메뉴 건너뛰기




Volumn 21, Issue 3, 2006, Pages 456-465

Pharmacological sequestration of intracellular cholesterol in late endosomes disrupts ruffled border formation in osteoclasts

Author keywords

Cholesterol; Late endosome; Lysosome; Osteoclast; Ruffled border

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; AMINE; CATHEPSIN K; CHOLESTEROL; LYSOPHOSPHATIDIC ACID; MEMBRANE LIPID; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

EID: 33644551201     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.051204     Document Type: Article
Times cited : (22)

References (50)
  • 1
    • 18844386517 scopus 로고    scopus 로고
    • Mechanism of osteoclast mediated bone resorption-rationale for the design of new therapeutics
    • Vaananen K 2005 Mechanism of osteoclast mediated bone resorption-rationale for the design of new therapeutics. Adv Drug Deliv Rev 57:959-971.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 959-971
    • Vaananen, K.1
  • 2
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum SL 2000 Bone resorption by osteoclasts. Science 289:1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 3
    • 0029127505 scopus 로고
    • The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure
    • Vaananen HK, Horton M 1995 The osteoclast clear zone is a specialized cell-extracellular matrix adhesion structure. J Cell Sci 108:2729-2732.
    • (1995) J Cell Sci , vol.108 , pp. 2729-2732
    • Vaananen, H.K.1    Horton, M.2
  • 4
    • 0030895688 scopus 로고    scopus 로고
    • Trafficking of matrix collagens through bone-resorbing osteoclasts
    • Nesbitt SA, Horton MA 1997 Trafficking of matrix collagens through bone-resorbing osteoclasts. Science 276:266-269.
    • (1997) Science , vol.276 , pp. 266-269
    • Nesbitt, S.A.1    Horton, M.A.2
  • 6
    • 0024461376 scopus 로고
    • Osteoclastic bone resorption by a polarized vacuolar proton pump
    • Blair HC, Teitelbaum SL, Ghiselli R, Gluck S 1989 Osteoclastic bone resorption by a polarized vacuolar proton pump. Science 245:855-857.
    • (1989) Science , vol.245 , pp. 855-857
    • Blair, H.C.1    Teitelbaum, S.L.2    Ghiselli, R.3    Gluck, S.4
  • 9
    • 0032748995 scopus 로고    scopus 로고
    • Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification
    • Li YP, Chen W, Liang Y, Li E, Stashenko P 1999 Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet 23:447-451.
    • (1999) Nat Genet , vol.23 , pp. 447-451
    • Li, Y.P.1    Chen, W.2    Liang, Y.3    Li, E.4    Stashenko, P.5
  • 12
    • 0029809357 scopus 로고    scopus 로고
    • Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
    • Gelb BD, Shi GP, Chapman HA, Desnick RJ 1996 Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273:1236-1238.
    • (1996) Science , vol.273 , pp. 1236-1238
    • Gelb, B.D.1    Shi, G.P.2    Chapman, H.A.3    Desnick, R.J.4
  • 18
    • 0036423664 scopus 로고    scopus 로고
    • Formation and function of the ruffled border in osteoclasts
    • Stenbeck G 2002 Formation and function of the ruffled border in osteoclasts. Semin Cell Dev Biol 13:285-292.
    • (2002) Semin Cell Dev Biol , vol.13 , pp. 285-292
    • Stenbeck, G.1
  • 19
    • 0032174579 scopus 로고    scopus 로고
    • Lipids, lipid domains and lipid-protein interactions in endocytic membrane traffic
    • Kobayashi T, Gu F, Gruenberg J 1998 Lipids, lipid domains and lipid-protein interactions in endocytic membrane traffic. Semin Cell Dev Biol 9:517-526.
    • (1998) Semin Cell Dev Biol , vol.9 , pp. 517-526
    • Kobayashi, T.1    Gu, F.2    Gruenberg, J.3
  • 21
    • 0034529050 scopus 로고    scopus 로고
    • How cells handle cholesterol
    • Simons K, Ikonen E 2000 How cells handle cholesterol. Science 290:1721-1726.
    • (2000) Science , vol.290 , pp. 1721-1726
    • Simons, K.1    Ikonen, E.2
  • 22
    • 0033922431 scopus 로고    scopus 로고
