Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium II. In vivo study

Circulation

Volumn 96, Issue 11, 1997, Pages 4019-4026

  Anyukhovsky, Evgeny P ^a   Sosunov, Eugene A ^a   Feinmark, Steven J ^a   Rosen, Michael R ^a  

^a The New York Presbyterian Hospital   (United States)

Author keywords

Quinidine; Repolarization

Indexed keywords

QUINIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; ATRIOVENTRICULAR BLOCK; CONTROLLED STUDY; DOG; DRUG EFFICACY; ELECTROCARDIOGRAM; ENDOCARDIUM; EPICARDIUM; FEMALE; HEART CYCLE; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE PACING; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL;

EID: 0030667344     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.11.4019     Document Type: Article

References (39)

1. Cosin-Agular J, Hernandiz-Martinez A. The clinical usefulness of the antiarrhythmic drug quinidine. Eur Heart J. 1987;8(suppl A):1-9.
2. Kim SY, Benowitz NL. Poisoning due to the class IA antiarrhythmic drugs quinidine, procainamide and disopyramide. Drug Safety. 1990;5:393-420.
3. Gessman L, Danilo P Jr, Rosen MR. An electrophysiologic study of the digoxin-quinidine interaction. J Clin Pharmacol. 1983;23:16-23.
4. Franz MR, Costard A. Frequency-dependent effects of quinidine on the relationship between action potential duration and refractoriness in the canine heart in situ. Circulation. 1988;77:1177-1184.
5. Costard-Jaeckle A, Liem LB, Franz MR. Frequency-dependent effects of quinidine, mexiletine, and their combination on postrepolarization refractoriness in vivo. J Cardiovasc Pharmacol. 1989;14:810-817.
6. Newman D, Herre JM, Chin M, Scheinman MM, Franz M, Katzung B. Effects of sympathetic stimulation on use dependence of lidocaine, mexiletine, and quinidine in an intact canine model. Can J Physiol Pharmacol. 1992;70:219-224.
7. Duker G, Almgren O, Carlsson L. Electrophysiologic and hemodynamic effects of H 23344/09 (Almokalant), quinidine, and (+)-sotalol in the anesthetized dog. J Cardiovasc Pharmacol. 1992;20:458-465.
8. Prinzmetal M, Ishikawa K, Oishi H, Ozkan E, Wakayama J, Baines JM. Effects of quinidine on electrical behavior in cardiac muscle. J Pharmacol Exp Ther. 1967;157:659-664.
9. Brugada J, Sassine A, Escande D, Masse C, Puech P. Effects of quinidine on ventricular repolarization. Eur Heart J. 1987;8:1340-1345.
10. Wallace AG, Cline RE, Sealy WC, Young WG Jr, Troyer WG Jr. Electrophysiologic effects of quinidine: studies using chronically implanted electrodes in awake dogs with and without cardiac denervation. Circ Res. 1966;19:960-969.
11. Morikawa Y, Rosen TS, Hordof AJ, Rosen MR. Developmental changes in the effects of lidocaine and quinidine on the canine heart. J Cardiovasc Pharmacol. 1987;10:450-455.
12. Sosunov EA, Anyukhovsky EP, Rosen MR. Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium. I. In vitro study. Circulation. 1997;96:4011-4018.
13. Anyukhovsky EP, Sosunov EA, Rosen MR. Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium: in vitro and in vivo correlations. Circulation. 1996;94:1981-1988.
14. Janse MJ. The Effect of Changes in Heart Rate on the Refractory Period of the Heart. Amsterdam, Netherlands: Mondeel-Offset-Drukkerij; 1971;41-42. Thesis.
15. Burgess MJ, Green LS, Millar K, Wyatt R, Abildskov JA. The sequence of normal ventricular recovery. Am Heart J. 1972;84:660-669.
16. Freigang KD, Becker R, Bauer A, Voss F, Senges J, Brachmann J, Schoels W. Electrophysiological properties of individual muscle layers in the in vivo canine heart. J Am Coll Cardiol. 1996;27(suppl A):124A. Abstract.
17. Weissenburger J, Nesterenko VV, Antzelevitch C. Intramural monophasic action potentials (MAP) display steeper APD-rate relations and higher sensitivity to class III agents than epicardial and endocardial MAPs: characteristics of the M cell in vivo. Circulation. 1995;92(suppl I):I-300. Abstract.
