Mechanisms of glucose-induced secretion of pancreatic-derived factor (PANDER or FAM3B) in pancreatic β-cells

Diabetes

Volumn 54, Issue 11, 2005, Pages 3217-3228

  Yang, Jichun ^a   Robert, Claudia E ^a   Burkhardt, Brant R ^a   Young, Robert A ^a   Wu, Jianmei ^a   Gao, Zhiyong ^a   Wolf, Bryan A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CYSTEINE; CYTOKINE; GLUCOSE; GLUTAMINE; INSULIN; LEUCINE; LEVO GLUCOSE; MUTANT PROTEIN; NIFEDIPINE; PANCREATIC DERIVED FACTOR; POTASSIUM CHLORIDE; SERINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CELL LINE; CELL SECRETION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISULFIDE BOND; GENE MUTATION; GENE OVEREXPRESSION; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS SECRETION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RAT; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; GLUTAMINE; INSULIN-SECRETING CELLS; LEUCINE; MICE; MUTATION; NIFEDIPINE; POTASSIUM CHLORIDE; TIME FACTORS;

EID: 33644675373     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/diabetes.54.11.3217     Document Type: Article

References (45)

1. Tisch R, McDevitt H: Insulin-dependent diabetes mellitus. Cell 85:291-297, 1996
2. Nerup J, Mandrup-Poulsen T, Helqvist S, Andersen HU, Pociot F, Reimers JI, Cuartero BG, Karlsen AE, Bjerre U, Lorenzen T: On the pathogenesis of IDDM. Diabetologia 37 (Suppl. 2):S82-S89, 1994
3. Rabinovitch A, Suarez-Pinzon WL: Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 55:1139-1149, 1998
4. 2-terminal kinase activity in insulin-secreting cells: evidence for cytoplasmic restriction. Diabetes 50:2721-2728, 2001
5. Kutlu B, Darville MI, Cardozo AK, Eizirik DL: Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic β-cells. Diabetes 52:348-355, 2003
6. Ohara-Imaizumi M, Cardozo AK, Kikuta T, Eizirik DL, Nagamatsu S: The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis. J Biol Chem 279:41271-41274, 2004
7. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY: Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851-860, 2002
8. Maedler K, Sergeev P, Ehses JA, Mathe Z, Bosco D, Berney T, Dayer JM, Reinecke M, Halban PA, Donath MY: Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci U S A 101:8138-8143, 2004
9. Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR: Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics 80:144-150, 2002
10. Cao X, Gao Z, Robert CE, Greene S, Xu G, Xu W, Bell E, Campbell D, Zhu Y, Young R, Trucco M, Markmann JF, Naji A, Wolf BA: Pancreatic-derived factor (FAM3B), a novel islet cytokine, induces apoptosis of insulin-secreting β-cells. Diabetes 52:2296-2303, 2003
11. Aurora R, Rose GD: Seeking an ancient enzyme in Methanococcus jannaschii using ORF, a program based on predicted secondary structure comparisons. Proc Natl Acad Sci U S A 95:2818-2823, 1998
12. Abdel-Meguid SS, Shieh HS, Smith WW, Dayringer HE, Violand BN, Bentle LA: Three-dimensional structure of a genetically engineered variant of porcine growth hormone. Proc Natl Acad Sci U S A 84:6434-6437, 1987
13. Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, Di Marchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW: Crystal structure of the obese protein leptin-E100. Nature 387:206-209, 1997
14. Xu W, Gao Z, Wu J, Wolf B: Interferon-γ-induced regulation of the pancreatic derived cytokine FAM3B in islets and insulin-secreting βTC3 cells. Mol Cell Endocrinol 240:74-81, 2005
15. Shushan EB, Cerasi E, Melloul D: Regulation of the insulin gene by glucose: stimulation of trans-activation potency of human PDX-1 N-terminal domain. DNA Cell Biol 18:471-479, 1999
16. Yang J, Wong RK, Wang X, Moibi J, Hessner MJ, Greene S, Wu J, Sukumvanich S, Wolf BA, Gao Z: Leucine culture reveals that ATP: synthase functions as a fuel sensor in pancreatic {beta}-cells. J Biol Chem 279:53915-53923, 2004
17. Hanson RL, Isaacson CM: Stimulation of insulin secretion from isolated rat islets by SaRI 59-801: relation to cAMP concentration and Ca2+ uptake. Diabetes 34:691-695, 1985
18. Nunemaker CS, Zhang M, Satin LS: Insulin feedback alters mitochondrial activity through an ATP-sensitive K+ channel-dependent pathway in mouse islets and β-cells. Diabetes 53:1765-1772, 2004
19. Donath MY, Gross DJ, Cerasi E, Kaiser N: Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 48:738-744, 1999
20. Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F: High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50:1290-1301, 2001
