Role of B-cell and Fc receptors in the selection of T-cell epitopes

Current Opinion in Immunology

Volumn 10, Issue 1, 1998, Pages 88-92

  Amigorena, Sebastian ^a   Bonnerot, Christian ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTATION; B LYMPHOCYTE; ENDOCYTOSIS; HELPER CELL; INTERNALIZATION; NONHUMAN; REVIEW; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0032005383     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80037-X     Document Type: Article

References (42)

1. Sercarz EE, Lehmann PV, Ametani A, Benichou G, A. Miller A, Moudgil K. Dominance and crypticity of T cell antigenic determinants. Annu Rev Immunol. 11:1993;729-766.
2. Germain RN. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell. 76:1994;287-299.
3. Watts C. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu Rev Immunol. 15:1997;821-850.
4. Rammensee HG. Chemestry of peptides associated with MHC class I and II molecules. Curr Opin Immunol. 7:1995;85-96.
5. Escola JM, Grivel JC, Chavrier P, Gorvel JP. Different endocytic compartments are involved in the tight association of class II molecules with processed hen egg lysozyme and ribonuclease A in B cells. J Cell Sci. 108:1995;2337-2345.
6. Griffin JP, Chu R, Harding CV. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms. of special interest J Immunol. 158:1997;1523-3152 Using subcellular fractionation and different T cell hybridomas, this paper shows evidence indicating that two T cell epitopes, one from HEL and another from RNAse, are generated in early and late endocytic compartments, respectively. This is the first evidence for selectivity in the epitopes generated in different endocytic compartments.
7. Kropshofer H, Vogt AB, Moldenhaur G, Hammer J, Blum JS, Hammerling GJ. Editing of HLA-DR peptide repertoire by HLA-DM. of special interest EMBO J. 15:1996;5144-5154 Together with [8], this paper shows that the effect of HLA-DM on the dissociation of peptides is selective. Thus depending on the on and off rates of peptide binding to MHC class II molecules, HLA-DM promotes peptide dissociation with different efficiencies. HLA-DM may therefore perform an editing function on the peptide repertoire presented on polymorphic MHC class II molecules.
8. Weber DA, Brian DE, Jensen PE. Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. of special interest Science. 274:1996;618-620 Together with [7], this paper shows that the effect of HLA-DM on the dissociation of peptides is selective. Thus, depending on the on and off rates of peptide binding to MHC class II molecules, HLA-DM promotes peptide dissociation with different efficiencies. HLA-DM may therefore perform an editing function on the peptide repertoire presented on polymorphic MHC class II molecules.
9. Lanzavecchia A. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu Rev Immunol. 8:1990;773-793.
10. Lanzavecchia A. Antigen-specific interaction between T and B cells. Nature. 314:1985;537-539.
11. Manca F, Fenoglio D, Li PG, Kunkl A, Celada F. Effect of antigen/antibody ratio on macrophage uptake, processing, and presentation to T cells of antigen complexed with polyclonal antibodies. J Exp Med. 173:1991;37-48.
12. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 182:1995;389-400.
13. Jiang W, Swiggard WJ, Heufler C, Peng M, Mirza A, Steinman RM, Nussenzweig MC. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature. 375:1995;151-155.
14. Neuberger MS, Patel KJ, Dariavach P, Nelms K, Peaker CJ, Williams GT. The mouse B-cell antigen receptor: definition and assembly of the core receptor of the five immunoglobulin isotypes. Immunol Rev. 132:1993;147-161.
15. Daeron M. Fc receptor biology. Annu Rev Immunol. 15:1997;203-234.
16. Weinshank RL, Luster AD, Ravetch JV. Function and regulation of a murine macrophage-specific IgG Fc receptor, Fc gamma R-alpha. J Exp Med. 167:1988;1909-1925.
17. Rock KL, Benacerraf B, Abbas AK. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J Exp Med. 160:1984;1102-1113.
18. Amigorena S, Bonnerot C, Drake JR, Choquet D, Hunziker W, Guillet JG, Webster P, Sautes C, Mellman I, Fridman WH. Cytoplasmic domain heterogeneity and functions of IgG Fc receptors in B lymphocytes. Science. 256:1992;1808-1812.
19. Amigorena S, Salamero J, Davoust J, Fridman WH, Bonnerot C. Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG. Nature. 358:1992;337-341.
20. Niebling WL, Pierce SK. Antigen entry into early endosomes is insufficient for MHC class II processing. J Immunol. 150:1993;2687-2697.
21. West MA, Lucocq JM, Watts C. Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells. Nature. 369:1994;147-151.
