메뉴 건너뛰기




Volumn 7, Issue 3, 2006, Pages 229-242

A review of the clinical use of anti-inflammatory therapies for reperfusion injury in myocardial infarction and stroke: Where do we go from here?

Author keywords

Adenosine; Anti inflammatory; Ischemia; Myocardial infarction; Reperfusion

Indexed keywords

ABCIXIMAB; ACETYLCYSTEINE; ADENOSINE; ALTEPLASE; ANTIINFLAMMATORY AGENT; CORTICOSTEROID; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOCORTICOID RECEPTOR; GLUCOSE; HEPARIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G2A ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; LOW MOLECULAR WEIGHT HEPARIN; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; PADGEM PROTEIN; PEXELIZUMAB; PLACEBO; RECOMBINANT PROTEIN; ROVELIZUMAB; TP 10; UK 279276; UNCLASSIFIED DRUG;

EID: 33644943740     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (9)

References (118)
  • 1
    • 0035997536 scopus 로고    scopus 로고
    • The neutrophil as a mediator of myocardial ischemia-reperfusion injury: Time to move on
    • Baxter GF: The neutrophil as a mediator of myocardial ischemia-reperfusion injury: Time to move on. Basic Res Cardiol (2002) 97(4)268-275.
    • (2002) Basic Res Cardiol , vol.97 , Issue.4 , pp. 68-275
    • Baxter, G.F.1
  • 2
    • 0034053099 scopus 로고    scopus 로고
    • Pathophysiology of ischaemia-reperfusion injury
    • Carden DL, Granger DN: Pathophysiology of ischaemia-reperfusion injury. J Pathol (2000) 190(3):255-266.
    • (2000) J Pathol , vol.190 , Issue.3 , pp. 255-266
    • Carden, D.L.1    Granger, D.N.2
  • 3
    • 12144267045 scopus 로고    scopus 로고
    • Anti-adhesion molecule strategies as potential neuroprotective agents in cerebral ischemia: A critical review of the literature
    • Sughrue ME, Mehra A, Connolly ES Jr, D'Ambrosio AL: Anti-adhesion molecule strategies as potential neuroprotective agents in cerebral ischemia: A critical review of the literature. Inflamm Res (2004) 53(10):497-508.
    • (2004) Inflamm Res , vol.53 , Issue.10 , pp. 497-508
    • Sughrue, M.E.1    Mehra, A.2    Connolly Jr., E.S.3    D'Ambrosio, A.L.4
  • 4
    • 0035376112 scopus 로고    scopus 로고
    • The role of the complement cascade in ischemia/reperfusion injury: Implications for neuroprotection
    • D'ambrosio AL, Pinsky DJ, Connolly ES: The role of the complement cascade in ischemia/reperfusion injury: Implications for neuroprotection. Mol Med (2001) 7(6):367-382.
    • (2001) Mol Med , vol.7 , Issue.6 , pp. 367-382
    • D'ambrosio, A.L.1    Pinsky, D.J.2    Connolly, E.S.3
  • 5
    • 0036326170 scopus 로고    scopus 로고
    • Inflammatory cell adhesion molecules in ischemic cerebrovascular disease
    • Frijns CJ, Kappelle LJ: Inflammatory cell adhesion molecules in ischemic cerebrovascular disease. Stroke (2002) 33(8):2115-2122.
    • (2002) Stroke , vol.33 , Issue.8 , pp. 2115-2122
    • Frijns, C.J.1    Kappelle, L.J.2
  • 6
    • 2342519916 scopus 로고    scopus 로고
    • NF-κB and reperfusion injury
    • Nichols TC: NF-κB and reperfusion injury. Drug News Perspec (2004) 17(2):99-104.
    • (2004) Drug News Perspec , vol.17 , Issue.2 , pp. 99-104
    • Nichols, T.C.1
  • 7
    • 18844412788 scopus 로고    scopus 로고
    • Reactive oxygen species and the modulation of stroke
    • Crack PJ, Taylor JM: Reactive oxygen species and the modulation of stroke. Free Rad Biol Med (2005) 38(11):1433-1444.
    • (2005) Free Rad Biol Med , vol.38 , Issue.11 , pp. 1433-1444
    • Crack, P.J.1    Taylor, J.M.2
  • 8
    • 0029686631 scopus 로고    scopus 로고
    • Inflammatory reactions at the blood-endothelial interface in acute stroke
    • Hallenbeck JM: Inflammatory reactions at the blood-endothelial interface in acute stroke. Adv Neurol (1996) 71:281-297.
    • (1996) Adv Neurol , vol.71 , pp. 281-297
    • Hallenbeck, J.M.1
  • 9
    • 0035846605 scopus 로고    scopus 로고
    • Consequences of brief ischemia: Stunning, preconditioning and their clinical implications. Part 1
    • Kloner RA, Jennings RB: Consequences of brief ischemia: Stunning, preconditioning and their clinical implications. Part 1. Circulation (2001) 104(24):2981-2989.
    • (2001) Circulation , vol.104 , Issue.24 , pp. 2981-2989
    • Kloner, R.A.1    Jennings, R.B.2
  • 10
    • 0035909985 scopus 로고    scopus 로고
    • Consequences of brief ischemia: Stunning, preconditioning and their clinical implications
    • Kloner RA, Jennings RB: Consequences of brief ischemia: Stunning, preconditioning and their clinical implications. Part 2. Circulation (2001) 104(25):3158-5167.
