Effect of alcohol on iron storage diseases of the liver

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 17, Issue 4, 2003, Pages 663-677

  Fletcher, Linda M ^a   Bridle, Kim R ^b   Crawford, Darrell H G ^a  

^a PRINCESS ALEXANDRA HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Alcohol; Cirrhosis; End stage liver disease; Haemochromatosis; Iron; Oxidative stress

Indexed keywords

ALCOHOL; IRON; FERRITIN; TRANSFERRIN;

ALCOHOL CONSUMPTION; DISEASE COURSE; DISEASE EXACERBATION; EUROPE; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; LIPID PEROXIDATION; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FAILURE; LIVER FIBROSIS; LIVER HEMOSIDEROSIS; OXIDATIVE STRESS; PATHOGENESIS; REVIEW; RISK ASSESSMENT; TISSUE INJURY; FERRITIN BLOOD LEVEL; FIBROGENESIS; GENETIC DISORDER; IRON ABSORPTION; IRON METABOLISM; IRON OVERLOAD; IRON STORAGE; PHENOTYPE; TRANSFERRIN BLOOD LEVEL;

ALCOHOL DRINKING; BIOLOGICAL MARKERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; INTESTINAL ABSORPTION; IRON; LIVER; LIVER DISEASES; MEMBRANE PROTEINS; MUTATION; OXIDATIVE STRESS; PHENOTYPE; TRANSFERRIN;

EID: 0347353504     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6918(03)00020-9     Document Type: Review

References (77)

