The controversial M cell

Journal of Cardiovascular Electrophysiology

Volumn 10, Issue 2, 1999, Pages 244-260

  Anyukhovsky, Evgeny P ^b   Sosunov, Eugene A ^a   Gainullin, Ravil Z ^c   Rosen, Michael R ^a  

^a The New York Presbyterian Hospital   (United States)

^b INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

^c INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

Author keywords

Activation recovery intervals; Cardiac electrophysiology; Transmural gradients; Ventricular action potentials; Ventricular electrograms

Indexed keywords

CALCIUM CHANNEL STIMULATING AGENT; NEUROTOXIN; POTASSIUM CHANNEL BLOCKING AGENT; QUINIDINE; SODIUM CHANNEL BLOCKING AGENT;

ARTICLE; CELL TYPE; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; HEART VENTRICLE; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT;

EID: 0009657580     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.1999.tb00667.x     Document Type: Article

References (101)

1. Myerburg RJ, Stewart JW, Hoffman BF: Electrophysiological properties of the canine peripheral A-V conducting system. Circ Res 1970;26:361-378.
2. Myerburg RJ, Gelband H, Hoffman BF: Functional characteristics of the gating mechanism in the canine A-V conducting system. Circ Res 1971:28:136-147.
3. Myerburg RJ: The gating mechanism in the distal atrioventricular conducting system. Circulation 1971; 43:955-960.
4. Mendez C, Mueller WJ, Meredith J, et al: Interaction of transmembrane potentials in canine Purkinje fibers and at Purkinje fiber-muscle junction. Circ Res 1969; 24:361-372.
5. Moe GK: Oscillating concepts in arrhythmia research: A personal account. Int J Cardiol 1984;5:109-113.
6. Anyukhovsky EP, Sosunov EA, Rosen MR: Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium: In vitro and in vivo correlations. Circulation 1996;94:1981-1988.
7. Sicouri S, Antzelevitch C: A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell. Circ Res 1991;68:1729-1741.
8. Sicouri S, Fish J, Antzelevitch C: Distribution of M cells in canine ventricle. J Cardiovasc Electrophysiol 1994;5:824-837.
9. Sicouri S, Antzelevitch C: Electrophysiologic characteristics of M cells in the canine left ventricular free wall. J Cardiovasc Electrophysiol 1995;6:591-603.
10. Weissenburger J, Nesterenko VV, Antzelevitch C: Intramural monophasic action potentials (MAPs) display steeper APD-rate relations and higher sensitivity to class III agents than epicardial and endocardial MAPs: Characteristics of M cells in vivo. (Abstract) Circulation 1995;92(Suppl I):I-300.
11. El-Sherif N, Caref E, Yin H, et al: The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: Tridimensional mapping of activation and recovery patterns. Circ Res 1996;79:474-492.
12. Hoffman BF, Cranefield PF: Electrophysiology of the Heart. McGraw-Hill Book Company Inc., New York, 1960, p. 323.
13. Kamiyama A, Matsuda K: Electrophysiologic properties of the canine ventricular fiber. Jpn J Physiol 1966;16:407-420.
14. Litovsky SH, Antzelevitch C: Transient outward current prominent in canine ventricular epicardium but not in endocardium. Circ Res 1988;62:116-125.
15. Litovsky SH, Antzelevitch C: Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: The role of the transient outward current. J Am Coll Cardiol 1989;14:1053-1066.
16. Furukawa T, Myerburg RJ, Furukawa N, et al: Differences in transient outward currents of feline endocardial and epicardial myocytes. Circ Res 1990;67:1287-1291.
17. Litovsky SH, Antzelevitch C: Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol: A direct effect of acetylcholine in ventricular myocardium. Circ Res 1990;67:615-627.
