메뉴 건너뛰기




Volumn 5, Issue 1, 2006, Pages 64-74

Treatments for behavioural disorders in neurodegenerative diseases: Drug development strategies

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SECRETASE; ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BETA SECRETASE; BETA SECRETASE INHIBITOR; BIOLOGICAL MARKER; CHOLINESTERASE INHIBITOR; CLOZAPINE; DONEPEZIL; FLUORODEOXYGLUCOSE; GALANTAMINE; GAMMA SECRETASE INHIBITOR; IMMUNOMODULATING AGENT; LITHIUM; MEMANTINE; NATURAL PRODUCT; NOOTROPIC AGENT; OLANZAPINE; PSYCHOTROPIC AGENT; QUETIAPINE; RISPERIDONE; RIVASTIGMINE; SELEGILINE; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; TAU PROTEIN; VALPROIC ACID;

EID: 33644864745     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd1928     Document Type: Review
Times cited : (46)

References (127)
  • 1
    • 0029887389 scopus 로고    scopus 로고
    • The spectrum of behavioral changes in Alzheimer's disease
    • Mega, M. S., Cummings, J. L., Fiorello, T. & Gornbein, J. The spectrum of behavioral changes in Alzheimer's disease. Neurology 46, 130-135 (1996).
    • (1996) Neurology , vol.46 , pp. 130-135
    • Mega, M.S.1    Cummings, J.L.2    Fiorello, T.3    Gornbein, J.4
  • 2
    • 0035114397 scopus 로고    scopus 로고
    • Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease
    • Aarsland, D., Cummings, J. L. & Larsen, J. P. Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease. Int. J. Geriatr. Psychiatry 16, 184-191 (2001).
    • (2001) Int. J. Geriatr. Psychiatry , vol.16 , pp. 184-191
    • Aarsland, D.1    Cummings, J.L.2    Larsen, J.P.3
  • 3
    • 0037058753 scopus 로고    scopus 로고
    • The incremental direct costs associated with behavioral symptoms in AD
    • Murman, D. L. et al. The incremental direct costs associated with behavioral symptoms in AD. Neurology 25, 1721-1729 (2002).
    • (2002) Neurology , vol.25 , pp. 1721-1729
    • Murman, D.L.1
  • 4
    • 33646477268 scopus 로고    scopus 로고
    • Assessing neuropsychiatric symptoms in clinical practice: The Neuropsychiatric Inventory Questionnaire (NPI-Q)
    • Kaufer, D. I. et al. Assessing neuropsychiatric symptoms in clinical practice: The Neuropsychiatric Inventory Questionnaire (NPI-Q). J. Neuropsychiatry Clin. Neurosci. 11, 145-146 (1999).
    • (1999) J. Neuropsychiatry Clin. Neurosci. , vol.11 , pp. 145-146
    • Kaufer, D.I.1
  • 6
    • 0027985334 scopus 로고
    • The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
    • Cummings, J. L. et al. The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 44, 2308-2314 (1994).
    • (1994) Neurology , vol.44 , pp. 2308-2314
    • Cummings, J.L.1
  • 7
    • 1542283790 scopus 로고    scopus 로고
    • Reduction of behavioral disturbances and caregiver distress by galantamine in patients with Alzheimer's disease
    • Cummings, J. L., Schneider, L., Tariot, P. N., Kershaw, P. R. & Yuan, W. Reduction of behavioral disturbances and caregiver distress by galantamine in patients with Alzheimer's disease. Am. J. Psychiatry 161, 532-538 (2004).
    • (2004) Am. J. Psychiatry , vol.161 , pp. 532-538
    • Cummings, J.L.1    Schneider, L.2    Tariot, P.N.3    Kershaw, P.R.4    Yuan, W.5
  • 8
    • 25844529437 scopus 로고    scopus 로고
    • The neuropsychiatric burden of neurological diseases in the elderly
    • (in the press)
    • Cummings, J. L. The neuropsychiatric burden of neurological diseases in the elderly. Int. Psychogeriatr. (in the press).
    • Int. Psychogeriatr
    • Cummings, J.L.1
  • 9
    • 0029987454 scopus 로고    scopus 로고
    • Alzheimer disease and frontotemporal dementias: Behavioral distinctions
    • Levy, M. L., Miller, B. L., Cummings, J. L., Fairbanks, L. A. & Craig, A. Alzheimer disease and frontotemporal dementias: Behavioral distinctions. Arch. Neurol. 53, 687-690 (1996).
    • (1996) Arch. Neurol. , vol.53 , pp. 687-690
    • Levy, M.L.1    Miller, B.L.2    Cummings, J.L.3    Fairbanks, L.A.4    Craig, A.5
  • 10
    • 0006164301 scopus 로고    scopus 로고
    • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
    • Mckeith, I. G. et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 47, 1113-1124 (1996).
    • (1996) Neurology , vol.47 , pp. 1113-1124
    • Mckeith, I.G.1
  • 11
    • 0029854681 scopus 로고    scopus 로고
    • Neuropsychiatric aspects of progressive supranuclear palsy
    • Litvan, I., Mega, M. S., Cummings, J. L. & Fairbanks, L. Neuropsychiatric aspects of progressive supranuclear palsy. Neurology 47, 1184-1189 (1996).
    • (1996) Neurology , vol.47 , pp. 1184-1189
    • Litvan, I.1    Mega, M.S.2    Cummings, J.L.3    Fairbanks, L.4
  • 13
    • 12844274439 scopus 로고    scopus 로고
    • Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence
    • Sink, K. M., Holden, K. F. & Yaffe, K. Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence. JAMA 293, 596-608 (2005).
    • (2005) JAMA , vol.293 , pp. 596-608
    • Sink, K.M.1    Holden, K.F.2    Yaffe, K.3
  • 14
    • 3042857903 scopus 로고    scopus 로고
    • Drug therapy: Alzheimer's disease
    • Cummings, J. L. Drug therapy: Alzheimer's disease. N. Engl. J. Med. 351, 56-67 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 56-67
    • Cummings, J.L.1
  • 15
    • 0042344905 scopus 로고    scopus 로고
    • Towards a molecular neuropsychiatry of neurodegenerative diseases
    • Cummings, J. L. Towards a molecular neuropsychiatry of neurodegenerative diseases. Ann. Neurol. 54, 147-154 (2003).
