Genetic engineering of Streptomyces coelicolor A3(2) for the enantioselective reduction of unnatural β-keto-ester substrates

Angewandte Chemie - International Edition

Volumn 39, Issue 1, 2000, Pages 224-227

  Anson, Christopher E ^a   Bibb, Maureen J ^b   Booker Milburn, Kevin I ^a,c   Clissold, Cole ^a   Haley, Patrick J ^a   Hopwood, David A ^b   Ichinose, Koji ^b,d   Revill, W Peter ^b   Stephenson, G Richard ^a   Surti, Chandres M ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b JOHN INNES CENTRE   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

Biosynthesis; Enzyme catalysis; Genetic engineering; Polyketides; Reductions

Indexed keywords

ACTINORHODINE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BIOTECHNOLOGY; BIOTRANSFORMATION; CONTROLLED STUDY; ENZYME SUBSTRATE COMPLEX; GENETIC ENGINEERING; NONHUMAN; STEREOCHEMISTRY; STREPTOMYCES COELICOLOR;

EID: 0034598535     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(20000103)39:1<224::AID-ANIE224>3.0.CO;2-R     Document Type: Article

References (17)

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17. 3. Crystallographic data (excluding structure factors) for the structure reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as Supplementary Publication no. CCDC-127928. Copies of the data can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK (fax: (+ 44) 1223-336-033; e-mail: deposit@ccdc.cam.uk.ac).