Clozapine and haloperidol differentially alter the constitutive activity of central serotonin2C receptors in vivo

Biological Psychiatry

Volumn 59, Issue 6, 2006, Pages 568-575

  Navailles, Sylvia ^a   De Deurwaerdère, Philippe ^a   Spampinato, Umberto ^a,b  

^a Centre National   (France)

^b CNRS   (France)

Author keywords

5 HT2C receptor; Clozapine; Constitutive activity; Dopamine release; Haloperidol; Inverse agonist

Indexed keywords

1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL] 6 TRIFLUOROMETHYLINDOLINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; CLOZAPINE; DOPAMINE; HALOPERIDOL; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOSE RESPONSE; DRUG EFFECT; IN VIVO STUDY; MALE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT;

AMINOPYRIDINES; ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOZAPINE; CORPUS STRIATUM; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; HALOPERIDOL; INDOLES; MALE; MICRODIALYSIS; NERVE NET; NUCLEUS ACCUMBENS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUBSTANTIA NIGRA;

EID: 33644617695     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.07.035     Document Type: Article

References (57)

1. E.L. Barker, R.S. Westphal, D. Schmidt, E. Sanders-Bush Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands J Biol Chem 269 1994 11687 11690
2. 2C receptor systems Mol Pharmacol 55 1999 863 872
3. T.P. Blackburn, Y. Minabe, D.N. Middlemiss, Y. Shirayama, K. Hashimoto, C.R. Ashby Jr Effect of acute and chronic administration of the selective 5-HT2C receptor antagonist SB-243213 on midbrain dopamine neurons in the rat An in vivo extracellular single cell study Synapse 46 2002 129 139
4. N. Bonhomme, P. De Deurwaerdère, M. Le Moal, U. Spampinato Evidence for 5-HT4 receptor subtype involvement in the enhancement of striatal dopamine release induced by serotonin A microdialysis study in the halothane-anesthetized rat Neuropharmacology 34 1995 269 279
5. P. De Deurwaerdère, S. Navailles, K.A. Berg, W.P. Clarke, U. Spampinato Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens J Neurosci 24 2004 3235 3241
6. P. De Deurwaerdère, U. Spampinato The nigrostriatal dopamine system A neglected target for 5-HT2C receptors Trends Pharmacol Sci 22 2001 502 504
7. G. Di Giovanni, V. Di Matteo, E. Esposito Serotonin/dopamine interaction-focus on 5-HT2C receptor, a new target of psychotropic drugs Indian J Exp Biol 40 2002 1344 1352
8. V. Di Matteo, M. Cacchio, C. Di Giulio, G. Di Giovanni, E. Esposito Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo Pharmacol Biochem Behav 71 2002 607 613
9. 2C receptors in the control of central dopamine function Trends Pharmacol Sci 22 2001 229 232
10. Y. Dwivedi, G.N. Pandey Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide- specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain J Pharmacol Exp Ther 291 1999 688 704
11. S. Ferré, F. Artigas Clozapine decreases serotonin extracellular levels in the nucleus accumbens by a dopamine receptor-independent mechanism Neurosci Lett 187 1995 61 64
12. M. Filip, K.A. Cunningham Hyperlocomotive and discriminative stimulus effects of cocaine are under the control of serotonin(2C) (5-HT(2C)) receptors in rat prefrontal cortex J Pharmacol Exp Ther 306 2003 734 743
13. A. Gobert, J.M. Rivet, F. Lejeune, A. Newman-Tancredi, A. Adhumeau-Auclair, J.P. Nicolas Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways A combined dialysis and electrophysiological analysis in the rat Synapse 36 2000 205 221
14. A.J. Grottick, P.J. Fletcher, G.A. Higgins Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior J Pharmacol Exp Ther 295 2000 1183 1191