1. Bothwell T.H. MacPhail A.P. Hereditary hemochromatosis: etiologic, pathologic, and clinical aspects Seminars in Hematology 35 1998 55-71
2. Merryweather-Clarke A.T. Pointon J.J. Shearman J.D. et al. Global prevalence of putative haemochromatosis mutations Journal of Medical Genetics 34 1997 275-278
3. Lucotte G. Celtic origin of the C282Y mutation of hemochromatosis Blood, Cells, Molecules and Diseases 24 1998 433-438
4. Olynyk J.K. Cullen D.J. Aquilia S. et al. A population-based study of the clinical expression of the hemochromatosis gene New England Journal of Medicine 341 1999 718-724
5. Tavill A.S. Diagnosis and management of hemochromatosis Hepatology 33 2001 1321-1328
6. Substance Abuse and Mental Health Services Administration Summary of Findings from the 2000 National Household Survey on Drug Abuse 2001 DHHS Rockville NHSDA Series: H-13, DHHS Publication No. SMA 01-3549
7. Powell L.W. Leggett B.A. Crawford D.H.G. Hemochromatosis and other iron storage disorders. In Schiff E.R. Sorrell M.F. Maddrey W.C. (Eds.), Schiffs' Diseases of the Liver 8th edn1999 1107-1130 Lippincott-Raven Philadelphia
8. Sheldon J.H. Haemochromatosis 1935 Oxford University Press Oxford
9. MacDonald R.A. Hemochromatosis and Hemosiderosis 1964 Charles C. Thomas Springfield, IL
10. Simon M. Bourel M. Fauchet R. et al. Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis Gut 17 1976 332-334
11. Simon M. Bourel M. Genetet B. et al. Idiopathic hemochromatosis and iron overload in alcoholic liver disease: differentiation by HLA phenotype Gastroenterology 73 1977 655-658
12. Feder J.N. Gnirke A. Thomas W. et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis Nature Genetics 13 1996 399-408
13. Camaschella C. Roetto A. Cali A. et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 Nature Genetics 25 2000 14-15
14. Njajou O.T. Vaessen N. Joosse M. et al. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis Nature Genetics 28 2001 213-214
15. Wallace D.F. Pedersen P. Dixon J.L. et al. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis Blood 100 2002 692-694
16. Britton R.S. Metal-induced hepatotoxicity Seminars in Liver Disease 16 1996 3-12
17. Houglum K. Ramm G.A. Crawford D.H. et al. Excess iron induces hepatic oxidative stress and transforming growth factor beta1 in genetic hemochromatosis Hepatology 26 1997 605-610
18. Paradis V. Kollinger M. Fabre M. et al. In situ detection of lipid peroxidation by-products in chronic liver diseases Hepatology 26 1997 135-142
19. Roy C.N. Enns C.A. Iron homeostasis: new tales from the crypt Blood 96 2000 4020-4027
20. McKie A.T. Barrow D. Latunde-Dada G.O. et al. An iron-regulated ferric reductase associated with the absorption of dietary iron Science 291 2001 1755-1759
21. Frazer D.M. Wilkins S.J. Becker E.M. et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats Gastroenterology 123 2002 835-844
22. Nicolas G. Bennoun M. Devaux I. et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Proceedings of the National Academy of Sciences of the USA 98 2001 8780-8785
23. Pigeon C. Ilyin G. Courselaud B. et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload Journal of Biological Chemistry 276 2001 7811-7819
24. Leggett B.A. Halliday J.W. Brown N.N. et al. Prevalence of haemochromatosis amongst asymptomatic Australians British Journal of Haematology 74 1990 525-530
25. Smith B.N. Kantrowitz W. Grace N.D. et al. Prevalence of hereditary hemochromatosis in a Massachusetts corporation: is Celtic origin a risk factor? Hepatology 25 1997 1439-1446
26. Summers K.M. Tam K.S. Halliday J.W. et al. HLA determinants in an Australian population of hemochromatosis patients and their families American Journal of Human Genetics 45 1989 41-48
27. Crawford D.H. Halliday J.W. Summers K.M. et al. Concordance of iron storage in siblings with genetic hemochromatosis: evidence for a predominantly genetic effect on iron storage Hepatology 17 1993 833-837
28. Whiting P. Fletcher L. Dixon J. et al. Concordance of iron indices in homozygote and heterozygote sibling pairs in hemochromatosis families: implications for family screening Journal of Hepatology 37 2002 309-314
29. Bulaj Z.J. Ajioka R.S. Phillips J.D. et al. Disease-related conditions in relatives of patients with hemochromatosis New England Journal of Medicine 343 2000 1529-1535
30. Crawford D.H. Powell L.W. Leggett B.A. et al. Evidence that the ancestral haplotype in Australian hemochromatosis patients may be associated with a common mutation in the gene American Journal of Human Genetics 57 1995 362-367
31. Piperno A. Fargion S. Panaiotopoulos N. et al. Idiopathic haemochromatosis and HLA antigens in Italy: is A3 Bw35 HLA haplotype a marker for idiopathic haemochromatosis gene in north east regions? Journal of Clinical Pathology 39 1986 125-128
32. Cullen L.M. Summerville L. Glassick T.V. et al. Neonatal screening for the hemochromatosis defect Blood 90 1997 4236-4237
33. Beutler E. Felitti V.J. Koziol J.A. et al. Penetrance of 845G→ A (C282Y) HFE hereditary haemochromatosis mutation in the USA Lancet 359 2002 211-218
34. Asberg A. Hveem K. Thorstensen K. et al. Screening for hemochromatosis: high prevalence and low morbidity in an unselected population of 65,238 persons Scandinavian Journal of Gastroenterology 36 2001 1108-1115
35. Prieto J. Barry M. Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases Gastroenterology 68 1975 525-533
36. Moirand R. Lescoat G. Delamaire D. et al. Increase in glycosylated and nonglycosylated serum ferritin in chronic alcoholism and their evolution during alcohol withdrawal Alcoholism, Clinical and Experimental Research 15 1991 963-969
37. Fletcher L.M. Halliday J.W. Haemochromatosis: understanding the mechanism of disease and implications for diagnosis and patient management following the recent cloning of novel genes involved in iron metabolism Journal of Internal Medicine 251 2002 181-192
38. Scheuer P.J. Williams R. Muir A.R. Hepatic pathology in relatives of patients with haemochromatosis Journal of Pathology and Bacteriology 84 1962 53-64