    • (2003) Ann. Neurol. , vol.54 , pp. 147-154
    • Cummings, J.L.1
  • 16
    • 0037077040 scopus 로고    scopus 로고
    • Toxic proteins in neurodegenerative disease
    • Taylor, J. P., Hardy, J. & Fischbeck, K. H. Toxic proteins in neurodegenerative disease. Science 296, 1991-1995 (2002).
    • (2002) Science , vol.296 , pp. 1991-1995
    • Taylor, J.P.1    Hardy, J.2    Fischbeck, K.H.3
  • 17
    • 0037264120 scopus 로고    scopus 로고
    • Unfolding the role of protein misfolding in neurodegenerative diseases
    • Soto, C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nature Rev. Neurosci. 4, 49-60 (2003).
    • (2003) Nature Rev. Neurosci. , vol.4 , pp. 49-60
    • Soto, C.1
  • 18
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J. & Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 19
    • 0031902295 scopus 로고    scopus 로고
    • Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities
    • Cummings, J. L., Vinters, H. V., Cole, G. M. & Khachaturian, Z. S. Alzheimer's disease: Etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 51, S2-S17 (1998).
    • (1998) Neurology , vol.51
    • Cummings, J.L.1    Vinters, H.V.2    Cole, G.M.3    Khachaturian, Z.S.4
  • 20
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders
    • Masliah, E. et al. Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders. Science 287, 1265-1269 (2000).
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1
  • 21
    • 0036752026 scopus 로고    scopus 로고
    • The p38 pathway is activated in Pick disease and progressive supranuclear palsy: A mechanistic link between mitogenic pathways, oxidative stress, and tau
    • Hartzler, A. W. et al. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: A mechanistic link between mitogenic pathways, oxidative stress, and tau. Neurobiol. Aging 23, 855-859 (2002).
    • (2002) Neurobiol. Aging , vol.23 , pp. 855-859
    • Hartzler, A.W.1
  • 22
    • 0032484089 scopus 로고    scopus 로고
    • Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
    • Hong, M. et al. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282, 1914-1917 (1998).
    • (1998) Science , vol.282 , pp. 1914-1917
    • Hong, M.1
  • 23
    • 0034084817 scopus 로고    scopus 로고
    • Left frontotemporal hypoperfusion is associated with aggression in patients with dementia
    • Hirono, N., Mega, M. S., Dinov, I. D., Mishkin, F. & Cummings, J. L. Left frontotemporal hypoperfusion is associated with aggression in patients with dementia. Arch. Neurol. 57, 861-866 (2000).
    • (2000) Arch. Neurol. , vol.57 , pp. 861-866
    • Hirono, N.1    Mega, M.S.2    Dinov, I.D.3    Mishkin, F.4    Cummings, J.L.5
  • 24
    • 7744238182 scopus 로고    scopus 로고
    • Medial temporal hypoperfusion and aggression in Alzheimer disease
    • Lanctot, K. L. et al. Medial temporal hypoperfusion and aggression in Alzheimer disease. Arch. Neurol. 61, 1731-1737 (2004).
    • (2004) Arch. Neurol. , vol.61 , pp. 1731-1737
    • Lanctot, K.L.1
  • 26
    • 0033924945 scopus 로고    scopus 로고
    • Cerebral correlates of psychotic symptoms in Alzheimer's disease
    • Mega, M. et al. Cerebral correlates of psychotic symptoms in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 69, 167-171 (2000).
    • (2000) J. Neurol. Neurosurg. Psychiatry , vol.69 , pp. 167-171
    • Mega, M.1
  • 27
    • 0028849215 scopus 로고
    • Psychometric and SPECT studies in Alzheimer's disease with and without delusions
    • Ponton, M. O. et al. Psychometric and SPECT studies in Alzheimer's disease with and without delusions. Neuropsychiatry Neuropsychol. Behav. Neurol. 8, 264-270 (1995).
    • (1995) Neuropsychiatry Neuropsychol. Behav. Neurol. , vol.8 , pp. 264-270
    • Ponton, M.O.1
  • 28
    • 0032867142 scopus 로고    scopus 로고
    • Delusions in Alzheimer's disease: SPET evidence of right hemispheric dysfunction
    • Staff, R. T. et al. Delusions in Alzheimer's disease: SPET evidence of right hemispheric dysfunction. Cortex 35, 549-560 (1999).
    • (1999) Cortex , vol.35 , pp. 549-560
    • Staff, R.T.1
  • 29
    • 0028020880 scopus 로고
    • A SPECT study of delusions in Alzheimer's disease
    • Starkstein, S. E., Vazquez, S. & Petracca, G. A SPECT study of delusions in Alzheimer's disease. Neurology 44, 2055-2059 (1994).
    • (1994) Neurology , vol.44 , pp. 2055-2059
    • Starkstein, S.E.1    Vazquez, S.2    Petracca, G.3
  • 30
    • 0025086913 scopus 로고
    • Subgroups in dementia of the Alzheimer type identified using positron emission tomography
    • Grady, C. L. et al. Subgroups in dementia of the Alzheimer type identified using positron emission tomography. J. Neuropsychiatry Clin. Neurosci. 2, 373-384 (1990).
    • (1990) J. Neuropsychiatry Clin. Neurosci. , vol.2 , pp. 373-384
    • Grady, C.L.1
  • 31
    • 0028783527 scopus 로고
    • Abnormal brain glucose metabolism in the delusional misidentification syndromes: A positron emission tomography study in Alzheimer disease
    • Mentis, M. J. et al. Abnormal brain glucose metabolism in the delusional misidentification syndromes: A positron emission tomography study in Alzheimer disease. Biol. Psychiatry 38, 438-449 (1995).
    • (1995) Biol. Psychiatry , vol.38 , pp. 438-449
    • Mentis, M.J.1
  • 32
    • 0036253061 scopus 로고    scopus 로고
    • Psychosis in Alzheimer disease: Postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology
    • Sweet, R. A. et al. Psychosis in Alzheimer disease: Postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology. Neurobiol. Aging 23, 547-553 (2002).
    • (2002) Neurobiol. Aging , vol.23 , pp. 547-553
    • Sweet, R.A.1
  • 33
    • 3042715688 scopus 로고    scopus 로고
    • Evidence for an association between the CSF HVA:5-HIAA ratio and aggressiveness in frontotemporal dementia but not in Alzheimer's disease
    • Engelborghs, S., Vloeberghs, E., Maertens, K., Marescau, B. & De Deyn, P. P. Evidence for an association between the CSF HVA:5-HIAA ratio and aggressiveness in frontotemporal dementia but not in Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 75, 1080 (2004).