22. Cambier JC. New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL). Immunol Today. 16:1995;110.
23. Reth M. Antigen receptor tail clue. Nature. 338:1989;383.
24. Mao SY, Pfeiffer JR, Oliver JM, Metzger H. Effects of subunit mutation on the localization to coated pits and internalization of cross-linked IgE-receptor complexes. J Immunol. 151:1993;2760-2774.
25. Bonnerot C, Amigorena S, Choquet D, Pavlovich R, Choukroun V, Fridman WH. Role of associated gamma-chain in tyrosine kinase activation via murine Fc gamma RIII. EMBO J. 11:1992;2747-2757.
26. Van den Herik-Oudijk IE, Ter Bekke MW, Tempelman MJ, Capel PJ, Van de Winkel JG. Functional differences between two Fc receptor ITAM signaling motifs. Blood. 86:1995;3302-3307.
27. Lanzavecchia A. How can cryptic epitopes trigger autoimmunity? J Exp Med. 181:1995;1945-1948.
28. Cambier JC. Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol. 155:1995;3281-3285.
29. Davidson HW, Watts C. Epitope-directed processing of specific antigen by B lymphocytes. J Cell Biol. 109:1989;85-92.
30. Watts C, Lanzavecchia A. Suppressive effect of antibody on processing of T cell epitopes. J Exp Med. 178:1993;1459-1463.
31. Aluvihare VR, Khamlichi AA, Williams GT, Adorini L, Neuberger MS. Acceleration intracellular targeting of antigen by the B-cell antigen receptor: importance depends on the nature of the antigen-antibody interaction. of special interest EMBO J. 16:1997;3553-3562 This work examines the presentation of different T-cell epitopes from two antigens, hen egg lysozyme and ovalbumin, by B lymphoma cells expressing different antigen receptors. Two factors influence the presentation of different T-cell epitopes: the cytosolic domain of the receptors mediating antigen internalization and the nature of the antigen-antibody interaction.
32. Simitsek PD, Campbell DG, Lanzavecchia A, Fairweather N, Watts C. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J Exp Med. 181:1995;1957-1963.
33. Weiser P, Riesterer C, Reth M. The internalization of the IgG2a antigen receptor does not require the association with Ig-α and Ig-β but the activation of protein tyrosin kinases does. Eur J Immunol. 24:1994;665-671.
34. Knight AM, Lucocq JM, Prescott AR, Ponnambalam S, Watts C. Antigen endocytosis and presentation mediated by human membrane IgG1 in the absence of the Igα/Igβ dimer. of outstanding interest EMBO J. 16:1997;3842-3850 Besides the associated Igα/Igβ heterodimers, the cytosolic domain for surface IgG also mediates, through a tyrosine-based motif, the internalization and efficient presentation of different T-cell epitopes.
35. Shaw AC, Mitchell RN, Weaver YK, Campos TJ, Abbas AK, Leder P. Mutations of immunoglobulin transmembrane and cytoplasmic domains: effects on intracellular signaling and antigen presentation. Cell. 63:1990;381-392.
36. Mitchell RN, Barnes KA, Grupp SA, Sanchez M, Misulovin Z, Nussenzweig MC, Abbas AK. Intracellular targering of antigens internalized by membrane immunoglobulin in B lymphocytes. J Exp Med. 181:1995;1705-1714.
37. Bonnerot C, Lankar D, Hanau D, Spehner D, Davoust J, Salamero J, Fridman WH. Role of B cell receptor Ig alpha and Ig beta subunits in MHC class II-restricted antigen presentation. Immunity. 3:1995;335-347.
38. Lindner R, Unanue ER. Distinct antigen MHC class II complexes generated by separate processing pathways. of special interest EMBO J. 15:1996;6910-6920 Using iodinated hen egg lysozyme, this work shows that intact, unfolded antigen may associate to recycling MHC class II molecules and yield to the formation of SDS-stable complexes.
39. Guangming Z, Romagnoli P, Germain RN. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein. of outstanding interest J Exp Med. 185:1997;429-438 This work examines the involvement of newly synthesized and recycling MHC class II molecules in the presentation of two T-cell epitopes from the same antigen, hen egg lysozyme. Presentation of only one of the epitopes is dependent on MHC class II cytoplasmic domain internalization signal, indicating that internalized class II molecules may only be loaded with some peptides.
40. Amigorena S, Drake JR, Webster P, Mellman I. Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes. Nature. 369:1994;113-120.
41. Amigorena S, Webster P, Drake J, Newcomb J, Cresswell P, Mellman I. Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles. J Exp Med. 181:1995;1729-1741.
42. Amigorena S, Lankar D, Briken V, Gapin L, Viguier M, Bonnerot C. Type II and III receptors for IgG control the presentation of different T-cell epitopes from single IgG-complexed antigens. J Exp Med. 187:1998;1-11.