18. El-Sherif N, Caref EB, Yin H, Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: tridimensional mapping of activation and recovery patterns. Circ Res. 1996;79:474-492.
19. Sicouri S, Antzelevitch C. Afterdepolarizations and triggered activity develop in a selected population of cells (M cells) in canine ventricular myocardium: the effects of acetylstrophanthidin and Bay K8644. Pacing Clin Electrophysiol. 1991;14:1714-1720.
20. Sicouri S, Antzelevitch C. Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cells (M cells) in the canine heart: quinidine and digitalis. J Cardiovasc Electrophysiol. 1993;4:48-58.
21. Scherlag BJ, Kosowsky BD, Damato AN. A technique for ventricular pacing from the His bundle of the intact heart. J Appl Physiol. 1967;22:584-587.
22. Scherlag BJ, El-Sherif N, Hope R, Lazzara R. Characterization and localization of ventricular arrhythmias resulting from myocardial ischemia and infarction. Circ Res. 1974;35:372-383.
23. Spach MS, Barr RC. Ventricular intramural and epicardial potential distributions during ventricular activation and repolarization in the intact dog. Circ Res. 1975;37:243-257.
24. Winer BJ, Brown DR, Michels KM. Statistical Principles in Experimental Design. New York, NY: McGraw-Hill Inc; 1991.
25. Sicouri S, Fish J, Antzelevitch C. Distribution of M cells in the canine ventricle. J Cardiovasc Electrophysiol. 1994;5:824-837.
26. Dahlstrom A, Fuxe F, Mya-Tu M, Zetterstrom BEM. Observation on adrenergic innervation of the dog heart. Am J Physiol. 1965;209:689-692.
27. Kent KM, Epstein SE, Cooper T, Jacobowitz DM. Cholinergic innervation of the canine and human ventricular conducting system. Circulation. 1974;50:948-955.
28. Martins JB, Zipes DP. Effects of sympathetic and vagal nerves on recovery properties of the endocardium and epicardium of the canine left ventricle. Circ Res. 1980;46:100-110.
29. Jeck CD, Boyden PA. Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization. Circ Res. 1992;71:1390-1403.
30. Hoffman BF, Rosen MR, Wit AL. Electrophysiology and pharmacology of cardiac arrhythmias, VII: cardiac effects of quinidine and procainamide. Am Heart J. 1975;89:804-808.
31. Malcolm AD, David GK. Quinidine in cardiology. Acta Leidensia. 1987;55:87-98.
32. Sicouri S, Antzelevitch C. Electrophysiologic characteristics of M cells in canine left ventricular free wall. J Cardiovasc Electrophysiol. 1995;6:591-603.
33. Liu DW, Gintant GA, Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res. 1993;72:671-687.
34. + current differs among canine ventricular mycocytes of epicardial, midmyocardial and endocardial origin. Pacing Clin Electrophysiol. 1993;16:870. Abstract.
35. Eddlestone GT, Zygmunt AC, Antzelevitch C. Larger late sodium current contributes to the longer action potential of the M cell in canine ventricular myocardium. Pacing Clin Electrophysiol. 1996;19:569. Abstract.
36. Steinhaus BM. Estimating cardiac transmembrane activation and recovery times from unipolar and bipolar extracellular electrograms: simulation study. Circ Res. 1989;64:449-462.
37. Millar CK, Kralios FA, Lux RL. Correlation between refractory periods and activation-recovery intervals from electrograms: effects of rate and adrenergic interventions. Circulation. 1985;72:1372-1379.
38. Haws CW, Lux RL. Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms. Circulation. 1990;81:281-288.
39. Wyatt RF, Burgess MJ, Evans AK, Lux RL, Abildskov JA. Estimation of ventricular transmembrane action potential durations and repolarization times from unipolar electrograms. Am J Cardiol. 1981;97:488. Abstract.