Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme

Journal of Molecular Biology

Volumn 303, Issue 3, 2000, Pages 405-421

  Barbosa, J A R G ^a   Smith, B J ^a   DeGori, R ^a   Ooi, H C ^a,b   Marcuccio, S M ^a   Campi, E M ^b   Jackson, W R ^b   Brossmer, R ^c   Sommer, M ^c   Lawrence, M C ^a  

^a CSIRO   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Active site modulation; Enzyme sub family; N acetylneuraminate lyase; Schiff base; X ray structure

Indexed keywords

BACTERIAL ENZYME; LYASE; N ACETYLNEURAMINIC ACID DERIVATIVE;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; HAEMOPHILUS INFLUENZAE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE;

EID: 0034721945     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4138     Document Type: Article

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