Differential Interaction of Nuclear Factors with the PRE-I Enhancer Element of the Human IL-4 Promoter in Different T Cell Subsets

Journal of Immunology

Volumn 158, Issue 3, 1997, Pages 1194-1200

  Li Weber, Min ^a   Salgame, Padmini ^b   Hu, Chenggang ^b   Davydov, Ilia V ^a,c   Krammer, Peter H ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; INTERLEUKIN 4; NUCLEAR PROTEIN; PROTEIN C JUN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT;

ANIMAL; ARTICLE; CELL LINE; ENHANCER REGION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MACROMOLECULE; METABOLISM; MOUSE; PHYSIOLOGY; PROMOTER REGION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TRANSACTIVATION;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE; DNA-BINDING PROTEINS; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-4; MACROMOLECULAR SUBSTANCES; MICE; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-JUN; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0031068113     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279.
2. Musmann, T. R., H. Cherwinski, M. Bond, M. W. Giedlin, and R. L. Coffman. 1986. Two types of m urine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
3. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
4. Mosmann, T. R. 1991. Cytokine secretion phenotypes of TH cells: how many subsets, how much regulation? Res. Immunol. 142:9.
5. Kelso, A., and N. M. Gough. 1988. Coexpression of granulocyte-macrophage colony-stimulating factor, γ interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones. Proc. Natl. Acad. Sci. USA 85:9189.
6. + T cell subset with an unrestricted cytokine protile. J. Immunol. 143:518.
7. Street, N. E., J. H. Schumacher, T. A. Fong, H. Bass, D. F. Fiorentino, J. A. Leverah, and T. L. Mosmann. 1990. Heterogeneity of mouse helper T cells evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells. J. Immunol. 144:1629.
8. Bendelac, A., P. Matzinger, R. A. Seder, W. E. Paul, and H. Schwarz. 1992. Activation events during thymic selection. J. Exp. Med. 175:731.
9. Kamogawa, Y., L. E. Minasi, S. R. Carding, K. Bottomly, and R. A. Flavell. 1993. The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75:985.
10. Arai, K., F. Lee, A. Miyajima, S. Miyatake, N. Arai, and T. Yokota. 1990. Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59:783.
11. Paul, W. E. 1991. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 77:1859.
12. Le Gros, G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921.
13. Parronchi, P., M. de Carli, R. Manetti, C. Simonelli, S. Samognaro, M. P. Piccinni, D. Macchia, E. Maggi, G. del Prete, and S. Romagnani. 1992. IL-4 and IFN (α and γ) exert opposite regulatory effects on the development of cytolytic potential by Th1 and Th2 human T cell clones. J. Immunol. 149:2977.
14. Abehsira-Amar, O., M. Gibert, M. Joliy, J. Theze, and D. L. Jankovic. 1992. IL-4 plays a dominant role in the differential development of Th0 into Th1 and Th2 cells. J. Immunol. 148:3820.
15. Kopf, M., G. Le Gros, M. Bachmann, M. C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362:245.
16. Maggi, E., P. Parronchi, R. Manetti, C. Simonnelli, M. P. Piccini, F. S. Rugiu, M. De Carli, M. Ricci, and S. Romagnani. 1992. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J. Immunol. 148:2142.
17. - cells that make Th2 cytokines and help B cells. Science 260:1802.
18. Li-Weber, M., H. Krafft, and P. H. Krammer. 1993. A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer. J. Immunol. 151:1371.
19. c. Mol. Cell. Biol. 13:4793.
20. Chuvpilo, S., C. Schomberg, R. Gerwig, A. Heinfling, R. Reeves, F. Grummt, and E. Serfling. 1993. Multiple closely-linked NF-AT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 21:5694.
21. Li-Weber, M., I. V. Davydov, H. Krafft, and P. H. Krammer. 1994. The role of NF-Y and IRF-2 in the regulation of human IL-4 gene expression. J. Immunol. 153:4122.
22. Davydov, I. V., P. H. Krammer and M. Li-Weber. 1995. Nuclear factor-IL6 activates the human IL-4 promoter in T cells. J. Immunol. 155:5273.
23. Davydov, I. V., D. Bohmann, P. H. Krammer, and M. Li-Weber. 1995. Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. Gene 161:271.
24. Lamb, J. R., D. D. Eckels, P. Lake, J. N. Woody, and N. Green. 1982. Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin. Nature 300:66.
25. Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells. Nucleic Acids Res. 17:6419.
26. Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajama, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897.
27. Li-Weber, M., A. Eder, H. Krafft-Czepa, and P. H. Krammer. 1992. T cell-specific negative regulation of transcription of the human cytokine IL-4. J. Immunol. 148:1913.
28. Toledano, M. B., and W. J. Leonard. 1991. Modulation of transcription factor NF-kB binding activity by oxidation-reduction in vitro. Proc. Natl. Acad. Sci. USA 88:4328.
29. Hentsch, B., A. Mouzaki, I. Pfeuffer, D. Rungger, and E. Serfling. 1992. The weak, fine-tuned binding of ubiquitous transcription factors to the IL-2 enhancer contributes to its T cell-restricted activity. Nucleic Acids Res. 20:2657.
30. Kinoshita, S., S. Akira, and T. Kishimoto. 1992. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc. Natl. Acad. Sci. USA 89:1473.
31. Northrop, J. P., S. N. Ho, L. Chen, D. J. Thomas, L. A. Timmerman, G. P. Nolan, A. Admon, and G. R. Crabtree. 1994. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369:497.
32. Rooney, J. W., M. R. Hodge, P. G. McCaffrey, A. Rao, and L. H. Glimcher. 1994. A common factor regulates both Th1- and Th2-specific cytokine gene expression. EMBO J. 13:625.
33. Ho, I.-C. M. R. Hodge, J. W. Rooney, and L. H. Glimcher. 1996. The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85:973.