Cortical cholinergic denervation elicits vascular Aβ deposition

Annals of the New York Academy of Sciences

Volumn 903, Issue , 2000, Pages 366-373

  Roher, Alex E ^a   Kuo, Yu Min ^a   Potter, Pamela E ^a   Emmerling, Mark R ^b   Durham, Robert A ^b   Walker, Douglas G ^a   Sue, Lucia I ^a   Honer, William G ^c   Beach, Thomas G ^a  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; AMYLOID BETA PROTEIN; CHOLINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; CHOLINERGIC SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; DENERVATION; NONHUMAN; OLIVARY NUCLEUS; PERFUSION; RABBIT; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0034101474     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06388.x     Document Type: Conference Paper

References (41)

1. 1. KIDD, M. 1964. Alzheimer's disease: an electron microscopical study. Brain 87: 307-320.
2. 2. TERRY, R.D., N.K. GONATAS & M. WEISS. 1964. Ultrastructural studies in Alzheimer's presenile dementia. Am. J. Pathol. 44: 269-297.
3. 3. LEE, V.M., B.J. BALIN, L.J. OTVOS, & J.Q. TROJANOWSKI. 1991. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. Science 251: 675-678.
4. 4. GOUX, W.J., S. RODRIGUEZ & D.R. SPARKMAN. 1996. Characterization of the glycolipid associated with Alzheimer paired helical filaments. J. Neurochem. 67: 723-733.
5. 5. VINTERS, H.V., D.L. SECOR, S.L. READ, J.G. FRAZEE, U. TOMIYASU, T.M. STANLEY, J.A. FERREIRO & M.A. AKERS. 1994. Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: an immunohistochemical and ultrastructural study. Ultrastruct. Pathol. 18: 333-348.
6. 6. MIYAKAWA, T. & R. KURAMOTO. 1989. Ultrastructural study of senile plaques and microvessels in the brain with Alzheimer's disease and Down's syndrome. Ann. Med. 21: 99-102.
7. 7. KAWAI, M., R.N. KALARIA, P. CRAS, S.L. SIEDLAK, M.E. VELASCO, E.R. SHELTON, H.W. CHAN, B.D. GREENBERG & G. PERRY. 1993. Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease. Brain Res. 623: 142-146.
8. 8. ZAROW, C., E. BARRON, H.C. CHUI & L.S. PERLMUTTER. 1997. Vascular basement membrane pathology and Alzheimer's disease. Ann. N.Y. Acad. Sci. 826: 147-160.
9. 9. GRAMMAS, P., A.E. ROHER & M.J. BALL. 1994. Increased accumulation of cAMP in cerebral microvessels in Alzheimer's disease. Neurobiol. Aging 15: 113-116.
10. 10. GRAMMAS, P., P. MOORE, T. BOTCHLET, O. HANSON-PAINTON, D.R. COOPER, M.J. BALL & A. ROHER. 1995. Cerebral microvessels in Alzheimer's have reduced protein kinase C activity. Neurobiol. Aging 16: 563-569.
11. 11. SIMPSON, I.A., K.R. CHUNDU, T. DAVIES-HILL, W.G. HONER & P. DAVIES. 1994. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann. Neurol. 35: 546-551.
12. 12. SHIMOHAMA, S., T. TANIGUCHI, M. FUJIWARA & M. KAMEYAMA. 1986. Biochemical characterization of alpha-adrenergic receptors in human brain and changes in Alzheimer-type dementia. J. Neurochem. 47: 1295-1301.
13. 13. BRUEL, A., G. CHERQUI, S. COLUMELLI, D. MARGELIN, M. ROUDIER, P.M. SINET, M. PRIEUR, J.L. PERIGNON & J. DELABAR. 1991. Reduced protein kinase C activity in sporadic Alzheimer's disease fibroblasts. Neurosci. Lett. 133: 89-92.
14. 14. DORHEIM, M.A., W.R. TRACEY, J.S. POLLOCK & P. GRAMMAS. 1994. Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease. Biochem. Biophys. Res. Commun. 205: 659-665.
15. 15. WISNIEWSKI, H.M., A.W. VORBRODT & J. WEGIEL. 1997. Amyloid angiopathy and blood-brain barrier changes in Alzheimer's disease. Ann. N.Y. Acad. Sci. 826: 161-172.
16. 16. ROHER, A.E., J.D. LOWENSON, S. CLARKE, A.S. WOODS, R.J. COTTER, E. GOWING & M.J. BALL. 1993. β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. Proc. Natl. Acad. Sci. USA 90: 10836-10840.
17. 17. GREENBERG, S.M., G.W. REBECK, J.P. VONSATTEL, T. GOMEZ-ISLA & B.T. HYMAN. 1995. Apolipoprotein E ε4 and cerebral hemorrhage associated with amyloid angiopathy. Ann. Neurol. 38: 254-259.
18. 18. PREMKUMAR, D.R., D.L. COHEN, P. HEDERA, R.P. FRIEDLAND & R.N. KALARIA. 1996. Apolipoprotein E-ε4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am. J. Pathol. 148: 2083-2095.
