Ceramide-induced TCR up-regulation

Journal of Immunology

Volumn 165, Issue 6, 2000, Pages 3065-3072

  Menne, C ^a   Lauritsen, J P H ^a   Dietrich, J ^a   Kastrup, J ^a   Wegener, A M K ^a   Odum, N ^a   Geisler, C ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; T LYMPHOCYTE RECEPTOR;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL SURFACE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR UPREGULATION; STEADY STATE; T LYMPHOCYTE ACTIVATION;

EID: 0034665108     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.6.3065     Document Type: Article

References (37)

1. T cell activation determined by T cell receptor number and tunable thresholds
2. Regulation and function of the CD3γ DxxxLL motif: A binding site for adaptor protein-1 and adaptor protein-2 in vitro
3. The phosphorylation state of CD3γ influences T cell responsiveness and controls T cell receptor cycling
4. Limiting TCR expression leads to quantitative but not qualitative changes in thymic selection
5. Internalization and cycling of the T cell antigen receptor
6. Endocytosis and recycling of the T3-T cell receptor complex: The role of T3 phosphorylation
7. T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: Evidence for a protein kinase C-independent staurosporine-sensitive step
8. CD3γ contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor
9. Two distinct pathways exist for down-regulation of the TCR
10. A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction
11. 2-terminal kinase
12. CD28 signals through acidic sphingomyelinase
13. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β
14. Tumor necrosis factor-alpha (TNF-α) signal transduction through ceramide: Dissociation of growth inhibitory effects of TNF-α from activation of nuclear factor-κ B
15. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown
16. The sphingomyelin cycle and the second messenger function of ceramide
17. Ceramide activates heterotrimeric protein phosphatase 2A
18. Purification and characterization of ceramide-activated protein phosphatases
19. 2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene
20. Ceramide signalling and the immune response
21. The role of ceramide in cell signaling
22. Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production
23. Failure to synthesize the CD3-γ chain: Consequences for T cell antigen receptor assembly, processing, and expression
24. T cell receptor ζ allows stable expression of receptors containing the CD3γ leucine-based receptor-sorting motif
25. Characterization and expression of the human T cell receptor-T3 complex by monoclonal antibody F101.01
26. Conversion of dihydroceramide into ceramide: Involvement of a desaturase
27. 2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration
28. Molecular characterization of the di-leucine based internalization motiff of the T cell receptor
29. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
30. c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells
31. Ceramide inactivates cellular protein kinase Cα
32. Activation of acid sphingomyelinase by interleukin-1 (IL-I) requires the IL-1 receptor accessory protein
33. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
34. The sphingomyelin cycle and the second messenger function of ceramide
35. Three-dimensional segregation of supramolecular activation clusters in T cells
36. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
37. Serial triggering of TCRs: A basis for the sensitivity and specificity of antigen recognition