Mast cells express novel functional IL-15 receptor α isoforms

Journal of Immunology

Volumn 170, Issue 10, 2003, Pages 5045-5055

  Bulanova, Elena ^a   Budagian, Vadim ^a   Orinska, Zane ^a   Krause, Hans ^b   Paus, Ralf ^c   Bulfone Paus, Silvia ^a  

^a Centre for Research Borstel   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15 RECEPTOR; ISOPROTEIN; JANUS KINASE; JANUS KINASE 2; STAT3 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL STRAIN COS7; CELL SURVIVAL; CONFOCAL MICROSCOPY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0038561082     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.10.5045     Document Type: Article

References (50)

1. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, et al. 1994. Cloning of a T cell factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965.
2. Burton, J. D., R. N. Bamford, C. Peters, A. J. Grant, G. Kuris, C. K. Goldman, J. Brennan, E. Roessler, and T. A. Waldmann. 1994. A lymphokine, provisionally designated interleukin T and produced by T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91:4935.
3. Trentin, L., R. Zambello, M. Facco, R. Sancetta, C. Agostini, and G. Semenzato. 1997. Interleukin-15: a novel cytokine with regulatory properties on normal and neoplastic B lymphocytes. Leuk. Lymph. 27:35.
4. Bulfone-Paus, S., H. Dürkop, R. Paus, H. Krause, T. Pohl, and A. Onu. 1997. Differential regulation of human T lymphoblast functions by IL-2 and IL-15. Cytokine 9:507.
5. Armitage, R. G., B. M. Macduff, J. Eisenman, R. Paxton, and K. H. Grabstein. 1995. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 154:483.
6. Rueckert, R., U. Herz, R. Paus, D. Ungureanu, T. Pohl, H. Renz, and S. Bulfone-Paus. 1998. IL-15-1gG2b fusion protein accelerates and enhances a Th2 but not a Th1 response in vivo, while IL-2-1gG2b fusion protein inhibits both. Eur. J. Immunol. 28:3312.
7. Wilkinson, P. C., and F. Y. Liew. 1995. Chemoattraction of human blood T lymphocytes by IL-15. J. Exp. Med. 181:1255.
8. Waldman, T., and Y. Tagaya. 1999. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogenes. Annu. Rev. Immunol. 17:19.
9. Rückert, R., K. Asadullah, M. Seifert, V. Budagian, R. Arnold, C. Trombotto, R. Paus, and S. Bulfone-Paus. 2000. Inhibition of keratinocyte apoptosis by IL-15: a new parameter in the pathogenesis of psoriasis? J. Immunol. 165:2240.
10. Bulfone-Paus, S., D. Ungureanu, T. Pohl, G. Lindner, R. Paus, R. Rückert, H. Krause, and U. Kunzendorf. 1997. Interleukin-15 protects from lethal apoptosis in vivo. Nat. Med. 3:1124.
11. + T cell responsiveness to antigen. J. Immunol. 161:2141.
12. Pereno, R., J. Giron-Michel, A. Gaggero, R. Meazza, M. Monetti, E. Monaco, Z. Mishal, C. Jasmin, F. Indiveri, S. Ferrini, and B. Azzarone. 2000. IL-15/IL-15Rα intracellular trafficking in human melanoma cells and signal transduction through the IL-15Rα. Oncogene 19:5153.
13. L expression. J. Biol. Chem. 276:26107.
14. Tagaya, Y., J. D. Burton, Y. Miyamoto, and T. A. Waldmann. 1996. Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells. EMBO J. 15:4928.
15. Masuda, A., T. Matsuguchi, K. Yamaki, T. Hayakawa, M. Kubo, W. LaRochelle, and Y. Yoshikai. 2000. Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells. J. Biol. Chem. 275:29331.
16. Kennedy, M. K., M. Glaccum, S. N. Brown, E. A. Butz, J. L. Viney, M. Embers, N. Matsuki, K. Charrier, L. Sedger, C. R. Willis, et al. 2000. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J. Exp. Med. 191:771.
17. Lodolce, J. P., D. L. Boone, S. Chai, R. E. Swain, T. Dassopoulos, S. Trettin, and A. Ma. 1998. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9:669.
18. Carson, W. E., J. G. Giri, M. J. Lindemann, M. L. Linett, M. Ahdieh, R. Paxton, D. M. Anderson, J. Eisenman, K. H. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of IL-2 receptor. J. Exp. Med. 180:1395.
19. c. Immunol. Rev. 138:61.
20. Giri, J. G., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, A. Namen, L. S. Park, D. Cosman, and D. Anderson. 1994. Utilization of β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822.
21. Lehours, P., S. Racher, S. Dubois, J. Guo, A. Godard, and Y. Jacques. 2000. Subunit structure of the high and low affinity human interleukin-15 receptors. Eur. Cytokine Network 11:207.
22. Giri, J. G., S. Kumaki, M. Ahdieh, D. J. Friend, A. Loomis, K. Shanebeck, R. DuBose, D. Cosman, L. S. Park, and D. M. Anderson. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the α chain of the IL-2 receptor. EMBO J. 14:3654.
23. Doherty, T. M., R. A. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735.
24. Quinn, L. S., K. L. Haugk, and K. H. Grabstein. 1995. IL-15: a novel anabolic cytokine for skeletal muscle. Endocrinology 136:3669.
25. Satoh, J., K. Kurohara, M. Yukitake, and Y. Kuroda. 1998. Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues. J. Neuro. Sci. 155:170.
