Molecular/genetic determinants of repolarization and their modification by environmental stress

Journal of Internal Medicine

Volumn 259, Issue 1, 2006, Pages 7-23

  Rosen, M R ^a   Cohen, I S ^b  

^a College of Physicians and Surgeons of Columbia University ^*  (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Cardiac electrophysiology; Cardiac ion channels; Electrocardiography; ST T wave abnormalities

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ION CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROTEIN KCHIP2; SODIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; POTASSIUM CHANNEL;

CALCIUM CURRENT; CONFERENCE PAPER; DRUG INDUCED DISEASE; ELECTROCARDIOGRAPHY; ENVIRONMENTAL FACTOR; GAP JUNCTION; GENE; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC RISK; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HERITABILITY; HUMAN; KVLQT1 GENE; LONG QT SYNDROME; MINK GENE; MISSENSE MUTATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RISK FACTOR; SODIUM CURRENT; ST SEGMENT; ST SEGMENT DEPRESSION; ST SEGMENT ELEVATION; STRESS; T WAVE; ACTION POTENTIAL; ADAPTATION; ANIMAL; ENVIRONMENT; GENETICS; HEART; HEART VENTRICLE; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ACTION POTENTIALS; ADAPTATION, PHYSIOLOGICAL; ANIMALS; ELECTROCARDIOGRAPHY; ENVIRONMENT; HEART; HEART VENTRICLES; HUMANS; ION CHANNELS; LONG QT SYNDROME; POTASSIUM CHANNELS; SODIUM CHANNELS; STRESS;

EID: 33644826797     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2005.01592.x     Document Type: Conference Paper

References (98)

1. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology The Sicilian Gambit Circulation 1991 84 1831 51
2. Jiang Y Lee A Chen J et al X-ray structure of a voltage-dependent K+ channel Nature 2003 423 33 41
3. Hodgkin AL Huxley AF Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo J Physiol 1952 116 449 72
4. Hodgkin AL Huxley AF The components of membrane conductance in the giant axon of Loligo J Physiol 1952 116 473 96
5. Hodgkin AL Huxley AF The dual effects of membrane potential on sodium conductance in the giant axon of Loligo J Physiol 1952 116 497 506
6. Johnson EA Lieberman M Heart: excitation and contraction Ann Rev Physiol 1971 33 479 530
7. Neher E Sakmann B Steinbach JH The extracellular patch clamp: a method for resolving currents through individual open channels in biological membranes Pflugers Arch 1978 375 219 28
8. Nishida M MacKinnon R Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution Cell 2002 111 957 65
9. Tristani-Firouzi M Sanguinetti MC Structural determinants and biophysical properties of HERG and KCNQ1 channel gating JMCC 2003 35 27 35
10. Members of the Sicilian Gambit New approaches to antiarrhythmic therapy: emerging therapeutic applications of the cell biology of cardiac arrhythmias Cardiovasc Res 2001 52 345 60
11. Haverkamp W Breithardt G Camm AJ et al. The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications Eur Heart J 2002 21 1216 31
12. Sicouri S Antzelevitch C A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell Circ Res 1991 68 1729 41
13. Antzelevitch C Sicouri S Litovsky SH et al. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells Circ Res 1991 69 1427 49
14. Anyuhovsky EP Sosonuv EA Gainullin RZ Rosen MR The controversial M cell J Cardiovasc Electrophysiol 1999 10 244 60
15. Costantini O Drabek C Rosenbaum DS Can sudden cardiac death be predicted from the T wave of the ECG? A critical examination of T wave alternans and QT interval dispersion Pacing Clin Electrophysiol 2000 23 1407 16
16. Barr RC Genesis of the electrocardiogram In MacFarlane PW Lawrie TDV eds Comprehensive Electrocardiology: Theory and Practice in Health and Disease Vol. 1 New York Pergamon Press 1989 129 51
17. Janse MJ The effect of changes in heart rate on the refractory period of the heart Thesis Mondeel Offset Drukkerij Amsterdam, The Netherlands 1971
18. Zygmunt AC Eddlestone GT Thomas GP Nesterenko VV Antzelevitch C Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle Am J Physiol Heart Circ Physiol 2001 28 H689 97
19. Merot J Charpentier F Poirier JM Coutris G Weissenburger J Effects of chronic treatment by amiodarone on transmural heterogeneity of canine ventricular repolarization in vivo: interactions with acute sotalol Cardiovas Res 1999 44 303 14
20. Weissenburger J Nesterenko VV Antzelevitch C Transmural heterogeneity of ventricular repolarization under baseline and long QT conditions in the canine heart in vivo: torsades de pointes develops with halothane but not pentobarbital anesthesia J Cardiovasc Electrophysiol 2000 11 290 304
21. Anyukhovsky EP Sosunov EA Feinmark SJ Rosen MR Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium: II. In vivo study Circulation 1997 96 4019 26
22. Conrath CE Wilders R Coronel R et al Intercellular coupling through gap junctions masks M cells in the human heart Cardiovasc Res 2004 62 407 14
23. Ks heterogeneity on action potential duration and its rate dependence: a simulation study Circulation 1999 99 2466 74
24. Nerbonne JM Kass RS Physiology and molecular biology of ion channels contributing to ventricular repolarization In Gussak I Antzelevitch C eds Contemporary Cardiology: Cardiac Repolarization: Bridging Basic and Clinical Science Totowa, NJ Humana Press 2003 25 62
25. Adamson PB Barr RC Callans DJ et al. The perplexing complexity of cardiac arrhythmias: beyond electrical remodeling Heart Rhythm 2005 2 650 659
26. + channel diversity in the mammalian myocardium J Physiol 2000 1 285 98
27. Doronin SV Potapova IA Lu Z Cohen IS Angiotensin receptor type 1 forms a complex with the transient outward potassium channel Kv4.3 and regulates its gating properties and intracellular localization J Biol Chem 2004 279 48231 7
28. to in epicardial and endocardial ventricular myocytes from the canine heart Circ Res 2000 86 1062 8
29. Dixon JE Shi W Wang HS et al. Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current Circ Res 1996 79 659 68
30. Rosati B Grau F Rodriguez S Li H Nerbonne JM McKinnon D Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle J Physiol 2003 548 815 22
31. Rosati B Pan Z Lypen S et al Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle J Physiol 2001 533 119 25
