Regulatory T cells can mediate their function through the stimulation of APCs to produce immunosuppressive nitric oxide

Journal of Immunology

Volumn 176, Issue 6, 2006, Pages 3449-3460

  Chen, Cyndi ^a   Lee, Wen Hui ^a   Zhong, Lingwen ^a   Liu, Chih Pin ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; TRANSCRIPTION FACTOR T BET;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DIABETES MELLITUS; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL;

EID: 33644834674     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.6.3449     Document Type: Article

References (54)

1. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6: 345-352.
2. + immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin. Immunol. 16: 81-88.
3. + Tregs: limiting collateral damage. J. Clin. Invest. 114: 1372-1378.
4. Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2: 816-822.
5. Roncarolo, M. G., and M. K. Levings. 2000. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr. Opin. Immunol. 12: 676-683.
6. Fontenot, J. D., and A. Y. Rudensky. 2005. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6: 331-337.
7. + T regulatory cells. Nat. Immunol. 4: 337-342.
8. + regulatory T cells. Nat. Immunol. 4: 330-336.
9. + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199: 1467-1477.
10. Tang, Q., K. J. Henriksen, M. Bi, E. B. Finger, G. Szot, J. Ye, E. L. Masteller, H. McDevitt, M. Bonyhadi, and J. A. Bluestone. 2004. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 199: 1455-1465.
11. Chen, C., W. H. Lee, P. Yun, P. Snow, and C. P. Liu. 2003. Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes. J. Immunol. 171: 733-744.
12. You, S., C. Chen, W. H. Lee, T. Brusko, M. Atkinson, and C. P. Liu. 2004. Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice. J. Immunol. 173: 6777-6785.
13. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
14. von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6: 338-344.
15. O'Garra, A., and P. Vieira. 2004. Regulatory T cells and mechanisms of immune system control. Nat. Med. 10: 801-805.
16. + regulatory T cells. Int. J. Immunol. 16: 1189-1201.
17. + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc. Natl. Acad. Sci. USA 99: 8213-8218.
18. + regulatory T cells. J. Immunol. 172: 5986-5993.
19. Prochazka, M., D. V. Serreze, W. N. Frankel, and E. H. Leiter. 1992. NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice. Diabetes 41: 98-106.
20. Serreze, D. V., M. Prochazka, P. C. Reifsnyder, M. M. Bridgett, and E. H. Leiter. 1994. Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene. J. Exp. Med. 180: 1553-1558.
21. Szabo, S. J., B. M. Sullivan, S. L. Peng, and L. H. Glimcher. 2003. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21: 713-758.
22. Judkowski, V., C. Pinilla, K. Schroder, L. Tucker, N. Sarvetnick, and D. B. Wilson. 2001. Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice. J. Immunol. 166: 908-917.
23. You, S., C. Chen, W. H. Lee, C. H. Wu, V. Judkowski, C. Pinilla, D. B. Wilson, and C. P. Liu. 2003. Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides. J. Immunol. 170: 4011-4020.
24. g7 tetramers. Proc. Natl. Acad. Sci. USA 97: 14596-14601.
25. Huang, F. P., W. Niedbala, X. Q. Wei, D. Xu, G. J. Feng, J. H. Robinson, C. Lam, and F. Y. Liew. 1998. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthase by macrophages. Eur. J. Immunol. 28: 4062-4070.
26. + islet-specific T cell clone. Science 249: 1433-1436.
27. Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74: 1089-1100.
28. Hori, S., T. Nomure, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061.
29. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 629-644.
30. + regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