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 1080
    • Engelborghs, S.1    Vloeberghs, E.2    Maertens, K.3    Marescau, B.4    De Deyn, P.P.5
  • 34
    • 0033669090 scopus 로고    scopus 로고
    • Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis
    • Farber, N. B. et al. Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis. Arch. Gen. Psychiatry 57, 1165-1173 (2000).
    • (2000) Arch. Gen. Psychiatry , vol.57 , pp. 1165-1173
    • Farber, N.B.1
  • 35
    • 0035091670 scopus 로고    scopus 로고
    • Orbitofrontal and anterior cingulate cortex: Neurofibrillary tangle burden is associated with agitation in Alzheimer's disease
    • Tekin, S. et al. Orbitofrontal and anterior cingulate cortex: neurofibrillary tangle burden is associated with agitation in Alzheimer's disease. Ann. Neurol. 49, 355-361 (2001).
    • (2001) Ann. Neurol. , vol.49 , pp. 355-361
    • Tekin, S.1
  • 36
    • 33646489448 scopus 로고    scopus 로고
    • Neuropathologic correlates of apathy in Alzheimer's disease
    • Marshall, G. A., Fairbanks, L., Tekin, S. et al. Neuropathologic correlates of apathy in Alzheimer's disease. Ann. Neurol. 64, A136-A137 (2005).
    • (2005) Ann. Neurol. , vol.64
    • Marshall, G.A.1    Fairbanks, L.2    Tekin, S.3
  • 37
    • 0035845705 scopus 로고    scopus 로고
    • 2 binding in the cortex
    • 2 binding in the cortex. Neurology 57, 805-811 (2001).
    • (2001) Neurology , vol.57 , pp. 805-811
    • Lai, M.K.P.1
  • 38
    • 0034727605 scopus 로고    scopus 로고
    • Cholinergic deficits contribute to behavioral disturbance in patients with dementia
    • Minger, S. L. et al. Cholinergic deficits contribute to behavioral disturbance in patients with dementia. Neurology 55, 1460-1467 (2000).
    • (2000) Neurology , vol.55 , pp. 1460-1467
    • Minger, S.L.1
  • 39
    • 4043174258 scopus 로고    scopus 로고
    • Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease
    • Assal, F. et al. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Arch. Neurol. 61, 1249-1253 (2004).
    • (2004) Arch. Neurol. , vol.61 , pp. 1249-1253
    • Assal, F.1
  • 41
    • 0035884059 scopus 로고    scopus 로고
    • 2A receptor polymorphism and psychotic symptoms in Alzheimer's disease
    • 2A receptor polymorphism and psychotic symptoms in Alzheimer's disease. Biol. Psychiatry 50, 472-475 (2001).
    • (2001) Biol. Psychiatry , vol.50 , pp. 472-475
    • Nacmias, B.1
  • 42
    • 0031596208 scopus 로고    scopus 로고
    • A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease
    • Devanand, D. et al. A randomized, placebo-controlled dose-comparison trial of haloperidol for psychosis and disruptive behaviors in Alzheimer's disease. Am. J. Psychiatry 155, 1512-1520 (1998).
    • (1998) Am. J. Psychiatry , vol.155 , pp. 1512-1520
    • Devanand, D.1
  • 43
    • 0033595555 scopus 로고    scopus 로고
    • A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia
    • De Deyn, P. P. et al. A randomized trial of risperidone, placebo, and haloperidol for behavioral symptoms of dementia. Neurology 53, 946-955 (1999).
    • (1999) Neurology , vol.53 , pp. 946-955
    • De Deyn, P.P.1
  • 44
    • 0037328229 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia
    • Brodaty, H. et al. A randomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J. Clin. Psychiatry 64, 134-143 (2003).
    • (2003) J. Clin. Psychiatry , vol.64 , pp. 134-143
    • Brodaty, H.1
  • 45
    • 0032966714 scopus 로고    scopus 로고
    • Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: A randomized, double-blind trial
    • Katz, I. R. et al. Comparison of risperidone and placebo for psychosis and behavioral disturbances associated with dementia: A randomized, double-blind trial. J. Clin. Psychiatry 60, 107-115 (1999).
    • (1999) J. Clin. Psychiatry , vol.60 , pp. 107-115
    • Katz, I.R.1
  • 46
    • 0033799993 scopus 로고    scopus 로고
    • Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer's disease in nursing care facilities. A double-blind, randomized, placebo-controlled trial
    • Street, J. S. et al. Olanzapine treatment of psychotic and behavioral symptoms in patients with Alzheimer's disease in nursing care facilities. A double-blind, randomized, placebo-controlled trial. Arch. Gen. Psychiatry 57, 968-976 (2000).
    • (2000) Arch. Gen. Psychiatry , vol.57 , pp. 968-976
    • Street, J.S.1
  • 47
    • 26844504002 scopus 로고    scopus 로고
    • Quetiapine in the treatment of agitation in patients with Alzheimer's disease
    • Sweden, 20-24 September
    • Zhong, K. et al. Quetiapine in the treatment of agitation in patients with Alzheimer's disease. Int. Psychogeriatrics Stockholm, Sweden, 20-24 September, 325-326 (2005).
    • (2005) Int. Psychogeriatrics Stockholm , pp. 325-326
    • Zhong, K.1
  • 48
    • 0033545542 scopus 로고    scopus 로고
    • Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson's disease
    • Parkinson Study Group
    • Parkinson Study Group. Low-dose clozapine for the treatment of drug-induced psychosis in Parkinson's disease. N. Engl. J. Med. 340, 757-763 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 757-763
  • 49
    • 0033034191 scopus 로고    scopus 로고
    • Olanzapine in dementia with Lewy bodies: A clinical study
    • Walker, Z. et al. Olanzapine in dementia with Lewy bodies: A clinical study. Int. J. Geriatr. Psychiatry 14, 459-466 (1999).
    • (1999) Int. J. Geriatr. Psychiatry , vol.14 , pp. 459-466
    • Walker, Z.1
  • 50
    • 0033955214 scopus 로고    scopus 로고
    • Efficacy of quetiapine in Parkinson's patients with psychosis
    • Targum, S. D. & Abbott, J. L. Efficacy of quetiapine in Parkinson's patients with psychosis. J. Clin. Psychophormacol. 20, 54-60 (2000).