    • (2001) Circulation , vol.104 , Issue.25 PART 2 , pp. 3158-5167
    • Kloner, R.A.1    Jennings, R.B.2
  • 11
    • 1142297590 scopus 로고    scopus 로고
    • The first minutes of reperfusion: A window of opportunity for cardioprotection
    • Piper HM, Abdallah Y, Schafer C: The first minutes of reperfusion: A window of opportunity for cardioprotection. Cardiovasc Res (2004) 61(3):365-371.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 365-371
    • Piper, H.M.1    Abdallah, Y.2    Schafer, C.3
  • 12
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion - A target for cardioprotection
    • Halestrap AP, Clarke SJ, Javadov SA: Mitochondrial permeability transition pore opening during myocardial reperfusion - a target for cardioprotection. Cardiovasc Res (2004) 61(3):372-385.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 13
    • 1142297603 scopus 로고    scopus 로고
    • Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion
    • Garcia-Dorado D, Rodriguez-Sinovas A, Ruiz-Meana M: Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion. Cardiovasc Res (2004) 61(3):386-401.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 386-401
    • Garcia-Dorado, D.1    Rodriguez-Sinovas, A.2    Ruiz-Meana, M.3
  • 14
    • 1142285456 scopus 로고    scopus 로고
    • Nitric oxide in ischemia/reperfusion injury
    • Schulz R, Kelm M, Heusch G: Nitric oxide in ischemia/reperfusion injury. Cardiovasc Res (2004) 61(3):402-413.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 402-413
    • Schulz, R.1    Kelm, M.2    Heusch, G.3
  • 16
    • 1142309730 scopus 로고    scopus 로고
    • Protein kinase activation and myocardial ischemia/reperfusion injury
    • Armstrong SC: Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiovasc Res (2004) 61(3):427-436.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 427-436
    • Armstrong, S.C.1
  • 17
    • 1142273374 scopus 로고    scopus 로고
    • Molecular determinants of responses of myocardial ischemia/reperfusion injury: Focus on hypoxia-inducible and heat shock factors
    • Chi NC, Karliner JS: Molecular determinants of responses of myocardial ischemia/reperfusion injury: Focus on hypoxia-inducible and heat shock factors. Cardiovasc Res (2004) 61(3):437-447.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 437-447
    • Chi, N.C.1    Karliner, J.S.2
  • 18
    • 1142309743 scopus 로고    scopus 로고
    • New directions for protecting the heart against reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK)-pathway
    • Hausenloy DJ, Yellon DM: New directions for protecting the heart against reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res (2004) 61(3):448-460.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 448-460
    • Hausenloy, D.J.1    Yellon, D.M.2
  • 19
    • 1142297598 scopus 로고    scopus 로고
    • New concepts in reactive oxygen species and cardiovascular reperfusion physiology
    • Becker L: New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res (2004) 61(3):461-470.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 461-470
    • Becker, L.1
  • 20
    • 1142285446 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase activation in the reperfused myocardium
    • Szabo G, Liaudet L, Hagl S, Szabo C: Poly(ADP-ribose) polymerase activation in the reperfused myocardium. Cardiovasc Res (2004) 61(3):471-480.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 471-480
    • Szabo, G.1    Liaudet, L.2    Hagl, S.3    Szabo, C.4
  • 21
    • 1142309740 scopus 로고    scopus 로고
    • Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
    • Vinten-Johanssen J: Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res (2004) 61(3):481-497.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 481-497
    • Vinten-Johanssen, J.1
  • 22
    • 1142273373 scopus 로고    scopus 로고
    • Role of platelets In coronary thrombosis and reperfusion of ischemic myocardium
    • Gawaz M: Role of platelets In coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res (2004) 61(3):498-511.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 498-511
    • Gawaz, M.1
  • 23
    • 1142309737 scopus 로고    scopus 로고
    • Role of clinical pathologies in myocardial injury following ischaemia and reperfusion
    • Galinanes M, Fowler AG: Role of clinical pathologies in myocardial injury following ischaemia and reperfusion. Cardiovasc Res (2004) 61(3):512-521.
    • (2004) Cardiovasc Res , vol.61 , Issue.3 , pp. 512-521
    • Galinanes, M.1    Fowler, A.G.2
  • 24
    • 0345356539 scopus 로고    scopus 로고
    • Opposing roles of δ and εPKC in cardiac ischemia and reperfusion: Targeting the apoptotic machinery
    • Murriel CL, Mochly-Rosen D: Opposing roles of δ and εPKC in cardiac ischemia and reperfusion: Targeting the apoptotic machinery. Archiv Biochem Biophys (2003) 420(2):246-254.
    • (2003) Archiv Biochem Biophys , vol.420 , Issue.2 , pp. 246-254
    • Murriel, C.L.1    Mochly-Rosen, D.2
  • 25
    • 0037331561 scopus 로고    scopus 로고
    • Complement in ischemia reperfusion Injury
    • Riedemann NC, Ward PA: Complement in ischemia reperfusion Injury. Am J Pathol (2003) 162(2):363-367.
    • (2003) Am J Pathol , vol.162 , Issue.2 , pp. 363-367
    • Riedemann, N.C.1    Ward, P.A.2
  • 26
    • 0026005681 scopus 로고
    • Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanisms of localization during early reperfusion
    • Dreyer WJ, Michael LH, West MS, Smith CW, Rothlein R, Rossen RD, Anderson DC, Entman ML: Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanisms of localization during early reperfusion. Circulation (1991) 84(1):400-411.
    • (1991) Circulation , vol.84 , Issue.1 , pp. 400-411
    • Dreyer, W.J.1    Michael, L.H.2    West, M.S.3    Smith, C.W.4    Rothlein, R.5    Rossen, R.D.6    Anderson, D.C.7    Entman, M.L.8
  • 27
    • 85047680729 scopus 로고
    • Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury
    • Lefer AM, Weyrich AS, Buerke M: Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury. Cardiovasc Res (1994) 28(3):289-294.
    • (1994) Cardiovasc Res , vol.28 , Issue.3 , pp. 289-294
    • Lefer, A.M.1    Weyrich, A.S.2    Buerke, M.3
  • 28
    • 0028799710 scopus 로고
    • Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium
    • Weyrich AS, Buerke M, Albertine KH, Lefer AM: Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium. J Leuko Biol (1995) 57(1):45-55.
    • (1995) J Leuko Biol , vol.57 , Issue.1 , pp. 45-55
    • Weyrich, A.S.1    Buerke, M.2    Albertine, K.H.3    Lefer, A.M.4
  • 29
    • 0037022257 scopus 로고    scopus 로고
    • No-reflow phenomenon
    • Rezkalla SH, Kloner RA: No-reflow phenomenon. Circulation (2002) 105(5):656-662.
    • (2002) Circulation , vol.105 , Issue.5 , pp. 656-662
    • Rezkalla, S.H.1    Kloner, R.A.2
  • 30
    • 0025947863 scopus 로고
    • Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in
    • del Zoppo GJ, Schmid-Schonbein GW, Mori E, Copeland BR, Chang CM: Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons. Stroke (1991) 22(10):1276-1283.
    • (1991) Baboons Stroke , vol.22 , Issue.10 , pp. 1276-1283
    • del Zoppo, G.J.1    Schmid-Schonbein, G.W.2    Mori, E.3    Copeland, B.R.4    Chang, C.M.5
  • 31
    • 0041324898 scopus 로고    scopus 로고
    • The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: Molecular mechanisms for gene repression
    • de Bosscher K, Berghe VW, Haegeman G: The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1: Molecular mechanisms for gene repression. Endocrine Rev (2003) 24(4):488-522.
    • (2003) Endocrine Rev , vol.24 , Issue.4 , pp. 488-522
    • de Bosscher, K.1    Berghe, V.W.2    Haegeman, G.3
  • 32
    • 0020612909 scopus 로고
    • Dose-dependent effects of short-term methylprednisolone on myocardial infarct extent, scar formation, and ventricular function
    • Hammerman H, Klonesr RA, Hale S, Schoen FJ, Braunwald E: Dose-dependent effects of short-term methylprednisolone on myocardial infarct extent, scar formation, and ventricular function. Circulation (1983) 68(2):446-452.
    • (1983) Circulation , vol.68 , Issue.2 , pp. 446-452
    • Hammerman, H.1    Klonesr, R.A.2    Hale, S.3    Schoen, F.J.4    Braunwald, E.5
  • 33
    • 0023164980 scopus 로고
    • Relation between use of anti-inflammatory agents and left ventricular free well rupture during acute myocardial infarction
    • Silverman HS, Pfeifer MP: Relation between use of anti-inflammatory agents and left ventricular free well rupture during acute myocardial infarction. Am J Cardiol (1987) 59(4):363-364.