31. Gregg, R. K., R. Jain, S. J. Schoenleber, R. Divekar, J. J. Bell, H. H. Lee, P. Yu, and Z. H. 2004. A sudden decline in active membrane-bound TGF-β impairs both T regulatory cell function and protection against autoimmune diabetes. J. Immunol. 173: 7308-7316.
32. Boehm, U., T. Klamp, M. Groot, and J. C. Howard. 1997. Cellular responses to interferon-γ. Annu. Rev. Immunol. 15: 749-795.
33. Billiau, A., H. Heremans, K. Vermeire, and P. Matthys. 1998. Immunomodulatory properties of interferon-γ: an update. Ann. NY Acad. Sci. 856: 22-32.
34. Rosloniec, E. F., K. Latham, and Y. B. Guedez. 2002. Paradoxical roles of IFN-γ in models of Th1-mediated autoimmunity. Arthritis Res. 4: 333-336.
35. Flaishon, L., I. Topilski, D. Shoseyov, R. Hershkoviz, E. Fireman, Y. Levo, S. Marmor, and I. Shachar. 2002. Anti-inflammatory properties of low levels of IFN-γ. J. Immunol. 168: 3707-3711.
36. Liew, F. Y. 1995. Regulation of lymphocyte functions by nitric oxide. Curr. Opin. Immunol. 7: 396-399.
37. Macmicking, J., W. Q. Xie, and C. Nathan. 1997. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15: 323-350.
38. Zhang, M., H. Tang, Z. Guo, H. An, X. Zhu, W. Song, J. Guo, X. Huang, T. Chen, J. Wang, and X. Cao. 2004. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5: 1124-1133.
39. Bishop, A., and J. E. Anderson. 2005. NO signaling in the CNS: from the physiological to the pathological. Toxicology 208: 177-192.
40. James, S. L. 1995. Role of nitric oxide in parasitic infections. Microbiol. Rev. 59: 533-547.
41. Croen, K. 1993. Evidence for an antiviral effect of nitric oxide. J. Clin. Invest. 91: 2446-2452.
42. Moncada, S., R. M. J. Palmer, and E. A. Higgs. 1991. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142.
43. Chao, C. C., and H. O. McDevitt. 1997. Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice. Immunogenetics 46: 29-34.
44. Hoglund, P., J. Mintern, C. Walizinger, W. Heath, C. Benoist, and D. Mathis. 1999. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J. Exp. Med. 189: 331-339.
45. Schloot, N. C., P. Hanifi-Moghaddam, C. Goebel, S. V. Shatavi, S. Flohe, H. Kolb, and H. Rother. 2002. Serum IFN-γ and IL-10 levels are associated with disease progression in non-obese diabetic mice. Diab. Metabol. Res. Rev. 18: 64-70.
46. Wang, B., I. Andre, A. Gonzalez, J. D. Katz, M. Aguet, C. Benoist, and D. Mathis. 1997. Interferon-γ impacts a multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94: 13844-13849.
47. Steinman, L. 2001. Blockade of γ interferon might be beneficial in MS. Mult. Scler. 7: 275-276.
48. Singh, V. K., S. Mehrotra, P. Narayan, C. M. Pandey, and S. S. Agarwal. 2000. Modulation of autoimmune diseases by nitric oxide. Immunol. Res. 22: 1-19.
49. Vladutiu, A. O. 1995. Role of nitric oxide in autoimmunity. Clin. Immunol. Immunopathol. 76: 1-11.
50. Fenyk-Melody, J. E., A. E. Garrison, S. R. Brunnert, J. R. Weidner, F. Shen, B. A. Shelton, and J. S. Mudgett. 1998. Experimental autoimmune encephalomyelitis is exacerbated in mice lacking the NOS2 gene. J. Immunol. 160: 2940-2946.
51. Sahrbacher, U. C., F. Lechner, H. P. Eugster, K. Frei, H. Lassmann, and A. Fontana. 1998. Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis. Eur. J. Immunol. 28: 1332-1338.
52. Mazzoni, A., V. Bronte, A. Visintin, J. H. Spitze, E. Apolloni, P. Serafini, P. Zanovello, and D. M. Segal. 2002. Myeloid suppressor lines inhibits T cell responses by an NO-dependent mechanism. J. Immunol. 168: 689-695.
53. Van der Veen, R. C., T. A. Dietlin, L. Pen, and J. D. Gray. 1999. Nitric oxide inhibits the proliferation of Th1 and 2 lymphocytes without reduction in cytokine secretion. Cell. Immunol. 193: 194-201.
54. Krymskaya, L., W. H. Lee, L. W. Zhong, and C. P. Liu. 2005. Polarized development of memory cell-like IFN-γ-producing cells in the absence of TCR ζ-chain. J. Immunol. 174: 1188-1195.