    • (2000) J. Clin. Psychophormacol. , vol.20 , pp. 54-60
    • Targum, S.D.1    Abbott, J.L.2
  • 51
    • 0031746779 scopus 로고    scopus 로고
    • Quetiapine (Seroquel) in the treatment of psychosis in patients with Parkinson's disease
    • Parsa, M. A. & Bastani, B. Quetiapine (Seroquel) in the treatment of psychosis in patients with Parkinson's disease. J. Neuropsychiatry Clin. Neurosci. 10, 216-219 (1998).
    • (1998) J. Neuropsychiatry Clin. Neurosci. , vol.10 , pp. 216-219
    • Parsa, M.A.1    Bastani, B.2
  • 52
    • 0038016529 scopus 로고    scopus 로고
    • Treating depression in Alzheimer disease: Efficacy and safety of sertraline therapy, and the benefits of depression reduction, the DIADS
    • Lyketsos, C. G. et al. Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction, the DIADS. Arch. Gen. Psychiatry 60, 737-746 (2003).
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 737-746
    • Lyketsos, C.G.1
  • 53
    • 0034711133 scopus 로고    scopus 로고
    • Paroxetine in Parkinson's disease: Effects on motor and depressive symptoms
    • Ceravolo, R. et al. Paroxetine in Parkinson's disease: Effects on motor and depressive symptoms. Neurology 55, 1216-1218 (2000).
    • (2000) Neurology , vol.55 , pp. 1216-1218
    • Ceravolo, R.1
  • 54
    • 0030930208 scopus 로고    scopus 로고
    • Sertraline for the treatment of depression in Parkinson's disease
    • Hauser, R. & Zesiewicz, T A. Sertraline for the treatment of depression in Parkinson's disease. Mov. Disord. 12, 756-759 (1997).
    • (1997) Mov. Disord. , vol.12 , pp. 756-759
    • Hauser, R.1    Zesiewicz, T.A.2
  • 55
    • 0031974390 scopus 로고    scopus 로고
    • Efficacy and tolerability of carbamazepine for agitation and aggression in dementia
    • Tariot, P. N. et al. Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. Am. J. Psychiatry 155, 54-61 (1998).
    • (1998) Am. J. Psychiatry , vol.155 , pp. 54-61
    • Tariot, P.N.1
  • 56
    • 0030779517 scopus 로고    scopus 로고
    • An open trial of valproate for agitation in geriatric neuropsychiatric disorders
    • Porsteinsson, A. P., Tariot, P. N., Erb, R. & Gaile, S. An open trial of valproate for agitation in geriatric neuropsychiatric disorders. Am. J. Geriatr. Psychiatry 5, 344-351 (1997).
    • (1997) Am. J. Geriatr. Psychiatry , vol.5 , pp. 344-351
    • Porsteinsson, A.P.1    Tariot, P.N.2    Erb, R.3    Gaile, S.4
  • 57
    • 0038679746 scopus 로고    scopus 로고
    • Valproate therapy for agitation in dementia: Open-label extension of a double-blind trial
    • Porsteinsson, A. P. et al. Valproate therapy for agitation in dementia: open-label extension of a double-blind trial. Am. J. Geriatr. Psychiatry 11, 434-440 (2003).
    • (2003) Am. J. Geriatr. Psychiatry , vol.11 , pp. 434-440
    • Porsteinsson, A.P.1
  • 58
    • 26444597010 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, unforced titration parallel trial of quetiapine for dopaminergic-induced hallucinations in Parkinson's disease
    • Ondo, W. G., Tintner, R., Voung, K. D., Lai, D. & Ringholz, G. Double-blind, placebo-controlled, unforced titration parallel trial of quetiapine for dopaminergic-induced hallucinations in Parkinson's disease. Mov. Disord. 20, 958-963 (2005).
    • (2005) Mov. Disord. , vol.20 , pp. 958-963
    • Ondo, W.G.1    Tintner, R.2    Voung, K.D.3    Lai, D.4    Ringholz, G.5
  • 59
    • 20244384575 scopus 로고    scopus 로고
    • Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: Randomised double blind placebo controlled trial
    • Ballard, C. et al. Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease: Randomised double blind placebo controlled trial. BMJ 330, 874 (2005).
    • (2005) BMJ , vol.330 , pp. 874
    • Ballard, C.1
  • 60
    • 33646483914 scopus 로고    scopus 로고
    • Quetiapine for the treatment of agitation in elderly institutionalized patients with dementia: A randomized, double-blind trial
    • California, USA, 5-6 March
    • Zhong, K. et al. Quetiapine for the treatment of agitation in elderly institutionalized patients with dementia: A randomized, double-blind trial. Am. Assoc. Geriatric Psychiatry San Diego, California, USA, 5-6 March (2005).
    • (2005) Am. Assoc. Geriatric Psychiatry San Diego
    • Zhong, K.1
  • 61
    • 0031965423 scopus 로고    scopus 로고
    • Extra-pyramidal side effects in patients with Alzheimer's disease treated with low-dose neuroleptic medication
    • Caligiuri, M. P., Rockwell, E. & Jeste, D. V. Extra-pyramidal side effects in patients with Alzheimer's disease treated with low-dose neuroleptic medication. Am. J. Geriatr. Psychiatry 6, 75-82 (1998).
    • (1998) Am. J. Geriatr. Psychiatry , vol.6 , pp. 75-82
    • Caligiuri, M.P.1    Rockwell, E.2    Jeste, D.V.3
  • 62
    • 0033980910 scopus 로고    scopus 로고
    • Cholinesterase inhibitors: A new class of psychotropic agents
    • Cummings, J. L. Cholinesterase inhibitors: A new class of psychotropic agents. Am. J. Psychiatry 157, 4-15 (2000).
    • (2000) Am. J. Psychiatry , vol.157 , pp. 4-15
    • Cummings, J.L.1
  • 63
    • 0037425565 scopus 로고    scopus 로고
    • Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis
    • Trinh, N. H., Hoblyn, J., Mohanty S. & Yaffe, K. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis. JAMA 289, 210-216 (2003).
    • (2003) JAMA , vol.289 , pp. 210-216
    • Trinh, N.H.1    Hoblyn, J.2    Mohanty, S.3    Yaffe, K.4
  • 64
    • 0035964226 scopus 로고    scopus 로고
    • A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease
    • Feldman, H. et al. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology 57, 613-620 (2001).
