Mexiletine in the symptomatic treatment of diabetic peripheral neuropathy

Annals of Pharmacotherapy

Volumn 31, Issue 1, 1997, Pages 29-34

  Wright, Julie M ^a   Oki, Julie C ^a   Graves III, Leland ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEXILETINE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEUROPATHY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEADACHE; HUMAN; MALE; NAUSEA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; VOMITING;

EID: 0031026167     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1177/106002809703100103     Document Type: Article

References (21)

1. Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4400 patients observed between 1947 and 1973. Diabetes Care 1978;1:168-88.
2. Boulton AJM, Levin S, Comstock J. A multicentre trial of the aldose-reductase inhibitor, tolrestat, in patients with symptomatic diabetic neuropathy. Diabetologia 1990;33:431-7.
3. Giugliano D, Acampora R, Marfella R, Di Maro G, De Rosa N, Misso L, et al. Tolrestat in the primary prevention of diabetic neuropathy. Diabetes Care 1995;18:536-41.
4. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86.
5. Wright JM. Review of the symptomatic treatment of diabetic neuropathy. Pharmacotherapy 1994;14:689-97.
6. Sindrup SH, Ejlertsen B, Froland A, Sindrup EH, Brosen K, Gram LF. Imipramine treatment in diabetic neuropathy: relief of subjective symptoms without changes in peripheral and autonomic nerve function. Eur J, Clin Pharmacol 1989;37:151-3.
7. Sindrup SH, Gram LF, Brosen K, Eshoj O, Mogensen EF. The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms. Pain 1990;42:135-44.
8. Max MB, Kishore-Kumar R, Schafer SC, Meister B, Gracely RH, Smoller B, et al. Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial. Pain 1991;45:3-9.
9. Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 1992;326:1250-6.
10. Pfeifer MA. Painful or insensitive lower extremity. In: Lebovitz H, ed. Therapy for diabetes mellitus and related disorders. Alexandria, VA: American Diabetes Association, Inc., 1994:279-82.
11. Vinik AI, Holland MT, LeBeau JM, Liuzzi FJ, Stansberry KB, Colen LB. Diabetic neuropathies. Diabetes Care 1992;15:1926-75.
12. Dejgard A, Petersen P, Kastrup J. Mexiletine for the treatment of chronic painful diabetic neuropathy. Lancet 1988;1:9-11.
13. Cody RL, Slack MK. Crossover design in pharmacy research. Ann Pharmacother 1992;26:327-33.
14. Woods JR, Williams JG, Tavel M. The two-period crossover design in medical research. Ann Intern Med 1989;110:560-6.
15. Schrader BJ, Bauman JL. Mexiletine: a new type I antiarrhythmic agent. Drug Intell Clin Pharm 1986;20:255-60.
16. IMPACT Research Group. International mexiletine and placebo antiarrhythmic coronary trial: I. Report on arrhythmia and other findings. J Am Coll Cardiol 1984;4:1148-63.
17. Kastrup J, Petersen P, Dejgard A, Angelo HR, Hilsted J. Intravenous lidocaine infusion - a new treatment of chronic painful diabetic neuropathy. Pain 1987;28:69-75.
18. Cohen J. Statistical power analysis for the behavioral sciences. 5th ed. Orlando: Academic Press Inc., 1988:30.
19. Todd KH. Clinical versus statistical significance in the assessment of pain relief. Ann Emerg Med 1996;27:439-41.
20. Stracke H, Meyer UE, Schumacher HE, Federlin K. Mexiletine in the treatment of diabetic neuropathy. Diabetes Care 1992;15:1550-5.
21. Pfeifer MA, Ross DR, Schrage JP, Gelber DA, Schumer MP, Crain GM, et al. A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy. Diabetes Care 1993;16:1103-15.