32. Plotnikov AN Sosunov EA Patberg KW et al. Cardiac memory evolves with age in association with development of the transient outward current Circulation 2004 110 489 95
33. to1, is altered in cardiac memory Circulation 1999 99 1898 905
34. del Balzo U Rosen MR T wave changes persisting after ventricular pacing in canine heart are altered by 4-aminopyridine but not by lidocaine. Implications with respect to phenomenon of cardiac 'memory' Circulation 1992 85 1464 72
35. Ks in heterologous system Cardiovasc Res 2002 56 93 103
36. Ks potassium channels with HERG and is associated with cardiac arrhythmias Cell 1999 97 175 87
37. Weerapura M Nattel S Chartier D Caballero R Hebert TE A comparison of currents carried by HERG, with and without co expression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link J Physiol 2002 540 15 27
38. Pourrier M Zicha S Ehrlich J Han W Nattel S Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers Circ Res 2003 93 189 91
39. Jiang M Zhang M Tang DG et al. KCNE2 protein is expressed in ventricles of different species, and its expression contribute to electrical remodeling in diseased hearts Circulation 2004 109 1783 8
40. Ks channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions Circulation 2003 108 132 4
41. Ks in dog ventricular muscle and Purkinje fiber repolarization J Physiol 2000 523 67 81
42. Wetzel GT Klitzner TS Developmental cardiac electrophysiology: recent advances in cellular physiology Cardiovasc Res 1996 31 E52 60
43. + channels in mouse heart Circ Res 1996 79 79 85
44. Barajas-Martinez H Elizalde A Sanchez-Chapula JA Developmental differences in delayed rectifying outward current in feline ventricular myocytes Am J Physiol Heart Circ Physiol 2000 278 H484 92
45. Jeck CD Boyden PA Age related appearance of outward currents may contribute to developmental differences in ventricular repolarization Circ Res 1992 71 1390 403
46. to in canine epicardium Am J Physiol 1995 268 H2513 21
47. Abrahamsson C Palmer M Ljung B et al Induction of rhythm abnormalities in the fetal rat heart. A tentative mechanism for the embryotoxic effects of class III antiarrhythmic agent almokalant Cardiovasc Res 1994 28 337 44
48. Kilborn MJ Fedida D A study of the developmental changes in outward currents of rat ventricular myocytes J Physiol 1990 430 37 60
49. Kobayashi T Yamada Y Nagashima M Seki S Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes JMCC 2003 35 1073 82
50. + currents in rat epicardial myocytes Am J Physiol 1998 274 H915 22
51. (Ks) contributes to age related expression of dofetilide effects on repolarization and proarrhythmia Cardiovasc Res 2003 59 339 50
52. Zehelein J Zhang W Koenen M Graf M Heinemann SH Katus HA Molecular cloning and expression of cERG, the ether-a-go-go related gene from canine myocardium Pflugers Arch 2001 442 188 91
53. Wang J Della Penna K Wang H et al. Functional and pharmacological properties of canine ERG potassium channels Am J Physiol Heart Circ Physiol 2003 284 H256 67
54. ks in canine heart appears dependent on the β subunit mink Heart Rhythm 2004 1 704 11
55. Schwartz PJ The idiopathic long QT syndrome: progress and questions Am Heart J 1985 109 399 411
56. Schwartz PJ Prevention of the arrhythmias in the long QT syndrome In Kulbertus HE ed Medical Management of Cardiac Arrhythmias Edinburgh Churchill Livingston 1986 153 6
57. Moss AJ Schwartz PJ Crampton RS Locati E Carleen E The long QT syndrome: a prospective international study Circulation 1985 1 17 21
58. Ebert SN Liu XK Woosley RL Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence J Womens Health 1998 7 547 57
59. Schwartz PJ Priori SG Spazzolini C et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias Circulation 2001 103 89 95
60. Keating MT Atkinson D Dunn C Timothy K Vincent GM Leppert M Linkage of the long QT syndrome and the Harvey ras-1 gene Science 1991 252 704 6
61. Towbin JA Schwartz K Genetic approaches and familial arrhythmias In Spooner PM Rosen MR eds Foundations of Cardiac Arrhythmias New York Marcel Dekker Inc. 2000 665 9
62. Schwartz PJ Priori SG Dumaine R et al. A molecular link between the sudden infant death syndrome and the long QT syndrome N Engl J Med 2000 343 262 7
63. Chen Q Kirsch GE Zhang D et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation Nature 1998 392 293 6
64. Ks function Nat Genet 1997 17 338 40
65. Kr potassium channels with HERG and is associated with cardiac arrhythmia Cell 1999 97 175 87
66. Yao JA Hussain W Patel P Peters NS Boyden PA Wit AL Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts Circ Res 2003 92 437 43
67. 2+ currents in cells that survived in the epicardial border zone of canine healed infarcted heart Am J Physiol Heart Circ Physiol 2004 287 H1046 54
