Oxindole derivatives as orally active potent growth hormone secretagogues

Journal of Medicinal Chemistry

Volumn 44, Issue 26, 2001, Pages 4641-4649

  Tokunaga, T ^a   Hume, W E ^a   Umezome, T ^a   Okazaki, K ^a   Ueki, Y ^a   Kumagai, K ^a   Hourai, S ^b   Nagamine, J ^a   Seki, H ^a   Taiji, M ^a   Noguchi, H ^a   Nagata, R ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^b SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 3 METHYL N [2,3,4,5 TETRAHYDRO 2 OXO 1 [[2' (1H TETRAZOL 5 YL) 1,1' BIPHENYL 4 YL]METHYL] 1H 1 BENZAZEPIN 3 YL]BUTANAMIDE; 6 CARBAMOYL 3 (2 CHLOROPHENYL)(2 DIETHYLAMINOETHYL) 4 TRIFLUOROMETHYLOXINDOLE; CAPROMORELIN; GROWTH HORMONE DERIVATIVE; IBUTAMOREN; LY 444711; OXINDOLE; SM 130686; TABIMORELIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; FEMALE; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BODY WEIGHT; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; ETHYLAMINES; FEMALE; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; INDOLES; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PITUITARY GLAND, ANTERIOR; RATS; RATS, INBRED F344; RATS, WISTAR; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035924185     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0103763     Document Type: Article

References (49)

1. Consequences of growth hormone deficiency in adults and the benefits and risks of recombinant human growth hormone treatment
2. Human growth hormone
3. Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH
4. Effect of recombinant human growth hormone on donor site healing in severely burned children
5. Update on growth hormone therapy for Turner's syndrome
6. Growth hormone therapy in elderly people: An age-delaying drug?
7. Effects of human growth hormone in men over 60 years old
8. Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old
9. Effect of the enkephalins and enkephalin analogues on release of pituitary hormones in vitro
10. On the actions of growth hormone releasing peptide, GHRP
11. Structure-activity relationships of a synthetic pentapeptide that specifically releases growth hormone in vitro
12. Design, synthesis, and biological activity of peptides which release growth hormone in vitro
13. Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides
14. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
15. Oral activity of the growth hormone releasing peptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 in rats, dogs and monkeys
16. Growth hormone (GH) releasing peptide stimulates GH secretion in normal men and acts synergistically with GH releasing hormone
17. The growth hormone-releasing activity of a synthetic hexapeptide in normal men and short statured children after oral administration
18. Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men
19. Peptidomimetic growth hormone secretagogues. Design consideration and therapeutic potential
20. Benzolactam growth hormone secretagogues
21. Novel orally active growth hormone secretagogues
22. A novel non-peptidyl growth hormone secretagogue
23. A novel 3-substituted benzazepinone growth hormone secretagogue (L-692,429)
24. Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6
25. Enhancement of pulsatile growth hormone secretion by continuous infusion of a growth hormone releasing peptide (GHRP)-mimetic, L-692,429, in older adults
26. L-692,429, a nonpeptide growth hormone (GH) secretagogue, reverses glucocorticoid suppression of GH secretion
27. Neuroendocrine responses to a novel growth hormone secretagogue, L-692,429, in healthy older subjects
28. Pharmacokinetics and disposition of L-692,429, a novel nonpeptidyl growth hormone secretagogue in preclinical species
29. Design and biological activities of L-163,191 (MK-0677): A potent orally active growth hormone secretagogue
30. A receptor in pituitary and hypothalamus that functions in growth hormone release
31. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripherial tissues
32. Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors
33. 2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture
34. Ghrelin is a growth-hormone-releasing acylated peptide from stomach
35. 3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex
36. A convenient synthesis of acetylenes: Catalytic substitutions of acetylenic hydrogen with bromoalkens, iodoarenes, and bromopyridines
37. Generation of azasulfonium salts from halogen-sulfide complexes and anilines. The synthesis of indoles, oxindoles, and alkylated aromatic amines bearing cation stabilizing substituents
38. Synthesis of tricyclic indole-2-caboxylic acid as potent NMDA-glycine antagonists
39. A simple method for converting nitriles to amides. Hydrolysis with potassium hydroxide in tert-butyl alcohol
40. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
41. Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686
42. Ghrelin induces adiposity in rodents
43. Development of a high specific activity sulfur-35-labeled sulfonamide radioligand that allowed the identification of a new growth hormone secretagogue receptor
44. Adenosine is an agonist of the growth hormone secretagogue receptor
45. Adenosine: A partial agonist of the growth hormone secretagogue receptor