    • (2001) Neurology , vol.57 , pp. 613-620
    • Feldman, H.1
  • 65
    • 0036942425 scopus 로고    scopus 로고
    • Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease
    • Gauthier, S. et al. Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease. Int. Psychogeriatr. 14, 389-404 (2002).
    • (2002) Int. Psychogeriatr. , vol.14 , pp. 389-404
    • Gauthier, S.1
  • 66
    • 0034720864 scopus 로고    scopus 로고
    • A 5-month, randomized, placebo-controlled trial of galantamine in AD
    • Tariot, P. N. et al. A 5-month, randomized, placebo-controlled trial of galantamine in AD. Neurology 54, 2269-2276 (2000).
    • (2000) Neurology , vol.54 , pp. 2269-2276
    • Tariot, P.N.1
  • 67
    • 0141799784 scopus 로고    scopus 로고
    • Effects of two-year treatment with the cholinesterase inhibitor rivastigmine on behavioural symptoms in Alzheimer's disease
    • Rosler, M., Retz, W., Retz-Junginger, P. & Dennler, H. J. Effects of two-year treatment with the cholinesterase inhibitor rivastigmine on behavioural symptoms in Alzheimer's disease. Behav. Neurol. 11, 211-216 (1998).
    • (1998) Behav. Neurol. , vol.11 , pp. 211-216
    • Rosler, M.1    Retz, W.2    Retz-Junginger, P.3    Dennler, H.J.4
  • 68
    • 3242775357 scopus 로고    scopus 로고
    • The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease
    • Holmes, C. et al. The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease. Neurology 63, 214-219 (2004).
    • (2004) Neurology , vol.63 , pp. 214-219
    • Holmes, C.1
  • 69
    • 10044283107 scopus 로고    scopus 로고
    • Rivastigmine for dementia associated with Parkinson's disease
    • Emre, M. et al. Rivastigmine for dementia associated with Parkinson's disease. N. Engl. J. Med. 351, 2509-2518 (2004).
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2509-2518
    • Emre, M.1
  • 70
    • 10744224126 scopus 로고    scopus 로고
    • What happens when donepezil is suddenly withdrawn? An open label trial in dementia with Lewy bodies and Parkinson's disease with dementia
    • Minett, T. S. et al. What happens when donepezil is suddenly withdrawn? An open label trial in dementia with Lewy bodies and Parkinson's disease with dementia. Int. J. Geriatr. Psychiatry 18, 988-993 (2003).
    • (2003) Int. J. Geriatr. Psychiatry , vol.18 , pp. 988-993
    • Minett, T.S.1
  • 71
    • 0034676757 scopus 로고    scopus 로고
    • Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study
    • Mckeith, I. et al. Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study. Lancet 356, 2031-2036 (2000).
    • (2000) Lancet , vol.356 , pp. 2031-2036
    • Mckeith, I.1
  • 72
    • 0035661596 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting
    • Tariot, P. N. et al. A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting. J. Am. Geriatr. Soc. 49, 1590-1599 (2001).
    • (2001) J. Am. Geriatr. Soc. , vol.49 , pp. 1590-1599
    • Tariot, P.N.1
  • 73
    • 33646474253 scopus 로고    scopus 로고
    • Dementia: Clinical evaluation
    • Florida, USA, 18-23 March, Abstract number 84
    • Cummings, J. L. Dementia: Clinical evaluation. Annu. Conf. Acad. Molecular Imaging Orlando, Florida, USA, 18-23 March, Abstract number 84 (2005).
    • (2005) Annu. Conf. Acad. Molecular Imaging Orlando
    • Cummings, J.L.1
  • 74
    • 0032491494 scopus 로고    scopus 로고
    • Genetic neurodegenerative diseases: The human illness and transgenic models
    • Price, D. L., Sisodia, S. S. & Borchelt, D. R. Genetic neurodegenerative diseases: The human illness and transgenic models. Science 282, 1079-1083 (1998).
    • (1998) Science , vol.282 , pp. 1079-1083
    • Price, D.L.1    Sisodia, S.S.2    Borchelt, D.R.3
  • 75
    • 33646483498 scopus 로고    scopus 로고
    • Cognitive evaluation of disease-modifying efficacy of Galantamine and Memantine in the APP23 model
    • 8 August [epub ahead of print]
    • Van Dam, D. & De Deyn, P. P. Cognitive evaluation of disease-modifying efficacy of Galantamine and Memantine in the APP23 model. Eur. Neuropsychopharmacol. 8 August 2005 [epub ahead of print].
    • (2005) Eur. Neuropsychopharmacol.
    • Van Dam, D.1    De Deyn, P.P.2
  • 76
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • Jackson, G. et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 34, 509-519 (2002).
    • (2002) Neuron , vol.34 , pp. 509-519
    • Jackson, G.1
  • 77
    • 0030967165 scopus 로고    scopus 로고
    • A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease
    • Sano, M. et al. A controlled trial of selegiline, α-tocopherol, or both as treatment for Alzheimer's disease. N. Engl. J. Med. 336, 1216-1222 (1997).
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1216-1222
    • Sano, M.1
  • 78
    • 0035210562 scopus 로고    scopus 로고
    • Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly
    • Laks, J. et al. Efficacy and safety of risperidone oral solution in agitation associated with dementia in the elderly. Arq. Neuropsiquiatr. 59, 859-864 (2001).
    • (2001) Arq. Neuropsiquiatr. , vol.59 , pp. 859-864
    • Laks, J.1
  • 79
    • 0034751697 scopus 로고    scopus 로고
    • A regul atory perspective on psychiatric syndromes in Alzheimer disease
    • Laughren, T. A regul atory perspective on psychiatric syndromes in Alzheimer disease. Am. J. Geriatr. Psychiatry 9, 340-345 (2001).
    • (2001) Am. J. Geriatr. Psychiatry , vol.9 , pp. 340-345
    • Laughren, T.1
  • 80
    • 33646489943 scopus 로고    scopus 로고
    • Pharmacotherapy of neuropsychiatric syndromes in neurologic disorders: Definitional and regulatory aspects
    • Cummings, J. L. & Jeste, D. V. Pharmacotherapy of neuropsychiatric syndromes in neurologic disorders: Definitional and regulatory aspects. Econ. Neurosci. 5, 36-40 (2003).