68. Cerbai E Barbieri M Li Q Mugelli A Ionic basis of action potential prolongation of hypertrophied cardiac myocytes isolated from hypertensive rats of different ages Cardiovasc Res 1994 28 1180 7
69. Armoundas AA Wu R Juang G Marban E Tomaselli GF Electrical and structural remodeling of the failing ventricle Pharmacol Ther 2001 92 213 30
70. Wecke L Gadler F Linde C Lundahl G Rosen MR Bergfeldt L Temporal characteristics of cardiac memory in humans: vectorcardiographic quantification in a model of cardiac pacing Heart Rhythm 2005 2 28 34
71. Shvilkin A Ho KKL Rosen MR Josephson ME T-Vector direction differentiates postpacing from ischemic T-wave inversion in precordial leads Circulation 2005 111 969 74
72. Rosen MR Cohen IS Danilo P Steinberg SF The heart remembers Cardiovac Res 1998 40 469 82
73. Rosen MR The heart remembers: clinical implications Lancet 2001 357 468 71
74. Rosenbaum MB Blanco HH Elizari MV Lazzari JO Davidenko JM Electrotonic modulation of the T wave and cardiac memory Am J Cardiol 1982 50 213 22
75. Scherf D Alterations in the T wave in the changes in heart rate Am Heart J 1944 28 332 47
76. Parkinson J Papp C Repetitive paroxysmal tachycardia Br Heart J 1947 9 241 61
77. Chatterjee K Harris A Davies G Leatham A Electrocardiographic changes subsequent to artificial ventricular depolarization Br Heart J 1969 31 770 9
78. Gould L Venkataraman K Goswami MK Gomprecht RF Pacemaker-induced electrocardiographic changes simulating myocardial infarction Chest 1973 63 829 32
79. Luy G Bahl OP Massie E Intermittent left bundle branch block Am Heart J 1973 85 332 40
80. Nicolai P Medvedowsky JL Delaage M Barney C Blache E Pisapia A Wolff-Parkinson-White syndrome: T wave abnormalities during normal pathway conduction J Electrocardiol 1998 14 295 300
81. Shvilkin A Danilo P Wang J et al. Evolution and resolution of long-term cardiac memory Circulation 1998 97 1810 7
82. Plotnikov AN Shvilkin A Xiong W et al. Interactions between antiarrhythmic drugs and cardiac memory Cardiovasc Res 2001 50 335 44
83. Geller JC Rosen MR Persistent T-wave changes after alteration of the ventricular activation sequence. New insight into cellular mechanisms of 'cardiac memory' Circulation 1993 88 1811 9
84. Plotnikov AN Yu H Geller JC et al. Role of L-type calcium channels in pacing-induced short term and long term cardiac memory in canine heart Circulation 2003 107 2844 9
85. Ricard P Danilo P Jr. Cohen IS Burkhoff D Rosen MR A role for the renin-angiotensin system in the evolution of cardiac memory J Cardiovasc Electrophysiol 1999 10 545 51
86. Sadoshima J Izumo S Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism EMBO J 1993 12 1681 92
87. Sadoshima J Izumo S Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype Circ Res 1993 73 413 23
88. Kandel ER The molecular biology of memory storage: a dialogue between genes and synapses Science 2001 294 1030 8
89. Meghji P Nazir SA Dick DJ Bailey ME Johnson KJ Lab MJ Regional workload induced changes in electrophysiology and immediate early gene expression in intact in situ porcine heart JMCC 1997 29 3147 55
90. Patberg KW Plotnikov AN Quamina A et al. Cardiac memory is associated with decreased levels of the transcriptional factor CREB modulated by antiotensin II and calcium Circ Res 2003 93 472 8
91. Patberg KW Plotnikov AN Rybin AV et al Ventricular pacing to induce long-term cardiac memory is associated with reduced CREB binding and reduced mRNA and protein for KChlP2 Circulation 2003 108 IV-56
92. Patberg KW Obreztchilova MN Giardina SF et al. Mechanisms for cardiac memory: in vivo knockdown of the cAMP response element building protein diminishes the transient outward potassium current Circulation 2004 110 III-37
93. Patberg KW Rosen MR Molecular determinants of cardiac memory and their regulation J Mol Cell Cardiol 2004 36 195 204
94. Ks in canine ventricular myocytes Circulation 2003 108 IV-9
95. Kr in the canine heart is paralleled by a transmural ERG gradient and is modulated in the setting of cardiac memory Heart Rhythm 2004 1 S221
96. Rosen MR. Cardiac memory: what are the limits In Opie LH Yellon DM eds Cardiology at the Limits VI Landsdowne, South Africa University of Cape Town Press 2003 141 53
97. Bennett PB Johnson JP. Molecular physiology of cardiac ion channels In Zaza A Rosen MR eds An Introduction to Cardiac Electrophysiology Amsterdam, The Netherlands Harwood Academic Publishers 2000 29 57
98. Rosen MR Pham T. Impact of gender on the response to cardioactive drugs In Legato ML ed Principles of Gender-Specific Medicine London, UK Elsevier Academic Press 2004 241 54