19. 19. LUE, L.-F., Y.M. KOU, A.E. ROHER, L. BRACHOVA, Y. SHEN, L. SUE, T. BEACH, J.H. KURTH, R. RYDEL & J. ROGERS. 1999. Soluble amyloid peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155: 853-862.
20. 20. SATO, A. & Y. SATO. 1992. Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain. Neurosci. Res. 14: 242-274.
21. 21. EDVINSSON, L., E.T. MACKENZIE & J. MCCULLOCH. 1993. Cerebral Blood Flow and Metabolism. Raven Press. New York.
22. 22. ICHIMIYA, Y., H. ARAI, K. KOSAKA & R. IIZUKA. 1986. Morphological and biochemical changes in the cholinergic and monoaminergic systems in Alzheimer-type dementia. Acta Neuropathol. (Berl.) 70: 112-116.
23. 23. ZWEIG, R.M., C.A. Ross, J.C. HEDREEN, C. STEELE, J.E. CARDILLO, P.J. WHITEHOUSE, M.F. FOLSTEIN & D.L. PRICE. 1988. The neuropathology of aminergic nuclei in Alzheimer's disease. Ann. Neurol. 24: 233-242.
24. 24. BEACH, T.G., H. TAGO, T. NAGAI, H. KIMURA, P.L. MCGEER & E.G. MCGEER. 1987. Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation. J. Neurosci. Methods 19: 183-192.
25. 25. TAGO, H., H. KIMURA & T. MAEDA. 1986. Visualization of detailed acetylcholinesterase fiber and neuron staining in rat brain by a sensitive histochemical procedure. J. Histochem. Cytochem. 34: 1431-1438.
26. 26. FONNUM, F. 1975. A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24: 407-409.
27. 27. STREIT, W.J. 1990. An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4). J. Histochem. Cytochem. 38: 1683-1686.
28. 28. RABY, C.A., M.C. MORGANTI-KOSSMANN, T. KOSSMANN, P.F. STAHEL, M.D. WATSON, L.M. EVANS, P.D. MEHTA, K. SPIEGEL, Y.M. KOU, A.E. ROHER & M.R. EMMERLING. 1998. Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid. J. Neurochem. 71: 2505-2509.
29. 29. HONER, W.G., P. FALKAI, C. YOUNG, T. WANG, J. XIE, J. BONNER, L. HU, G.L. BOULIANNE, Z. LOU & W.S. TRIMBLE. 1997. Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience 78: 99-110.
30. 30. BEACH, T.G., L.I. SUE, S. SCOTT & D.L. SPARKS. 1998. Neurofibrillary tangles are constant in aging human nucleus basalis. Alzheimer's Reports 1: 375-380.
31. 31. DAVIES, P. & A.J. MALONEY. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 1403.
32. 32. FUNATO, H., M. YOSHIMURA, K. KUSUI, A. TAMAOKA, K. ISHIKAWA, N. OHKOSHI, K. NAMEKATA, R. OKEDA & Y. IHARA. 1998. Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease. Am. J. Pathol. 152: 1633-1640.
33. 33. NITSCH, R.M., B.E. SLACK, R.J. WURTMAN & J.H. GROWDON. 1992. Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors. Science 258: 304-307.
34. 34. WAITE, J.J., D.P. HOLSCHNEIDER & O.U. SCREMIN. 1999. Selective immunotoxin-induced cholinergic deafferentation alters blood flow distribution in the cerebral cortex. Brain Res. 818: 1-11.
35. 35. ARENDT, T., C. SCHINDLER, M.K. BRUCKNER, K. ESCHRICH, V. BIGL, D. ZEDLICK & L. MARCOVA. 1997. Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein ε4 allele. J. Neurosci. 17: 516-529.
36. 36. SKOOG, I., B. LERNFELT, S. LANDAHL, B. PALMERTZ, L.A. ANDREASSON, L. NILSSON, G. PERSSON, A. ODEN & A. SVANBORG. 1996. 15-year longitudinal study of blood pressure and dementia. Lancet 347: 1141-1145.
37. 37. KALMIJN, S., L.J. LAUNER, A. OTT, J.C. WITTEMAN, A. HOFMAN & M.M. BRETELER. 1997. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann. Neurol. 42: 776-782.
38. 38. MILLER, J.W. 1999. Homocysteine and Alzheimer's disease. Nutr. Rev. 57: 126-129.
39. 39. BIRGE, S.J. & K.F. MORTEL. 1997. Estrogen and the treatment of Alzheimer's disease. Am. J. Med. 103: 36S-45S.
40. 40. CRAWFORD, F., Z. SOU, C. FANG & M. MULLAN. 1998. Characteristics of the in vitro vasoactivity of beta-amyloid peptides. Exp. Neurol. 150: 159-168.
41. 41. SCHENK, D., R. BARBOUR, W. DUNN, G. GORDON, H. GRAJEDA, T. GUIDO, K. HU, J. HUANG, K. JOHNSON-WOOD, K. KHAN, D. KHOLODENKO, M. LEE, Z. LIAO, I. LIEBERBURG, R. MOTTER, L. MUTTER, F. SORIANO, G. SHOPP, N. VASQUEZ, C. VANDEVERT, S. WALKER, M. WOGULIS, T. YEDNOCK, D. GAMES & P. SEUBERT. 1999. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400: 173-177.