The role of the dorsal root ganglion in cervical radicular pain: Diagnosis, pathophysiology, and rationale for treatment

Regional Anesthesia and Pain Medicine

Volumn 31, Issue 2, 2006, Pages 152-167

  Van Zundert, Jan ^a,d,e   Harney, Donal ^a   Joosten, Elbert A J ^a,b   Durieux, Marcel E ^c   Patijn, Jacob ^a   Prins, Martin H ^b   Van Kleef, Maarten ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF VIRGINIA   (United States)

^d DEPARTMENT OF CARDIOLOGY   (Belgium)

^e NONE   (Belgium)

Author keywords

Cervical radicular pain; Dorsal root ganglion; Evidence; Pathophysiology; Radiculopathy; Treatment

Indexed keywords

CARBAMAZEPINE; CORTICOSTEROID; GABAPENTIN; ION CHANNEL; MEXILETINE; NONSTEROID ANTIINFLAMMATORY AGENT; OXCARBAZEPINE; STEROID; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; VALPROIC ACID;

CLINICAL TRIAL; ELECTROPHYSIOLOGY; HUMAN; IMAGING; INFLAMMATION; NERVE FUNCTION; NERVE INJURY; NEUROPATHIC PAIN; PATHOPHYSIOLOGY; PHYSICAL EXAMINATION; PHYSIOTHERAPY; PRIORITY JOURNAL; RADICULAR PAIN; RADIOFREQUENCY; REVIEW; SENSITIVITY AND SPECIFICITY; SPINAL GANGLION; SPINE SURGERY;

ANIMALS; DISEASE MANAGEMENT; GANGLIA, SPINAL; HUMANS; PAIN; RADICULOPATHY;

EID: 33644997664     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rapm.2005.11.014     Document Type: Review

References (152)

