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Volumn 58, Issue 4, 2006, Pages 469-479

Glucuronidation of trans-resveratrol by human liver and intestinal microsomes and UGT isoforms

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; 7 HYDROXYTRIFLUOROMETHYLCOUMARIN; BILIRUBIN; CARBON 14; COMPLEMENTARY DNA; COUMARIN DERIVATIVE; GLUCURONOSYLTRANSFERASE; PHYTOESTROGEN; RESVERATROL; STILBENE DERIVATIVE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 33645568250     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.4.0006     Document Type: Article
Times cited : (68)

References (60)
  • 3
    • 0346074656 scopus 로고    scopus 로고
    • Cancer chemoprevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms
    • Aziz, M. H., Kumar, R., Ahmad, N. (2003) Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review). Int. J. Oncol. 23: 17-28
    • (2003) Int. J. Oncol. , vol.23 , pp. 17-28
    • Aziz, M.H.1    Kumar, R.2    Ahmad, N.3
  • 6
    • 0028867826 scopus 로고
    • The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
    • Bosma, P. J., Chowdhury, J. R., Bakker, C., Gantla, S., Boer, A., Oostra, B. A. (1995) The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N. Engl. J. Med. 333: 1171-1175
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1171-1175
    • Bosma, P.J.1    Chowdhury, J.R.2    Bakker, C.3    Gantla, S.4    Boer, A.5    Oostra, B.A.6
  • 7
    • 0035192944 scopus 로고    scopus 로고
    • Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: Evidence for mechanism-based inactivation of CYP1A2
    • Chang, T. K., Chen, J., Lee, W. B. (2001) Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J. Pharmacol. Exp. Ther. 299: 874-882
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 874-882
    • Chang, T.K.1    Chen, J.2    Lee, W.B.3
  • 8
    • 0032862195 scopus 로고    scopus 로고
    • Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol
    • Ciolino, H. P., Yeh, G. C. (1999) Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol. Pharmacol. 56: 760-767
    • (1999) Mol. Pharmacol. , vol.56 , pp. 760-767
    • Ciolino, H.P.1    Yeh, G.C.2
  • 9
    • 0035197725 scopus 로고    scopus 로고
    • Interindividual variability in acetaminophen glucuronidation by human liver microsomes: Identification of relevant acetaminophen UDP- glucuronosyltransferase isoforms
    • Court, M. H., Duan, S. X., von Moltke, L. L., Greenblatt, D. J., Patten, C. J., Miners, J. O., Mackenzie, P. I. (2001) Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms. J. Pharmacol. Exp. Ther. 299: 998-1006
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 998-1006
    • Court, M.H.1    Duan, S.X.2    Von Moltke, L.L.3    Greenblatt, D.J.4    Patten, C.J.5    Miners, J.O.6    Mackenzie, P.I.7
  • 10
    • 0036842042 scopus 로고    scopus 로고
    • Stereoselective conjugation of oxazepam by human UDP- glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9
    • Court, M. H., Duan, S. X., Guillemette, C., Journault, K., Krishnaswamy, S., Von Moltke, L. L., Greenblatt, D. J. (2002) Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. Drug Metab. Dispos. 30: 1257-1265
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1257-1265
    • Court, M.H.1    Duan, S.X.2    Guillemette, C.3    Journault, K.4    Krishnaswamy, S.5    Von Moltke, L.L.6    Greenblatt, D.J.7
  • 11
    • 0001438682 scopus 로고
    • Congenital familial nonhemolytic jaundice with kernicterus
    • Crigler, J. F., Najjar, V. A. (1952) Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics 10: 169-180
