Inhibition by heparin of protein kinase C activation and hydroxyl radical generation in puromycin aminonucleoside treated isolated rat hepatocytes

Molecular and Cellular Biochemistry

Volumn 244, Issue 1-2, 2003, Pages 3-9

  Aoyagi, Kazumasa ^a   Kuzure, Yutaka ^b   Shahrzad, Siranoush ^b   Hirayama, Aki ^b   Nagase, Sohji ^b   Ueda, Atsushi ^b  

^a TSUKUBA UNIVERSITY OF TECHNOLOGY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Heparin puromycin aminonucleoside; Protein kinase C; Reactive oxygen

Indexed keywords

BICARBONATE; CREATININE; CREATOL; HEPARIN; HYDROXYL RADICAL; METHYLGUANIDINE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PUROMYCIN AMINONUCLEOSIDE;

ANIMAL CELL; CELL ISOLATION; CELL MEMBRANE; CHEMICAL REACTION KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; INCUBATION TIME; LIVER CELL; MALE; NONHUMAN; RAT; REVIEW; STATISTICAL SIGNIFICANCE; UREA CYCLE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTICOAGULANTS; CELL MEMBRANE; CELLS, CULTURED; CREATININE; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HEPARIN; HEPATOCYTES; HYDROXYL RADICAL; MALE; METHYLGUANIDINE; PROTEIN KINASE C; PUROMYCIN AMINONUCLEOSIDE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUBCELLULAR FRACTIONS; TIME FACTORS;

ANIMALIA;

EID: 0037307635     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022427000249     Document Type: Review

References (51)