    • (1987) Am J Cardiol , vol.59 , Issue.4 , pp. 363-364
    • Silverman, H.S.1    Pfeifer, M.P.2
  • 34
    • 16544381475 scopus 로고    scopus 로고
    • How do glucocorticoids compare to oligo decoys as inhibitors of collagen synthesis and potential toxicity of these therapeutics?
    • Cutroneo KR, Sterling KM Jr. How do glucocorticoids compare to oligo decoys as inhibitors of collagen synthesis and potential toxicity of these therapeutics? J Cell Biochem (2004) 92(1):6-15.
    • (2004) J Cell Biochem , vol.92 , Issue.1 , pp. 6-15
    • Cutroneo, K.R.1    Sterling Jr., K.M.2
  • 35
    • 0035808003 scopus 로고    scopus 로고
    • Double-blind, randomized trial of an anti-CD-18 antibody in conjunction with recombinant tissue plasminogen activator for acute myocardial infarction. Limitation of myocardial infarction following thrombolysis in acute myocardial infarction (LIMIT AMI) study
    • for the LIMIT AMI Investigators:
    • Baran KW, Nguyen M, McKendall GR, Lambrew CT, Dykstra G, Palmeri ST, Gibbons RJ, Borzak S, Sobel BE, Gourlay SG, Rundle AC et al for the LIMIT AMI Investigators: Double-blind, randomized trial of an anti-CD-18 antibody in conjunction with recombinant tissue plasminogen activator for acute myocardial infarction. Limitation of myocardial infarction following thrombolysis in acute myocardial infarction (LIMIT AMI) study. Circulation (2001) 104(23):2778-2783.
    • (2001) Circulation , vol.104 , Issue.23 , pp. 2778-2783
    • Baran, K.W.1    Nguyen, M.2    McKendall, G.R.3    Lambrew, C.T.4    Dykstra, G.5    Palmeri, S.T.6    Gibbons, R.J.7    Borzak, S.8    Sobel, B.E.9    Gourlay, S.G.10    Rundle, A.C.11
  • 36
    • 0037010009 scopus 로고    scopus 로고
    • The effect of blockade of the CD11/CD18 Integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: The result of the HALTMI study
    • for the HALT-MI Investigators:
    • Faxon DP, Gibbons RJ, Chronos NA, Gurbel PA, Sheehan F, for the HALT-MI Investigators: The effect of blockade of the CD11/CD18 Integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: The result of the HALTMI study. J Am Col Cardiol (2002) 40(7):1199-1204.
    • (2002) J Am Col Cardiol , vol.40 , Issue.7 , pp. 1199-1204
    • Faxon, D.P.1    Gibbons, R.J.2    Chronos, N.A.3    Gurbel, P.A.4    Sheehan, F.5
  • 38
    • 20344394410 scopus 로고    scopus 로고
    • A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II)
    • for the AMISTAD-II Investigators:
    • Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW, for the AMISTAD-II Investigators: A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). J Am Coll Cardiol (2005) 45(11):1775-1780.
    • (2005) J Am Coll Cardiol , vol.45 , Issue.11 , pp. 1775-1780
    • Ross, A.M.1    Gibbons, R.J.2    Stone, G.W.3    Kloner, R.A.4    Alexander, R.W.5
  • 39
    • 0030934389 scopus 로고    scopus 로고
    • 7E2 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1
    • Simon D, Xu H, Ortlepp S, Rogers C, Rao NK: 7E2 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1. Arterioscler Thromb Vasc Biol (1997) 17(3):528-535.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , Issue.3 , pp. 528-535
    • Simon, D.1    Xu, H.2    Ortlepp, S.3    Rogers, C.4    Rao, N.K.5
  • 40
    • 0032896239 scopus 로고    scopus 로고
    • Chimeric 7E3 Fab (ReoPro) decreases detectable CD11b on neutrophils from patients undergoing coronary angioplasty
    • Mickeson JK, Nadir AM, Kleiman NS, Lakkis NM, Chow TW, Hughes BJ, Smith CW: Chimeric 7E3 Fab (ReoPro) decreases detectable CD11b on neutrophils from patients undergoing coronary angioplasty. J Am Coll Cardiol (1999) 33(1):97-106.
    • (1999) J Am Coll Cardiol , vol.33 , Issue.1 , pp. 97-106
    • Mickeson, J.K.1    Nadir, A.M.2    Kleiman, N.S.3    Lakkis, N.M.4    Chow, T.W.5    Hughes, B.J.6    Smith, C.W.7
  • 41
    • 0032790988 scopus 로고    scopus 로고
    • Potential non-glycoprotein IIb/IIIa effects of abciximab
    • Coller BS: Potential non-glycoprotein IIb/IIIa effects of abciximab. Am Heart J (1999) 138(1 Pt 2)S1-5.
    • (1999) Am Heart J , vol.138 , Issue.1 PART 2
    • Coller, B.S.1
  • 42
    • 0032534461 scopus 로고    scopus 로고
    • Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction
    • Neumann FJ, Blasini R, Schmitt C, Alt E, Dirschinger J, Gawaz M, Kastrati A, Schomig A: Effect of glycoprotein IIb/IIIa receptor blockade on recovery of coronary flow and left ventricular function after the placement of coronary-artery stents in acute myocardial infarction. Circulation (1998) 98(24):2895-2701.
    • (1998) Circulation , vol.98 , Issue.24 , pp. 2695-2701
    • Neumann, F.J.1    Blasini, R.2    Schmitt, C.3    Alt, E.4    Dirschinger, J.5    Gawaz, M.6    Kastrati, A.7    Schomig, A.8
  • 45
    • 0036308072 scopus 로고    scopus 로고
    • Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
    • Wang L, Brown JR, Varki A, Esko JD: Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest (2002) 110(1):127-136.
    • (2002) J Clin Invest , vol.110 , Issue.1 , pp. 127-136
    • Wang, L.1    Brown, J.R.2    Varki, A.3    Esko, J.D.4
  • 46
    • 0032519957 scopus 로고    scopus 로고
    • Differential interactions of heparin and heparin sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents
    • Koenig A, Norgard-Sumnicht K, Linhardt R, Varki A: Differential interactions of heparin and heparin sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. J Clin Invest (1998) 101(4):877-889.
    • (1998) J Clin Invest , vol.101 , Issue.4 , pp. 877-889
    • Koenig, A.1    Norgard-Sumnicht, K.2    Linhardt, R.3    Varki, A.4
  • 47
    • 0033527375 scopus 로고    scopus 로고
    • Heparin inhibits ligand binding to the leukocyte integrin MAC-1 (CD11b/CD18)
    • Peter K, Schwarz, M. Conradt C, Nordt T, Moser M, Kubler W, Bode C: Heparin inhibits ligand binding to the leukocyte integrin MAC-1 (CD11b/CD18). Circulation (1999) 100(14):1533-1539.