    • Lipid trafficking and sorting: How cholesterol is filling gaps
    • Hoekstra D, van Ijzendoorn SC 2000 Lipid trafficking and sorting: How cholesterol is filling gaps. Curr Opin Cell Biol 12:496-502.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 496-502
    • Hoekstra, D.1    Van Ijzendoorn, S.C.2
  • 24
    • 0034672696 scopus 로고    scopus 로고
    • Niemann-Pick type C: A disorder of cellular cholesterol trafficking
    • Ory DS 2000 Niemann-Pick type C: A disorder of cellular cholesterol trafficking. Biochim Biophys Acta 1529:331-339.
    • (2000) Biochim Biophys Acta , vol.1529 , pp. 331-339
    • Ory, D.S.1
  • 28
    • 0034623958 scopus 로고    scopus 로고
    • Niemann-Pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis
    • Millard EE, Srivastava K, Traub LM, Schaffer JE, Ory DS 2000 Niemann-Pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis. J Biol Chem 275:38445-38451.
    • (2000) J Biol Chem , vol.275 , pp. 38445-38451
    • Millard, E.E.1    Srivastava, K.2    Traub, L.M.3    Schaffer, J.E.4    Ory, D.S.5
  • 29
    • 7044260932 scopus 로고    scopus 로고
    • Where sterols are required for endocytosis
    • Pichler H, Riezman H 2004 Where sterols are required for endocytosis. Biochim Biophys Acta 1666:51-61.
    • (2004) Biochim Biophys Acta , vol.1666 , pp. 51-61
    • Pichler, H.1    Riezman, H.2
  • 31
    • 0024848865 scopus 로고
    • Organization of osteoclast microfilaments during the attachment to bone surface in vitro
    • Lakkakorpi P, Tuukkanen J, Hentunen T, Jarvelin K, Vaananen K 1989 Organization of osteoclast microfilaments during the attachment to bone surface in vitro. J Bone Miner Res 4:817-825.
    • (1989) J Bone Miner Res , vol.4 , pp. 817-825
    • Lakkakorpi, P.1    Tuukkanen, J.2    Hentunen, T.3    Jarvelin, K.4    Vaananen, K.5
  • 32
    • 0030797216 scopus 로고    scopus 로고
    • Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts
    • Palokangas H, Mulari M, Vaananen HK 1997 Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts. J Cell Sci 110:1767-1780.
    • (1997) J Cell Sci , vol.110 , pp. 1767-1780
    • Palokangas, H.1    Mulari, M.2    Vaananen, H.K.3
  • 33
    • 0037936890 scopus 로고    scopus 로고
    • From lysosomes to the plasma membrane: Localization of vacuolar type H+-ATPase with the a3 isoform during osteoclast differentiation
    • Toyomura T, Murata Y, Yamamoto A, Oka T, Sun-Wada G-H, Wada Y, Futai M 2003 From lysosomes to the plasma membrane: Localization of vacuolar type H+-ATPase with the a3 isoform during osteoclast differentiation. J Biol Chem 278:22023-22030.
    • (2003) J Biol Chem , vol.278 , pp. 22023-22030
    • Toyomura, T.1    Murata, Y.2    Yamamoto, A.3    Oka, T.4    Sun-Wada, G.-H.5    Wada, Y.6    Futai, M.7
  • 34
    • 0032510559 scopus 로고    scopus 로고
    • A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
    • Kobayashi T, Stang E, Fang KS, de Moerloose P, Parton RG, Gruenberg J 1998 A lipid associated with the antiphospholipid syndrome regulates endosome structure and function. Nature 392:193-197.
    • (1998) Nature , vol.392 , pp. 193-197
    • Kobayashi, T.1    Stang, E.2    Fang, K.S.3    De Moerloose, P.4    Parton, R.G.5    Gruenberg, J.6
  • 35
    • 0035914465 scopus 로고    scopus 로고
    • Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption
    • Zhao H, Laitala-Leinonen T, Parikka V, Vaananen HK 2001 Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption. J Biol Chem 276:39295-39302.
    • (2001) J Biol Chem , vol.276 , pp. 39295-39302
    • Zhao, H.1    Laitala-Leinonen, T.2    Parikka, V.3    Vaananen, H.K.4
  • 37
    • 0032403962 scopus 로고    scopus 로고
    • Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur
    • Yamaza T, Goto T, Kamiya T, Kobayashi Y, Sakai H, Tanaka T 1998 Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur. Bone 23:499-509.
    • (1998) Bone , vol.23 , pp. 499-509