18. Krishan SC, Antzelevitch C: Sodium channel blockade produces opposite electrophysiologic effects in canine ventricular epicardium and endocardium. Circ Res 1991;69:277-291.
19. Tande PM, Mortensen E, Refsum H: Rate-dependent differences in dog epi- and endocardial monophasic action potential configuration in vivo. Am J Physiol 1991;261:H1387-H1391.
20. Furukawa T, Kimura S, Furukawa N, et al: Potassium rectifier currents differ in myocytes of endocardial and epicardial origin. Circ Res 1992;70:91-103.
21. Lukas A, Antzelevitch C: Differences in physiological response of canine ventricular epicardium and endocardium to ischemia: Role of the transient outward current. Circulation 1993;88:2903-2915.
22. Levine JH, Spear JF, Guarnieri T, et al: Cesium chloride-induced long QT syndrome: Demonstration of afterdepolarization and triggered activity in vivo. Circulation 1985;72:1092-1103.
23. Litovsky SH, Sicouri S, Antzelevitch C: Electrophysiologic effects of amiodarone on canine ventricular epicardium and endocardium differ. (Abstract) Circulation 1990;82(Suppl III):III-529.
24. + channel activators in cardiac electrophysiology and arrhythmias. Circulation 1992;85:1627-1629.
25. Di Diego JM, Antzelevitch C: Pinacidil-induced electrical heterogeneity and extrasystolic activity in canine ventricular tissues. Does activation of ATP-regulated potassium current promote phase 2 reentry? Circulation 1993;88:1177-1189.
26. Di Diego JM, Antzelevitch C: The electrophysiologic effects of amiloride in canine ventricular myocardial tissues. (Abstract) FASEB J 1990;4:A-562.
27. Krishnan SC, Antzelevitch C: Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry? Circulation 1993;87:562-572.
28. Liu DW, Gintant GA, Antzelevitch C: Ionic bases for electrophysiologicai distinctions among epicardiai, midmyocardial and endocardial myocytes from the free wall of the canine left ventricle. Circ Res 1993; 72:671-687.
29. + current differs among canine ventricular myocytes of epicardial, midmyocardial and endocardial origin. (Abstract) PACE 1993;16(Pt II):870.
30. Kimura S, Basset AL, Furukawa T, et al: Differences in the effect of metabolic inhibition on action potentials and calcium currents in endocardial and epicardial cells. Circulation 1991;84:768-777.
31. Takano M, Noma A: Distribution of the isoprenaline-induced chloride current in rabbit heart. Pflügers Arch 1992;420:223-226.
32. Furukawa T, Kimura S, Cuevas J, et al: Role of cardiac ATP-regulated potassium channels in differential responses of endocardial and epicardial cells to ischemia. Circ Res 1991;68:1693-1702.
33. Van Dam RTH, Durrer D: Experimental study of the intramural distribution of the excitability cycle and on the form of the epicardial T wave in the dog heart in situ. Am Heart J 1961;61:537-542.
34. Janse MJ: Effects of Changes in Heart Rate on the Refractory Period of the heart. Thesis. Mondeel-Offset-Drukkerij, Amsterdam, 1971, pp. 41-42.
35. Burgess MJ, Green LS, Millar K, et al: The sequence of normal ventricular recovery. Am Heart J 1972;84: 660-669.
36. Freigang KD, Becker R, Bauer A, et al: Electrophysiological properties of individual muscle layers in the in vivo canine heart. (Abstract) J Am Coll Cardiol 1996;27(Suppl A):124A.
37. Durrer D, van der Tweel LH, Blickman JR: Spread of activation in the left ventricular wall of the dog. III Transmural and intramural analysis. Am Heart J 1954; 48:13-35.
38. Wang Y, Hariman RJ, Gintant GA, et al: A method for recording of intramyocardial monophasic action potential in intact dogs: In vivo evidence of M cells. (Abstract) PACE 1992;15:559.