    • (1999) Circulation , vol.100 , Issue.14 , pp. 1533-1539
    • Peter, K.1    Schwarz, M.2    Conradt, C.3    Nordt, T.4    Moser, M.5    Kubler, W.6    Bode, C.7
  • 48
    • 0033945430 scopus 로고    scopus 로고
    • Heparin attenuates TNF-α induced inflammatory response through a CD11b dependent mechanism
    • Salas A, Sans M, Soriano A, Reverter JC, Anderson DC, Pique JM, Panes J: Heparin attenuates TNF-α induced inflammatory response through a CD11b dependent mechanism. Gut (2000) 47(1):88-96.
    • (2000) Gut , vol.47 , Issue.1 , pp. 88-96
    • Salas, A.1    Sans, M.2    Soriano, A.3    Reverter, J.C.4    Anderson, D.C.5    Pique, J.M.6    Panes, J.7
  • 49
    • 0036369590 scopus 로고    scopus 로고
    • Anti-leukocyte antibodies: LeukArrest (Hu23F2G) and enlimomab (R6.5) in acute stroke
    • Becker KJ: Anti-leukocyte antibodies: LeukArrest (Hu23F2G) and enlimomab (R6.5) in acute stroke. Curr Med Res Opin (2002) 18(Suppl 2):S18-S22.
    • (2002) Curr Med Res Opin , vol.18 , Issue.SUPPL. 2
    • Becker, K.J.1
  • 50
    • 0035940577 scopus 로고    scopus 로고
    • Use of anti-ICAM-1 therapy in ischemic stroke. Results of the enlimomab acute stroke trial
    • Enlimomab Acute Stroke Trial Investigators:
    • Enlimomab Acute Stroke Trial Investigators: Use of anti-ICAM-1 therapy in ischemic stroke. Results of the enlimomab acute stroke trial. Neurology (2001) 57(8):1428-1434.
    • (2001) Neurology , vol.57 , Issue.8 , pp. 1428-1434
  • 51
    • 0029096735 scopus 로고
    • Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat
    • Zhang RL, Chopp M, Jiang N, Tang WX, Prostak J, Manning AM, Anderson DC: Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke (1995) 26(8):1438-1442.
    • (1995) Stroke , vol.26 , Issue.8 , pp. 1438-1442
    • Zhang, R.L.1    Chopp, M.2    Jiang, N.3    Tang, W.X.4    Prostak, J.5    Manning, A.M.6    Anderson, D.C.7
  • 52
    • 0028952814 scopus 로고
    • Spontaneous middle cerebral artery reperfusion in ischemic stroke. A follow-up study with franscranial Doppler
    • Zanette EM, Roberti C, Mancini G, Pozzilli C, Bragoni M, Toni D: Spontaneous middle cerebral artery reperfusion in ischemic stroke. A follow-up study with franscranial Doppler. Stroke (1995) 26(3):430-433.
    • (1995) Stroke , vol.26 , Issue.3 , pp. 430-433
    • Zanette, E.M.1    Roberti, C.2    Mancini, G.3    Pozzilli, C.4    Bragoni, M.5    Toni, D.6
  • 53
    • 0021999401 scopus 로고
    • Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy
    • Schroff RW, Foon KA, Beatty SM, Oldham RK, Morgan AC Jr: Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Res (1985) 45(2):879-885.
    • (1985) Cancer Res , vol.45 , Issue.2 , pp. 879-885
    • Schroff, R.W.1    Foon, K.A.2    Beatty, S.M.3    Oldham, R.K.4    Morgan Jr., A.C.5
  • 54
    • 0031848946 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and biological activity of enlimomab (anti-ICAM-1 antibody): An open-label, dose escalation study in patients hospitalized for acute stroke
    • Schneider D, Berrouschot J, Brandt T, Hacke W, Ferbert A Norris SH, Polmar SH, Schafer E: Safety, pharmacokinetics and biological activity of enlimomab (anti-ICAM-1 antibody): An open-label, dose escalation study in patients hospitalized for acute stroke. Eur Neurol (1998) 40(2):78-83.
    • (1998) Eur Neurol , vol.40 , Issue.2 , pp. 78-83
    • Schneider, D.1    Berrouschot, J.2    Brandt, T.3    Hacke, W.4    Ferbert, A.5    Norris, S.H.6    Polmar, S.H.7    Schafer, E.8
  • 55
    • 0033557749 scopus 로고    scopus 로고
    • Anti-ICAM-1 monoclonal antibody R6.5 (enlimomab) promotes activation of neutrophils in whole blood
    • Vuorte J, Lindsberg PJ, Kaste M, Meri S, Jansson S-E, Rothlein R, Repo H: Anti-ICAM-1 monoclonal antibody R6.5 (enlimomab) promotes activation of neutrophils in whole blood. J Immunol (1999) 162(4):2353-2357.
    • (1999) J Immunol , vol.162 , Issue.4 , pp. 2353-2357
    • Vuorte, J.1    Lindsberg, P.J.2    Kaste, M.3    Meri, S.4    Jansson, S.-E.5    Rothlein, R.6    Repo, H.7
  • 56
    • 0035164475 scopus 로고    scopus 로고
    • Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intracellular adhesion molecule-1 antibody. A bedside-to-bench study
    • Furuya K, Takeda HJ, Azhar S, McCarron RM, Chen Y, Ruetzler CA, Wolcott KM, DeGraba TJ, Rothlein R, Hugli TE, del Zoppo GH, Hallenbeck JM: Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intracellular adhesion molecule-1 antibody. A bedside-to-bench study. Stroke (2001) 32(11):2665-2674.
    • (2001) Stroke , vol.32 , Issue.11 , pp. 2665-2674
    • Furuya, K.1    Takeda, H.J.2    Azhar, S.3    McCarron, R.M.4    Chen, Y.5    Ruetzler, C.A.6    Wolcott, K.M.7    DeGraba, T.J.8    Rothlein, R.9    Hugli, T.E.10    del Zoppo, G.H.11    Hallenbeck, J.M.12
  • 57
    • 0038507204 scopus 로고    scopus 로고
    • UK-279,276, a neutrophil inhibitory glycoprotein, in acute stroke. Tolerability and pharmacokinetics
    • for the UK-279,276-301 Study Investigators
    • Lees KR, Diener H-C, Asplund K, Krams M, for the UK-279,276-301 Study Investigators: UK-279,276, a neutrophil inhibitory glycoprotein, in acute stroke. Tolerability and pharmacokinetics. Stroke (2003) 34(7):1704-1709.
    • (2003) Stroke , vol.34 , Issue.7 , pp. 1704-1709
    • Lees, K.R.1    Diener, H.-C.2    Asplund, K.3    Krams, M.4
  • 58
    • 0242694372 scopus 로고    scopus 로고
    • Acute stroke therapy by inhibition of neutrophils (ASTIN). An adaptive dose-response study of UK-279,276 in acute ischemic stroke
    • for the ASTIN Study Investigators
    • Krams M, Lees KR, Hacke W, Grieve AP, Orgogozo J-M, Ford GA, for the ASTIN Study Investigators: Acute stroke therapy by inhibition of neutrophils (ASTIN). An adaptive dose-response study of UK-279,276 in acute ischemic stroke. Stroke (2003) 34(11):2543-2548.
