Mechanism of the Class I KDPG aldolase

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 9, 2006, Pages 3002-3010

  Fullerton, Stephen W B ^a,d   Griffiths, Jennifer S ^b   Merkel, Alexandra B ^a   Cheriyan, Manoj ^c   Wymer, Nathan J ^b,e   Hutchins, Michael J ^a   Fierke, Carol A ^a,c   Toone, Eric J ^b   Naismith, James H ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b DUKE UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

^e zuChem Inc   (United States)

Author keywords

Carbinolamine; Class I mechanism; KDPG aldolase; Schiff base

Indexed keywords

2 KETO 3 DEOXY 6 PHOSPHOGLUCONATE ALDOLASE; DEXTRO 2 KETO 3 DEOXY 6 PHOSPHOGLUCONATE ALDOLASE; FRUCTOSE BISPHOSPHATE ALDOLASE; SCHIFF BASE; SULFATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CRYSTALLOGRAPHY; ESCHERICHIA COLI; PROTEIN ANALYSIS; THERMOTOGA MARITIMA;

ALDEHYDE-LYASES; BINDING SITES; CATALYSIS; ESCHERICHIA COLI; GLUTAMIC ACID; MODELS, MOLECULAR; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; THERMOTOGA MARITIMA;

ESCHERICHIA COLI; THERMOTOGA MARITIMA;

EID: 33644969048     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.022     Document Type: Article

References (38)

1. T. Conway FEMS Microbiol. Rev. 103 1992 1 28
2. W.D. Fessner, and C. Walter Bioorg. Chem. 184 1997 97 194
3. G. Seoane Curr. Org. Chem. 4 2000 283 304
4. M.G. Silvestri, G. Desantis, M. Mitchell, and C.-H. Wong Top. Stereochem. 23 2003 267 342
5. N. Wymer, and E.J. Toone Curr. Opin. Chem. Biol. 4 2000 110 119
6. K. Hult, and P. Berglund Curr. Opin. Biotechnol. 14 2003 395 400
7. A.C. Joerger, S. Mayer, and A.R. Fersht Proc. Natl. Acad. Sci. U.S.A. 100 2003 5694 5699
8. G.J. Williams, S. Domann, A. Nelson, and A. Berry Proc. Natl. Acad. Sci. U.S.A. 100 2003 3143 3148
9. S. Fong, T.D. Machajewski, C.C. Mak, and C.H. Wong Chem. Biol. 7 2000 873 883
10. A.C. Joerger, C. Mueller-Dieckmann, and G.E. Schulz J. Mol. Biol. 303 2000 531 543
11. M. Kroemer, I. Merkel, and G.E. Schulz Biochemistry 42 2003 10560 10568
12. S.J. Cooper, G.A. Leonard, S.M. McSweeney, A.W. Thompson, J.H. Naismith, S. Qamar, A. Plater, A. Berry, and W.N. Hunter Structure 4 1996 1303 1315
13. A.R. Plater, S.M. Zgiby, G.J. Thomson, S. Qamar, C.W. Wharton, and A. Berry J. Mol. Biol. 285 1999 843 855
14. J. Jia, U. Schorken, Y. Lindqvist, G.A. Sprenger, and G. Schneider Protein Sci. 6 1997 119 124
15. A. Dalby, Z. Dauter, and J.A. Littlechild Protein Sci. 8 1999 291 297
16. S. Thorell, M. Schurmann, G.A. Sprenger, and G. Schneider J. Mol. Biol. 319 2002 161 171
17. J. Allard, P. Grochulski, and J. Sygusch Proc. Natl. Acad. Sci. U.S.A. 98 2001 3679 3684
18. A. Heine, G. DeSantis, J.G. Luz, M. Mitchell, C.H. Wong, and I.A. Wilson Science 294 2001 369 374
19. A. Heine, J.G. Luz, C.H. Wong, and I.A. Wilson J. Mol. Biol. 343 2004 1019 1034
20. E. Lorentzen, B. Siebers, R. Hensel, and E. Pohl Biochemistry 44 2005 4222 4229
21. M.C. Shelton, I.C. Cotterill, S.T.A. Novak, R.M. Poonawala, S. Sudarshan, and E.J. Toone J. Am. Chem. Soc. 118 1996 2117 2125
22. D.F. Henderson, M.J. Shelton, and E.J. Toone J. Org. Chem. 62 1997 7910 7912
23. S. Fong, T.D. Machajewski, C.C. Mak, and C. Wong Chem. Biol. 7 2000 873 883
24. N. Wymer, L.V. Buchanan, D. Henderson, N. Mehta, C.H. Botting, L. Pocivavsek, C.A. Fierke, E.J. Toone, and J.H. Naismith Structure (Camb) 9 2001 1 9
25. J.S. Griffiths, N.J. Wymer, E. Njolito, S. Niranjanakumari, C.A. Fierke, and E.J. Toone Bioorg. Med. Chem. 10 2002 545 550
26. B.J. Bell, L. Watanabe, J.L. Rios-Steiner, A. Tulinsky, L. Lebioda, and R.K. Arni Acta Crystallogr. D Biol. Crystallogr. 59 2003 1454 1458
27. N. Nagano, C.A. Orengo, and J.M. Thornton J. Mol. Biol. 321 2002 741 765
28. B.J. Smith, M.C. Lawrence, and J.A.R.G. Barbosa J. Org. Chem. 64 1999 945 949
29. D. Kruger, R. Schauer, and C. Traving Eur. J. Biochem. 268 2001 3831 3839
30. A. Theodossis, H. Waldden, E.J. Westwick, H. Connaris, H.J. Lamble, D.W. Hough, M.J. Danson, and G.L. Taylor J. Biol. Chem 279 2004 43886 43892
31. J.A.R.G. Barbosa, B.J. Smith, R. DeGori, H.C. Ooi, S.M. Marcuccio, E.M. Campi, W.R. Jackson, R. Brossmer, M. Sommer, and M.C. Lawrence J. Mol. Biol. 303 2000 405 421
32. C. Hertweck J. Fur Praktische Chemie-Practical Appl. Appl. Chem. 342 2000 832 835
33. G.N. Murshudov, A.A. Vagin, and E.J. Dodson Acta Crystallogr. D Biol. Crystallogr. 53 1997 240 255
34. S. Bailey Acta Crystallogr. D Biol. Crystallogr. 50 1994 760 763
35. T.A. Jones, J.-Y. Zou, S.W. Cowan, and M. Kjeldgaard Acta Crystallogr. A 47 1991 110 119
36. J.E. Fradkin, and D.G. Fraenkel J. Bacteriol. 108 1971 1277 1283
37. J.S. Griffiths, M. Cheriyan, J.B. Corbell, L. Pocivavsek, C.A. Fierke, and E.J. Toone Bioorg. Med. Chem. 12 2004 4067 4074
38. H.P. Meloche, and W.A. Wood J. Biol. Chem. 239 1964 3511 3514