    • (1952) Pediatrics , vol.10 , pp. 169-180
    • Crigler, J.F.1    Najjar, V.A.2
  • 12
    • 0034491047 scopus 로고    scopus 로고
    • Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver
    • De Santi, C., Pietrabissa, A., Mosca, F., Pacifici, G. M. (2000a) Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver. Xenobiotica 30: 1047-1054
    • (2000) Xenobiotica , vol.30 , pp. 1047-1054
    • De Santi, C.1    Pietrabissa, A.2    Mosca, F.3    Pacifici, G.M.4
  • 13
    • 0033777342 scopus 로고    scopus 로고
    • Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids
    • De Santi, C., Pietrabissa, A., Spisni, R., Mosca, F., Pacifici, G. M. (2000b) Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica 30: 857-866
    • (2000) Xenobiotica , vol.30 , pp. 857-866
    • De Santi, C.1    Pietrabissa, A.2    Spisni, R.3    Mosca, F.4    Pacifici, G.M.5
  • 14
    • 0033937909 scopus 로고    scopus 로고
    • Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum
    • De Santi, C., Pietrabissa, A., Spisni, R., Mosca, F., Pacifici, G. M. (2000c) Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum. Xenobiotica 30: 609-617
    • (2000) Xenobiotica , vol.30 , pp. 609-617
    • De Santi, C.1    Pietrabissa, A.2    Spisni, R.3    Mosca, F.4    Pacifici, G.M.5
  • 15
    • 0027521059 scopus 로고
    • Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol
    • Ebner, T., Remmel, R. P., Burchell, B. (1993) Human bilirubin UDP-glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol. Mol. Pharmacol. 43: 649-654
    • (1993) Mol. Pharmacol. , vol.43 , pp. 649-654
    • Ebner, T.1    Remmel, R.P.2    Burchell, B.3
  • 16
    • 0034458006 scopus 로고    scopus 로고
    • Characterization of the uridine diphosphate-glucuronosyl-transferase- catalyzing thyroid hormone glucuronidation in man
    • Findlay, K. A., Kaptein, E., Visser, T. J., Burchell, B. (2000) Characterization of the uridine diphosphate-glucuronosyl-transferase-catalyzing thyroid hormone glucuronidation in man. J. Clin. Endocrinol. Metab. 85: 2879-2883
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 2879-2883
    • Findlay, K.A.1    Kaptein, E.2    Visser, T.J.3    Burchell, B.4
  • 17
  • 18
    • 0026724017 scopus 로고
    • Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine
    • Frances, B., Gout, R., Monsarrat, B., Cros, J., Zajac, J. M. (1992) Further evidence that morphine-6 beta-glucuronide is a more potent opioid agonist than morphine. J. Pharmacol. Exp. Ther. 262: 25-31
    • (1992) J. Pharmacol. Exp. Ther. , vol.262 , pp. 25-31
    • Frances, B.1    Gout, R.2    Monsarrat, B.3    Cros, J.4    Zajac, J.M.5
  • 19
    • 0142243190 scopus 로고    scopus 로고
    • Relationship between mechanisms, bioavailability, and preclinical chemopreventive efficacy of resveratrol: A conundrum
    • Gescher, A. J., Steward, W. P. (2003) Relationship between mechanisms, bioavailability, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol. Biomarkers Prev. 12: 953-957
    • (2003) Cancer Epidemiol. Biomarkers Prev. , vol.12 , pp. 953-957
    • Gescher, A.J.1    Steward, W.P.2
  • 20
    • 4143072423 scopus 로고    scopus 로고
    • Identification of common polymorphisms in the promoter of the UGT1A9 gene: Evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver
    • Girard, H., Court, M. H., Bernard, O., Fortier, L. C., Villeneuve, L., Hao, Q., Greenblatt, D. J., von Moltke, L. L., Perussed, L., Guillemette, C. (2004) Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver. Pharmacogenetics 14: 501-515
    • (2004) Pharmacogenetics , vol.14 , pp. 501-515
