Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction - Results of a multicenter, randomized, placebo-controlled trial: The acute myocardial infarction STudy of ADenosine (AMISTAD) trial

Journal of the American College of Cardiology

Volumn 34, Issue 6, 1999, Pages 1711-1720

  Mahaffey, Kenneth W ^{a,b,c,d,e,f,g,h}   Puma, Joseph A ^{a,b,c,d,e,f,g,h}   Barbagelata, N Alejandro ^b   Dicarli, Marcelo F ^c   Leesar, Massoud A ^d   Browne, Kevin F ^e   Eisenberg, Paul R ^f   Bolli, Roberto ^d   Casas, A Cecilia ^{a,b,c,d,e,f,g,h}   Molina Viamonte, Victor ^g   Orlandi, Cesare ^g   Blevins, Roger ^g   Gibbons, Raymond J ^h   Califf, Robert M ^{a,b,c,d,e,f,g,h}   Granger, Christopher B ^{a,b,c,d,e,f,g,h}  

^a DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^b HOSPITAL UNIVERSITARIO FUNDACIÓN FAVALORO   (Argentina)

^c HARPER UNIVERSITY HOSPITAL   (United States)

^d UNIVERSITY OF LOUISVILLE   (United States)

^e Watson Clinic   (United States)

^f WASHINGTON UNIVERSITY   (United States)

^g Medco Research Inc   (United States)

^h MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ALTEPLASE; FIBRINOLYTIC AGENT; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; PLACEBO; STREPTOKINASE;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MIXTURE; DRUG SAFETY; FEMALE; FIBRINOLYTIC THERAPY; HEART INFARCTION SIZE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TREATMENT OUTCOME;

ADENOSINE; ADULT; AGED; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PROSPECTIVE STUDIES; THROMBOLYTIC THERAPY; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 0033571512     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(99)00418-0     Document Type: Article

References (58)