    • (2003) Stroke , vol.34 , Issue.11 , pp. 2543-2548
    • Krams, M.1    Lees, K.R.2    Hacke, W.3    Grieve, A.P.4    Orgogozo, J.-M.5    Ford, G.A.6
  • 59
    • 0032579788 scopus 로고    scopus 로고
    • Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat
    • Jiang N, Chopp M, Chahwala S: Neutrophil inhibitory factor treatment of focal cerebral ischemia in the rat. Brain Res (1998) 788(1-2):25-34.
    • (1998) Brain Res , vol.788 , Issue.1-2 , pp. 25-34
    • Jiang, N.1    Chopp, M.2    Chahwala, S.3
  • 60
    • 0038506990 scopus 로고    scopus 로고
    • Effects of a selective CD11b/CD18 antagonist and recombinant tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke
    • Zhang L, Zhang ZG, Zhang RL, Lu M, Krams M, Chopp M: Effects of a selective CD11b/CD18 antagonist and recombinant tissue plasminogen activator treatment alone and in combination in a rat embolic model of stroke. Stroke (2003) 34(7):1790-1795.
    • (2003) Stroke , vol.34 , Issue.7 , pp. 1790-1795
    • Zhang, L.1    Zhang, Z.G.2    Zhang, R.L.3    Lu, M.4    Krams, M.5    Chopp, M.6
  • 62
    • 0033613528 scopus 로고    scopus 로고
    • Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass
    • Fitch JC, Rollins S, Matis L, Alford B, Aranki S, Collard CD, Dewar M, Elefteriades J, Hines R, Kopf G, Kraker P et al: Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass. Circulation (1999) 100(25):2499-2506.
    • (1999) Circulation , vol.100 , Issue.25 , pp. 2499-2506
    • Fitch, J.C.1    Rollins, S.2    Matis, L.3    Alford, B.4    Aranki, S.5    Collard, C.D.6    Dewar, M.7    Elefteriades, J.8    Hines, R.9    Kopf, G.10    Kraker, P.11
  • 63
    • 0041732120 scopus 로고    scopus 로고
    • Effect of pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to fibrinolysis in acute myocardial infarction. The COMPlement inhibition in myocardial infarction treated with throboLYtics (COMPLY) trial
    • for the COMPLY Investigators
    • Mahaffey KW, Granger CB, Nicolau JC, Ruzyllo W, Weaver WD, Theroux P, Hochman JS, Filloon TG, Mojcik CF, Todaro TG, Armstrong PW for the COMPLY Investigators: Effect of pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to fibrinolysis in acute myocardial infarction. The COMPlement inhibition in myocardial infarction treated with throboLYtics (COMPLY) trial. Circulation (2003) 108(10):1176-1183.
    • (2003) Circulation , vol.108 , Issue.10 , pp. 1176-1183
    • Mahaffey, K.W.1    Granger, C.B.2    Nicolau, J.C.3    Ruzyllo, W.4    Weaver, W.D.5    Theroux, P.6    Hochman, J.S.7    Filloon, T.G.8    Mojcik, C.F.9    Todaro, T.G.10    Armstrong, P.W.11
  • 64
    • 0042917638 scopus 로고    scopus 로고
    • Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction. The COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial
    • for the COMMA Investigators
    • Granger CB, Mahaffey KW, Weaver D, Theroux P, Hochman JS, Filloon TG, Rollins S, Todaro TG, Nicolau JC, Ruzyllo W, Armstrong PW for the COMMA Investigators: Pexelizumab, an anti-C5 complement antibody, as adjunctive therapy to primary percutaneous coronary intervention in acute myocardial infarction. The COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial. Circulation (2003) 108(10):1184-1190.
    • (2003) Circulation , vol.108 , Issue.10 , pp. 1184-1190
    • Granger, C.B.1    Mahaffey, K.W.2    Weaver, D.3    Theroux, P.4    Hochman, J.S.5    Filloon, T.G.6    Rollins, S.7    Todaro, T.G.8    Nicolau, J.C.9    Ruzyllo, W.10    Armstrong, P.W.11
  • 65
    • 17844391259 scopus 로고    scopus 로고
    • Assessment of pexelizumab in acute myocardial infarction (APEX AMI): A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of pexelizumab in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention
    • Armstmng PW, Adams PX, Al-Khalidi HR, Hamm C, Holmes D, O'Neill W, Todaro TG, Vahanian A, Van de Werf F, Granger CB: Assessment of pexelizumab in acute myocardial infarction (APEX AMI): A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of pexelizumab in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Am Heart J (2005) 149(3):402-407.
    • (2005) Am Heart J , vol.149 , Issue.3 , pp. 402-407
    • Armstmng, P.W.1    Adams, P.X.2    Al-Khalidi, H.R.3    Hamm, C.4    Holmes, D.5    O'Neill, W.6    Todaro, T.G.7    Vahanian, A.8    Van de Werf, F.9    Granger, C.B.10
  • 66
    • 2442613898 scopus 로고    scopus 로고
    • Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass. A randomized trial
    • for the PRIMO-CABG Investigators
    • Verrier ED, Shernan SK, Taylor KM, Van de Werf F, Newman MF, Chen JC, Carrier M, Haverich A, Malloy KJ, Adams PX, Todaro TG at al for the PRIMO-CABG Investigators: Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass. A randomized trial. J Am Med Ass (2004) 291(19):2319-2327.
    • (2004) J Am Med Ass , vol.291 , Issue.19 , pp. 2319-2327
    • Verrier, E.D.1    Shernan, S.K.2    Taylor, K.M.3    Van de Werf, F.4    Newman, M.F.5    Chen, J.C.6    Carrier, M.7    Haverich, A.8    Malloy, K.J.9    Adams, P.X.10    Todaro, T.G.11
  • 67
    • 12844265263 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of complement inhibition in ischemia-reperfusion injury after lung transplantation in human beings
    • Keshavjee S, Davis RD, Zamora MR, de Parrot M, Patterson GA: A randomized, placebo-controlled trial of complement inhibition in ischemia-reperfusion injury after lung transplantation in human beings. J Thorac Cardiovasc Surg (2005) 129(2):423-428.
    • (2005) J Thorac Cardiovasc Surg , vol.129 , Issue.2 , pp. 423-428
    • Keshavjee, S.1    Davis, R.D.2    Zamora, M.R.3    de Parrot, M.4    Patterson, G.A.5
  • 68
    • 0015417933 scopus 로고
    • Estimation of infarct size in man and its relation to prognosis
    • Sobel BE, Bresnahan GF, Shell WE, Yoder RD: Estimation of infarct size in man and its relation to prognosis. Circulation (1972) 46(4):640-648.
    • (1972) Circulation , vol.46 , Issue.4 , pp. 640-648
    • Sobel, B.E.1    Bresnahan, G.F.2    Shell, W.E.3    Yoder, R.D.4
  • 69
    • 0017352607 scopus 로고
    • Infarct size estimated from serial serum creatine phosphokinase in relation to left ventricular hemodynamics
    • Bleifeld W, Mathey D, Hanrath P, Buss H, Effert S: Infarct size estimated from serial serum creatine phosphokinase in relation to left ventricular hemodynamics. Circulation (1977) 55(2):303-311.