1. Freedman P, Meister HP, De la Paz A, Ronaghy H: The clinical, functional, and histologic response to heparin in chronic renal disease. Invest Urol 7: 398-409, 1970
2. Barsotti G, Cupisti A, Gervasi GB, Bartoli C, Barsotti M, Pasquariello A, Moriconi L, Giovannetti S: Effects of oral administration of heparan sulphate in the rat remnant kidney model. Nephron 81: 10-316, 1999
3. Yokoyama H, Myrup B, Oturai P, Deckert T: Heparin, a possible therapy for diabetic complications: The effect on mesangial and myomedial cells in vivo and in vitro, especially in relation to extracellular matrix. J Diabetes Comp 9: 97-103, 1995
4. Myrup B, Hansen PM, Jensen T, Kofoed-Enevoldsen A, Feldt-Rasmussen B, Gram J, Kluft C, Jespersen J, Deckert T: Effect of low-dose heparin on urinary albumin excretion in insulin-dependent diabetes mellitus. Lancet 345: 421-422, 1995
5. Diamond JR, Karnovsky MJ: Nonanticoagulant protective effect of heparin in chronic aminonucleoside nephrosis. Renal Physiol 9: 366-374, 1986
6. Frenk S, Antonowicz I, Chaig JM, Metecoff J: Experimental nephrotic syndrome induced in rats by aminonucleoside renal lesion and body electrolyte composition. Proc Soc Exp Biol Med 89: 424-427, 1955
7. Glasser RJ, Velosa JA, Michael AF: Experimental model of focal sclerosis. 1. Relationship to protein excretion in aminonucleoside nephrosis. Lab Invest 36: 527-534, 1977
8. Castellot JJ Jr, Pukac LA, Caleb BL, Wright TC Jr, Karnovsky MJ: Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells. J Cell Biol 109: 3147-3155, 1989
9. Xuereb JM, Herbert JM, Sie P, Boneu B, Constans J: Effects of heparin and related sulfated polysaccharides on tissue factor expression induced by mitogenic and non-mitogenic factors in human vascular smooth muscle cells. Thromb Haemost 81: 151-156, 1999
10. Pukac LA, Castellot JJ Jr, Wright TC Jr, Caleb BL, Karnovsky MJ: Heparin inhibits c-fos and c-myc mRNA expression in vascular smooth muscle cells. Cell Reg 1: 435-443, 1990
11. Au YP, Kenagy RD, Clowes AW: Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis. J Biol Chem 267: 3438-3444, 1992
12. Kenagy RD, Nikkari ST, Welgus HG, Clowes AW: Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92-kD gelatinase, and collagenase) in primate arterial smooth muscle cells. J Clin Invest 93: 1987-1993, 1994
13. Adachi T, Nakashima S, Saji S, Nakamura T, Nozawa Y: Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C. Hepatology 23: 1244-1253, 1996
14. Imai T, Hirata Y, Emori T, Marumo F: Heparin has an inhibitory effect on endothelin-1 synthesis and release by endothelial cells. Hypertension 21: 353-358, 1993
15. Diamond JR, Bonventre JV, Karnovsk MJ: A role for oxygen free radicals in aminonucleoside nephrosis. Kidney Int 29: 478-483, 1986
16. Srivastava RN, Diviven S, Kalia A, Travis LB, Ansari NH: Increased glomerular and urinary malondialdehyde in puromycin aminonucleoside-induced proteinuria in rats. Pediatr Nephrol 9: 48-51, 1995
17. Aoyagi K, Nagase S, Narita M, Tojo S: Role of active oxygen on methylguanidine synthesis in isolated rat hepatocytes. Kidney Int 22: S229-S233, 1987
18. Aoyagi K, Nagase S, Sakamoto M, Narita M, Tojo S: Puromycin aminonucleoside stimulates the synthesis of methylguanidine: A possible marker of active oxygen generation in isolated rat hepatocytes. In: A. Mori, B.D. Cohen, H. Koide (eds). Guanidines 2. Plenum Press, New York, 1989, pp 71-77
19. Aoyagi K, Akiyama K, Kuzure Y, Takemura K, Nagase S, Ienaga K, Nakamura K, Koyama A, Narita M: Synthesis of creatol, a hydroxyl radical adduct of creatinine and its increase by puromycin amino-nucleoside in isolated rat hepatocytes. Free Radic Res 29: 221-226, 1998
20. Aoyagi K, Akiyama K, Tomida C, Gotoh M, Hirayama A, Takemura K, Ueda A, Nagase S, Koyama A, Narita M: Imaging of hydroperoxides in a rat glomerulus stimulated by puromycin aminonucleoside. Kidney Int 71 (suppl): S153-S155, 1999
21. Aoyagi K, Takemura K, Tomida C, Goto M, Koyama A, Narita M: Inhibition of methylguanidine synthesis in isolated rat hepatocytes by protein kinase C inhibitor and calmodulin antagonist. In: P.P. De Deyn, B. Maeacau, A. Qureshi, A. Mori (eds). Guanidino Compounds in Biology and Medicine 2. John Libbey & Co. Ltd., London, 1997, pp 311-316
22. Nakamura K, Lenaga K, Yokozawa T, Fujitsuka N, Oura H: Production of methylguanidine from creatinine via creatol by active oxygen species: Analyses of the catabolism in vitro. Nephron 58: 42-44, 1991
23. 13C-labeling to prove that creatinine is oxidized by mammals into creatol and 5-hydroxy-1-methylhydantonin. J Chem Soc Chem Commun: 509-510, 1991
24. Aoyagi K, Nagase S, Koyama A, Narita M, Tojo S: Products of creatinine with hydroxyl radical as a useful marker of oxidative stress in vivo. Meth Mol Biol 108: 157-164, 1998
