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Volumn 173, Issue 5, 2004, Pages 3193-3200

Ceramide inhibits IL-2 production by preventing protein kinase C-dependent NF-κB activation: Possible role in protein kinase Cθ regulation

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; GLYCOSPHINGOLIPID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE;

EID: 4344710126     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.5.3193     Document Type: Article
Times cited : (34)

References (43)
  • 1
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Hannun, Y. A., and L. M. Obeid. 2002. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277:25847.
    • (2002) J. Biol. Chem. , vol.277 , pp. 25847
    • Hannun, Y.A.1    Obeid, L.M.2
  • 2
    • 4344703763 scopus 로고    scopus 로고
    • Biological significance of tumor gangliosides: Shedding, transfer, and immunosuppression
    • J. Y. Vanderhoek, ed. Plenum Press, New York
    • Ladisch, S. 1996. Biological significance of tumor gangliosides: shedding, transfer, and immunosuppression. In Frontiers of Bioactive Lipids. J. Y. Vanderhoek, ed. Plenum Press, New York, p. 215.
    • (1996) Frontiers of Bioactive Lipids , pp. 215
    • Ladisch, S.1
  • 3
    • 0030588610 scopus 로고    scopus 로고
    • Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells
    • Irani, D. N., K. I. Lin, and D. E. Griffin. 1996. Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells. J. Immunol. 157:4333.
    • (1996) J. Immunol. , vol.157 , pp. 4333
    • Irani, D.N.1    Lin, K.I.2    Griffin, D.E.3
  • 5
    • 0029780435 scopus 로고    scopus 로고
    • Inhibition of human peripheral blood mononuclear cell proliferative response by glycosphingolipids from metacestodes of Echinococcus multilocularis
    • Persat, F., C. Vincent, D. Schmitt, and M. Mojon. 1996. Inhibition of human peripheral blood mononuclear cell proliferative response by glycosphingolipids from metacestodes of Echinococcus multilocularis. Infect. Immun. 64:3682.
    • (1996) Infect. Immun. , vol.64 , pp. 3682
    • Persat, F.1    Vincent, C.2    Schmitt, D.3    Mojon, M.4
  • 6
    • 0030044445 scopus 로고    scopus 로고
    • Down-regulation of T lymphocyte activation in vitro and in vivo induced by glycoinositolphospholipids from Trypanosoma cruzi: Assignment of the T cell-suppressive determinant to the ceramide domain
    • Gomes, N. A., J. O. Previato, B. Zingales, L. Menonça-Previato, and G. A. DosReis. 1996. Down-regulation of T lymphocyte activation in vitro and in vivo induced by glycoinositolphospholipids from Trypanosoma cruzi: assignment of the T cell-suppressive determinant to the ceramide domain. J. Immunol. 156:628.
    • (1996) J. Immunol. , vol.156 , pp. 628
    • Gomes, N.A.1    Previato, J.O.2    Zingales, B.3    Menonça-Previato, L.4    DosReis, G.A.5
  • 7
    • 0027461121 scopus 로고
    • Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β
    • Mathias, S., A. Younes, C.-C. Kan, I. Orlow, C. Joseph, and R. N. Kolesnick. 1993. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 259:519.
    • (1993) Science , vol.259 , pp. 519
    • Mathias, S.1    Younes, A.2    Kan, C.-C.3    Orlow, I.4    Joseph, C.5    Kolesnick, R.N.6
  • 8
    • 0026458406 scopus 로고
    • TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown
    • Schütze, S., K. Potthoff, T. Machleidt, D. Berkovic, K. Wiegmann, and M. Krönke. 1992. TNF activates NF-κB by phosphatidylcholine- specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71:765.