39. Hall P. Alcoholic liver disease. In MacSween R.N. Burt A. Portmann B.C. Ishak K.G. Scheuer P.J. Anthony P.P. (Eds.), Pathology of the Liver 4th edn 2002 273-311 Churchill Livingstone London
40. Hall P. Pathological spectrum of alcoholic liver disease. In Hall P. (Ed.), Alcoholic Liver Disease: Pathology and Pathogenesis 1995 41-68 Edward Arnold London
41. Chapman R.W. Morgan M.Y. Laulicht M. et al. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis Digestive Diseases and Sciences 27 1982 909-916
42. Duane P. Raja K.B. Simpson R.J. et al. Intestinal iron absorption in chronic alcoholics Alcohol and Alcoholism 27 1992 539-544
43. Celada A. Rudolf H. Donath A. Effect of a single ingestion of alcohol on iron absorption American Journal of Hematology 5 1978 225-237
44. Chapman R.W. Morgan M.Y. Boss A.M. et al. Acute and chronic effects of alcohol on iron absorption Digestive Diseases and Sciences 28 1983 321-327
45. Pascoe A. Kerlin P. Steadman C. et al. Spur cell anaemia and hepatic iron stores in patients with alcoholic liver disease undergoing orthotopic liver transplantation Gut 45 1999 301-305
46. Suzuki Y. Saito H. Suzuki M. et al. Up-regulation of transferrin receptor expression in hepatocytes by habitual alcohol drinking is implicated in hepatic iron overload in alcoholic liver disease Alcoholism, Clinical and Experimental Research 26 2002 26S-31S
47. Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury Journal of Biological Chemistry 275 2000 2247-2250
48. Eng F.J. Friedman S.L. Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex American Journal of Physiology, Gastrointestinal and Liver Physiology 279 2000 G7-G11
49. Friedman S.L. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies New England Journal of Medicine 328 1993 1828-1835
50. Friedman S.L. Hepatic stellate cells Progress in Liver Diseases 14 1996 101-130
51. Pinzani M. Novel insights into the biology and physiology of the Ito cell Pharmacology and Therapeutics 66 1995 387-412
52. Lieber C.S. Alcoholic liver disease: new insights in pathogenesis lead to new treatments Journal of Hepatology 32 2000 113-128
53. Reinke L.A. Spin trapping evidence for alcohol-associated oxidative stress Free Radical Biology and Medicine 32 2002 953-957
54. Ekstrom G. Ingelman-Sundberg M. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1) Biochemical Pharmacology 38 1989 1313-1319
55. Nieto N. Friedman S.L. Cederbaum A.I. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species Hepatology 35 2002 62-73
56. Ramm G.A. Crawford D.H. Powell L.W. et al. Hepatic stellate cell activation in genetic haemochromatosis. Lobular distribution, effect of increasing hepatic iron and response to phlebotomy Journal of Hepatology 26 1997 584-592
57. Maher J.J. Tzagarakis C. Gimenez A. Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture Alcohol and Alcoholism 29 1994 605-610
58. Montosi G. Garuti C. Martinelli S. et al. Hepatic stellate cells are not subjected to oxidant stress during iron-induced fibrogenesis in rodents Hepatology 27 1998 1611-1622
59. Svegliati Baroni G. D'Ambrosio L. Ferretti G. et al. Fibrogenic effect of oxidative stress on rat hepatic stellate cells Hepatology 27 1998 720-726
60. Tsukamoto H. Horne W. Kamimura S. et al. Experimental liver cirrhosis induced by alcohol and iron Journal of Clinical Investigation 96 1995 620-630
61. Pietrangelo A. Iron, oxidative stress and liver fibrogenesis Journal of Hepatology 28 1998 8-13
62. Reeves H.L. Burt A.D. Wood S. et al. Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis Journal of Hepatology 25 1996 677-683
63. Pietrangelo A. Gualdi R. Casalgrandi G. et al. Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis Hepatology 19 1994 714-721
64. Niemela O. Parkkila S. Britton R.S. et al. Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury Journal of Laboratory and Clinical Medicine 133 1999 451-460
65. Loreal O. Deugnier Y. Moirand R. et al. Liver fibrosis in genetic hemochromatosis. Respective roles of iron and non-iron-related factors in 127 homozygous patients Journal of Hepatology 16 1992 122-127
66. LeSage G.D. Baldus W.P. Fairbanks V.F. et al. Hemochromatosis: genetic or alcohol-induced? Gastroenterology 84 1983 1471-1477
67. Adams P.C. Agnew S. Alcoholism in hereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings Hepatology 23 1996 724-727
68. Fletcher L.M. Dixon J.L. Purdie D.M. et al. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis Gastroenterology 122 2002 281-289
69. Niederau C. Fischer R. Purschel A. et al. Long-term survival in patients with hereditary hemochromatosis Gastroenterology 110 1996 1107-1119
70. Bradbear R.A. Bain C. Siskind V. et al. Cohort study of internal malignancy in genetic hemochromatosis and other chronic nonalcoholic liver diseases Journal of the National Cancer Institute 75 1985 81-84
71. Fargion S. Mandelli C. Piperno A. et al. Survival and prognostic factors in 212 Italian patients with genetic hemochromatosis Hepatology 15 1992 655-659
72. Kowdley K.V. Hassanein T. Kaur S. et al. Primary liver cancer and survival in patients undergoing liver transplantation for hemochromatosis Liver Transplantation and Surgery 1 1995 237-241
73. Ludwig J. Hashimoto E. Porayko M.K. et al. Hemosiderosis in cirrhosis: a study of 447 native livers Gastroenterology 112 1997 882-888
74. Cotler S.J. Bronner M.P. Press R.D. et al. End-stage liver disease without hemochromatosis associated with elevated hepatic iron index Journal of Hepatology 29 1998 257-262
75. Brandhagen D.J. Alvarez W. Therneau T.M. et al. Iron overload in cirrhosis-HFE genotypes and outcome after liver transplantation Hepatology 31 2000 456-460
76. Stuart K.A. Fletcher L.M. Clouston A.D. et al. Increased hepatic iron and cirrhosis: no evidence for an adverse effect on patient outcome following liver transplantation Hepatology 32 2000 1200-1207
77. Pascoe A. Kerlin P. Jones D. Spur cell anemia explains the iron overload in advanced cirrhosis (C282Y negative) Hepatology 32 2000 159