    • (2003) Econ. Neurosci. , vol.5 , pp. 36-40
    • Cummings, J.L.1    Jeste, D.V.2
  • 81
    • 0033987420 scopus 로고    scopus 로고
    • Psychosis of Alzheimer's disease and related dementias
    • Jeste, D. V. & Finkel, S. I. Psychosis of Alzheimer's disease and related dementias. Am. J. Geriatr. Psychiatry 8, 29-34 (2000).
    • (2000) Am. J. Geriatr. Psychiatry , vol.8 , pp. 29-34
    • Jeste, D.V.1    Finkel, S.I.2
  • 82
    • 0036082191 scopus 로고    scopus 로고
    • Provisional diagnostic criteria for depression of Alzheimer disease
    • Olin, J. T. et al. Provisional diagnostic criteria for depression of Alzheimer disease. Am. J. Geriatr. Psychiatry 10, 125-128 (2002).
    • (2002) Am. J. Geriatr. Psychiatry , vol.10 , pp. 125-128
    • Olin, J.T.1
  • 83
    • 0030958347 scopus 로고    scopus 로고
    • The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients
    • Cummings, J. L. The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology 48, S10-S16 (1997).
    • (1997) Neurology , vol.48
    • Cummings, J.L.1
  • 84
    • 0033989218 scopus 로고    scopus 로고
    • The use of the neuropsychiatric inventory in nursing home residents. Characterization and measurement
    • Wood, S. et al. The use of the neuropsychiatric inventory in nursing home residents. Characterization and measurement. Am. J. Geriatr. Psychiatry 8, 75-83 (2000).
    • (2000) Am. J. Geriatr. Psychiatry , vol.8 , pp. 75-83
    • Wood, S.1
  • 85
    • 0032709113 scopus 로고    scopus 로고
    • The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer's disease
    • Mega, M. S., Masterman, D. M., O'connor, S. M., Barclay, T. R. & Cummings, J. L. The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer's disease. Arch. Neurol. 56, 1388-1393 (1999).
    • (1999) Arch. Neurol. , vol.56 , pp. 1388-1393
    • Mega, M.S.1    Masterman, D.M.2    O'connor, S.M.3    Barclay, T.R.4    Cummings, J.L.5
  • 86
    • 0023272506 scopus 로고
    • Behavioral symptoms in Alzheimer's disease: Phenomenology and treatment
    • Reisberg, B. et al. Behavioral symptoms in Alzheimer's disease: phenomenology and treatment. J. Clin. Psychiatry 48, 9-15 (1987).
    • (1987) J. Clin. Psychiatry , vol.48 , pp. 9-15
    • Reisberg, B.1
  • 87
    • 0000503515 scopus 로고
    • The Brief Psychiatric Rating Scale
    • Overall, J. E. & Gorham, D. R. The Brief Psychiatric Rating Scale. Psychol. Rep. 10, 799-812 (1962).
    • (1962) Psychol. Rep. , vol.10 , pp. 799-812
    • Overall, J.E.1    Gorham, D.R.2
  • 89
    • 0023864144 scopus 로고
    • Cornell scale for depression in dementia
    • Alexopoulos, G. S. et al. Cornell scale for depression in dementia. Biol. Psychiatry 23, 271-284 (1988).
    • (1988) Biol. Psychiatry , vol.23 , pp. 271-284
    • Alexopoulos, G.S.1
  • 91
    • 1942436064 scopus 로고    scopus 로고
    • An excitement subscale of the Positive and Negative Syndrome Scale
    • Lindenmayer, J. P. et al. An excitement subscale of the Positive and Negative Syndrome Scale. Schizophr. Res. 68, 331-337 (2004).
    • (2004) Schizophr. Res. , vol.68 , pp. 331-337
    • Lindenmayer, J.P.1
  • 92
    • 0030818237 scopus 로고    scopus 로고
    • Disruptive behavior and actigraphic measures in home-dwelling patients with Alzheimer's disease: Preliminary report
    • Friedman, L. et al. Disruptive behavior and actigraphic measures in home-dwelling patients with Alzheimer's disease: Preliminary report. J. Geriatr. Psychiatry Neurol. 10, 58-62 (1997).
    • (1997) J. Geriatr. Psychiatry Neurol. , vol.10 , pp. 58-62
    • Friedman, L.1
  • 93
    • 0030862602 scopus 로고    scopus 로고
    • Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change
    • Schneider, L. S. et al. Validity and reliability of the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change. Alzheimer Dis. Assoc. Disord. 11, S22-S32 (1997).
    • (1997) Alzheimer Dis. Assoc. Disord. , vol.11
    • Schneider, L.S.1
  • 94
    • 0021520020 scopus 로고
    • A new rating scale for Alzheimer's disease
    • Rosen, W. G., Mohs, R. C. & Davis, K. L. A new rating scale for Alzheimer's disease. Am. J. Psychiatry 141, 1356-1364 (1984).
    • (1984) Am. J. Psychiatry , vol.141 , pp. 1356-1364
    • Rosen, W.G.1    Mohs, R.C.2    Davis, K.L.3
  • 95
    • 0030814418 scopus 로고    scopus 로고
    • Development of cognitive instruments for use in clinical trials of antidementia drugs: Additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study Alzheimer Dis
    • Mohs, R. C. et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: Additions to the Alzheimer's Disease Assessment Scale that broaden its scope. The Alzheimer's Disease Cooperative Study Alzheimer Dis. Assoc. Disord. 11 (Suppl. 2), S13-S21 (1997).
    • (1997) Assoc. Disord. , vol.11 , Issue.SUPPL. 2
    • Mohs, R.C.1
  • 97
    • 0030771116 scopus 로고    scopus 로고
    • An inventory to assess activities of daily living for clinical trials in Alzheimer's disease
    • Galasko, D. et al. An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. Alzheimer Dis. Assoc. Disord. 11, S33-S39 (1997).
    • (1997) Alzheimer Dis. Assoc. Disord. , vol.11
    • Galasko, D.1
  • 98
    • 0037371473 scopus 로고    scopus 로고
    • Executive dysfunction and apathy predict functional impairment in Alzheimer disease
    • Boyle, P. A. et al. Executive dysfunction and apathy predict functional impairment in Alzheimer disease. Am. J. Geriatr. Psychiatry 11, 214-221 (2003).