    • Girard, H.1    Court, M.H.2    Bernard, O.3    Fortier, L.C.4    Villeneuve, L.5    Hao, Q.6    Greenblatt, D.J.7    Von Moltke, L.L.8    Perussed, L.9    Guillemette, C.10
  • 21
    • 0037292971 scopus 로고    scopus 로고
    • Cytochrome P450 1B1: A target for inhibition in anticarcinogenesis strategies
    • Guengerich, F. P., Chun, Y. J., Kim, D., Gillam, E. M., Shimada, T. (2003) Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies. Mutat. Res. 523-524: 173-182
    • (2003) Mutat. Res. , vol.523-524 , pp. 173-182
    • Guengerich, F.P.1    Chun, Y.J.2    Kim, D.3    Gillam, E.M.4    Shimada, T.5
  • 22
    • 0034778246 scopus 로고    scopus 로고
    • Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin
    • Hanioka, N., Ozawa, S., Jinno, H., Ando, M., Saito, Y., Sawada, J. (2001) Human liver UDP-glucuronosyltransferase isoforms involved in the glucuronidation of 7-ethyl-10-hydroxycamptothecin. Xenobiotica 31: 687-699
    • (2001) Xenobiotica , vol.31 , pp. 687-699
    • Hanioka, N.1    Ozawa, S.2    Jinno, H.3    Ando, M.4    Saito, Y.5    Sawada, J.6
  • 23
    • 0032519431 scopus 로고    scopus 로고
    • Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes
    • Iyer, L., King, C. D., Whitington, P. F., Green, M. D., Roy, S. K., Tephly, T. R., Coffman, B. L., Ratain, M. J. (1998) Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J. Clin. Invest. 101: 847-854
    • (1998) J. Clin. Invest. , vol.101 , pp. 847-854
    • Iyer, L.1    King, C.D.2    Whitington, P.F.3    Green, M.D.4    Roy, S.K.5    Tephly, T.R.6    Coffman, B.L.7    Ratain, M.J.8
  • 24
    • 0032934383 scopus 로고    scopus 로고
    • Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism
    • Iyer, L., Hall, D., Das, S., Mortell, M. A., Ramirez, J., Kim, S., Di Rienzo, A., Ratain, M. J. (1999) Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism. Clin. Pharmacol. Ther. 65: 576-582
    • (1999) Clin. Pharmacol. Ther. , vol.65 , pp. 576-582
    • Iyer, L.1    Hall, D.2    Das, S.3    Mortell, M.A.4    Ramirez, J.5    Kim, S.6    Di Rienzo, A.7    Ratain, M.J.8
  • 26
    • 0038663111 scopus 로고    scopus 로고
    • Glucuronidation of 1′-hydroxyestragole (1′-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9
    • Iyer, L. V., Ho, M. N., Shinn, W. M., Bradford, W. W., Tanga, M. J., Nath, S. S., Green, C. E. (2003) Glucuronidation of 1′-hydroxyestragole (1′-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9. Toxicol. Sci. 73: 36-43
    • (2003) Toxicol. Sci. , vol.73 , pp. 36-43
    • Iyer, L.V.1    Ho, M.N.2    Shinn, W.M.3    Bradford, W.W.4    Tanga, M.J.5    Nath, S.S.6    Green, C.E.7
  • 27
    • 2342572781 scopus 로고    scopus 로고
    • Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4
    • Kaku, T., Ogura, K., Nishiyama, T., Ohnuma, T., Muro, K., Hiratsuka, A. (2004) Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Biochem. Pharmacol. 67: 2093-2102
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 2093-2102
    • Kaku, T.1    Ogura, K.2    Nishiyama, T.3    Ohnuma, T.4    Muro, K.5    Hiratsuka, A.6
  • 28
    • 0037355909 scopus 로고    scopus 로고
    • Resveratrol transport and metabolism by human intestinal Caco-2 cells
    • Kaldas, M. I., Walle, U. K., Walle, T. (2003) Resveratrol transport and metabolism by human intestinal Caco-2 cells. J. Pharm. Pharmacol. 55: 307-312
    • (2003) J. Pharm. Pharmacol. , vol.55 , pp. 307-312
    • Kaldas, M.I.1    Walle, U.K.2    Walle, T.3
  • 29
    • 0031839670 scopus 로고    scopus 로고
    • Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?