39. Solberg LE, Singer DH, Ten Eick RE, et al: Glass microelectrode studies on intramural papillary muscle cells: Description of preparation and studies on normal dog papillary muscle. Circ Res 1974;34:783-797.
40. Deleze J: Recovery of resting potential and input resistance in sheep heart injured by knife and laser. J Physiol (Lond) 1970;208:547-562.
41. DeMello WC, Motta G, Chapeal M: The healing over in myocardial cells of toads. Circ Res 1969;2:475-487.
42. Hoffman BF, Cranefield PF, Lepeshkin E, et al: Comparison of cardiac monophasic action potentials recorded by intracellular and suction electrodes. Am J Physiol 1959;196:1297-1301.
43. Sicouri S, Antzelevitch C: Electrophysiological characteristics and transmural distribution of M cells in the canine ventricle. (Abstract) Circulation 1991;84(Suppl III):II-179.
44. Antzelevitch C, Sicouri S, Litovsky SH, et al: Heterogeneity within the ventricular wall: Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res 1991;69:1427-1449.
45. Antzelevitch C, Sicouri S, Lukas A, et al: Regional differences in the electrophysiology of ventricular cells: Physiological and clinical implications. In Zipes DP, Jalife J, eds: Cardiac Electrophysiology: From Cell to Bedside. Second Edition. WB Saunders Co., Philadelphia, 1994, pp. 228-245.
46. Sosunov EA, Anyukhovsky EP, Rosen MR: Comparison of repolarizatron of cells from different layers of myocardium in vitro and in vivo. (Abstract) Biophys J 1996;70(Pt 2):A276.
47. Drouin E, Charpentier F, Gauthier C, et al: Evidence for the presence of M cells in the human ventricle. (Abstract) PACE 1993;16(Pt II):876.
48. Drouin E, Charpentier F, Gauthier C, et al: Electrophysiological characteristics of cells spanning the left ventricular wall of human heart. J Am Coll Cardiol 1995;26:185-192.
49. Sicouri S, Quist M, Antzelevitch C: Evidence for the presence of M cells in the guinea pig ventricle. J Cardiovasc Electrophysiol 1996;7:503-511.
50. Rodriguez-Sinovas A, Cinca J, Tapias A, et al: Lack of evidence of M-cells in porcine left ventricular myocardium. Cardiovasc Res 1997;33:307-313.
51. Jeck CD, Boyden PA: Age-related appearance of outward currents may contribute to the developmental differences in ventricular repolarization. Circ Res 1992;71:1390-1403.
52. Pacioretty LM, Gilmour RF: Developmental changes in the transient outward potassium current and action potential characteristics in canine epicardium. (Abstract) Circulation 1992;86(Suppl I):I-93.
53. + channel in ventricular muscle: A molecular correlate for the transient outward current. Circ Res 1996; 79:659-668.
54. Ks contributes to the longer action potential of the M cell. Circ Res 1995;76:351-365.
55. Eddlestone GT, Zygmunt AC, Antzelevitch C: Larger late sodium current contributes to the longer action potential of M cell in canine ventricular myocardium. (Abstract) PACE 1996;19:II-569.
56. Main MC, Bryant SM, Hart G: Electrical and mechanical characteristics of guinea pig left ventricular mid-myocardial myocytes compared with surface myocytes. (Abstract) J Physiol 1995;483:9P.
57. Main MC, Bryant SM, Hart G: Heterogeneity in electrical characteristics of guinea pig ventricular myocytes from epicardial, endocardial and mid-myocardial regions. (Abstract) Eur Heart J 1995;16:271.
58. Stankovicova T, Wang K, Scheerder I, et al: Action potential characteristics in the different layers of the pig left ventricle: Are there any M-cells? (Abstract) Circulation 1997;96(Suppl I):I-500.
59. Antzelevitch C, Sun ZQ, Zhang ZQ, et al: Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes. J Am Coll Cardiol 1996;28:1836-1848.