25. Sakamoto M, Aoyagi K, Nagase S, Ishikawa T, Takemura K, Narita M: Methylguanidine synthesis by reactive oxygen species from human leukocytes. Japanese J Nephrol 31: 851-858, 1998 (in Japanese)
26. Takemura K, Aoyagi K, Nagase S, Sakamoto M, Ishikawa T, Narita M: Effect of hyperbaric therapy on urinary methylguanidine excretion in normal human and patients with renal failure. In: P.P. De Deyn, B. Marescau, V. Stalon, I.A. Qureshi (eds). Guanidino Compounds in Biology and Medicine. John Libbey & Co. Ltd., London, 1992, pp 301-330
27. Berry MN, Friend DS: High-yield preparation of isolated liver cells. J Cell Biol 43: 506-520, 1969
28. Zahlten RN, Stratman FW, Lardy HA: Regulation of glucose synthesis in hormone-sensitive isolated rat hepatocytes. Proc Natl Acad Sci USA 70: 3213-3218, 1973
29. Aoyagi K, Ohba S, Narita M, Tojo S: Regulation of biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes and in vivo. Kidney Int 24: S224-S228, 1983
30. Nakamura K, Ienaga K, Nakano K, Nakai M, Nakamura Y, Hasegawa G, Sawada M, Kondo M, Mori H, Kanatsuna T: Creatol, a creatinine metabolite, as a useful determinant of renal function. Nephron 66: 140-146, 1994
31. Smith PK, Krohn RI, Hermanson GT, Malia AK, Gartner FH, Provenzano MD, Goeke EK, Olson BJ, Klenk DC: Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985
32. Nishizuka Y: Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607-614, 1992
33. Dekker LV, Parker PJ: Protein kinase C - a question of specificity. Trends Biochem Sci 19: 73-77, 1984
34. Nishizuka Y: Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9: 484-496, 1995
35. Hardy JF, Belisle S, Robitaille D, Perrault J, Roy M, Gagnon L: Measurement of heparin concentration in whole blood with the Hepcon/ HMS device does not agree with laboratory determination of plasma heparin concentration using a chromogenic substrate for activated factor X. J Thoracic Cardiovasc Surg 112: 154-161, 1996
36. Lapenna D, Mezzetti A, de Gioia S, Ciofani G, Marzio L, Di Ilio C, Cuccurullo F: Heparin: Does it act as an antioxidant in vivo? Biochem Pharmacol 44: 188-191, 1992
37. Laghi-Pasini F, Pasqui AL, Ceccatelli L, Di Perr T: Heparin inhibits FMLP and Con-A dependent activation of human polymorphonuclear leucocytes in vitro. Int J Tissue React 5: 145-151, 1983
38. Tanabe T, Otani H, Mishima K, Ogawa R, Inagaki C: Mechanisms of oxyradical production in substance P stimulated rheumatoid synovial cells. Rheumatol Int 16: 159-167, 1996
39. Liu W, Pitcher DE, Morris SL, Pugmire JE, Shores JT, Ingram CE, Glew RH, Morris DM, Fry DE: Differential effects of heparin on the early and late phases of hepatic ischemia and reperfusion injury in the pig. Shock 12: 134-138, 1999
40. Burg M, Ostendorf T, Mooney A, Koch KM, Floege J: Treatment of experimental mesangioproliferative glomerulonephritis with non-anticoagulant heparin: Therapeutic efficacy and safety. Lab Invest 6: 505-516, 1997
41. Wang ZQ, Liang KH, Pahl MV, Vaziri ND: Effect of heparin on mesangial growth and gene expression of matrix proteins. Nephrol Dialysis Transplant 13: 3052-3057, 1998
42. Hoffman A, Levy G: Kinetics of drug action in disease states. XXIX. Effect of experimental nephrotic syndrome on the pharmacodynamics of eptabarbital: Implications of severe hypoalbuminemia. J Pharmacol Exp Ther 249: 117-122, 1989
43. Sidhu JS, Omiecinski CJ: Protein synthesis inhibitors exhibit a non-specific effect on phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocytes. J Biol Chem 273: 4769-4775, 1998
44. Pedraza-Chaverri J, Arevalos AE: Tissue lipoperoxidation and glutathione peroxidase activity in puromycin aminonucleoside injected rats. Int J Biochem 26: 1139-1145, 1994
45. Roma MG, Orsler DJ, Coleman R: Canalicular retention as an in vitro assay of tight junctional permeability in isolated hepatocyte couplets: Effects of protein kinase modulation and cholestatic agents. Fund Appl Toxicol 37: 71-81, 1997
46. 2+ on exocytosis in the isolated perfused rat liver. Hepatology 20: 1032-1040, 1994
47. Adachi T, Nakashima S, Saji S, Nakamura T, Nozaw Y: Mitogen-activated protein kinase activation in hepatocyte growth factor-stimulated rat hepatocytes: Involvement of protein tyrosine kinase and protein kinase C. Hepatology 23: 1244-1253, 1996
48. 2+. Hepatology 24: 1274-1281, 1996
49. Yu P, Chen Q, Xiao Z, Harnett K, Biancani P, Behar J: Signal transduction pathways mediating CCK-induced gall bladder muscle contraction. Am J Physiol 275: G203-G211, 1998
50. 2+ mobilization in isolated intestinal muscle cells. J Pharmacol Exp Ther 260: 90-97, 1992
51. Tanabe T, Otani H, Mishima K, Ogawa R, Inagaki C: Mechanisms of oxyradical production in substance P stimulated rheumatoid synovial cells. Rheumatol Int 16: 159-167, 1996