    • (1977) Circulation , vol.55 , Issue.2 , pp. 303-311
    • Bleifeld, W.1    Mathey, D.2    Hanrath, P.3    Buss, H.4    Effert, S.5
  • 70
    • 0019422388 scopus 로고
    • Acute myocardial infarct size estimated by serum CK-MB determinations: Clinical accuracy prognostic relevance utilizing a practical modification of the isoenzyme approach
    • Grande P, Hansen BG, Christiansen C, Naestoft J: Acute myocardial infarct size estimated by serum CK-MB determinations: Clinical accuracy and prognostic relevance utilizing a practical modification of the isoenzyme approach. Am Heart J (1981) 101(5):582-586.
    • (1981) Am Heart J , vol.101 , Issue.5 , pp. 582-586
    • Grande, P.1    Hansen, B.G.2    Christiansen, C.3    Naestoft, J.4
  • 72
    • 0033622525 scopus 로고    scopus 로고
    • sCR1sLe ameliorates ischemia/reperfusion injury in experimental lung transplantation
    • Stammberger U, Hamacher J, Hillinger S, Schmid RA: sCR1sLe ameliorates ischemia/reperfusion injury in experimental lung transplantation. J Thorac Cardiovasc Surg (2000) 120(6):1078-1084.
    • (2000) J Thorac Cardiovasc Surg , vol.120 , Issue.6 , pp. 1078-1084
    • Stammberger, U.1    Hamacher, J.2    Hillinger, S.3    Schmid, R.A.4
  • 73
    • 0035080989 scopus 로고    scopus 로고
    • TP2O is superior to TP10 in reducing ischemia/reperfuslon injury in rat lung grafts
    • Schmidt RA, Hillinger S, Hamacher J, Stammberger U: TP2O is superior to TP10 in reducing ischemia/reperfuslon injury in rat lung grafts. Transplant Proc (2001) 33(1-2):948-949.
    • (2001) Transplant Proc , vol.33 , Issue.1-2 , pp. 948-949
    • Schmidt, R.A.1    Hillinger, S.2    Hamacher, J.3    Stammberger, U.4
  • 77
    • 0025611759 scopus 로고
    • Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts
    • Tsao PS, Lefer AM: Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts. Am J Physiol (1990) 259(6 Pt 2):H1860-H1666.
    • (1990) Am J Physiol , vol.259 , Issue.6 PART 2
    • Tsao, P.S.1    Lefer, A.M.2
  • 79
    • 0038807809 scopus 로고    scopus 로고
    • Left ventricular function and cardiovascular events following adjuvant therapy with adenosine in acute myocardial infarction treated with thrombolysis
    • for the ATTACC Investigators
    • Quintana M, Hjemdahl P, Sollevi A, Kahan T, Edner M, Rehnqvist N, Kjerr ES-C, Nasman P for the ATTACC Investigators: Left ventricular function and cardiovascular events following adjuvant therapy with adenosine in acute myocardial infarction treated with thrombolysis. Eur J Clin Pharmacol (2003) 59(1):1-9.
    • (2003) Eur J Clin Pharmacol , vol.59 , Issue.1 , pp. 1-9
    • Quintana, M.1    Hjemdahl, P.2    Sollevi, A.3    Kahan, T.4    Edner, M.5    Rehnqvist, N.6    Kjerr, E.S.-C.7    Nasman, P.8
  • 80
    • 0038499269 scopus 로고    scopus 로고
    • A randomized, double-blinded, placebo-controlled, dose-ranging study measuring the effect of an adenosine agonist on infarct size reduction in patients undergoing primary percutaneous transluminal coronary angioplasty: The ADMIRE (AmP579 Delivery for Myocardial Infarction Reduction) study
    • Kopecky SL, Aviles RJ, Bell MR, Lobl JK, Tipping D, Frommell G, Ramsey K, Holland AE, Midei M, Jain A, Kellett M, Gibbons RJ: A randomized, double-blinded, placebo-controlled, dose-ranging study measuring the effect of an adenosine agonist on infarct size reduction in patients undergoing primary percutaneous transluminal coronary angioplasty: The ADMIRE (AmP579 Delivery for Myocardial Infarction Reduction) study. Am Heart J (2003) 146(1):146-152.
    • (2003) Am Heart J , vol.146 , Issue.1 , pp. 146-152
    • Kopecky, S.L.1    Aviles, R.J.2    Bell, M.R.3    Lobl, J.K.4    Tipping, D.5    Frommell, G.6    Ramsey, K.7    Holland, A.E.8    Midei, M.9    Jain, A.10    Kellett, M.11    Gibbons, R.J.12
  • 81
    • 0033586633 scopus 로고    scopus 로고
    • Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: Importance of microvascular reperfusion injury on clinical outcome
    • Claeys MJ, Bosmans J, Veenstra L, Jorens P, De Raedt H, Vrints CJ: Determinants and prognostic implications of persistent ST-segment elevation after primary angioplasty for acute myocardial infarction: importance of microvascular reperfusion injury on clinical outcome. Circulation (1999) 99(15): 1972-1977.
    • (1999) Circulation , vol.99 , Issue.15 , pp. 1972-1977
    • Claeys, M.J.1    Bosmans, J.2    Veenstra, L.3    Jorens, P.4    De Raedt, H.5    Vrints, C.J.6
  • 82
    • 0034625177 scopus 로고    scopus 로고
    • Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction
    • Marzilla M, Orsini E, Marraccini P, Testa R: Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation (2000) 101(18):2154-2159.
    • (2000) Circulation , vol.101 , Issue.18 , pp. 2154-2159
    • Marzilla, M.1    Orsini, E.2    Marraccini, P.3    Testa, R.4
  • 84
    • 3042568987 scopus 로고    scopus 로고
    • Effect of intracoronary adenosine infusion during coronary intervention on myocardial reperfusion injury in patients with acute myocardial infarction
    • Claeys MJ, Bosmans J, De Ceuninck M, Beunis A, Vergauwen W, Vorlat A, Vrints CJ: Effect of intracoronary adenosine infusion during coronary intervention on myocardial reperfusion injury in patients with acute myocardial infarction. Am J Cardiol (2004) 94(1):9-13.
    • (2004) Am J Cardiol , vol.94 , Issue.1 , pp. 9-13
    • Claeys, M.J.1    Bosmans, J.2    De Ceuninck, M.3    Beunis, A.4    Vergauwen, W.5    Vorlat, A.6    Vrints, C.J.7
  • 85
    • 0037117134 scopus 로고    scopus 로고
    • Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: A randomised trial
    • for the Stent versus Thrombolysis for Occluded Coronary Arteries in Patients Wth Acute Myocardial infarction (STOPAMI-2) Study Investigators
    • Kastrati A, Mehilli J, Dirschinger J, Schricke U, Neverve J, Pache J, Martinoff S, Neumann FJ, Nekolla S, Blasini R, Seyfarth M et al for the Stent versus Thrombolysis for Occluded Coronary Arteries in Patients Wth Acute Myocardial infarction (STOPAMI-2) Study Investigators. Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: A randomised trial. Lancet (2002) 359(9310):920-925.