1. J.P. Rathmell, C. Aprill, N. Bogduk Cervical transforaminal injection of steroids Anesthesiology 100 2004 1595 1600
2. N. Bogduk Medical Management of Acute Cervical Radicular Pain An Evidence-Based Approach 1st ed. 1999 The Newcastle Bone and Joint Institute Newcastle, Australia
3. J. Parkinson An Essay on the Shaking Palsy 1817 Paternoster Row London
4. J. Dejerine Sémiologie des Affections du Système Nerveux 1914 Masson et cie Paris
5. H. Merskey, N. Bogduk Classification of Chronic Pain Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms 2nd ed. 1994 IASP Press Seattle, WA
6. J.S. Saal, J.A. Saal, E.F. Yurth Nonoperative management of herniated cervical intervertebral disc with radiculopathy Spine 21 1996 1877 1883
7. M.W. Devereaux Neck and low back pain Med Clin North Am 87 2003 643 662
8. J. Bland Cervical spine syndromes J Muscoloskel Med 3 1986 23 41
9. C.W. Slipman, C.T. Plastaras, R.A. Palmitier, C.W. Huston, E.B. Sterenfeld Symptom provocation of fluoroscopically guided cervical nerve root stimulation. Are dynatomal maps identical to dermatomal maps? Spine 23 1998 2235 2242
10. A. Dwyer, C.A. Aprill, N. Bogduk Cervical zygapophysial joint pain patterns. I/ A study in normal volunteers Spine 15 1990 453 457
11. K.P. Schellhas, M. Smith, C. Grundy, S. Pollei Cervical discogenic pain. Prospective correlation of magnetic resonance imaging and discography in asymptomatic subjects and pain sufferers Spine 21 1996 300 311
12. K. Radhakrishnan, W.J. Litchy, W.M. O'Fallon, L.T. ? Epidemiology of cervical radiculopathy. A population-based study from Rochester, Minnesota, 1976 through 1990 Brain 117 1994 325 335
13. M.E. Sluijter Cervicobrachialgia M.E. Sluijter Radiofrequency, Part 2 2003 Flivopress, SA Meggen, Switzerland 9 22
14. E. Date, L. Gray Electrodiagnostic evidence for cervical radiculopathy and suprascapular neuropathy in shoulder pain Electromyogr Clin Neurophysiol 36 1996 333 339
15. C.A. Fager Identification and management of radiculopathy Neurosurg Clin N Am 4 1993 1 12
16. R. Spurling, W. Scoville Lateral rupture of the cervical intervertebral discs A common cause of shoulder and arm pain Surg Gynecol Obstet 78 1944 350 358
17. R.I. Davidson, E.J. Dunn, J.N. Metzmaker The shoulder abduction test in the diagnosis of radicular pain in cervical extradural compressive monoradiculopathies Spine 6 1981 441 446
18. E. Viikari-Juntura, M. Porras, E.M. Laasonen Validity of clinical tests in the diagnosis of root compression in cervical disc disease Spine 14 1989 253 257
19. H.C. Tong, A.J. Haig, K. Yamakawa The Spurling test and cervical radiculopathy Spine 27 2002 156 159
20. R.S. Wainner, H. Gill Diagnosis and nonoperative management of cervical radiculopathy J Orthop Sports Phys Ther 30 2000 728 744
21. G.K. Nguyen, R. Clark Adequacy of plain radiography in the diagnosis of cervical spine injuries Emerg Radiol 11 2005 158 161
22. B.M. Brown, R.H. Schwartz, E. Frank, N.K. Blank Preoperative evaluation of cervical radiculopathy and myelopathy by surface-coil MR imaging AJR Am J Roentgenol 151 1988 1205 1212
23. R.W. Jahnke, B.L. Hart Cervical stenosis, spondylosis, and herniated disc disease Radiol Clin North Am 29 1991 777 791
24. M.T. Modic, T.J. Masaryk, G.P. Mulopulos Cervical radiculopathy Prospective evaluation with surface coil MR imaging, CT with metrizamide, and metrizamide myelography Radiology 161 1986 753 759
25. S.D. Boden, P.R. McCowin, D.O. Davis Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation J Bone Joint Surg Am 72 1990 1178 1184
26. L.M. Teresi, R.B. Lufkin, M.A. Reicher Asymptomatic degenerative disk disease and spondylosis of the cervical spine MR imaging Radiology 164 1987 83 88
27. J.F. Healy, B.B. Healy, W.H. Wong, E.M. Olson Cervical and lumbar MRI in asymptomatic older male lifelong athletes Frequency of degenerative findings J Comput Assist Tomogr 20 1996 107 112
