Serum interleukin-6 and interleukin-6 soluble receptor in Alzheimer's disease

Neuroscience Letters

Volumn 244, Issue 2, 1998, Pages 106-108

  Angelis, Pela ^a   Scharf, Simon ^a   Mander, Alastair ^b   Vajda, Frank ^a   Christophidis, Nicholas ^a  

^a ST VINCENT S HOSPITAL   (Australia)

^b Grace McKellar Centre   (Australia)

Author keywords

Alzheimer's disease; Interleukin 6; Interleukin 6 soluble receptor; Serum

Indexed keywords

INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6 RECEPTOR;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-6; REFERENCE VALUES;

EID: 0032513251     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00136-0     Document Type: Article

References (19)

1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edn., American Psychiatric Association, Washington DC, 1994.
2. Bauer J., Ganter U., Strauss S., Stadtmuller G., Frommberger V., Bauer H., Volk B., Berger M. The reported participation of interleukin-6 in the pathogenesis of Alzheimer's disease. Res. Immunol. 143:1992;650-657.
3. Blum-Degen D., Muller T., Kuhn W., Gerlach M., Przuntek H., Riederer P. Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 202:1995;17-20.
4. Chao C.C., Ala T.A., Hu S., Crossley K.B., Sherman R.E., Peterson P.K., Frey II W.H. Serum cytokine levels in patients with Alzheimer's disease. Clin. Diagn. Lab. Immunol. 1:1994;433-436.
5. Ershler W.B. Interleukin-6: cytokine for gerontologists. J. Am. Ger. Soc. 41:1993;176-181.
6. Frieling J.T., Deuren M.V., Wijdenes J., van der Meer J.W., Clement C., van der Linden C.J., Sauerwein R.W. Circulating interleukin-6 receptor in patients with sepsis syndrome. J. Infect. Dis. 171:1995;469-472.
7. Gauldie J., Richards C., Harnish D., Lansdorp P., Baumann H. Interferon β2 /BSF-2 shares identity with monocyte-derived hepatocyte-stimulating factor (HSF) and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA. 84:1987;7251-7255.
8. Ikebuchi K., Wong G.G., Clark S.C., Ihle J.N., Hirai Y., Ogawa M. Interleukin-6 enhancement of interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci. USA. 84:1987;9035-9039.
9. Mehta P.D., Pirttila T., Mehta S.P., Dalton A.J., Wisniewski H.M., Percy M., Frey H. Serum levels of interleukin-6 (IL-6) and acute phase proteins in Down's syndrome (DS) and Alzheimer's disease (AD). Neurology. 45(Suppl. 4):1995;A472.
10. Mullberg J., Schooltink H., Stoyan T., Gunther M., Graeve L., Buse G., Mackiewicz A., Heinrich P.C., Rose-John S. The soluble interleukin-6 receptor is generated by shedding. Eur. J. Immunol. 23:1993;473-480.
11. Selkoe D.J. The molecular pathology of Alzheimer's disease. Neuron. 6:1991;487-498.
12. Toren A., Novick D., Or R., Ackerstein A., Slavin S., Nagler A. Soluble interleukin-6 receptors in haematology patients undergoing bone marrow transplantation. Transplantation. 62:1996;138-142.
13. Uyttenhove C., Coulie P.G., Van Snick J. T Cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor. J. Exp. Med. 167:1988;1417-1427.
14. Van Damme J., Opdenakker G., Simpson R.J., Rubira M.R., Cayphas S., Vink A., Billiau A., Van Snick J. Identification of the human 26-kD protein, interferon β2, as a B-cell hybridoma/plasmacytoma growth factor induced by interleukin-1 and tumor necrosis factor. J. Exp. Med. 165:1987;914-919.
15. Vandenabeele P., Fiers W. Is amyloidogenesis during Alzheimer's disease due to an IL-1/IL-6 mediated 'acute-phase response' in the brain? Immunol. Today. 12:1991;217-219.
16. Van Duijn C.M., Hofman A., Nagelkerken L. Serum levels of interleukin-6 are not elevated in patients with Alzheimer's disease. Neurosci. Lett. 108:1990;350-354.
17. Yamada K., Kono K., Umegaki H., Yamada K., Iguchi A., Fukatsu T., Nakashima N., Nishiwaki H., Shimada Y., Sugita Y., Yamamoto T., Hasegawa T., Nabeshima T. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Neurosci. Lett. 186:1995;219-222.
18. Yasukawa K., Saito T., Fukunaga T., Sekimori Y., Koishihara V., Fukui H., Ohsugi Y., Matsuda T., Yawata H., Hirano T., Taga T., Kishimoto T. Purification and characterization of soluble human IL-6 receptor expressed in CHO cells. J. Biochem. 108:1990;673-676.
19. Zohlnhofer D., Graeve L., Rose-John S., Schooltink H., Dittrich E., Heinrich P.C. The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand. FEBS Lett. 306:1992;219-222.