    • (2002) Lancet , vol.359 , Issue.9310 , pp. 920-925
    • Kastrati, A.1    Mehilli, J.2    Dirschinger, J.3    Schricke, U.4    Neverve, J.5    Pache, J.6    Martinoff, S.7    Neumann, F.J.8    Nekolla, S.9    Blasini, R.10    Seyfarth, M.11
  • 86
    • 0028783948 scopus 로고
    • Tissue plasminogen activator for acute ischemic stroke
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
    • The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N Engl J Med (1995) 333(24):1581-1587.
    • (1995) N Engl J Med , vol.333 , Issue.24 , pp. 1581-1587
  • 88
    • 0033485522 scopus 로고    scopus 로고
    • Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: A randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke
    • Clark WM, Wissman S, Albers GW, Jhamandas JH, Madden KP, Hamilton S: Recombinant tissue-type plasminogen activator (alteplase) for ischemic stroke 3 to 5 hours after symptom onset. The ATLANTIS Study: A randomized controlled trial. Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke. J Am Med Ass (1999) 282(21):2019-2026.
    • (1999) J Am Med Ass , vol.282 , Issue.21 , pp. 2019-2026
    • Clark, W.M.1    Wissman, S.2    Albers, G.W.3    Jhamandas, J.H.4    Madden, K.P.5    Hamilton, S.6
  • 89
    • 0034793545 scopus 로고    scopus 로고
    • Heterogeneity affecting outcome from acute stroke therapy. Making reperfusion worse
    • Kent TA, Soukup VM, Fabian RH: Heterogeneity affecting outcome from acute stroke therapy. Making reperfusion worse. Stroke (2001) 32(10):2328-2327.
    • (2001) Stroke , vol.32 , Issue.10 , pp. 2327-2328
    • Kent, T.A.1    Soukup, V.M.2    Fabian, R.H.3
  • 91
    • 0031034091 scopus 로고    scopus 로고
    • Hyperglycemia and the vascular effects of cerebral ischemia
    • Kawai N, Keep RF, Betz AL: Hyperglycemia and the vascular effects of cerebral ischemia. Stroke (1997) 28(1):149-154.
    • (1997) Stroke , vol.28 , Issue.1 , pp. 149-154
    • Kawai, N.1    Keep, R.F.2    Betz, A.L.3
  • 92
    • 0033556078 scopus 로고    scopus 로고
    • Acute blood glucose levels and outcome from ischemia stroke: Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators
    • Bruno A, Biller J, Adams HP Jr, Clarke WW, Woolson RF, Williams LS, Hansen MD: Acute blood glucose levels and outcome from ischemia stroke: Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Investigators. Neurology (1999) 52(2):280-284.
    • (1999) Neurology , vol.52 , Issue.2 , pp. 280-284
    • Bruno, A.1    Biller, J.2    Adams Jr., H.P.3    Clarke, W.W.4    Woolson, R.F.5    Williams, L.S.6    Hansen, M.D.7
  • 94
    • 0034603545 scopus 로고    scopus 로고
    • Stress hyperglycemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview
    • Capes SE, Hunt D, Malmberg K, Gerstein HC: Stress hyperglycemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview. Lancet (2000) 355(9206):773-778.
    • (2000) Lancet , vol.355 , Issue.9206 , pp. 773-778
    • Capes, S.E.1    Hunt, D.2    Malmberg, K.3    Gerstein, H.C.4
  • 95
    • 0037145914 scopus 로고    scopus 로고
    • Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era?
    • for the ICONS Investigators:
    • Wahab NN, Cowden EA, Pearce NJ, Gardner NJ, Merry H, Cox JL, for the ICONS Investigators: Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era? J Am Coll Cardiol (2002) 40(10):1748-1754.
    • (2002) J Am Coll Cardiol , vol.40 , Issue.10 , pp. 1748-1754
    • Wahab, N.N.1    Cowden, E.A.2    Pearce, N.J.3    Gardner, N.J.4    Merry, H.5    Cox, J.L.6
  • 97
    • 15944403234 scopus 로고    scopus 로고
    • Hyperglycemia is an important predictor of impaired coronary flow before reperfusion therapy in ST-segment elevation myocardial infarction
    • for the Zwolle Myocardial Infarction Study Group
    • Timmer JR, Ottervanger JP, de Boer MJ, Dambrink JH, Hoorntje JC, Gosselink AT, Surpapranata H, Zijlstra F, van't Hof AW for the Zwolle Myocardial Infarction Study Group: Hyperglycemia is an important predictor of impaired coronary flow before reperfusion therapy in ST-segment elevation myocardial infarction. J Am Coll Cardiol (2005) 45(7):999-1002.
    • (2005) J Am Coll Cardiol , vol.45 , Issue.7 , pp. 999-1002
    • Timmer, J.R.1    Ottervanger, J.P.2    de Boer, M.J.3    Dambrink, J.H.4    Hoorntje, J.C.5    Gosselink, A.T.6    Surpapranata, H.7    Zijlstra, F.8    van't Hof, A.W.9
  • 98
    • 0142025085 scopus 로고    scopus 로고
    • Impact of acute hyperglycemia on left ventricular function after reperfusion therapy in patients with a first anterior wall acute myocardial infarction
    • Ishihara M, Inoue I, Kawagoe T, Shimatani Y, Kurisu S, Nishioka K, Umemura T, Nakamura S, Yoshida M: Impact of acute hyperglycemia on left ventricular function after reperfusion therapy in patients with a first anterior wall acute myocardial infarction. Am Heart J (2003) 146(4):674-678.
    • (2003) Am Heart J , vol.146 , Issue.4 , pp. 674-678
    • Ishihara, M.1    Inoue, I.2    Kawagoe, T.3    Shimatani, Y.4    Kurisu, S.5    Nishioka, K.6    Umemura, T.7    Nakamura, S.8    Yoshida, M.9
  • 99
    • 0034795140 scopus 로고    scopus 로고
    • The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
    • Schmidt AM, Yan SD, Yan SF, Stern DM: The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest (2001) 108(7):949-955.
    • (2001) J Clin Invest , vol.108 , Issue.7 , pp. 949-955
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 100
    • 4043145689 scopus 로고    scopus 로고
    • Protein glycation: A firm link to endothelial cell dysfunction
    • Wautier JL, Schmidt AM: Protein glycation: A firm link to endothelial cell dysfunction. Circ Res (2004) 95(3):233-238.
    • (2004) Circ Res , vol.95 , Issue.3 , pp. 233-238
    • Wautier, J.L.1    Schmidt, A.M.2
  • 102
    • 0141865574 scopus 로고    scopus 로고
    • Inflammation and infections as risk factors for ischemic stroke
    • Lindsberg PJ, Grau AJ: Inflammation and infections as risk factors for ischemic stroke. Stroke (2003) 34(10):2518-2532.