28. D. Dimitru Electrodiagnostic Medicine 1995 Hanley & Belfus, Inc Philadelphia, PA
29. S. Haldeman The electrodiagnostic evaluation of nerve root function Spine 9 1984 42 48
30. A. Eisen The utility of proximal nerve conduction in radiculopathies The cons Electroencephalogr Clin Neurophysiol 78 1991 171 172 discussion 67
31. J. Partanen, K. Partanen, H. Oikarinen Preoperative electroneuromyography and myelography in cervical root compression Electromyogr Clin Neurophysiol 31 1991 21 26
32. E. Schiff, E. Eisenberg Can quantitative sensory testing predict the outcome of epidural steroid injections in sciatica? A preliminary study Anesth Analg 97 2003 828 832
33. S.A. Clar, J.C. Cianca Intracranial tumor masquerading as cervical radiculopathy A case study Arch Phys Med Rehabil 79 1998 1301 1302
34. D.P. Friedmand, J.R. Hills Cervical epidural spinal infection MR imaging characteristics AJR Am J Roentgenol 163 1994 699 704
35. A. Hetzel, W. Berger, M. Schumacher, C.H. Lucking Dissection of the vertebral artery with cervical nerve root lesions J Neurol 243 1996 121 125
36. L. Anderberg, M. Annertz, L. Brandt, H. Saveland Selective diagnostic cervical nerve root block - Correlation with clinical symptoms and MRI-pathology Acta Neurochir (Wien) 146 2004 559 565 discussion 565
37. M. van Kleef, L. Liem, R. Lousberg Radiofrequency lesion adjacent to the dorsal root ganglion for cervicobrachial pain A prospective double blind randomized study Neurosurgery 38 1996 1127 1131 discussion 31-32
38. A.P. Wolff, G.J. Groen, B.J. Crul Diagnostic lumbosacral segmental nerve blocks with local anesthetics A prospective double-blind study on the variability and interpretation of segmental effects Reg Anesth Pain Med 26 2001 147 155
39. Q.H. Hogan, S.E. Abram Neural blockade for diagnosis and prognosis. A review Anesthesiology 86 1997 216 241
40. J.S. Mogil The genetic mediation of individual differences in sensitivity to pain and its inhibition Proc Natl Acad Sci U S A 96 1999 7744 7751
41. J.S. Mogil, S.G. Wilson, K. Bon Heritability of nociception II. "Types" of nociception revealed by genetic correlation analysis Pain 80 1999 83 93
42. W. Guo, S. Zou, Y. Guan Tyrosine phosphorylation of the NR2B subunit of the NMDA receptor in the spinal cord during the development and maintenance of inflammatory hyperalgesia J Neurosci 22 2002 6208 6217
43. J.F. Howe, J.D. Loeser, W.H. Calvin Mechanosensitivity of dorsal root ganglia and chronically injured axons A physiological basis for the radicular pain of nerve root compression Pain 3 1977 25 41
44. P.D. Wall, M. Devor Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats Pain 17 1983 321 339
45. M. Devor, Z. Saltzer Pathophysiology of damaged nerves in relation to chronic pain M.R. Wall PD Textbook of Pain 1999 Churchill Livingstone London 129 164
46. J.D. Kang, H.I. Georgescu, L. McIntyre-Larkin Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 Spine 20 1995 2373 2378
47. H. Vanegas, H.G. Schaible Prostaglandins and cyclooxygenases [correction of cycloxygenases] in the spinal cord Prog Neurobiol 64 2001 327 363
48. H.R. Herschman Prostaglandin synthase 2 Biochim Biophys Acta 1299 1996 125 140
49. A. Ebersberger, B.D. Grubb, H.L. Willingale The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord Neuroscience 93 1999 775 781
50. C. McCrory, D. Fitzgerald Spinal prostaglandin formation and pain perception following thoracotomy A role for cyclooxygenase-2 Chest 125 2004 1321 1327
51. C.J. Woolf, A. Allchorne, B. Safieh-Garabedian, S. Poole Cytokines, nerve growth factor and inflammatory hyperalgesia The contribution of tumour necrosis factor alpha Br J Pharmacol 121 1997 417 424
52. Y. Murata, A. Onda, B. Rydevik Distribution and appearance of tumor necrosis factor-alpha in the dorsal root ganglion exposed to experimental disc herniation in rats Spine 29 2004 2235 2241