    • (1992) Cell , vol.71 , pp. 765
    • Schütze, S.1    Potthoff, K.2    Machleidt, T.3    Berkovic, D.4    Wiegmann, K.5    Krönke, M.6
  • 9
    • 0027183695 scopus 로고
    • Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor κB translocation in intact HL-60 cells
    • Yang, Z., M. Costanzo, D. W. Golde, and R. N. Kolesnick. 1993. Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor κB translocation in intact HL-60 cells. J. Biol. Chem. 268:20520.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20520
    • Yang, Z.1    Costanzo, M.2    Golde, D.W.3    Kolesnick, R.N.4
  • 10
    • 0037087402 scopus 로고    scopus 로고
    • 2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester
    • 2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J. Immunol. 168:2644.
    • (2002) J. Immunol. , vol.168 , pp. 2644
    • Majumdar, S.1    Lamothe, B.2    Aggarwal, B.B.3
  • 11
    • 0027327212 scopus 로고
    • TNFα signal transduction through ceramide: Dissociation of growth inhibitory effects of TNFα from activation of NF-κB
    • Dbaibo, G. S., L. M. Obeid, and Y. A. Hannun. 1993. TNFα signal transduction through ceramide: dissociation of growth inhibitory effects of TNFα from activation of NF-κB. J. Biol. Chem. 268:17762.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17762
    • Dbaibo, G.S.1    Obeid, L.M.2    Hannun, Y.A.3
  • 12
    • 0028292774 scopus 로고
    • Dissociation of endogenous cellular ceramide from NF-KB activation
    • Betts, J. C., A. B. Agranoff, G. J. Nabel, and J. A. Shayman. 1994. Dissociation of endogenous cellular ceramide from NF-KB activation. J. Biol. Chem. 269:8455.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8455
    • Betts, J.C.1    Agranoff, A.B.2    Nabel, G.J.3    Shayman, J.A.4
  • 13
    • 0027960631 scopus 로고
    • Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor-and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts
    • Andrieu, N., R. Salvayre, and T. Levade. 1994. Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts. Biochem. J. 303:341.
    • (1994) Biochem. J. , vol.303 , pp. 341
    • Andrieu, N.1    Salvayre, R.2    Levade, T.3
  • 14
    • 0035163570 scopus 로고    scopus 로고
    • Ceramide inhibition of NF-κB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: Requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response
    • Signorelli, P., C. Luberto, and Y. A. Hannun. 2001. Ceramide inhibition of NF-κB activation involves reverse translocation of classical protein kinase C (PKC) isoenzymes: requirement for kinase activity and carboxyl-terminal phosphorylation of PKC for the ceramide response. FASEB J. 15:2401.
    • (2001) FASEB J. , vol.15 , pp. 2401
    • Signorelli, P.1    Luberto, C.2    Hannun, Y.A.3
  • 15
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and I κB proteins: New discoveries and insights
    • Baldwin, A. S., Jr. 1996. The NF-κB and I κB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649
    • Baldwin Jr., A.S.1
  • 16
    • 0029041568 scopus 로고
    • Transcriptional regulation of the IL-2 gene
    • Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7:333.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 333
    • Jain, J.1    Loh, C.2    Rao, A.3
  • 17
    • 0029815848 scopus 로고    scopus 로고
    • A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation
    • Rothenberg, E., and S. Ward. 1996. A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation. Proc. Natl. Acad. Sci. USA 93:9358.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9358
    • Rothenberg, E.1    Ward, S.2
  • 18
    • 0027527545 scopus 로고
    • Selectivity of ceramide-mediated biology: Lack of activity of erythro-dihydroceramide
    • Bielawska, A., H. M. Crane, D. Liotta, L. M. Obeid, and Y. A. Hannun. 1993. Selectivity of ceramide-mediated biology: lack of activity of erythro-dihydroceramide. J. Biol. Chem. 268:26226.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26226
    • Bielawska, A.1    Crane, H.M.2    Liotta, D.3    Obeid, L.M.4    Hannun, Y.A.5
  • 19
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh, E. G., and W. J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911
    • Bligh, E.G.1    Dyer, W.J.2
  • 20
    • 0031041448 scopus 로고    scopus 로고
    • Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)α: CrmA and Bcl-2 target distinct components in the apoptotic pathway
    • Dbaibo, G. S., D. K. Perry, C. J. Gamard, R. Platt, G. G. Poirier, L. M. Obeid, and Y. A. Hannun. 1997. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)α: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J. Exp. Med. 185:481.