26. Musso, T., L. Calosso, M. Zucca, M. Millesimo, D. Ravarino, M. Giovarelli, F. Malavasi, A. Negro Ponzi, R. Paus, and S. Bulfone-Paus. 1999. Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-up-regulated interleukin- 15. Blood 93:3531.
27. Bulfone-Paus, S., E. Bulanova, T. Pohl, V. Budagian, H. Dürkop, R. Rückert, U. Kunzendorf, R. Paus, and H. Krause. 1999. Death deflected: IL-15 inhibits TNF-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Rα chain. FASEB J. 13:1575.
28. Bulanova, E., V, Budagian, T. Pohl, H. Krause, H. Dürkop, R. Paus, and S. Bulfone Paus. 2001. The IL-15Rα chain signals through association with Syk in human B cells. J. Immunol. 167:6292.
29. Galli, S. J., J. Wedemeyer, and M. Tsai. 2002. Analyzing the roles of mast cells and basophils in host defense and other biological responses. Int. J. Hematol. 75:363.
30. Wedemeyer, J., T. Mindy, and S. J. Galli. 2000. Role of mast cells and basophils in innate and acquired immunity. Curr. Opin. Immunol. 12:624.
31. Henz, B. M., M. Maurer, U. Lippert, M. Worm, and M. Babina. 2001. Mast cells as initiators of immunity and host defense. Exp. Dermatol. 10:1.
32. + mast cells and their progenitors to IL-3 and stem factor. J. Immunol. 155:4024.
33. Johnston, J. A., C. M. Bacon, D. S. Finbloom, R. C. Rees, D. Kaplan, K. Shibuya, J. R. Ortaldo, S. Gupta, Y. Q. Chen, J. D. Giri, and J. J. O'Shea. 1995. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukin 2 and 15. Proc. Natl. Acad. Sci. USA 92:8705.
34. Huff, T. F., and C. S. Lantz. 1997. Culture of mast cells. In Immunology Methods Manual I. Lefkovits, ed. Academic Press, London, p. 1393.
35. Schreiber, E., P. Matthias, M. M. Mueller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res. 17:6918.
36. Lowenthal, J. W., T. R. Malek, and H. Saragivi. 1997. Measurement of lymphokine receptors. In Current Protocols in Immunology. J. E. Coligan, A. M. Fruisbeek, D. H. Margulies, E. M. Shevach, and W. C. Strober, eds. John Wiley and Sons, New York, p. 6.1.1.
37. Scatchard, G. 1949. The attraction of proteins for small molecules and ions. Ann. NY Acad. Sci. 51:660.
38. Sugamura, K., H. Asao, M. Kondo, N. Tanaka, N. Ishii, K. Ohbo, M. Nakamura, and T. Takeshita. 1996. The interleukin-2 receptor γ chain: its role in the multiple cytokine receptor complexes and T cells development in XSCID. Annu. Rev. Immunol. 14:179.
39. Dubois, S., F. Magrangeas, P. Lehours, S. Raher, J. Bernard, O. Boisteau, S. Leroy, S. Minvielle, A. Godard, and Y. Jacques. 1999. Natural splicing of exon 2 of human interleukin-15 receptor α-chain mRNA in shortened form with a distinct pattern of expression. J. Biol. Chem. 274:26978.
40. Stanley, P. 1998. Structures and metabolism of polysaccharides and glycoproteins. In Biochemistry. G. L. Zubay and R. Worthington, eds. William C. Brown Publishers, Dubuque, p. 402.
41. Anderson, D. M., S. Kumaki, M. Ahdieh, J. Bertles, M. Tometsko, A. Loomis, J. G. Giri, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, et al. 1995. Functional characterization of the human interleukin-15 receptor a chain and close linkage of IL15RA and IL2RA genes. J. Biol. Chem. 270:29862.
42. Sherman, M. A., V. H. Secor, and M. A. Brown. 1999. IL-4 preferentially activates a novel STAT6 isoform in mast cells. J. Immunol. 162:2703.
43. Nelson, B. H., J. D. Lord, and P. D. Greenberg. 1994. Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation. Nature 369:333.
44. Deutsch, H. H., J. Chung, and F. S. Kalthoff. 1998. Function of the human interleukin 4 receptor (IL-4R)-derived acidic motif revealed by cytoplasmic domain chimeras of the IL-4Rα chain and the IL-2Rβ chain. Cytokine 10:331.
45. c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 41:8725.
46. Zhang, J., E. H. Berenstein, R. L. Evans, and R. P. Siraganian. 1996. Transfection of Syk protein kinase reconstitutes high affinity IgE-receptor mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells. J. Exp. Med. 184:71.
47. Smith. X. G., E. M. Bolton, H. Ruchatz, X. Wei, F. Y. Liew, and J. A. Bradley. 2000. Selective blockade of IL-15 by soluble IL-15 receptor α-chain enhances cardiac allograft survival. J. Immunol. 165:3444.
48. c)- and Jak3-dependent signaling in the proliferation and survival of murine mast cells. Blood 96:2171.
49. Malaviya, R., D. Zhu, I. Dibirdik, and F. M. Uckun. 1999. Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis. J. Biol. Chem. 274:27028.
50. Malaviya, R., C.-L. Chen, C. Navara, R. Malaviya, X.-P. Lui, M. Keenan, B. Waurzyniak, and F. M. Uckun. 2000. Treatment of allergic asthma by targeting Janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3′,5′-dibromo-4′-hydroxyphenyl)amino-6, 7-dimethoxyquinazoline (WHI-P97). J. Pharmacol. Exp. Ther. 295:912.