Regulation of BNIP3 in normal and cancer cells

Molecules and Cells

Volumn 21, Issue 1, 2006, Pages 1-6

  Lee, Hayyoung ^a   Paik, Sang Gi ^a  

^a Chungnam National University   (South Korea)

Author keywords

Apoptosis; Bcl 2; BH3; BNIP3; Hypoxia

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BH3 PROTEIN; FLUOROURACIL; GEMCITABINE; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN BCL 2; PROTEIN BNIP3; BNIP3 PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BINDING SITE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER RESISTANCE; CELLULAR DISTRIBUTION; COLORECTAL CANCER; CPG ISLAND; DOWN REGULATION; DRUG TARGETING; GENE SILENCING; GLIOBLASTOMA; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; LUNG NON SMALL CELL CANCER; LYMPHATIC LEUKEMIA; MULTIPLE MYELOMA; NONHUMAN; PANCREAS CANCER; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METHYLATION; SHORT SURVEY; SOLID TUMOR; STOMACH CANCER; TUMOR PROMOTION; UPREGULATION; CELL DEATH; CELL HYPOXIA; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; NEOPLASM; REVIEW;

ADENOVIRIDAE; ANIMALIA;

CELL DEATH; CELL HYPOXIA; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; NEOPLASMS; PROTO-ONCOGENE PROTEINS;

EID: 33645730274     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (50)