53. N. Andreev, N. Dimitrieva, M. Koltzenburg, S.B. McMahon Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones Pain 63 1995 109 115
54. G. Bennett, S. al-Rashed, J.R. Hoult, S.D. Brain Nerve growth factor induced hyperalgesia in the rat hind paw is dependent on circulating neutrophils Pain 77 1998 315 322
55. X. Shu, L.M. Mendell Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin Neurosci Lett 274 1999 159 162
56. M. Tominaga, M.J. Caterina, A.B. Malmberg The cloned capsaicin receptor integrates multiple pain-producing stimuli Neuron 21 1998 531 543
57. J.M. Chung, K. Chung Importance of hyperexcitability of DRG neurons in neuropathic pain Pain Practice 2 2002 87 97
58. K. Obata, H. Yamanaka, T. Fukuoka Contribution of injured and uninjured dorsal root ganglion neurons to pain behavior and the changes in gene expression following chronic constriction injury of the sciatic nerve in rats Pain 101 2003 65 77
59. R.M. Lindsay, A.J. Harmar Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons Nature 337 1989 362 364
60. S.C. Apfel, D.E. Wright, A.M. Wiideman Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous system Mol Cell Neurosci 7 1996 134 142
61. G.J. Michael, S. Averill, A. Nitkunan Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord J Neurosci 17 1997 8476 8490
62. S.W. Thompson, D.L. Bennett, B.J. Kerr Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord Proc Natl Acad Sci U S A 96 1999 7714 7718
63. I. Lever, J. Cunningham, J. Grist Release of BDNF and GABA in the dorsal horn of neuropathic rats Eur J Neurosci 18 2003 1169 1174
64. K. Obata, H. Yamanaka, Y. Dai Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body Neuroscience 126 2004 1011 1021
65. X.F. Zhou, R.A. Rush Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neurons Neuroscience 74 1996 945 953
66. H.J. Cho, J.K. Kim, X.F. Zhou, R.A. Rush Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation Brain Res 764 1997 269 272
67. R. Groth, L. Aanonsen Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia Pain 100 2002 171 181
68. B.J. Kerr, E.J. Bradbury, D.L. Bennett Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord J Neurosci 19 1999 5138 5148
69. S.G. Waxman Acquired channelopathies in nerve injury and MS Neurology 56 2001 1621 1627
70. O. Matzner, M. Devor Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channels J Neurophysiol 72 1994 349 359
71. J.M. Zhang, D.F. Donnelly, X.J. Song, R.H. Lamotte Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons J Neurophysiol 78 1997 2790 2794
72. T.R. Cummins, F. Aglieco, M. Renganathan Nav1.3 sodium channels Rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons J Neurosci 21 2001 5952 5961
73. M. Abe, T. Kurihara, W. Han Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain Spine 27 2002 1517 1524 discussion 1525
74. B. Everill, J.D. Kocsis Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy J Neurophysiol 82 1999 700 708
75. M. Devor Potassium channels moderate ectopic excitability of nerve-end neuromas in rats Neurosci Lett 40 1983 181 186
76. X. Liu, J.L. Zhou, K. Chung, J.M. Chung Ion channels associated with the ectopic discharges generated after segmental spinal nerve injury in the rat Brain Res 900 2001 119 127
77. L.M. Boland, J.A. Morrill, B.P. Bean Omega-conotoxin block of N-type calcium channels in frog and rat sympathetic neurons J Neurosci 14 1994 5011 5027
78. D. Churchill, B.A. Macvicar Biophysical and pharmacological characterization of voltage-dependent Ca2+ channels in neurons isolated from rat nucleus accumbens J Neurophysiol 79 1998 635 647
79. K.C. Chou Insights from modeling three-dimensional structures of the human potassium and sodium channels J Proteome Res 3 2004 856 861
80. T.R. Muth, M.J. Caplan Transport protein trafficking in polarized cells Annu Rev Cell Dev Biol 19 2003 333 366
