A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase

Journal of Antibiotics

Volumn 56, Issue 6, 2003, Pages 543-551

  Petkovic, Hrvoje ^a   Lill, Rachel E ^a   Sheridan, Rose M ^a   Wilkinson, Barrie ^a   McCormick, Ellen L ^c   McArthur, Hamish A I ^c   Staunton, James ^a,b   Leadlay, Peter F ^a,b   Kendrew, Steven G ^a  

^a BIOTICA TECHNOLOGY LTD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 DESMETHYL ERYTHROMYCIN D; ACYLTRANSFERASE; BERYTHROMYCIN; CLARITHROMYCIN; ERYTHROMYCIN C; ERYTHROMYCIN DERIVATIVE; MALONYL COENZYME A; METHYLMALONYL COENZYME A MUTASE; POLYKETIDE SYNTHASE; RAPAMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME SPECIFICITY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 0038264233     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.56.543     Document Type: Article

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