1. Abe, T., Toyota, M., Suzuki, H., Murai, M., Akino, K., et al. (2005) Upregulation ot BNIP3 by 5-aza-2′-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death. J. Gastroenterol. 40, 504-510.
2. Agani, F. H., Puchowicz, M., Chavez, J. C., Pichiule, P., and LaManna, J. (2002) Role of nitric oxide in the regulation of HIF-1alpha expression during hypoxia. Am. J. Physiol. Cell Physiol. 283, C178-186.
3. Akada, M., Crnogorac-Jurcevic, T., Lattimore, S., Mahon, P., Lopes, R., et al. (2005) Intrinsic chemoresistance to gemcitabine is associated with decreased expression ot BNIP3 in pancreatic cancer. Clin. Cancer Res. 11, 3094-3101.
4. Bacon, A. L. and Harris, A. L. (2004) Hypoxia-inducible factors and hypoxic cell death in tumour physiology. Ann. Med. 36, 530-539.
5. Baetz, D., Regula, K. M., Ens, K., Shaw, J., Kothari, S., et al. (2005) Nuclear factor-kappaB-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation 112, 3777-3785.
6. Blouin, C. C., Page, E. L., Soucy, G. M., and Richard, D. E. (2004) Hypoxic gene activation by lipopolysaccharide in macrophages: implication ot hypoxia-inducible factor 1 alpha. Blood 103, 1124-1130.
7. Boyd, J. M., Malstrom, S., Subramanian, T., Venkatesh, L. K., Schaeper, U., et al. (1994) Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell 79, 341-351.
8. Bruick, R. K. (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. USA 97, 9082-9087.
9. Burton, T. R., Henson, E. S., Baijal, P., Eisenstat, D. D., and Gibson, S. B. (2005) The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia. Int. J. Cancer 118, 1660-1669.
10. Chen, G., Ray, R., Dubik, D., Shi, L., Cizeau, J., et al. (1997) The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. J. Exp. Med. 186, 1975-1983.
11. Chen, G., Cizeau, J., Vande Velde, C., Park, J. H., Bozek, G., et al. (1999) Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J. Biol. Chem. 274, 7-10.
12. Chun, Y. S., Kim, M. S., and Park, J. W. (2002) Oxygen-dependent and -independent regulation of HIF-1alpha. J. Korean. Med. Sci. 17, 581-588.
13. Crow, M. T. (2002) Hypoxia, BNip3 proteins, and the mitochondrial death pathway in cardiomyocytes. Circ. Res. 91, 183-185.
14. de Angelis, P. M., Fjell, B., Kravik, K. L., Haug, T., Tunheim, S. H., et al. (2004) Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil. Int. J. Oncol. 24, 1279-1288.
15. Erkan, M., Kleeff, J., Esposito, I., Giese, T., Ketterer, K., et al. (2005) Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene 24, 4421-4432.
16. Fei, P., Wang, W., Kim, S. H., Wang, S., Burns, T. F., et al. (2004) Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. Cancer Cell 6, 597-609.
17. Giatromanolaki, A., Koukourakis, M. I., Sowter, H. M., Sivridis, E., Gibson, S., et al. (2004) BNIP3 expression is linked with hypoxia-regulated protein expression and with poor prognosis in non-small cell lung cancer. Clin. Cancer Res. 10, 5556-5571.
18. Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., et al. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379, 88-91.
19. Guo, K., Searfoss, G., Krolikowski, D., Pagnoni, M., Franks, C., et al. (2001) Hypoxia induces the expression of the proapoptotic gene BNIP3. Cell Death. Differ. 8, 367-376.
20. Guscetti, F., Nath, N., and Denko, N. (2005) Functional characterization of human proapoptotic molecules in yeast S. cerevisiae. FASEB J. 19, 464-466.
21. Hemish, J., Nakaya, N., Mittal, V., and Enikolopov, G. (2003) Nitric oxide activates diverse signaling pathways to regulate gene expression. J. Biol. Chem. 278, 42321-42329.
22. Kanzawa, T., Zhang, L., Xiao, L., Germano, I. M., Kondo, Y., et al. (2005) Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mithochondrial cell death protein BNIP3. Oncogene 24, 980-991.
23. Kennedy, A. S., Harrison, G. H., Mansfield, C. M., Zhou, X. J., Xu, J. F., et al. (2000) Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: effect of TP53 or hMLH1 defeciency. Int. J. Cancer 90, 175-185.
24. Kim, J. Y., Cho, J. J., Ha, J., and Park, J. H. (2002) The carboxy terminal C-tail of BNip3 is crucial in induction of mitochondrial permiability transition in isolated mitochondria. Arch. Biochem. Biophys. 398, 147-152.
25. Kimura, H., Weisz, A., Kurashima, Y., Hashimoto, K., Ogura, T., et al. (2000) Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 95, 189-197.
26. Kothari, S., Cizeau, J., McMillan-Ward, E., Israels, S. J., Bailes, M., et al. (2003) BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene 22, 4734-4744.
27. Kubasiak, L. A., Hernandez, O. M., Bishopric, N. H., and Webster, K. A. (2002) Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3. Proc. Natl. Acad. Sci. USA 99, 12825-12830.
28. Lamy, L., Ticchioni, M., Rouquette-Jazdanian, A. K., Samson, M., Deckert, M., et al. (2003) CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apooptosis. J. Biol. Chem. 278, 23915-23921.
29. Marsden, V. S. and Strasser, A. (2003) Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu. Rev. Immunol. 21, 71-105.
30. Mateo, J., Garcia-Lecea, M., Cadenas, S., Hernandez, C., and Moncada, S. (2003) Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and - independent pathways. Biochem. J. 376, 537-544.
31. Matsushima, M., Fujiwara, T., Takahashi, E., Minaguchi, T., Eguchi, Y., et al. (1998) Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. Genes Chromosomes Cancer 21, 230-235.
32. Metzen, E., Zhou, J., Jelkmann, W., Fandrey, J., and Brune, B. (2003) Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases. Mol. Biol. Cell. 14, 3470-3481.
33. Mizutani, A., Fukurawa, T., Adachi, Y., Ikehara, S., and Taketani, S. (2002) A zinc-finger protein, PLAGL2, induces the expression of proapoptotic protein Nip3, leading to cellular apoptosis. J. Biol. Chem. 277, 15851-15858.
34. Murai, M., Toyota, M., Satoh, A., Suzuki, H., Akino, K., et al. (2005a) Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tomours. Br. J. Cancer 92, 1165-1172.
35. Murai, M., Toyota, M., Suzuki, H., Satoh, A., Sasaki, Y., et al. (2005b) Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer. Clin. Cancer Res. 11, 1021-1027.
36. Okami, J., Simeone, D. M., and Logsdon, C. D. (2004) Silencing of the hypoxia-inducible cell death protein BNIP3 in pancreatic cancer. Cancer Res. 64, 5338-5346.
37. Palmer, L. A., Gaston, B., and Johns, R. A. (2000) Normoxic stabilization of hypoxia-inducible factor-1 expression and activity: redox-dependent effect of nitrogen oxides. Mol. Pharmacol. 58, 1197-1203.
38. Piret, J. P., Mottet, D., Raes, M., and Michiels, C. (2002) Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochem. Pharmacol. 64, 889-892.
39. Ray, R., Chen, G., Vande Velde, C., Cizeau, J., Park, J. H., et al. (2000) BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both miochondrial and nonmitochondrial sites. J. Biol. Chem. 275, 1439-1448.
40. Regula, K. M., Ens, K., and Kirshenbaum, L. A. (2002) Inducible expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes. Circ. Res. 91, 226-231.
41. Sandau, K. B., Fandrey, J., and Brune, B. (2001) Accumulation of HIF-1alpha under the influence of nitric oxide. Blood 97, 1009-1015.
42. Sowter, H. M., Ratcliffe, P. J., Watson, P., Greenberg, A. H., and Harris, A. L. (2001) HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61, 6669-6673.
43. Sowter, H. M., Ferguson, M., Pym, C., Watson, P., Fox, S. B., et al. (2003) Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade. J. Pathol. 201, 573-580.
44. Turpaev, K., Bouton, C., Diet, A., Glatigny, A., and Drapier, J. C. (2005) Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells. Free Radic. Biol. Med. 38, 1392-1400.
45. Vande Velde, C., Cizeau, J., Dubik, D., Alimonti, J., Brown, T., et al. (2000) BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol. Cell. Biol. 20, 5454-5468.
46. Wan, J., Martinvalet, D., Ji, X., Lois, C., Kaech, S. M. et al. (2003) The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activition-induced cell death of effector cytotoxic T lymphocytes. Immunology 110, 10-17.
47. Webster, K. A., Graham, R. M., and Bishopric, N. H. (2005) BNip3 and signal-specific programmed death in the heart. J. Mol. Cell. Cardiol. 38, 35-45.
48. Yamashita, S., Tsujino, Y., Moriguchi, K., Tatematsu, M., and Ushijima, T. (2006) Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2′-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 97, 64-71.
49. Yasuda, M., Theodorakis, P., Subramanian, T., and Chinnadurai, G. (1998) Adenovirus E1B-19K/BCL-2 interacting protein BNIP3 contains a BH3 domain and mitochondrial targeting sequence. J. Biol. Chem. 273, 12415-12421.
50. Yook, Y. H., Kang, K. H., Maeng, O., Kim, T. R., Lee, J. O., et al. (2004) Nitric oxide induces BNIP3 expression that causes cell death in macrophages. Biochem. Biophys. Res. Commun. 321, 298-305.