1. Indications for fibrinolytic therapy in suspected acute myocardial infarction collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1,000 patients . Lancet. 343:1994;311-322.
2. The effects of tissue plasminogen activator, streptokinase or both on coronary artery patency, ventricular function and survival after acute myocardial infarction. N Engl J Med. 329:1993;1615-1622.
3. Kloner R.A. Does reperfusion injury exist in humans. J Am Coll Cardiol. 21:1993;537-545.
4. Bolli R. Mechanisms of myocardial "stunning." Circulation. 82:1990;723-738.
5. Forman M.B., Velasco C.E., Jackson E.K. Adenosine attenuates reperfusion injury following regional myocardial ischemia. Cardiovasc Res. 27:1993;9-17.
6. 1 receptor system. Cardiovasc Res. 27:1993;28-35.
7. Zhou Z., Bunger R., Lasley R.D., et al. Adenosine pretreatment increases cytosolic phosphorylation potential and attenuates postischemic cardiac dysfunction in swine. Surg Forum. 44:1993;249-252.
8. Mauser M., Hoffmeister H.M., Nienaber C., Schaper W. Influence of ribose, adenosine and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog. Circ Res. 56:1985;220-230.
9. Yao Z., Gross G.J. A comparison of adenosine-induced cardioprotection and ischemic preconditioning in dogs. Efficacy, time course and role of KATP channels. Circulation. 89:1994;1229-1236.
10. Ely S.W., Berne R.M. Protective effects of adenosine in myocardial ischemia. Circulation. 85:1992;893-904.
11. Richardt G., Wass W., Kranzhofer R., et al. Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart a protective mechanism in early myocardial ischemia . Circ Res. 61:1987;117-123.
12. Cronstein B.N., Kramer S.B., Weissmann G., Hirschhorn R. Adenosine physiologic modulator of superoxide anion generation by human neutrophils . J Exp Med. 158:1983;1160-1177.
13. 2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence. J Pharmacol Exp Ther. 280:1997;301-309.
14. Cronstein B.N., Levin R.I., Belanoff J., et al. Adenosine an endogenous inhibitor of neutrophil-mediated injury to endothelial cells . J Clin Invest. 78:1986;760-770.
15. Pitarys C.J., Virmani R., Vildibill H.D., et al. Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period. Circulation. 83:1991;237-247.
16. 1 adenosine receptors in rabbit heart. Circulation. 84:1991;350-356.
17. 1-selective adenosine analogues protects the heart against infarction. Circulation. 85:1992;659-665.
18. ATP channels and ischemic preconditioning in dogs. Am J Physiol. 264:1993;H1327-H1336.
19. Krucoff M.W., Croll M.A., Pope J.E., et al. Continuously updated 12-lead ST-segment recovery analysis for myocardial infarct artery patency assessment and its correlation with multiple simultaneous early angiographic observations. Am J Cardiol. 71:1993;145-151.
20. Olafsson B., Forman M.B., Puett D.W., et al. Reduction of reperfusion injury in the canine preparation by intracoronary adenosine importance of the endothelium and the no-reflow phenomenon . Circulation. 76:1987;1135-1145.
21. Babbitt D.G., Bermani R., Forman M.B. Intracoronary adenosine administered after reperfusion limits vascular injury after prolonged ischemia in the canine model. Circulation. 80:1989;1388-1399.
22. Babbitt D.G., Virmani R., Vildibill H.D., et al. Intracoronary adenosine administration during reperfusion following 3 hours of ischemia effects on infarct size, ventricular function and regional myocardial blood flow . Am Heart J. 120:1990;808-818.
23. Homeister J.W., Hoff P.T., Fletcher D.D., Lucchesi B.R. Combined adenosine and lidocaine administration limits myocardial reperfusion injury. Circulation. 82:1990;595-608.
24. Velasco E.C., Turner M., Cobb M.A., et al. Myocardial reperfusion injury in the canine model after 40 minutes of ischemia effect of intracoronary adenosine . Am Heart J. 122:1991;1561-1570.
25. Todd J., Zhao Z.Q., Williams M.W., et al. Intravascular adenosine at reperfusion reduces infarct size and neutrophil adherence. Ann Thorac Surg. 62:1996;1364-1372.
26. Sekili S., Jeroudi M.O., Tang X.L., et al. Effect of adenosine on myocardial "stunning" in the dog. Circ Res. 76:1995;82-94.
27. Garratt K.N., Holmes D.R., Molina-Viamonte V., et al. Intravenous adenosine and lidocaine in patients with acute myocardial infarction. Am Heart J. 136:1998;196-204.
28. Marzilli M, Gliozheni E, Fedele S, et al. Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction. Circulation 1999. In Press.
29. Leesar M., Stoddard M., Ahmed M., et al. Preconditioning of human myocardium with adenosine during coronary angioplasty. Circulation. 95:1997;2500-2507.
30. O'Connor M.K., Gibbons R.J., Juni J.E., et al. Quantitative myocardial SPECT for infarct sizing feasibility of a multicenter trial evaluated using a cardiac phantom . J Nucl Med. 36:1995;1130-1136.
31. Topol E.J., Ellis S.G., Califf R.M., et al. Combined tissue-type plasminogen activator and prostacyclin therapy for acute myocardial infarction. J Am Coll Cardiol. 14:1989;877-884.
32. Wall T.C., Califf R.M., Blankenship J., et al. Intravenous Fluosol in the treatment of acute myocardial infarction. Results of the Thrombolysis and Angioplasty in Myocardial Infarction 9 Trial. Circulation. 90:1994;114-120.