    • (2003) Am. J. Geriatr. Psychiatry , vol.11 , pp. 214-221
    • Boyle, P.A.1
  • 99
    • 0035166668 scopus 로고    scopus 로고
    • Activities of daily living in Alzheimer's disease: Neuropsychiatric, cognitive, and medical illness influences
    • Tekin, S., Fairbanks, L. A., O'connor, S., Rosenberg, S. & Cummings, J. L. Activities of daily living in Alzheimer's disease: Neuropsychiatric, cognitive, and medical illness influences. Am. J. Geriatr. Psychiatry 9, 81-86 (2001).
    • (2001) Am. J. Geriatr. Psychiatry , vol.9 , pp. 81-86
    • Tekin, S.1    Fairbanks, L.A.2    O'connor, S.3    Rosenberg, S.4    Cummings, J.L.5
  • 100
    • 0031731320 scopus 로고    scopus 로고
    • Executive dysfunction in Alzheimer's disease: Association with neuropsychiatric symptoms and functional impairment
    • Chen, S. T., Sultzer, D. L., Hinkin, C. H., Mahler, M. E. & Cummings, J. L. Executive dysfunction in Alzheimer's disease: Association with neuropsychiatric symptoms and functional impairment. J. Neuropsychiatry Clin. Neurosci. 10, 426-432 (1998).
    • (1998) J. Neuropsychiatry Clin. Neurosci. , vol.10 , pp. 426-432
    • Chen, S.T.1    Sultzer, D.L.2    Hinkin, C.H.3    Mahler, M.E.4    Cummings, J.L.5
  • 101
    • 0037247048 scopus 로고    scopus 로고
    • Resource utilisation and cost analysis of memantine in patients with moderate to severe Alzheimer's disease
    • Wimo, A., Winblad, B., Stoffter, A., Wirth, Y. & Mobius, H. J. Resource utilisation and cost analysis of memantine in patients with moderate to severe Alzheimer's disease. Pharmacoeconomics 21, 327-340 (2003).
    • (2003) Pharmacoeconomics , vol.21 , pp. 327-340
    • Wimo, A.1    Winblad, B.2    Stoffter, A.3    Wirth, Y.4    Mobius, H.J.5
  • 102
    • 0029858216 scopus 로고    scopus 로고
    • Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease
    • Levy, M. L. et al. Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer's disease. Am. J. Psychiatry 153, 1438-1443 (1996).
    • (1996) Am. J. Psychiatry , vol.153 , pp. 1438-1443
    • Levy, M.L.1
  • 103
    • 14444273255 scopus 로고    scopus 로고
    • The course of psychopathologic features in mild to moderate Alzheimer's disease
    • Devanand, D. P. et al. The course of psychopathologic features in mild to moderate Alzheimer's disease. Arch. Gen. Psychiatry 54, 257-263 (1997).
    • (1997) Arch. Gen. Psychiatry , vol.54 , pp. 257-263
    • Devanand, D.P.1
  • 104
    • 0034649447 scopus 로고    scopus 로고
    • Treatment of agitation in Alzheimer's disease: A randomized placebo controlled clinical trial
    • Teri, L. et al. Treatment of agitation in Alzheimer's disease: A randomized placebo controlled clinical trial. Neurology 55, 1271-1278 (2000).
    • (2000) Neurology , vol.55 , pp. 1271-1278
    • Teri, L.1
  • 105
    • 0031135177 scopus 로고    scopus 로고
    • Turnover among nursing home staff. A review
    • 64
    • Cohen-Mansfield, J. Turnover among nursing home staff. A review. Nurs. Manage. 28, 59-62, 64 (1997).
    • (1997) Nurs. Manage. , vol.28 , pp. 59-62
    • Cohen-Mansfield, J.1
  • 106
    • 0034028606 scopus 로고    scopus 로고
    • Orbital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease
    • Mega, M. S. et al. Orbital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease. J. Neuropsychiatry Clin. Neurosci. 12, 209-218 (2000).
    • (2000) J. Neuropsychiatry Clin. Neurosci. , vol.12 , pp. 209-218
    • Mega, M.S.1
  • 107
    • 20844452049 scopus 로고    scopus 로고
    • Metabolic patterns associated with the clinical response to galantamine therapy
    • Mega, M. et al. Metabolic patterns associated with the clinical response to galantamine therapy. Arch. Neurol. 62, 721-728 (2005).
    • (2005) Arch. Neurol. , vol.62 , pp. 721-728
    • Mega, M.1
  • 108
    • 0035121827 scopus 로고    scopus 로고
    • The effects of olanzapine in reducing the emergence of psychosis among nursing home patients with Alzheimer's disease
    • Clark, W. S., Street, J. S., Feldman, P. D. & Breier, A. The effects of olanzapine in reducing the emergence of psychosis among nursing home patients with Alzheimer's disease. J. Clin. Psychiatry 62, 34-40 (2001).
    • (2001) J. Clin. Psychiatry , vol.62 , pp. 34-40
    • Clark, W.S.1    Street, J.S.2    Feldman, P.D.3    Breier, A.4
  • 109
    • 0036713318 scopus 로고    scopus 로고
    • A transcultural study of agitation in dementia
    • Fuh, J. L. et al. A transcultural study of agitation in dementia. J. Geriatr. Psychiatry Neurol. 15, 171-174 (2002).
    • (2002) J. Geriatr. Psychiatry Neurol. , vol.15 , pp. 171-174
    • Fuh, J.L.1
  • 110
    • 0035024960 scopus 로고    scopus 로고
    • Behavioral disorders and caregivers' reaction in Taiwanese patients with Alzheimer's disease
    • Fuh, J. L., Liu, C. K., Mega, M. S., Wang, S. J. & Cummings, J. L. Behavioral disorders and caregivers' reaction in Taiwanese patients with Alzheimer's disease. Int. Psychogeriatr. 13, 121-128 (2001).
    • (2001) Int. Psychogeriatr. , vol.13 , pp. 121-128
    • Fuh, J.L.1    Liu, C.K.2    Mega, M.S.3    Wang, S.J.4    Cummings, J.L.5
  • 111
    • 2442551789 scopus 로고    scopus 로고
    • Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with Lewy bodies
    • Ballard, C. G. et al. Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with Lewy bodies. Am. J. Psychiatry 161, 843-849 (2004).
    • (2004) Am. J. Psychiatry , vol.161 , pp. 843-849
    • Ballard, C.G.1
  • 112
    • 0035121818 scopus 로고    scopus 로고
    • The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: Persistence and new cases over 1 year of follow-up
    • Ballard, C. G. et al. The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: Persistence and new cases over 1 year of follow-up. J. Clin. Psychiatry 62, 46-49 (2001).
