Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons

Journal of Neurophysiology

Volumn 78, Issue 5, 1997, Pages 2790-2794

  Zhang, Jun Ming ^a   Donnelly, David F ^a   Song, Xue Jun ^a   LaMotte, Robert H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DEPOLARIZATION; MYELINATION; NERVE CELL EXCITABILITY; NERVE FIBER TRANSECTION; NERVE INJURY; NOCICEPTION; NONHUMAN; PATCH CLAMP; PATHOGENESIS; PRIORITY JOURNAL; RAT; SODIUM CURRENT; SPINAL GANGLION;

EID: 0030724424     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.78.5.2790     Document Type: Article

References (29)

1. AKOPIAN, A. N., SIVILOTTI, L., AND WOOD, J. N. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 379: 258-262, 1996.
2. BEZANILLA, F. AND ARMSTRONG, C. M. Inactivation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol. 70: 549-566, 1977.
3. BONDOK, A. A. AND SANSONE, F. M. Retrograde and transganglionic degeneration of sensory neurons after peripheral nerve lesion at birth. Exp. Neurol. 86: 322-330, 1984.
4. BURCHIEL, K. J. Spontaneous impulse generation in normal and denervated dorsal root ganglia: sensitivity to alpha-adrenergic stimulation and hypoxia. Exp. Neurol. 85: 257-272, 1984.
5. CUMMINS, T. R. AND WAXMAN, S. G. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J Neurosci. 17: 3503-3514, 1997.
6. CZEH, G., KUDO, N., AND KUNO, M. Membrane properties and conduction velocity in sensory neurones following central or peripheral axotomy. J. Physiol. (Lond.) 170: 165-180, 1977.
7. DEVOR, M. Pathophysiology of damaged peripheral nerves. In: Textbook of Pain, edited by P. D. Wall and R. Melzack. New York: Churchill Livingstone, 1994, p. 79-100.
8. + channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation. J. Neurosci. 13: 1976-1992, 1993.
9. DEVOR, M., GOVRIN-LIPPMANN, R., FRANK, I., AND RABER, P. Proliferation of primary sensory neurons in adult rat dorsal root ganglion and the kinetics of retrograde cell loss after sciatic nerve section. Somatosens. Res. 3: 139-167, 1985.
10. DEVOR, M., JANIG, W., AND MICHAELIS, M. Modulation of activity in dorsal root ganglion neurons by sympathetic activation in nerve-injured rats. J. Neurophysiol. 71: 38-47, 1994.
11. DIB-HAJJ, S., BLACK, J. A., FELTS, P., AND WAXMAN, S. G. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy. Proc. Natl. Acad. Sci. USA 93: 14950-14954, 1996.
12. EVERILL, B. AND KOCSIS, J. D. Nerve injury reduces total potassium conductance of two of three identified currents in adult cutaneous afferent dorsal root ganglion neurons. Soc. Neurosci. Abstr. 23: 1745, 1997.
13. FITZGERALD, M. AND GIBSON, S. The postnatal physiological and neurochemical development of peripheral sensory C fibres. Neuroscience 13: 933-944, 1984.
14. FULTON, B. P. Postnatal changes in conduction velocity and soma action potential parameters of rat dorsal root ganglion neurones. Neurosci. Lett. 73: 125-130, 1987.
15. GURTU, S. AND SMITH, P. A. Electrophysiological characteristics of hamster dorsal root ganglion cells and their response to axotomy. J. Neurophysiol. 59: 408-423, 1988.
16. NAGY, I., URBAN, L., AND WOOLF, C. J. Morphological and membrane properties of young rat lumbar and thoracic dorsal root ganglion cells with unmyelinated axons. Brain Res. 609: 193-200, 1993.
17. + channels in neurons of the rat dorsal root ganglia. Dev. Brain Res. 65: 93-100, 1992.
18. PETERSEN, M., ZHANG, J., ZHANG, J.-M., AND LAMOTTE, R. H. Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction. Pain 67: 391-397, 1996.
19. + currents in cutaneous afferent dorsal root ganglion neurons following axotomy. Neurobiol. Dis. 2: 87-96, 1995.
20. ROY, M. L. AND NARAHASHI, T. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J. Neurosci. 12: 2104-2111, 1992.
21. SANGAMESWARAN, L., DELGADO, S. G., FISH, L. M., KOCH, B. D., JAKEMAN, L. B., STEWART, G. R., SZE, P., HUNTER, J. C., EGLEN, R. M., AND HERMAN, R. C. Structure and function of a novel voltage-gated, tetrodoxtoxin-resistant sodium channel specific to sensory neurons. J. Biol. Chem. 271: 5953-5956, 1996.
22. STUDY, R. E. AND KRAL, M. G. Spontaneous firing in isolated rat dorsal root ganglion neurons from rats with a painful neuropathy. Pain 65: 235-242, 1996.
23. WADDELL, P. J. AND LAWSON, S. N. Electrophysiological properties of subpopulations of rat dorsal root ganglion neurons in vitro. Neuroscience 36: 811-822, 1990.
24. WALL, P. D. AND DEVOR, M. Sensory afferent impulse originate from dorsal root ganglia as well as from the periphery in normal and nerve injury rats. Pain 17: 321-339, 1983.
25. WAXMAN, S. G., KOCSIS, J. D., AND BLACK, J. A. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and reexpressed following axotomy. J. Neurophysiol. 72: 466-470, 1994.
26. XIE, Y. K., ZHANG, J.-M., PETERSEN, M., AND LAMOTTE, R. H. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat. J. Neurophysiol. 73: 1811-1819, 1995.
27. YIP, H. K., RICH, K. M., LAMPE, P. A., AND JOHNSON, E. M., JR. The effects of nerve growth factor and its antiserum on the postnatal development and survival after injury of sensory neurons in rat dorsal root ganglia. J. Neurosci. 4: 2986-2992, 1984.
28. ZHANG, J.-M., DONNELLY, D. F., SONG, X.-J., AND LAMOTTE, R. H. Measurement of conduction velocity, cell size, resting and threshold potentials with patch-clamping in the intact ganglion. Soc. Neurosci. Abstr. 22: 1805, 1996.
29. ZHANG, J.-M., SONG, X.-J., AND LAMOTTE, R. H. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain. 72: 51-57, 1997.