81. C.R. Rose, R. Blum, K.W. Kafitz From modulator to mediator rapid effects of BDNF on ion channels Bioessays 26 2004 1185 1195
82. K.W. Kafitz, C.R. Rose, H. Thoenen, A. Konnerth Neurotrophin-evoked rapid excitation through TrkB receptors Nature 401 1999 918 921
83. R. Amir, M. Michaelis, M. Devor Membrane potential oscillations in dorsal root ganglion neurons Role in normal electrogenesis and neuropathic pain J Neurosci 19 1999 8589 8596
84. S.D. Daffner, A.S. Hilibrand, B.S. Hanscom Impact of neck and arm pain on overall health status Spine 28 2003 2030 2035
85. J. Van Zundert, P. Raj, S. Erdine, M. van Kleef Application of radiofrequency treatment in practical pain management State of the art Pain Practice 2 2002 269 278
86. R.D. Kerns, S. Habib A critical review of the pain readiness to change model J Pain 5 2004 357 367
87. G. Guyatt, H.J. Schunemann, D. Cook Applying the grades of recommendation for antithrombotic and thrombolytic therapy The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest 126 2004 179S 187S
88. R. Vinegar, J.F. Truax, J.L. Selph Quantitative comparison of the analgesic and anti-inflammatory activities of aspirin, phenacetin and acetaminophen in rodents Eur J Pharmacol 37 1976 23 30
89. H. Baba, T. Kohno, K.A. Moore, C.J. Woolf Direct activation of rat spinal dorsal horn neurons by prostaglandin E2 J Neurosci 21 2001 1750 1756
90. E. Topol, G. Falk A coxib a day won't keep the doctor away Lancet 364 2004 639 640
91. W.A. Ray, C.M. Stein, J.R. Daugherty COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease Lancet 360 2002 1071 1073
92. M. Mamdani, D. Juurlink, D. Lee Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients A population-based cohort study Lancet 363 2004 1751 1756
93. C.J. Hawkey COX-2 inhibitors Lancet 353 1999 307 314
94. M.W. van Tulder, R.J. Scholten, B.W. Koes, R.A. Deyo Nonsteroidal anti-inflammatory drugs for low back pain A systematic review within the framework of the Cochrane Collaboration Back Review Group Spine 25 2000 2501 2513
95. I.C. Crocker, C.Y. Zhou, A.K. Bewtra Glucocorticosteroids inhibit leukotriene production Ann Allergy Asthma Immunol 78 1997 497 505
96. A. Johansson, J. Hao, B. Sjolund Local corticosteroid application blocks transmission in normal nociceptive C-fibres Acta Anaesthesiol Scand 34 1990 335 338
97. A. Stav, L. Ovadia, A. Sternberg Cervical epidural steroid injection for cervicobrachialgia Acta Anaesthesiol Scand 37 1993 562 566
98. P. Peloso, A. Gross, T. Haines Medicinal and injection therapies for mechanical neck disorders Cochrane Database Syst Rev 2005 CD000319
99. K. Botwin, R. Castellanos, S. Rao Complications of fluoroscopically guided interlaminar cervical epidural injections Arch Phys Med Rehabil 84 2003 627 633
100. S.D. Hodges, L. Castleberg, T. Miller Cervical epidural steroid injection with intrinsic spinal cord damage Spine 23 1998 2137 2141
101. J. Field, J.P. Rathmell, J.H. Stephenson, N.P. Katz Neuropathic pain following cervical epidural steroid injection Anesthesiology 93 2000 885 888
102. J.C. Rowlingson Epidural Steroids Do They Have a Place in Pain Management? 1996 V. Permanyer Publications Barcelona
103. W.G. Hession, J.D. Stanczak, K.W. Davis, J.J. Choi Epidural steroid injections Semin Roentgenol 39 2004 7 23
104. J.N. Vallee, A. Feydy, R.Y. Carlier Chronic cervical radiculopathy Lateral-approach periradicular corticosteroid injection Radiology 218 2001 886 892
105. C. Cyteval, E. Thomas, E. Decoux Cervical radiculopathy Open study on percutaneous periradicular foraminal steroid infiltration performed under CT control in 30 patients AJNR Am J Neuroradiol 25 2004 441 445
106. R. Baker, P. Dreyfuss, S. Mercer, N. Bogduk Cervical transforaminal injection of corticosteroids into a radicular artery A possible mechanism for spinal cord injury Pain 103 2003 211 215