60. Yan GX, Antzelevitch C: Cellular basis for the electrocardiographic J wave. Circulation 1996;93:372-379.
61. Shimizu W, Antzelevitch C: Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation 1997;96:2038-2047.
62. Zang ZQ, Antzelevitch C: Erythromycin produces prominent action potential prolongation and early afterdepolarization (EAD)-induced triggered activity in M but not epicardial or endocardial regions of the canine ventricle. (Abstract) Circulation 1993;88(Suppl): I-327.
63. Antzelevitch C, Sicouri S: Clinical relevance of cardiac arrhythmias generated by afterdepolarization: Role of M cells in the generation of U waves, triggered activity and torsade de pointes. J Am Coll Cardiol 1994;23:259-277.
64. Shimizu W, Antzelevitch C: Characteristics of spontaneous as well as stimulation-induced torsade de pointes in LQT2 and LQT3 models of the long QT syndrome. (Abstract) Circulation 1997;96(Suppl I):I-554.
65. Akar FG, Yan G, Antzelevitch C, et al: Optical maps reveal reentrant mechanism of torsade de pointes based on topography and electrophysiology of mid-myocardial cells. (Abstract) Circulation 1997; 96(Suppl I):I-555.
66. Sicouri S, Antzelevitch C: Afterdepolarizations and triggered activity develop in a select population of cells (M cells) in canine ventricular myocardium: The effects of acetylstrophanthidin and Bay K 8644. PACE 1991;14:1714-1720.
67. Sosunov EA, Anyukhovsky EP, Rosen MR: Effects of quinidine on repolarization in canine epicardium, mid-myocardium, and endocardium: I. In vitro study. Circulation 1997;96:4011-4018.
68. Anyukhovsky EP, Sosunov EA, Rosen MR: Modulation of repolarization by quinidine in different myocardial layers in vitro and in vivo. (Abstract) Biophys J 1997;72:A47.
69. Sicouri S, Antzelevitch C: Drug-induced afterdepolarizations and triggered activity occur in a discrete sub-population of ventricular muscle cell (M cells) in the canine heart: Quinidine and digitalis. J Cardiovasc Electrophysiol 1993;4:48-58.
70. Durrer D, van der Tweel LH: Excitation of the left ventricular wall of the dog and goat. Ann N Y Acad Sci 1957;65:779-803.
71. Hoffman BF, Cranefield PF: Electrophysiology of the Heart. McGraw-Hill Book Co., New York, 1960, p. 254.
72. Hariman RJ, Wang Y, Sharif MA, et al: Early afterdepolarizations arising from M cells in intact dogs. (Abstract) Circulation 1992;86(Suppl I):I-300.
73. Spach MS, Barr RC: Ventricular intramural and epicardial potential distributions during ventricular activation and repolarization in the intact dog. Circ Res 1975;37:243-257.
74. Kassel J, Gallagher JJ: Construction of a multipolar needle electrode for activation study of the heart. Am J Physiol 1977;233:H312-H317.
75. Anyukhovsky EP, Sosunov EA, Feinmark SJ, et al: Effects of quinidine on repolarization in canine epicardium, midmyocardium, and endocardium: II. In vivo study. Circulation 1997;96:4019-4026.
76. Spach MS, Barr RC, Server GS, et al: Extracellular potentials related to intracellular action potentials in the dog Purkinje system. Circ Res 1972;30:505-519.
77. Spach MS, Dolber PC: Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle: Evidence for electrical uncoupling of side-to-side fiber connections with increasing age. Circ Res 1986;58: 356-371.
78. Steinhaus BM: Estimating cardiac transmembrane activation and recovery times from unipolar and bipolar extracellular electrograms: A simulation study. Circ Res 1989;64:449-462.
79. Haws CW, Lux RL: Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms: Effects of interventions that alter repolarization time. Circulation 1990;81:281-288.
