5-HT2C receptor antagonists: Potential in schizophrenia

Drug Development Research

Volumn 54, Issue 2, 2001, Pages 88-94

  Wood, Martyn D ^a,b   Heidbreder, Christian ^a,b   Reavill, Charles ^a,b   Ashby Jr , Charles R ^a,b   Middlemiss, Derek N ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b ST JOHN'S UNIVERSITY   (United States)

Author keywords

5 HT2C receptor; 5 hydroxytryptamine; Dopamine; Schizophrenia

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 [3 FLUORO 5 (3 PYRIDYL)PHENYLCARBAMOYL] 5 METHOXY 6 TRIFLUOROMETHYLINDOLINE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL] 6 TRIFLUOROMETHYLINDOLINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; CLOZAPINE; DOPAMINE; DOPAMINE 2 RECEPTOR; HALOPERIDOL; MESULERGINE; NEUROLEPTIC AGENT; OLANZAPINE; QUETIAPINE; RISPERIDONE; SEROTONIN 2A ANTAGONIST; SEROTONIN 2C AGONIST; SEROTONIN 2C ANTAGONIST; SERTINDOLE; UNCLASSIFIED DRUG; ZIPRASIDONE;

BINDING AFFINITY; CATALEPSY; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; DRUG EFFICACY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; NEGATIVE SYNDROME; NONHUMAN; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PSYCHOSIS; REVIEW; SCHIZOPHRENIA; SIDE EFFECT; TREATMENT OUTCOME;

EID: 0035678041     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1208     Document Type: Review

References (2)

1. 2 receptors by dopamine in schizophrenia. Proc Natl Acad Sci USA 97:8104-8109.
2. Ashby CR Jr, Wang RY. 1996. The pharmacological actions of the atypical antipsychotic drug clozapine: a review. Synapse 24:349-394.