33. ISIS-4 a randomized factorial trial assessing early oral captopril, oral mononitrate and intravenous magnesium sulfate in 58,050 patients with suspected acute myocardial infarction . Lancet. 345:1995;669-685.
34. Effects of RheothRx on mortality, morbidity, left ventricular function and infarct size in patients with acute myocardial infarction. Circulation. 96:1997;192-201.
35. Free radicals, reperfusion and myocardial infarction therapy European Myocardial Infarction Project - Free Radicals pilot study . Eur Heart J. 14:(Suppl G):1993;48-51.
36. Schaer G.L., Spaccavento L.J., Browne K.F., et al. Beneficial effects of RheothRx injection in patients receiving thrombolytic therapy for acute myocardial infarction results of a randomized, double-blind, placebo-controlled trial . Circulation. 94:1996;298-307.
37. Gibbons R.J., Christian T.F., Hopfenspirger M., et al. Myocardium at risk and infarct size after thrombolytic therapy for acute myocardial infarction implications for the design of randomized trials of acute myocardial intervention . J Am Coll Cardiol. 24:1994;616-623.
38. Christian T.F., Schwartz R.S., Gibbons R.J. Determinants of infarct size in reperfusion therapy for acute myocardial infarction. Circulation. 86:1992;81-90.
39. Clements I.P., Christian T.F., Higano S.T., et al. Residual flow to the infarct zone as a determinant of infarct size after direct angioplasty. Circulation. 88:1993;1527-1533.
40. Fleming T.R., DeMets D.L. Surrogate end points in clinical trials are we being misled? Ann Intern Med. 125:1996;605-613.
41. Verani M.S., Mahmarian J.J., Hixson J.B., et al. Diagnosis of coronary artery disease by controlled coronary vasodilation with adenosine and thallium-201 scintigraphy in patients unble to exercise. Circulation. 82:1990;80-87.
42. Iskandrian A.S., Heo J., Nguyen T., et al. Assessment of coronary artery disease using single-photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia. Am J Cardiol. 67:1991;1190-1194.
43. Abreu A., Mahmarian J.J., Nishimura S., et al. Tolerance and safety of pharmacologic coronary vasodilation with adenosine in association with thallium-201 scintigraphy in patients with suspected coronary artery disease. J Am Coll Cardiol. 18:1991;730-735.
44. Gould K.L. Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilatation. I Physiologic basis and experimental validation . Am J Cardiol. 41:1978;267-268.
45. Kern M.J., Deligonul U., Tatineni S., et al. Intravenous adenosine continuous infusion and low dose bolus administration for determination of coronary vasodilator reserve in patients with and without coronary artery disease . J Am Coll Cardiol. 18:1991;718-729.
46. Gupta N.C., Esterbrooks D.J., Hilleman D.E., Mohiuddin S.M. Comparison of adenosine and exercise thallium-201 single-photon emission computed tomography (SPECT) myocardial perfusion imaging. J Am Coll Cardiol. 19:1992;248-257.
47. Iskandrian A.S., Heo J., Lemiek J., et al. Identification of high risk patients with left main and three vessel coronary artery disease by adenosine single-photon emission computed tomographic thallium imaging. Am Heart J. 125:1993;1130-1135.
48. Nishimura S., Mahmarian J.J., Boyce T.M., Verani M.S. Quantitative thallium-201 single-photon emission computed tomography during maximal pharmacologic coronary vasodilation with adenosine for assessing coronary artery disease. J Am Coll Cardiol. 18:1991;736-745.
49. Nguyen T., Heo J., Ogilby D., Iskandrian A.S. Single-photon emission computed tomography with thallium-201 during adenosine-induced coronary hyperemia correlation with coronary arteriography, exercise thallium imaging and two-dimensional echocardiography . J Am Coll Cardiol. 16:1990;1375-1383.
50. Taillefer R., Amyot R., Turpin S., et al. Comparison between dipyridamole and adenosine as pharmacologic coronary vasodilators in detection of coronary artery disease with thallium-201 imaging. J Nuclear Cardiol. 3:1996;204-211.
51. Cerqueira M.D., Verani M.S., Schwaiger M., et al. Safety profile of adenosine stress perfusion imaging in 9,256 patients results from the Adenoscan Multicenter Trial Registry . J Am Coll Cardiol. 23:1994;384-389.
52. Zoghbi W.A., Cheirif J., Kleiman N.S., et al. Diagnosis of ischemic heart disease using adenosine echocardiography. J Am Coll Cardiol. 18:1991;1271-1279.
53. 99mTc-MIBI single-photon emission computed tomography . Circulation. 87:1993;345-354.
54. Tawa C.B., Baker W.B., Kleiman N.S., et al. Comparison of adenosine echocardiography with and without isometric hand-grip, to exercise echocardiography in the detection of ischemia in patients with coronary artery diseases. J Am Soc Echocardiogr. 9:1996;33-43.
55. Edlund A., Albertsson P., Caidahl K., et al. Adenosine infusion to patients with ischemic heart disease may provoke left ventricular dysfunction detected by echocardiography. Clin Physiol. 11:1991;477-488.
56. Cheirif J., Zoghbi W.A. Adenosine echocardiography a new pharmacologic stress test . Coron Artery Dis. 2:1991;564-568.
57. Martin T.W., Seaworth J.F., Johns J.P., et al. Comparison of adenosine, dipyridamole and dobutamine in stress echocardiography. Ann Intern Med. 116:1992;190-196.
58. Kujacic V.G., Jablonskiene D., Emanuelsson H.U. Adenosine echocardiography - an alternative to dynamic stress echocardiography. Int J Card Imaging. 9:1991;169-177.