80. Wyatt RF, Burgess MJ, Evans AK, et al: Estimation of ventricular transmembrane action potential durations and repolarization times from unipolar electrograms. (Abstract) Am J Cardiol 1981;97:488.
81. Millar CK, Kralios FA, Lux RL: Correlation between refractory periods and activation-recovery intervals from electrograms: Effects of rate and adrenergic interventions. Circulation 1985;72:1372-1379.
82. Haws CW, Lux RL: Accuracy of the activation-recovery interval from electrograms as an estimate of transmembrane action potential duration. (Abstract) Clin Res 1988;36:107A.
83. Gettes LS, Engle CL, Sheman ZC, et al: Activation-recovery intervals accurately reflect action potential duration during acute ischemia. (Abstract) Circulation 1997;96(Suppl I):I-59.
84. Wyatt RF, Abildskov JA, Burgess MJ: Measurements of ventricular recovery properties and repolarization sequence from bipolar electrograms. (Abstract) Circulation 1978;58(Suppl II):II-46.
85. Osaka T, Kodama I, Toyama J, et al: Effects of bepridil on ventricular depolarization and repolarization of rabbit isolated hearts with particular reference to its possible proarrhythmic properties. Br J Pharmacol 1988;93:775-780.
86. Kléber AG, Riegger CB: Electrical constants of arterially perfused rabbit papillary muscle. J Physiol 1987; 385:307-324.
87. Weidman S: Passive properties of cardiac fibers. In Rosen MR, Janse MJ, Wit AL, eds: Cardiac Electrophysiology: A Textbook. Futura Publishing Company Inc., Armonk, NY. 1990, p. 33.
88. Burch GE, Wajszczuk WJ, Cronvich JA: Spread of activation in the anterolateral papillary muscle of the left ventricle of the dog under normal and pathologic conditions. Am Heart J 1970;79:769-788.
89. Gallagher JJ, Ticzon AR, Wallace AG, et al: Activation studies following experimental hemiblock in the dog. Circ Res 1974;35:752-763.
90. Martins JB, Zipes DP, Lund DD: Distribution of local repolarization changes produced by efferent vagal stimulation in the canine ventricles. J Am Coll Cardiol 1983;2:1191-1199.
91. Franz MR: Method and theory of monophasic action potential recording. Prog Cardiovasc Dis 1991; 33:347-368.
92. Franz MR: Bridging the gap between basic and clinical electrophysiology: What can be learned from monophasic action potential recordings? J Cardiovasc Electrophysiol 1994;5:699-710.
93. Franz MR: Long-term recording of monophasic action potentials from human endocardium. Am J Cardiol 1983;51:1629-1634.
94. Yuan S, Blomstrom-Lundquist C, Olsson SB: Monophasic action potentials: Concepts to practical applications. J Cardiovasc Electrophysiol 1994;5:287-308.
95. Coronel R, Opthof T, Taggart P, et al: Differential electrophysiology of repolarisation from clone to clinic. Cardiovasc Res 1997;33:503-517.
96. Tan RC, Joyner RW: Electrotonic influences on action potentials from isolated ventricular cells. Circ Res 1990;67:1071-1081.
97. LeGrice IJ, Smaill BH, Chai LZ, et al: Laminar structure of the heart: Ventricular myocyte arrangement and connective tissue architecture in the dog. Am J Physiol 1995;269:H571-H582.
98. Weidmann S: Effect of current flow on the membrane potential of cardiac muscle. J Physiol (Lond) 1951; 115:227-236.
99. + fluctuations in canine Purkinje fibers. Nature 1980;286:68-71.
100. Kline RP, Kupersmith J: Effects of extracellular potassium accumulation and sodium pump activation on automatic canine Purkinje fibers. J Physiol (Lond) 1982;324:507-533.
101. Kline RP: Ion accumulation and modulation of currents. In Rosen MR, Janse MJ, Wit LA, eds: Cardiac Electrophysiology: A Textbook. Futura Publishing Company, Inc., Armonk, NY, 1990, pp. 133-156.