    • (1997) J. Exp. Med. , vol.185 , pp. 481
    • Dbaibo, G.S.1    Perry, D.K.2    Gamard, C.J.3    Platt, R.4    Poirier, G.G.5    Obeid, L.M.6    Hannun, Y.A.7
  • 22
    • 0030971056 scopus 로고    scopus 로고
    • Selective involvement of ceramide in cytokine-induced apoptosis: Ceramide inhibits phorbol ester activation of nuclear factor κB
    • Gamard, C. J., G. S. Dbaibo, B. Liu, L. M. Obeid, and Y. A. Hannun. 1997. Selective involvement of ceramide in cytokine-induced apoptosis: ceramide inhibits phorbol ester activation of nuclear factor κB. J. Biol. Chem. 272:16474.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16474
    • Gamard, C.J.1    Dbaibo, G.S.2    Liu, B.3    Obeid, L.M.4    Hannun, Y.A.5
  • 23
    • 85047682875 scopus 로고    scopus 로고
    • Protein kinase Cθ in T cell activation
    • Isakov, N., and A. Altman. 2002. Protein kinase Cθ in T cell activation. Annu. Rev. Immunol. 20:761.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 761
    • Isakov, N.1    Altman, A.2
  • 25
  • 26
    • 15844387528 scopus 로고    scopus 로고
    • Ceramide inactivates cellular protein kinase Cα
    • Lee, J. Y., Y. A. Hannun, and L. M. Obeid. 1996. Ceramide inactivates cellular protein kinase Cα. J. Biol. Chem. 271:13169.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13169
    • Lee, J.Y.1    Hannun, Y.A.2    Obeid, L.M.3
  • 28
  • 29
    • 0034703090 scopus 로고    scopus 로고
    • Functional dichotomy of protein kinase C in TNFα signal transduction in L929 cells
    • Lee, J., Y. Hannun, and L. Obeid. 2000. Functional dichotomy of protein kinase C in TNFα signal transduction in L929 cells. J. Biol. Chem. 275:29290.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29290
    • Lee, J.1    Hannun, Y.2    Obeid, L.3
  • 30
    • 0035977067 scopus 로고    scopus 로고
    • FAS activation induces dephosphorylation of SR proteins: Dependence on the de novo generation of ceramide and activation of protein phosphatase-1
    • Chalfant, C. E., B. Ogretmen, S. H. Galadari, B.-J. Kroesen, B. J. Pettus, and Y. A. Hannun. 2001. FAS activation induces dephosphorylation of SR proteins: dependence on the de novo generation of ceramide and activation of protein phosphatase-1. J. Biol. Chem. 276:44848.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44848
    • Chalfant, C.E.1    Ogretmen, B.2    Galadari, S.H.3    Kroesen, B.-J.4    Pettus, B.J.5    Hannun, Y.A.6
  • 31
    • 0029805775 scopus 로고    scopus 로고
    • Activation of the sphingomyelin cycle by brefeldin A: Effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking
    • Linardic, C. M., S. Jayadev, and Y. A. Hannun. 1996. Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Cell Growth Differ. 7:765.
    • (1996) Cell Growth Differ. , vol.7 , pp. 765
    • Linardic, C.M.1    Jayadev, S.2    Hannun, Y.A.3
  • 33
    • 0029974372 scopus 로고    scopus 로고
    • Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades
    • Coroneos, E., Y. Wang, J. R. Panuska, D. J. Templeton, and M. Kester. 1996 Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades. Biochem. J. 316:13.