    • Kopp, P. (1998) Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'? Eur. J. Endocrinol. 138: 619-620
    • (1998) Eur. J. Endocrinol. , vol.138 , pp. 619-620
    • Kopp, P.1
  • 31
    • 0037254693 scopus 로고    scopus 로고
    • A concise synthesis of the 3-O-beta-D- and 4′-O-beta-D-glucuronide conjugates of trans-resveratrol
    • Learmonth, D. A. (2003) A concise synthesis of the 3-O-beta-D- and 4′-O-beta-D-glucuronide conjugates of trans-resveratrol. Bioconjug. Chem. 14: 262-267
    • (2003) Bioconjug. Chem. , vol.14 , pp. 262-267
    • Learmonth, D.A.1
  • 33
    • 0036714769 scopus 로고    scopus 로고
    • Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol
    • Li, Z. G., Hong, T., Shimada, Y., Komoto, I., Kawabe, A., Ding, Y., Kaganoi, J., Hashimoto, Y., Imamura, M. (2002) Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 23: 1531-1536
    • (2002) Carcinogenesis , vol.23 , pp. 1531-1536
    • Li, Z.G.1    Hong, T.2    Shimada, Y.3    Komoto, I.4    Kawabe, A.5    Ding, Y.6    Kaganoi, J.7    Hashimoto, Y.8    Imamura, M.9
  • 34
    • 0347512122 scopus 로고    scopus 로고
    • Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: Application to resveratrol absorption and metabolism
    • Li, Y., Shin, Y. G., Yu, C., Kosmeder, J. W., Hirschelman, W. H., Pezzuto, J. M., van Breemen, R. B. (2003) Increasing the throughput and productivity of Caco-2 cell permeability assays using liquid chromatography-mass spectrometry: application to resveratrol absorption and metabolism. Comb. Chem. High Throughput Screen. 6: 757-767
    • (2003) Comb. Chem. High Throughput Screen. , vol.6 , pp. 757-767
    • Li, Y.1    Shin, Y.G.2    Yu, C.3    Kosmeder, J.W.4    Hirschelman, W.H.5    Pezzuto, J.M.6    Van Breemen, R.B.7
  • 36
    • 0036082463 scopus 로고    scopus 로고
    • Metabolism and disposition of resveratrol in rats: Extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model
    • Marier, J. F., Vachon, P., Gritsas, A., Zhang, J., Moreau, J. P., Ducharme, M. P. (2002) Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther. 302: 369-373
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 369-373
    • Marier, J.F.1    Vachon, P.2    Gritsas, A.3    Zhang, J.4    Moreau, J.P.5    Ducharme, M.P.6
  • 37
    • 0028308373 scopus 로고
    • Radioassay of UDP-glucuronosyltransferase activities toward endogenous substrates using labeled UDP-glucuronic acid and an organic solvent extraction procedure
    • Matern, H., Heinemann, H., Matern, S. (1994) Radioassay of UDP-glucuronosyltransferase activities toward endogenous substrates using labeled UDP-glucuronic acid and an organic solvent extraction procedure. Anal. Biochem. 219: 182-188
    • (1994) Anal. Biochem. , vol.219 , pp. 182-188
    • Matern, H.1    Heinemann, H.2    Matern, S.3
  • 38
    • 0037180317 scopus 로고    scopus 로고
    • The 4′-hydroxy group is responsible for the in vitro cytogenetic activity of resveratrol
    • Matsuoka, A., Takeshita, K., Furuta, A., Ozaki, M., Fukuhara, K., Miyata, N. (2002) The 4′-hydroxy group is responsible for the in vitro cytogenetic activity of resveratrol. Mutat. Res. 521: 29-35
    • (2002) Mutat. Res. , vol.521 , pp. 29-35
    • Matsuoka, A.1    Takeshita, K.2    Furuta, A.3    Ozaki, M.4    Fukuhara, K.5    Miyata, N.6
  • 39
    • 0037813163 scopus 로고    scopus 로고
    • Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats
    • Miura, D., Miura, Y., Yagasaki, K. (2003) Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats. Life Sci. 73: 1393-1400
    • (2003) Life Sci. , vol.73 , pp. 1393-1400
    • Miura, D.1    Miura, Y.2    Yagasaki, K.3
  • 41
    • 17744372584 scopus 로고    scopus 로고