107. P.J. Brouwers, E.J. Kottink, M.A. Simon, R.L. Prevo A cervical anterior spinal artery syndrome after diagnostic blockade of the right C6-nerve root Pain 91 2001 397 399
108. M. Rosenkranz, U. Grzyska, W. Niesen Anterior spinal artery syndrome following periradicular cervical nerve root therapy J Neurol 251 2004 229 231
109. M. Karasek, N. Bogduk Temporary neurologic deficit after cervical transforaminal injection of local anesthetic Pain Med 5 2004 202 205
110. J.P. Rathmell, H.T. Benzon Transforaminal injection of steroids Should we continue? Reg Anesth Pain Med 29 2004 397 399
111. M.A. Huntoon, D.P. Martin Reply to Drs. Raghavendra and Harney Reg Anesth Pain Med 30 2005 208 209
112. A. Onda, Y. Murata, B. Rydevik Infliximab attenuates immunoreactivity of brain-derived neurotrophic factor in a rat model of herniated nucleus pulposus Spine 29 2004 1857 1861
113. T. Korhonen, J. Karppinen, A. Malmivaara Efficacy of infliximab for disc herniation-induced sciatica One-year follow-up Spine 29 2004 2115 2119
114. J. Karppinen, T. Korhonen, A. Malmivaara Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage severe sciatica Spine 28 2003 750 753
115. K. Shin Treatment of neck and back pain originating from herniated nucleus pulposus with tumor necrosis factor alpha inhibitor International Society for the Study of the Lumbar Spine 2004 SpineWeek vzw Porto, Portugal
116. S. Genevay, P.A. Guerne, C. Gabay [Efficacy of tumor necrosis factor-alpha blockade for severe sciatica?] Rev Med Suisse Romande 124 2004 543 545
117. H. McQuay, D. Carroll, A.R. Jadad Anticonvulsant drugs for management of pain A systematic review BMJ 311 1995 1047 1052
118. M. Otto, F.W. Bach, T.S. Jensen, S.H. Sindrup Valproic acid has no effect on pain in polyneuropathy A randomized, controlled trial Neurology 62 2004 285 288
119. K. Nishiyama, M. Sakuta Mexiletine for painful alcoholic neuropathy Intern Med 34 1995 577 579
120. J.M. Wright, J.C. Oki, L. Graves 3rd Mexiletine in the symptomatic treatment of diabetic peripheral neuropathy Ann Pharmacother 31 1997 29 34
121. M.S. Wallace, S. Magnuson, B. Ridgeway Efficacy of oral mexiletine for neuropathic pain with allodynia A double-blind, placebo-controlled, crossover study Reg Anesth Pain Med 25 2000 459 467
122. N.S. Gee, J.P. Brown, V.U. Dissanayake The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel J Biol Chem 271 1996 5768 5776
123. P.T. Hansson, A.H. Dickenson Pharmacological treatment of peripheral neuropathic pain conditions based on shared commonalities despite multiple etiologies Pain 113 2005 251 254
124. M. Backonja, A. Beydoun, K.R. Edwards Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus A randomized controlled trial JAMA 280 1998 1831 1836
125. M. Rowbotham, N. Harden, B. Stacey Gabapentin for the treatment of postherpetic neuralgia A randomized controlled trial JAMA 280 1998 1837 1842
126. T.C. Sist, V.A. Filadora 2nd, M. Miner, M. Lema Experience with gabapentin for neuropathic pain in the head and neck Report of ten cases Reg Anesth 22 1997 473 478
127. R. Sabatowski, R. Galvez, D.A. Cherry Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia Results of a randomised, placebo-controlled clinical trial Pain 109 2004 26 35
128. S.H. Sindrup, T.S. Jensen Efficacy of pharmacological treatments of neuropathic pain An update and effect related to mechanism of drug action Pain 83 1999 389 400
129. Y. Kanpolat, A. Savas, A. Bekar, C. Berk Percutaneous Controlled radiofrequency trigeminal rhizotomy for the treatment of idiopathic trigeminal neuralgia 25 years experience with 1600 patients Neurosurgery 48 2001 524 534
130. J. Geurts, R.M. van Wijk, R. Stolker, G.J. Groen Efficacy of radiofrequency procedures for the treatment of spinal pain A systematic review of randomized clinical trials Reg Anesth Pain Med 26 2001 394 400
