439-2441

  Yang, Lihu ^a   Morriello, Greg ^a   Patchett, Arthur A ^a   Leung, Kwan ^a   Jacks, Tom ^a   Cheng, Kang ^a   Schleim, Klaus D ^a   Feeney, William ^a   Chan, Wanda W S ^a   Chiu, Shuet Hing L ^a   Smith, Roy G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (2 AMINO 2 METHYLPROPIONYLAMINO) 3 (1H INDOL 3 YL)PROPIONYL] 3 BENZYLPIPERIDINE 3 CARBOXYLIC ACID ETHYL ESTER; 3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; BENZOLACTAM BIPHENYLTETRAZOLE; GROWTH HORMONE SECRETAGOGUE; IBUTAMOREN; L 163833; OLIGOPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CARPAL TUNNEL SYNDROME; DECHLORINATION; FLUID RETENTION; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HEIGHT; LETTER; MALE; NONHUMAN; RAT; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DOGS; ESTERS; GROWTH HORMONE; MALE; PIPERIDINES; PITUITARY GLAND; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 7344221463     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9800191     Document Type: Letter

References (23)

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23. Detailed SAR studies will be reported in due course.