15. J.A. Harvey, S.E. Welsh, H. Hood, A.G. Romano Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit Evidence for inverse agonism Psychopharmacology (Berl) 141 1999 162 168
16. S. Hernandez-Lopez, T. Tkatch, E. Perez-Garci, E. Galarraga, J. Bargas, H. Hamm D2 dopamine receptors in striatal medium spiny neurons reduce L-type Ca2+ currents and excitability via a novel PLC[β]1-IP3-calcineurin- signaling cascade J Neurosci 20 2000 8987 8995
17. K. Herrick-Davies, E. Grinde, M. Teitler Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors J Pharmacol Exp Ther 295 2000 226 232
18. D. Hoyer, J.P. Hannon, G.R. Martin Molecular, pharmacological and functional diversity of 5-HT receptors Pharmacol Biochem Behav 71 2002 533 554
19. 2C/2B receptor antagonists Neurochemical and behavioural studies Neuropharmacology 39 2000 2318 2328
20. J. Ichikawa, H. Ishii, S. Bonaccorso, W.L. Fowler, I.A. O'Laughlin, H.Y. Meltzer 5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation A possible mechanism of atypical antipsychotic-induced cortical dopamine release J Neurochem 76 2001 1521 1531
21. J. Ichikawa, T. Kuroki, J. Dai, H.Y. Meltzer Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens Eur J Pharmacol 351 1998 163 171
22. J. Ichikawa, H.Y. Meltzer The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens Brain Res 858 2000 252 263
23. B.J. Jones, T.P. Blackburn The medical benefit of 5-HT research Pharmacol Biochem Behav 71 2002 555 568
24. S. Kapur, G. Remington Serotonin-dopamine interaction and its relevance to schizophrenia Am J Psychiatry 153 1996 466 476
25. S. Kapur, R. Zipursky, C. Jones, G. Remington, S. Houle Relationship between dopamine D(2) occupancy, clinical response, and side effects A double-blind PET study of first-episode schizophrenia Am J Psychiatry 157 2000 514 520
26. G.A. Kennett, M.D. Wood, F. Bright, J. Cilia, D.C. Piper, T. Gager In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties Br J Pharmacol 117 1996 427 434
27. G.A. Kennett, M.D. Wood, F. Bright, B. Trail, G. Riley, V. Holland SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist Neuropharmacology 36 1997 609 620
28. T. Kuroki, H.Y. Meltzer, J. Ichikawa Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens J Pharmacol Exp Ther 288 1999 774 781
29. R.J. Lefkowitz, S. Cotecchia, P. Samama, T. Costa Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins Trends Pharmacol Sci 14 1993 303 307
30. T.I. Lidsky, S.P. Banerjee Clozapine's mechanisms of action Non-dopaminergic activity rather than anatomical selectivity Neurosci Lett 139 1992 100 103
31. J.F. Liégeois, J. Ichikawa, H.Y. Meltzer 5-HT(2A) receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner Brain Res 947 2002 157 165
32. 2C receptor subtypes and significance of the haloperidol dose used Neuropharmacology 39 2000 1053 1063
33. G. Lucas, U. Spampinato Role of striatal serotonin2A and serotonin2C receptor subtypes in the control of in vivo dopamine outflow in the rat striatum J Neurochem 74 2000 693 701
34. S. Masson, V. Avanzi, A.C. Troncoso, M.L. Brandao Effects of apomorphine and clozapine on conditioned freezing and latent inhibition Prog Neuropsychopharmacol Biol Psychiatry 27 2003 935 943
35. H.Y. Meltzer, Z. Li, Y. Kaneda, J. Ichikawa Serotonin receptors Their key role in drugs to treat schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 27 2003 1159 1172
36. M.J. Millan, A. Gobert, A. Newman-Tancredi, V. Audinot, F. Lejeune, J.M. Rivet S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol J Pharmacol Exp Ther 286 1998 1341 1355