131. R. Slappendel, B.J. Crul, G.J. Braak The efficacy of radiofrequency lesioning of the cervical spinal dorsal root ganglion in a double blinded randomized study No difference between 40 degrees C and 67 degrees C treatments Pain 73 1997 159 163
132. L. Niemisto, E. Kalso, A. Malmivaara Radiofrequency denervation for neck and back pain. A systematic review of randomized controlled trials Cochrane Database Syst Rev 2003 CD004058
133. M.E. Sluijter, E.R. Cosman, W.B. Rittman II, M. van Kleef The effects of pulsed radiofrequency field applied to the dorsal root ganglion - A preliminary report Pain Clin 11 1998 109 117
134. Y. Higuchi, B.S. Nashold, M.E. Sluijter Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons Neurosurgery 50 2002 850 856
135. J. Van Zundert, A.J. de Louw, E.A. Joosten Pulsed and continuous radiofrequency current adjacent to the cervical dorsal root ganglion of the rat induces late cellular activity in the dorsal horn Anesthesiology 102 2005 125 131
136. J. Van Zundert, I.E. Lamé, A. de Louw Percutaneous pulsed radiofrequency treatment of the cervical dorsal root ganglion in the treatment of chronic cervical pain syndromes A clinical audit Neuromodulation 6 2003 6 14
137. I.P. Fouyas, P.F. Statham, P.A. Sandercock Cochrane review on the role of surgery in cervical spondylotic radiculomyelopathy Spine 27 2002 736 747
138. L.C. Persson, C.A. Carlsson, J.Y. Carlsson Long-lasting cervical radicular pain managed with surgery, physiotherapy, or a cervical collar. A prospective, randomized study Spine 22 1997 751 758
139. W. Jacobs, P. Anderson, J. Limbeek Single or double-level anterior interbody fusion techniques for cervical degenerative disc disease Cochrane Database Syst Rev 2004 CD004958
140. L.C. Persson, A. Lilja Pain, coping, emotional state and physical function in patients with chronic radicular neck pain. A comparison between patients treated with surgery, physiotherapy or neck collar - A blinded, prospective randomized study Disabil Rehabil 23 2001 325 335
141. J. Saklatvala The p38 MAP kinase pathway as a therapeutic target in inflammatory disease Curr Opin Pharmacol 4 2004 372 377
142. M. Lazzeri, M. Spinelli, P. Beneforti Intravesical infusion of resiniferatoxin by a temporary in situ drug delivery system to treat interstitial cystitis A pilot study Eur Urol 45 2004 98 102
143. V.A. Mitchell, D.M. White, M.J. Cousins The long-term effect of epidural administration of butamben suspension on nerve injury-induced allodynia in rats Anesth Analg 89 1999 989 994
144. P. Gerner, T. Nakamura, C.F. Quan Spinal tonicaine Potency and differential blockade of sensory and motor functions Anesthesiology 92 2000 1350 1360
145. G.T. Carter, M.D. Sullivan Antidepressants in pain management Curr Opin Investig Drugs 3 2002 454 458
146. J.P. Feighner Mechanism of action of antidepressant medications J Clin Psychiatry 60 Suppl 4 1999 4 11 discussion 2-3
147. J.J. Pancrazio, G.L. Kamatchi, A.K. Roscoe, C. Lynch 3rd Inhibition of neuronal Na+ channels by antidepressant drugs J Pharmacol Exp Ther 284 1998 208 214
148. D. Strumper, M.E. Durieux Antidepressants as long-acting local anesthetics Reg Anesth Pain Med 29 2004 277 285
149. Y. Sudoh, E.E. Cahoon, P. Gerner, G.K. Wang Tricyclic antidepressants as long-acting local anesthetics Pain 103 2003 49 55
150. Y. Sudoh, E.E. Cahoon, U. De Girolami, G.K. Wang Local anesthetic properties of a novel derivative, N-methyl doxepin, versus doxepin and bupivacaine Anesth Analg 98 2004 672 676
151. P. Fridrich, S. Eappen, W. Jaeger Phase Ia and Ib study of amitriptyline for ulnar nerve block in humans Side effects and efficacy Anesthesiology 100 2004 1511 1518
152. J.C. Glorioso, D.J. Fink Herpes vector-mediated gene transfer in treatment of diseases of the nervous system Annu Rev Microbiol 58 2004 253 271