An open trial of valproate for agitation in geriatric neuropsychiatric disorders

American Journal of Geriatric Psychiatry

Volumn 5, Issue 4, 1997, Pages 344-351

  Porsteinsson, Anton P ^a,b   Tariot, Pierre N ^a   Erb, Rosemary ^a   Gaile, Susan ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b Monroe Community Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAL HYDRATE; DOXEPIN; HALOPERIDOL; LITHIUM CARBONATE; LORAZEPAM; PERPHENAZINE; PSYCHOTROPIC AGENT; RISPERIDONE; THIORIDAZINE; TRAZODONE; VALPROATE SEMISODIUM;

AGED; AGITATION; ALZHEIMER DISEASE; APRAXIA; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; GAIT DISORDER; HUMAN; MALE; MENTAL DISEASE; MULTIINFARCT DEMENTIA; NEUROLOGIC DISEASE; SCHIZOIDISM; SCHIZOPHRENIA; SOMNOLENCE;

EID: 0030779517     PISSN: 10647481     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019442-199700540-00010     Document Type: Article

References (37)

1. Tariot PN, Blazina L: The psychopathology of dementia, in Handbook of Dementing Illnesses. Edited by Morris J. New York, Marcel Dekker, 1993, pp 461-475
2. Cohen-Mansfield J, Billig N: Agitated behaviors in the elderly. J Am Geriatr Soc 1986; 34:711-721
3. Leibovici A, Tariot PN: Agitation associated with dementia: a systematic approach to treatment. Psychopharmacol Bull 1988; 24:49-53
4. Reisberg B, Franssen E, Sclan S, et al: Stage-specific incidence of potentially remedial behavioral symptoms in aging and Alzheimer's disease: a study of 120 patients using the Behave-AD. Bull Clin Neurosci 1989; 54:95-112
5. Avorn J, Dreyer P, Connelly K, et al: Use of psychoactive medication and the quality of care in rest homes. N Engl J Med 1989; 320:227-232
6. Aronson MK, Cox D, Guastadisegni P, et al: Dementia and the nursing home: association with care needs. J Am Geriatr Soc 1992; 40:27-33
7. Schnelle JF, Simmons SF, Ory MG: Risk factors that predict staff failure to release nursing home residents from restraints. Gerontologist 1992; 32:767-770
8. Salzman C: Treatment of the elderly agitated patient. J Clin Psychiatry 1987; 48(suppl):19-21
9. Fairburn C, Hope R: Changes in behavior in dementia: a neglected research area. Br J Psychiatry 1988; 152:406-407
10. Schneider LS, Pollock VE, Lyness SA: A metaanalysis of controlled trials of neuroleptic treatment in dementia. J Am Geriatr Soc 1990; 38:553-563
11. Schneider LS, Sobin PB: Non-neuroleptic medications in the management of agitation in Alzheimer's disease and other dementia: a selective review. Int J Geriatr Psychiatry 1991; 6:691-708
12. Katzman R, Jackson JE: Alzheimer disease: basic and clinical advances. J Am Geriatr Soc 1991; 39:516-525
13. Cocaro EF, Kramer E, Zemishlany Z, et al: Pharmacologic treatment of noncognitive behavioral disturbances in elderly demented patients. Am J Psychiatry 1990; 147:1640-1645
14. Risse SC, Barnes R: Pharmacologic treatment of agitation associated with dementia: J Am Geriatr Soc 1986; 34:368-376
15. Tariot PN, Schneider LS, Katz IR: Anticonvulsant and other non-neuroleptic treatment of agitation in dementia. J Geriatr Psychiatry Neurol 1995; 8:1-12
16. Tariot PN, Erb R, Leibovici A, et al: Carbamazepine treatment of agitation in nursing home patients with dementia: a preliminary study. J Am Geriatr Soc 1994; 42:1160-1166
17. Patlick WH, Levy RH: Carbamazepine: interactions with other drugs, in Antiepileptic Drugs, 3rd Edition. Edited by Levy R, Mattson R, Meldrum B, et al. New York, Raven, 1989, pp 521-531
18. Mattson RU, Cramer JA: Valproate: interactions with other drugs, in Antiepileptic Drugs, 3rd Edition. Edited by Levy R, Mattson R, Meldrum B, et al. New York, Raven, 1989, pp 621-632
19. Brown R: U.S. experience with valproate in manic-depressive illness: a multicenter trial. J Clin Psychiatry 1989; 50:6-13
20. Pope HG, McElroy SL, Keck PE, et al: Valproate in the treatment of acute mania. Arch Gen Psychiatry 1991; 48:62-68
21. Stein DJ, Simeon D, Frenkel M, et al: An open trial of valproate in borderline personality disorder. J Clin Psychiatry 1995; 56:506-510
22. Mazure CM, Druss BG, Cellar JS: Valproate treatment of older psychotic patients with organic mental syndromes and behavioral dyscontrol. J Am Geriatr Soc 1992; 40:914-916
23. Mellow AM, Solano-Lopez C, Davis S: Sodium valproate in the treatment of behavioral disturbance in dementia. J Geriatr Psychiatry Neurol 1993; 6:205-209
24. Sandborn WD, Bendfeldt F, Hamdy R: Valproic acid for physically aggressive behavior in geriatric patients. Am J Geriatr Psychiatry 1995; 3:239-242
25. Yassa R, Cvejic J: Valproate in the treatment of posttraumatic bipolar disorder in a psychogeriatric patient. J Geriatr Psychiatry Neurol 1994; 7:55-57
26. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. Washington, DC, American Psychiatric Association, 1994
27. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group, Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34:939-944
28. Schneider LS, Olin JT: Clinical Global Impression in Alzheimer's clinical trials. Int Psychogeriatr 1996 8:277-290
29. Post RM, Uhde TW, Putnam FW, et al: Kindling and carbamazepine in affective illness. J Nerv Ment Dis 1982; 170:717-731
30. Albright PS, Burnham WM: Development of new pharmacological seizure model: effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat. Epilepsia 1980; 21:681-689
31. Lloyd KG, Morselli PL: Psychopharmacology of GABAergic drugs, in Psychopharmacology: The Third Generation of Progress. Edited by Meltzer HY. New York, Raven, 1987, pp 183-195
32. Post RM, Weiss SRB, Chuang D-M: Mechanisms of action of anticonvulsants in affective disorders: comparisons with lithium. J Clin Psychopharmacol 1992; 12:23S-35S
33. Rimmer EM, Richens A: An update on sodium valproate. Pharmacotherapy 1985; 5:171-184
34. Shuckla GS: Combined lithium and valproate treatment and subsequent withdrawal: serotonergic mechanism of their interaction in discrete brain regions. Prog Neuropsychopharmacol Biol Psychiatry 1985; 9:153-156
35. Mitsikostas D, Sfikakis A, Papadopoulov-Daifoti Z, et al: The effects of valproate in brain monoamines of juvenile rats after stress. Prog Neuropsychopharmacol Biol Psychiatry 1993; 17: 295-310
36. Beckers A, Stevenaert A, Pirens G, et al: Cyclical Cushing's disease and its successful control under sodium valproate. J Endocrinol Invest 1990; 13:923-929
37. 2+ deregulation, and cytoskeletal pathology. Neurobiol Aging 1995; 16:187-198