37. G. Milligan, R.A. Bond Inverse agonism and the regulation of receptor number Trends Pharmacol Sci 18 1997 468 474
38. G. Milligan, R.A. Bond, M. Lee Inverse agonism Pharmacological curiosity or potential therapeutic strategy? Trends Pharmacol Sci 16 1995 10 13
39. S. Navailles, P. De Deurwaerdère, G. Porras, U. Spampinato In vivo evidence that 5-HT2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum Neuropsychopharmacology 29 2004 319 326
40. C.M. Niswender, S.C. Copeland, K. Herrick-Davis, R.B. Emeson, E. Sanders-Bush RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity J Biol Chem 274 1999 9472 9478
41. G. Paxinos, C. Watson The Rat Brain in Stereotaxic Coordinates 1986 Academic Press New York
42. A. Pazos, R. Cortés, J.M. Palacios Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors Brain Res 346 1985 231 249
43. L. Pozzi, S. Acconcia, I. Ceglia, R.W. Invernizzi, R. Samanin Stimulation of 5-hydroxytryptamine (5-HT(2C)) receptors in the ventrotegmental area inhibits stress-induced but not basal dopamine release in the rat prefrontal cortex J Neurochem 82 2002 93 100
44. 2C receptor alters receptor-mediated activation of G13 protein J Biol Chem 276 2001 44663 44668
45. E.P. Prinssen, W. Koek, M.S. Kleven The effects of antipsychotics with 5-HT(2C) receptor affinity in behavioral assays selective for 5-HT(2C) receptor antagonist properties of compounds Eur J Pharmacol 388 2000 57 67
46. S. Prisco, S. Pagannone, E. Esposito Serotonin-dopamine interaction in the rat ventral tegmental area An electrophysiological study in vivo J Pharmacol Exp Ther 271 1994 83 90
47. L. Rauser, J.E. Savage, H.Y. Meltzer, B.L. Roth Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor J Pharmacol Exp Ther 299 2001 83 89
48. H. Rollema, Y. Lu, A.W. Schmidt, J.S. Sprouse, S.H. Zorn 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex Biol Psychiatry 48 2000 229 237
49. B.L. Roth, R.D. Ciaranello, H.Y. Meltzer Binding of typical and atypical antipsychotic agents to transiently expressed 5-HT1C receptors J Pharmacol Exp Ther 260 1992 1361 1365
50. A. Schotte, P.F. Janssen, W. Gommeren, W.H. Luyten, P. Van Gompel, A. Lesage Risperidone compared with new and reference antipsychotic drugs In vitro and in vivo receptor binding Psychopharmacology (Berl) 124 1996 57 73
51. C.S. Shilliam, L.A. Dawson The effect of clozapine on extracellular dopamine levels in the shell subregion of the rat nucleus accumbens is reversed following chronic administration Comparison with a selective 5-HT(2C) receptor antagonist Neuropsychopharmacology 30 2005 372 380
52. P.G. Strange Antipsychotic drugs Importance of dopamine receptors for mechanisms of therapeutic actions and side effects Pharmacol Rev 53 2001 119 133
53. F.I. Tarazi, K. Zhang, R.J. Baldessarini Long-term effects of olanzapine, risperidone, and quetiapine on serotonin 1A, 2A and 2C receptors in rat forebrain regions Psychopharmacology (Berl) 161 2002 263 270
54. L.H. Tecott, L.M. Sun, S.F. Akana, A.M. Strack, D.H. Lowenstein, M.F. Dallman Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors Nature 374 1995 542 546
55. 2C receptors and their atypical regulation properties Life Sci 72 2003 2429 2449
56. W.A. Wolf, L.J. Schutz The serotonin 5-HT2C receptor is a prominent serotonin receptor in basal ganglia Evidence from functional studies on serotonin-mediated phosphoinositide hydrolysis J Neurochem 69 1997 1449 1458
57. M.D. Wood, C. Heidbreder, C. Reavill, C.R. Ashby Jr, D.N. Middlemiss 5-HT2C receptor antagonists Potential in schizophrenia Drug Dev Res 54 2001 88 94