21. Leibowitz G, Yuli M, Donath MY, Nesher R, Melloul D, Cerasi E, Gross DJ, Kaiser N: β-Cell glucotoxicity in the Psammomys obesus model of type 2 diabetes. Diabetes 50 (Suppl. 1):S113-S117, 2001
22. Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D: Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 106:2067-2072, 2002
23. Coughlan MT, Oliva K, Georgiou HM, Permezel JM, Rice GE: Glucose-induced release of tumour necrosis factor-alpha from human placental and adipose tissues in gestational diabetes mellitus. Diabet Med 18:921-927, 2001
24. Didier N, Romero IA, Creminon C, Wijkhuisen A, Grassi J, Mabondzo A: Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability. J Neurochem 86:246-254, 2003
25. Bailer RT, Holloway A, Sun J, Margolick JB, Martin M, Kostman J, Montaner LJ: IL-13 and IFN-gamma secretion by activated T cells in HIV-1 infection associated with viral suppression and a lack of disease progression. J Immunol 162:7534-7542, 1999
26. Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai X-D, McKay DM, Tintner R, Frangione B, Younkin SG: Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science 258:126-129, 1992
27. Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB, Selkoe DJ: Amyloid β-peptide is produced by cultured cells during normal metabolism. Nature 359:322-325, 1992
28. Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM: Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci U S A 90:9513-9517, 1993
29. Yang AJ, Knauer M, Burdick DA, Glabe C: Intracellular Aβ1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells. J Biol Chem 270:14786-14792, 1995
30. Skovronsky DM, Doms RW, Lee VM: Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture. J Cell Biol 141:1031-1039, 1998
31. MacFarlane WM, Campbell SC, Elrick LJ, Oates V, Bermano G, Lindley KJ, Aynsley-Green A, Dunne MJ, James RF, Docherty K: Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner. J Biol Chem 275:15330-15335, 2000
32. Schmitz O, Brock B, Rungby J: Amylin agonists: a novel approach in the treatment of diabetes. Diabetes 53 (Suppl. 3):S233-S238, 2004
33. Fineman M, Weyer C, Maggs DG, Strobel S, Kolterman OG: The human amylin analog, pramlintide, reduces postprandial hyperglucagonemia in patients with type 2 diabetes mellitus. Horm Metab Res 34:504-508, 2002
34. Whitehouse F, Kruger DF, Fineman M, Shen L, Ruggles JA, Maggs DG, Weyer C, Kolterman OG: A randomized study and open-label extension evaluating the long-term efficacy of pramlintide as an adjunct to insulin therapy in type 1 diabetes. Diabetes Care 25:724-730, 2002
35. Fineman MS, Koda JE, Shen LZ, Strobel SA, Maggs DG, Weyer C, Kolterman OG: The human amylin analog, pramlintide, corrects postprandial hyperglucagonemia in patients with type 1 diabetes. Metabolism 51:636-641, 2002
36. Clark A, Nilsson MR: Islet amyloid: a complication of islet dysfunction or an aetiological factor in type 2 diabetes? Diabetologia 47:157-169, 2004
37. Janson J, Soeller WC, Roche PC, Nelson RT, Torchia AJ, Kreutter DK, Butler PC: Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci U S A 93:7283-7288, 1996
38. Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC: Diabetes due to a progressive defect in β-cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): a new model for type 2 diabetes. Diabetes 53:1509-1516, 2004
39. Janson J, Ashley RH, Harrison D, McIntyre S, Butler PC: The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles. Diabetes 48:491-498, 1999
40. Ritzel RA, Butler PC: Replication increases β-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. Diabetes 52:1701-1708, 2003
41. Chan CB, Saleh MC, Koshkin V, Wheeler MB: Uncoupling protein 2 and islet function. Diabetes 53 (Suppl. 1):S136-S142, 2004
42. Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St Pierre J, Grey ST, Lowell BB: Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 112:1831-1842, 2003
43. Yang J, Gao Z, Robert CE, Burkhardt BR, Gaweska H, Wager A, Wu J, Greene R, Young RA, Wolf BA: Structure-function studies of pander, an islet specific cytokine inducing cell death of insulin-secreting beta cells. Biochemistry 44:11342-11352, 2005
44. Saunders CW, Pedroni JA, Monahan PM: Optimization of the signal-sequence cleavage site for secretion from Bacillus subtilis of a 34-amino acid fragment of human parathyroid hormone. Gene 102:277-282, 1991
45. Burkhardt BR, Yang MC, Robert CE, Greene SR, McFadden K, Yang J, Wu J, Gao Z, Wolf BA: Tissue-specific and glucose-responsive expression of the pancreatic derived factor (PANDER) promoter. Biochim Biophys Acta. In press