    • Resveratrol: A whiff that induces a biologically specific tsunami
    • Pezzuto, J. M. (2004) Resveratrol: a whiff that induces a biologically specific tsunami. Cancer Biol. Ther. 3: 889-890
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 889-890
    • Pezzuto, J.M.1
  • 42
    • 0035976379 scopus 로고    scopus 로고
    • Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components
    • Piver, B., Berthou, F., Dreano, Y., Lucas, D. (2001) Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol. Lett. 125: 83-91
    • (2001) Toxicol. Lett. , vol.125 , pp. 83-91
    • Piver, B.1    Berthou, F.2    Dreano, Y.3    Lucas, D.4
  • 43
    • 3242676024 scopus 로고    scopus 로고
    • Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes
    • Piver, B., Fer, M., Vitrac, X., Merillon, J. M., Dreano, Y., Berthou, F., Lucas, D. (2004) Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Biochem. Pharmacol. 68: 773-782
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 773-782
    • Piver, B.1    Fer, M.2    Vitrac, X.3    Merillon, J.M.4    Dreano, Y.5    Berthou, F.6    Lucas, D.7
  • 45
    • 0036001388 scopus 로고    scopus 로고
    • In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes
    • Ramirez, J., Iyer, L., Journault, K., Belanger, P., Innocenti, F., Ratain, M. J., Guillemette, C. (2002) In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes. Pharm. Res. 19: 588-594
    • (2002) Pharm. Res. , vol.19 , pp. 588-594
    • Ramirez, J.1    Iyer, L.2    Journault, K.3    Belanger, P.4    Innocenti, F.5    Ratain, M.J.6    Guillemette, C.7
  • 46
    • 0036893374 scopus 로고    scopus 로고
    • Inhibition and active sites of UDP-glucuronosyltransferases 2B7 and 1A1
    • Rios, G. R., Tephly, T. R. (2002) Inhibition and active sites of UDP-glucuronosyltransferases 2B7 and 1A1. Drug Metab. Dispos. 30: 1364-1367
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1364-1367
    • Rios, G.R.1    Tephly, T.R.2
  • 47
    • 0027991904 scopus 로고
    • Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation
    • Senafi, S. B., Clarke, D. J., Burchell, B. (1994) Investigation of the substrate specificity of a cloned expressed human bilirubin UDP- glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation. Biochem. J. 303 (Pt 1): 233-240
    • (1994) Biochem. J. , vol.303 , Issue.PART 1 , pp. 233-240
    • Senafi, S.B.1    Clarke, D.J.2    Burchell, B.3
  • 48
    • 22844450866 scopus 로고    scopus 로고
    • Resveratrol as an anticancer nutrient: Molecular basis, open questions and promises
    • Signorelli, P., Ghidoni, R. (2005) Resveratrol as an anticancer nutrient: molecular basis, open questions and promises. J. Nutr. Biochem. 16: 449-466
    • (2005) J. Nutr. Biochem. , vol.16 , pp. 449-466
    • Signorelli, P.1    Ghidoni, R.2
  • 49
    • 0030800075 scopus 로고    scopus 로고
    • Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: Identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
    • Strassburg, C. P., Oldhafer, K., Manns, M. P., Tukey, R. H. (1997) Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue. Mol. Pharmacol. 52: 212-220
    • (1997) Mol. Pharmacol. , vol.52 , pp. 212-220
    • Strassburg, C.P.1    Oldhafer, K.2    Manns, M.P.3    Tukey, R.H.4
  • 50
    • 0032502764 scopus 로고    scopus 로고
    • Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8
    • Strassburg, C. P., Manns, M. P., Tukey, R. H. (1998) Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J. Biol. Chem. 273: 8719-8726
    • (1998) J. Biol. Chem. , vol.273 , pp. 8719-8726
    • Strassburg, C.P.1    Manns, M.P.2    Tukey, R.H.3
  • 51
    • 22344455999 scopus 로고    scopus 로고
    • Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms
    • Tallman, M. N., Ritter, J. K., Smith, P. C. (2005) Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP- glucuronosyltransferase isoforms. Drug Metab. Dispos. 33: 977-983
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 977-983
    • Tallman, M.N.1    Ritter, J.K.2    Smith, P.C.3
  • 52
    • 0033860505 scopus 로고    scopus 로고
    • Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression
    • Tessitore, L., Davit, A., Sarotto, I., Caderni, G. (2000) Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis 21: 1619-1622
    • (2000) Carcinogenesis , vol.21 , pp. 1619-1622
    • Tessitore, L.1    Davit, A.2    Sarotto, I.3    Caderni, G.4
  • 53
    • 0027496717 scopus 로고
    • Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol
    • Thakkar, K., Geahlen, R. L., Cushman, M. (1993) Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. J. Med. Chem. 36: 2950-2955
    • (1993) J. Med. Chem. , vol.36 , pp. 2950-2955
    • Thakkar, K.1    Geahlen, R.L.2    Cushman, M.3
  • 54
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., Jr., Walle, U. K. (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 32: 1377-1382
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    DeLegge, M.H.3    Oatis Jr., J.E.4    Walle, U.K.5
  • 55
    • 0037404036 scopus 로고    scopus 로고
    • Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1
    • Watanabe, Y., Nakajima, M., Ohashi, N., Kume, T., Yokoi, T. (2003) Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1. Drug Metab. Dispos. 31: 589-595
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 589-595
    • Watanabe, Y.1    Nakajima, M.2    Ohashi, N.3    Kume, T.4    Yokoi, T.5
  • 56
    • 20344364428 scopus 로고    scopus 로고
    • Metabolism and bioavailability of trans-resveratrol
    • Wenzel, E., Somoza, V. (2005) Metabolism and bioavailability of trans-resveratrol. Mol. Nutr. Food Res. 49: 472-481
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 472-481
    • Wenzel, E.1    Somoza, V.2
  • 57
    • 20344371723 scopus 로고    scopus 로고
    • Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
    • Wenzel, E., Soldo, T., Erbersdobler, H., Somoza, V. (2005) Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol. Nutr. Food Res. 49: 482-494
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 482-494
    • Wenzel, E.1    Soldo, T.2    Erbersdobler, H.3    Somoza, V.4
  • 58
    • 2442547653 scopus 로고    scopus 로고
    • A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity
    • Yamanaka, H., Nakajima, M., Katoh, M., Hara, Y., Tachibana, O., Yamashita, J., McLeod, H. L., Yokoi, T. (2004) A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity. Pharmacogenetics 14: 329-332
    • (2004) Pharmacogenetics , vol.14 , pp. 329-332
    • Yamanaka, H.1    Nakajima, M.2    Katoh, M.3    Hara, Y.4    Tachibana, O.5    Yamashita, J.6    McLeod, H.L.7    Yokoi, T.8
  • 59
    • 0037273329 scopus 로고    scopus 로고
    • Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate
    • Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., van Breemen, R. B. (2003) Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun. Mass Spectrom. 17: 307-313
    • (2003) Rapid Commun. Mass Spectrom. , vol.17 , pp. 307-313
    • Yu, C.1    Shin, Y.G.2    Kosmeder, J.W.3    Pezzuto, J.M.4    Van Breemen, R.B.5
  • 60
    • 0038267325 scopus 로고    scopus 로고
    • Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs
    • Zern, T. L., West, K. L., Fernandez, M. L. (2003) Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs. J. Nutr. 133: 2268-2272
    • (2003) J. Nutr. , vol.133 , pp. 2268-2272
    • Zern, T.L.1    West, K.L.2    Fernandez, M.L.3


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