    • (2001) J. Clin. Psychiatry , vol.62 , pp. 46-49
    • Ballard, C.G.1
  • 113
    • 0035195760 scopus 로고    scopus 로고
    • Current concepts in mild cognitive impairment
    • Petersen, R. C. et al. Current concepts in mild cognitive impairment. Arch. Neurol. 58, 1985-1992 (2001).
    • (2001) Arch. Neurol. , vol.58 , pp. 1985-1992
    • Petersen, R.C.1
  • 114
    • 0032988610 scopus 로고    scopus 로고
    • Mild cognitive impairment: Clinical characterization and outcome
    • Petersen, R. C. et al. Mild cognitive impairment: Clinical characterization and outcome. Arch. Neurol. 56, 303-308 (1999).
    • (1999) Arch. Neurol. , vol.56 , pp. 303-308
    • Petersen, R.C.1
  • 115
    • 0344520378 scopus 로고    scopus 로고
    • A pilot study on a home-based caregiver training program for improving caregiver self-efficacy and decreasing the behavioral problems of elders with dementia in Taiwan
    • Huang, H. L., Shyu, Y. I., Chen, M. C., Chen, S. T. & Lin, L. C. A pilot study on a home-based caregiver training program for improving caregiver self-efficacy and decreasing the behavioral problems of elders with dementia in Taiwan. Int. J. Geriatr. Psychiatry 18, 337-345 (2003).
    • (2003) Int. J. Geriatr. Psychiatry , vol.18 , pp. 337-345
    • Huang, H.L.1    Shyu, Y.I.2    Chen, M.C.3    Chen, S.T.4    Lin, L.C.5
  • 116
    • 0037174346 scopus 로고    scopus 로고
    • Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study
    • Lyketsos, C. G. et al. Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: Results from the cardiovascular health study. JAMA 288, 1475-1483 (2002).
    • (2002) JAMA , vol.288 , pp. 1475-1483
    • Lyketsos, C.G.1
  • 117
    • 0141889853 scopus 로고    scopus 로고
    • Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: Part 2
    • Lopez, O. L. et al. Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: Part 2. Arch. Neurol. 60, 1394-1399 (2003).
    • (2003) Arch. Neurol. , vol.60 , pp. 1394-1399
    • Lopez, O.L.1
  • 118
    • 0037221965 scopus 로고    scopus 로고
    • Psychiatric symptomatology and prodromal Alzheimer's disease
    • Copeland, M. P. et al. Psychiatric symptomatology and prodromal Alzheimer's disease. Alzheimer Dis. Assoc. Disord. 17, 1-8 (2003).
    • (2003) Alzheimer Dis. Assoc. Disord. , vol.17 , pp. 1-8
    • Copeland, M.P.1
  • 119
    • 0034671366 scopus 로고    scopus 로고
    • Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
    • Malberg, J. E., Eisch, A. J., Nestler, E. J. & Duman, R. S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20, 9104-9110 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 9104-9110
    • Malberg, J.E.1    Eisch, A.J.2    Nestler, E.J.3    Duman, R.S.4
  • 120
    • 0042528720 scopus 로고    scopus 로고
    • Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    • Santarelli, L. et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809 (2003).
    • (2003) Science , vol.301 , pp. 805-809
    • Santarelli, L.1
  • 121
    • 0035734335 scopus 로고    scopus 로고
    • The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease
    • Sweet, R. A. et al. The 5-HTTPR polymorphism confers liability to a combined phenotype of psychotic and aggressive behavior in Alzheimer disease. Int. Psychogeriatr. 13, 401-409 (2001).
    • (2001) Int. Psychogeriatr. , vol.13 , pp. 401-409
    • Sweet, R.A.1
  • 122
    • 0034741763 scopus 로고    scopus 로고
    • The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease
    • Sukonick, D. L. et al. The 5-HTTPR*S/*L polymorphism and aggressive behavior in Alzheimer disease. Arch. Neurol. 58, 1425-1428 (2001).
    • (2001) Arch. Neurol. , vol.58 , pp. 1425-1428
    • Sukonick, D.L.1
  • 123
    • 25444518037 scopus 로고    scopus 로고
    • Aripiprazole for the treatment of psychosis in patients with Alzheimer's disease: A randomized, placebo-controlled study
    • De Deyn, P., Jeste, D. V., Swanink, R., Kostic, D. & Breder, C. Aripiprazole for the treatment of psychosis in patients with Alzheimer's disease: A randomized, placebo-controlled study. J. Clin. Psychopharmacol. 25, 463-467 (2005).
    • (2005) J. Clin. Psychopharmacol. , vol.25 , pp. 463-467
    • De Deyn, P.1    Jeste, D.V.2    Swanink, R.3    Kostic, D.4    Breder, C.5
  • 124
    • 0035172216 scopus 로고    scopus 로고
    • Placebo-controlled study of divalproex sodium for agitation in dementia
    • Porsteinsson, A. P. et al. Placebo-controlled study of divalproex sodium for agitation in dementia. Am. J. Geriatr. Psychiatry 9, 58-66 (2001).
    • (2001) Am. J. Geriatr. Psychiatry , vol.9 , pp. 58-66
    • Porsteinsson, A.P.1
  • 125
    • 0037070773 scopus 로고    scopus 로고
    • Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: A randomized trial
    • Erkinjuntti, T. et al. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomized trial. Lancet 359, 1283-1290 (2002).
    • (2002) Lancet , vol.359 , pp. 1283-1290
    • Erkinjuntti, T.1
  • 126
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
    • Tariot, P. N. et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial. JAMA 291, 317-324 (2004).
    • (2004) JAMA , vol.291 , pp. 317-324
    • Tariot, P.N.1
  • 127
    • 0036195522 scopus 로고    scopus 로고
    • Comparison of rapidly acting intramuscular olanzapine, lorazepam, and placebo: A double-blind, randomized study in acutely agitated patients with dementia
    • Meehan, K. et al. Comparison of rapidly acting intramuscular olanzapine, lorazepam, and placebo: A double-blind, randomized study in acutely agitated patients with dementia. Neuropsychopharmacology 26, 494-504 (2002).
    • (2002) Neuropsychopharmacology , vol.26 , pp. 494-504
    • Meehan, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.