    • (1996) Biochem. J. , vol.316 , pp. 13
    • Coroneos, E.1    Wang, Y.2    Panuska, J.R.3    Templeton, D.J.4    Kester, M.5
  • 34
    • 0025267782 scopus 로고
    • Protein kinase C-independent activation of nuclear factor κB by tumor necrosis factor
    • Meichle, A., S. Schütze, G. Hensel, D. Brunsing, and M. Krönke. 1990. Protein kinase C-independent activation of nuclear factor κB by tumor necrosis factor. J. Biol. Chem. 265:8339.
    • (1990) J. Biol. Chem. , vol.265 , pp. 8339
    • Meichle, A.1    Schütze, S.2    Hensel, G.3    Brunsing, D.4    Krönke, M.5
  • 36
    • 0027355755 scopus 로고
    • Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances
    • Radin, N. S., J. A. Shayman, and J.-I. Inokuchi. 1993. Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances. Adv. Lipid Res. 26:183.
    • (1993) Adv. Lipid Res. , vol.26 , pp. 183
    • Radin, N.S.1    Shayman, J.A.2    Inokuchi, J.-I.3
  • 37
    • 0022974603 scopus 로고
    • Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and human platelets
    • Hannun, Y. A., C. R. Loomis, A. H. Merrill, Jr., and R. M. Bell. 1986. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and human platelets. J. Biol. Chem. 261:12604.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12604
    • Hannun, Y.A.1    Loomis, C.R.2    Merrill Jr., A.H.3    Bell, R.M.4
  • 38
    • 0033829278 scopus 로고    scopus 로고
    • The effect of a ceramide analog, N-acetyl-sphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats
    • Pahlavani, M., and D. Vargas. 2000. The effect of a ceramide analog, N-acetyl-sphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats. Immunopharmacology 49:345.
    • (2000) Immunopharmacology , vol.49 , pp. 345
    • Pahlavani, M.1    Vargas, D.2
  • 39
    • 0032032140 scopus 로고    scopus 로고
    • Different protein kinase C isoenzymes regulate IL-2 receptor expression or IL-2 synthesis in human lymphocytes stimulated via the TCR
    • Szamel, M., A. Appel, R. Schwinzer, and K. Resch. 1998. Different protein kinase C isoenzymes regulate IL-2 receptor expression or IL-2 synthesis in human lymphocytes stimulated via the TCR. J. Immunol. 160:2207.
    • (1998) J. Immunol. , vol.160 , pp. 2207
    • Szamel, M.1    Appel, A.2    Schwinzer, R.3    Resch, K.4
  • 40
    • 0031012266 scopus 로고    scopus 로고
    • Selective modulation of protein kinase C-θ during T-cell activation
    • Monks, C., H. Kupfer, I. Tamir, A. Barlow, and A. Kupfer. 1997. Selective modulation of protein kinase C-θ during T-cell activation. Nature 385:83.
    • (1997) Nature , vol.385 , pp. 83
    • Monks, C.1    Kupfer, H.2    Tamir, I.3    Barlow, A.4    Kupfer, A.5
  • 41
    • 0032101707 scopus 로고    scopus 로고
    • Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes
    • Werlen, G., E. Jacinto, Y. Xia, and M. Karin. 1998. Calcineurin preferentially synergizes with PKC-θ to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17:3101.
    • (1998) EMBO J. , vol.17 , pp. 3101
    • Werlen, G.1    Jacinto, E.2    Xia, Y.3    Karin, M.4
  • 42
    • 0033551804 scopus 로고    scopus 로고
    • Protein kinase C and calcineurin synergize to activate IκB kinase and NF-κB in T lymphocytes
    • Trushin, S., K. Pennington, A. Algeciras-Schimnich, and C. Paya. 1999. Protein kinase C and calcineurin synergize to activate IκB kinase and NF-κB in T lymphocytes. J. Biol. Chem. 274:22923.
    • (1999) J. Biol. Chem. , vol.274 , pp. 22923
    • Trushin, S.1    Pennington, K.2    Algeciras-Schimnich, A.3    Paya, C.4


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