    • (2003) Stroke , vol.34 , Issue.10 , pp. 2518-2532
    • Lindsberg, P.J.1    Grau, A.J.2
  • 103
    • 0348014416 scopus 로고    scopus 로고
    • Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk
    • Engstrom G, Stavenow L, Hedblad B, Lind P, Tyden P, Janzon L, Lindgarde F: Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk. Arterioscler Thromb Vasc Biol (2003) 23(12):2247-2251.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , Issue.12 , pp. 2247-2251
    • Engstrom, G.1    Stavenow, L.2    Hedblad, B.3    Lind, P.4    Tyden, P.5    Janzon, L.6    Lindgarde, F.7
  • 104
    • 10344265934 scopus 로고    scopus 로고
    • Risk of myocardial infarction and stroke after acute infection or vaccination
    • Smeeth L, Thomas SL, Hall AJ, Hubbard R, Farrington P, Vallance P: Risk of myocardial infarction and stroke after acute infection or vaccination. N Engl J Med (2004) 351 (25):2611-2618.
    • (2004) N Engl J Med , vol.351 , Issue.25 , pp. 2611-2618
    • Smeeth, L.1    Thomas, S.L.2    Hall, A.J.3    Hubbard, R.4    Farrington, P.5    Vallance, P.6
  • 106
    • 0026529491 scopus 로고
    • Heparin and modified heparin inhibit complement activation in vivo
    • Weiler JM, Edems RE, Linhardt RJ, Kapelanski DP: Heparin and modified heparin inhibit complement activation in vivo. J Immunol (1992) 148(10):3210-3215.
    • (1992) J Immunol , vol.148 , Issue.10 , pp. 3210-3215
    • Weiler, J.M.1    Edems, R.E.2    Linhardt, R.J.3    Kapelanski, D.P.4
  • 109
    • 0039165192 scopus 로고
    • Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway
    • Wright TC Jr, Pukac LA, Castellot JJ Jr, Karnovsky MJ, Levine RA, Kim-Park H-Y, Campisi J: Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway. Proc Natl Acad Sci USA (1989) 88(9):3199-3203.
    • (1989) Proc Natl Acad Sci USA , vol.88 , Issue.9 , pp. 3199-3203
    • Wright Jr., T.C.1    Pukac, L.A.2    Castellot Jr., J.J.3    Karnovsky, M.J.4    Levine, R.A.5    Kim-Park, H.-Y.6    Campisi, J.7
  • 110
    • 0032953498 scopus 로고    scopus 로고
    • Heparin down-regulates the phorbol ester-induced protein kinase C gene expression in human endothelial cells: Enzyme-mediated autoregulation of protein kinase C-α and -δ genes
    • Pintus G, Tadolini B, Maioli M, Posadino AM, Gaspa L, Ventura C: Heparin down-regulates the phorbol ester-induced protein kinase C gene expression in human endothelial cells: Enzyme-mediated autoregulation of protein kinase C-α and -δ genes. FEBS Lett (1999) 449(2-3): 135-140.
    • (1999) FEBS Lett , vol.449 , Issue.2-3 , pp. 135-140
    • Pintus, G.1    Tadolini, B.2    Maioli, M.3    Posadino, A.M.4    Gaspa, L.5    Ventura, C.6
  • 111
    • 0037307635 scopus 로고    scopus 로고
    • Inhibition by heparin of protein kinase C activation and hydroxyl radical generation in puromycin aminonucleoside treated isolated rat hepatocytes
    • Aoyagi K, Kuzure Y, Shahrzad S, Hirayama A, Nagase S, Ueda A: Inhibition by heparin of protein kinase C activation and hydroxyl radical generation in puromycin aminonucleoside treated isolated rat hepatocytes. Mol Cell Biochem (2003) 244(1-2):3-9.
    • (2003) Mol Cell Biochem , vol.244 , Issue.1-2 , pp. 3-9
    • Aoyagi, K.1    Kuzure, Y.2    Shahrzad, S.3    Hirayama, A.4    Nagase, S.5    Ueda, A.6
  • 112
    • 0028060072 scopus 로고
    • Effects of heparin and N-acetyl heparin on ischemia/reperfusion- induced alterations in myocardial function in the rabbit isolated heart
    • Friedrichs GS, Kilgore KS, Manley PJ, Gralinski MR, Lucchesi BR: Effects of heparin and N-acetyl heparin on ischemia/reperfusion- induced alterations in myocardial function in the rabbit isolated heart. Circ Res (1994) 75(4):701-710.
    • (1994) Circ Res , vol.75 , Issue.4 , pp. 701-710
    • Friedrichs, G.S.1    Kilgore, K.S.2    Manley, P.J.3    Gralinski, M.R.4    Lucchesi, B.R.5
  • 113
    • 0029071894 scopus 로고
    • Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury
    • Black SC, Gralinski MR, Friedrichs GS, Kilgoer KS, Driscoll EM, Lucchesi BR: Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury. Cardiovasc Res (1995) 29(5):629-636.
    • (1995) Cardiovasc Res , vol.29 , Issue.5 , pp. 629-636
    • Black, S.C.1    Gralinski, M.R.2    Friedrichs, G.S.3    Kilgoer, K.S.4    Driscoll, E.M.5    Lucchesi, B.R.6
  • 114
    • 0037112549 scopus 로고    scopus 로고
    • HuEPSC7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke
    • Mocco J, Choudhri T, Huang J, Harfeldt E, Efros L, Klingbeil C, Vexler V, Hall W, Zhang Y, Mack W, Popilskis S et al: HuEPSC7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke. Circ Res (2002) 91(10):907-914.
    • (2002) Circ Res , vol.91 , Issue.10 , pp. 907-914
    • Mocco, J.1    Choudhri, T.2    Huang, J.3    Harfeldt, E.4    Efros, L.5    Klingbeil, C.6    Vexler, V.7    Hall, W.8    Zhang, Y.9    Mack, W.10    Popilskis, S.11
  • 116
    • 33644933693 scopus 로고    scopus 로고
    • Acetadote®, acetylcysteine injection
    • Cumberland Pharmaceuticals Inc, Nashville, TN, USA
    • Acetadote®, acetylcysteine injection. Cumberland Pharmaceuticals Inc, Nashville, TN, USA (2004).
    • (2004)
  • 117
    • 0036569113 scopus 로고    scopus 로고
    • N-acetylcysteine in acute cardiology: 10 years later. What do we know and what would we like to know?
    • Sochman J: N-acetylcysteine in acute cardiology: 10 years later. What do we know and what would we like to know? J Am Cardiol (2002) 39(9):1422-1428.
    • (2002) J Am Cardiol , vol.39 , Issue.9 , pp. 1422-1428
    • Sochman, J.1
  • 118
    • 0029795838 scopus 로고    scopus 로고
    • Acute N-acetylcystine Defense (ISLAND trial): Preliminary analysis and report after the first 30 patients
    • for the ISLAND Trial Group. Infarct Size Limitation
    • Sochman J, Vrbska J, Musilova B, Rocek M, for the ISLAND Trial Group. Infarct Size Limitation: Acute N-acetylcystine Defense (ISLAND trial): Preliminary analysis and report after the first 30 patients. Clin Cardiol (1996) 19(2):94-100.
    • (1996) Clin Cardiol , vol.19 , Issue.2 , pp. 94-100
    • Sochman, J.1    Vrbska, J.2    Musilova, B.3    Rocek, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.