Executive dysfunction in Alzheimer disease

Archives of Neurology

Volumn 61, Issue 4, 2004, Pages 556-560

  Swanberg, Margaret M ^a   Tractenberg, Rochelle E ^b   Mohs, Richard ^d   Thal, Leon J ^c,d   Cummings, Jeffrey L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; COGNITION; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DEMENTIA; DISEASE SEVERITY; FEMALE; FRONTAL LOBE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHIATRY; PRIORITY JOURNAL; PSYCHOSIS; RETROSPECTIVE STUDY; ATTENTION; CLASSIFICATION; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DISCRIMINATION LEARNING; MENTAL HEALTH; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; PROBLEM SOLVING; PSYCHOLOGICAL ASPECT; PSYCHOMETRY; REFERENCE VALUE; STATISTICS;

ACTIVITIES OF DAILY LIVING; AGED; ALZHEIMER DISEASE; ATTENTION; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; DISCRIMINATION LEARNING; FEMALE; FRONTAL LOBE; HUMANS; MALE; MENTAL STATUS SCHEDULE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PROBLEM SOLVING; PSYCHOMETRICS; REFERENCE VALUES; RETROSPECTIVE STUDIES; STATISTICS;

EID: 2342535779     PISSN: 00039942     EISSN: None     Source Type: Journal    
DOI: 10.1001/archneur.61.4.556     Document Type: Article

References (40)

1. Cummings JL, Cole G. Alzheimer disease. JAMA. 2002;287:2335-2338.
2. Collette F, Van der Linden M, Salmon E. Executive dysfunction in Alzheimer's disease. Cortex. 1999;35:57-72.
3. Sgaramella TM, Borgo F, Mondini S, et al. Executive deficits appearing in the initial stage of Alzheimer's disease. Brain Cogn. 2001;46:264-268.
4. Binetti G, Magni E, Padovani A, et al. Executive dysfunction in early Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1996;60:91-93.
5. Johnson JK, Head E, Kim R, et al. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol. 1999;56:1233-1239.
6. Tekin S, Fairbanks LA, O'Connor S, et al. Activities of daily living in Alzheimer's disease. Am J Geriatr Psychiatry. 2001;9:81-86.
7. Skurla R, Rogers JC, Sunderland T. Direct assessment of activities of daily living in Alzheimer's disease: a controlled study. J Am Geriatr Soc. 1988;36:97-103.
8. Sultzer DL, Mahler M, Mandelkern MA, et al. The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer's disease. J Neuropsychiatry Clin Neurosci. 1995;7:476-484.
9. Mann UM, Mohr E, Gearing M, et al. Heterogeneity in Alzheimer's disease: progression rate segregated by distinct neuropsychological and cerebral metabolic profiles. J Neurol Neurosurg Psychiatry. 1992;55:956-959.
10. Tekin S, Mega MS, Masterman DM, et al. Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease. Ann NeuroL 2001;49:355-361.
11. Mega MS, Cummings JL. Frontal-subcortical circuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci, 1994;6:358-370.
12. Cummings JL. Frontal-subcortical circuits and human behavior. Arch Neurol. 1993;50:873-880.
13. Adcock RA, Constable RT, Gore JC, Goldman-Rakic PS. Functional neuroanatomy of executive processes involved in dual-task performance. Proc Natl Acad Sci U S A. 2000;97:3567-3572.
14. Mega MS, Lee L, Dinov ID, et al. Cerebral correlates of psychotic symptoms in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2000;69:167-171.
15. Auer SR, Sclan SG, Yaffee RA, et al. The neglected half of Alzheimer's disease: cognitive and functional concomitants of severe dementia. J Am Geriatr Soc. 1994;42:1266-1272.
16. Chen ST, Sultzer DL, Hinkin CH, et al. Executive dysfunction in Alzheimer's disease: association with neuropsychiatric symptoms and functional impairment. J Neuropsychiatry Clin Neurosci. 1998;10:426-432.
17. Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol. 1935;18:643-663.
18. Nelson HE. A modified card sorting test sensitive to frontal lobe defects. Cortex. 1976;12:313-324.
19. Benton AL, Hamsher KdeS, eds. Multilingual Aphasia Examination. Iowa City: University of Iowa; 1976.
20. Mohs RC, Knopman D, Petersen RC, et al. Development of cognitive instruments for use in clinical trials of antidementia drugs: additions to the Alzheimer's Disease Assessment Scale that broaden its scope. Alzheimer Dis Assoc Disord. 1997;11(suppl 2):S13-S21.
21. Ferris SF, Mackell JM, Mohs R. A multicenter evaluation of new treatment efficacy instruments for Alzheimer's disease clinical trials: overview and general results. Alzheimer Dis Assoc Disord. 1997;11(suppl 2):S1-S12.
22. Teri L, Logsdon RG, Peskind E, et al. Alzheimer's Disease Cooperative Study Group. Treatment of agitation in AD: a randomized, placebo-controlled clinical trial. Neurology. 2000;55:1271-1278,
23. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944.
24. Folstein M, Folstein S, McHugh P. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189-198.
25. Morris JC. Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993;43:2412-2414.
26. Cohen-Mansfield J, Marx MS, Rosenthal AS. A description of agitation in a nursing borne. J Gerontol. 1989;44:M77-M84.
27. Tariot PN, Mack JL, Patterson MB, et al. The Behavioral Rating Scale for Dementia of the Consortium to Establish a Registry for Alzheimer's Disease. Am J Psychiatry. 1995;152:1349-1357.
28. Galasko D, Bennett D, Sano M, et al. An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. Alzheimer Dis Assoc Disord. 1997;11(suppl 2):S33-S39.
29. Stevens J. Applied Multivariate Statistics for the Social Sciences. 3rd ed. Mahwah, NJ: Lawrence Erlbaum; 1996.
30. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat. 1979;6:65-70.
31. Pfeffer RI, Kurosaki MS, Harrah CH Jr, et al. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37:323-329.
32. Freels S, Cohen D, Eisdorfer C, et al. Functional status and clinical findings in patients with Alzheimer's disease. J Gerontol. 1992;47:M177-M182.
33. Paulsen JS, Salmon DP, Thai LJ, et al. Incidence of and risk factors for hallucinations and delusions in patients with probable AD. Neurology. 2000;54:1965-1971.
34. Jeste DV, Wragg RE, Salmon DP, et al. Cognitive deficits of patients with Alzheimer's disease with and without delusions. Am J Psychiatry. 1992;149:184-189.
35. Harwood DG, Barker WW, Ownby RL, Duara R. Relationship of behavioral and psychological symptoms to cognitive impairment and functional status in Alzheimer's disease. Int J Geriatr Psychiatry. 2000;15:393-400.
36. Wilson RS, Gilley DW, Bennett DA, et al. Hallucinations, delusions, and cognitive decline in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2000;69:172-177.
37. Paulsen JS, Ready RE, Stout JC, et al. Neurobehaviors and psychotic symptoms in Alzheimer's disease. J Int Neuropsychol Soc. 2000;6:815-820.
38. Nefsser U. Visual search. Sci Am. 1964;210:94-102.
39. Flynn FG, Cummings JL, Gornbein J. Delusions in dementia syndromes: investigation of behavioral and neuropsychological correlates. J Neuropsychiatry Clin Neurosci. 1991;3:364-370.
40. Christensen KJ, Mutchup KS, Norstrom S, et al. A cognitive battery for dementia: development and measurement characteristics. Psychol Assess. 1991;3:168-174.