    • Yamaza, T.1    Goto, T.2    Kamiya, T.3    Kobayashi, Y.4    Sakai, H.5    Tanaka, T.6
  • 38
    • 0023686835 scopus 로고
    • Polarized secretion of lysosomal enzymes: Codistribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway
    • Baron R, Neff L, Brown W, Courtoy PJ, Louvard D, Farquhar M 1988 Polarized secretion of lysosomal enzymes: Codistribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway. J Cell Biol 106:1863-1872.
    • (1988) J Cell Biol , vol.106 , pp. 1863-1872
    • Baron, R.1    Neff, L.2    Brown, W.3    Courtoy, P.J.4    Louvard, D.5    Farquhar, M.6
  • 39
    • 0036297659 scopus 로고    scopus 로고
    • Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins
    • Zhao H, Ettala O, Vaananen HK 2002 Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins. Biochem Biophys Res Commun 293:1060-1065.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1060-1065
    • Zhao, H.1    Ettala, O.2    Vaananen, H.K.3
  • 40
    • 0037648426 scopus 로고    scopus 로고
    • Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake
    • Mulari MT, Zhao H, Lakkakorpi PT, Vaananen HK 2003 Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake. Traffic 4:113-125.
    • (2003) Traffic , vol.4 , pp. 113-125
    • Mulari, M.T.1    Zhao, H.2    Lakkakorpi, P.T.3    Vaananen, H.K.4
  • 41
    • 0029752791 scopus 로고    scopus 로고
    • Endocytosis and molecular sorting
    • Mellman I 1996 Endocytosis and molecular sorting. Annu Rev Cell Dev Biol 12:575-625.
    • (1996) Annu Rev Cell Dev Biol , vol.12 , pp. 575-625
    • Mellman, I.1
  • 44
    • 0033523774 scopus 로고    scopus 로고
    • Regulated secretion from hemopoietic cells
    • Stinchcombe JC, Griffiths GM 1999 Regulated secretion from hemopoietic cells. J Cell Biol 147:1-6.
    • (1999) J Cell Biol , vol.147 , pp. 1-6
    • Stinchcombe, J.C.1    Griffiths, G.M.2
  • 45
    • 0035163949 scopus 로고    scopus 로고
    • Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events
    • Ko DC, Gordon MD, Jin JY, Scott MP 2001 Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events. Mol Biol Cell 12:601-614.
    • (2001) Mol Biol Cell , vol.12 , pp. 601-614
    • Ko, D.C.1    Gordon, M.D.2    Jin, J.Y.3    Scott, M.P.4
  • 46
    • 0024312609 scopus 로고
    • The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3- Beta-[2-(diethylamino)ethoxy]androst-5-en-17-one
    • Liscum L, Faust J 1989 The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3- beta-[2-(diethylamino)ethoxy]androst-5-en-17-one. J Biol Chem 264:11796-11806.
    • (1989) J Biol Chem , vol.264 , pp. 11796-11806
    • Liscum, L.1    Faust, J.2
  • 48
    • 0041709185 scopus 로고    scopus 로고
    • The role of prenylated small GTP-binding proteins in the regulation of osteoclast function
    • Coxon FP, Rogers MJ 2003 The role of prenylated small GTP-binding proteins in the regulation of osteoclast function. Calcif Tissue Int 72:80-84.
    • (2003) Calcif Tissue Int , vol.72 , pp. 80-84
    • Coxon, F.P.1    Rogers, M.J.2
  • 49
    • 0036083829 scopus 로고    scopus 로고
    • Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells
    • Choudhury A, Dominguez M, Puri V, Sharma DK, Narita K, Wheatley CL, Marks DL, Pagano RE 2002 Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells. J Clin Invest 109:1541-1550.
    • (2002) J Clin Invest , vol.109 , pp. 1541-1550
    • Choudhury, A.1    Dominguez, M.2    Puri, V.3    Sharma, D.K.4    Narita, K.5    Wheatley, C.L.6    Marks, D.L.7    Pagano, R.E.8
  • 50
    • 0032498539 scopus 로고    scopus 로고
    • Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent
    • Mullock BM, Bright NA, Fearon CW, Gray SR, Luzio J 1998 Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent. J Cell Biol 140:591-601.
    • (1998) J Cell Biol , vol.140 , pp. 591-601
    • Mullock, B.M.1    Bright, N.A.2    Fearon, C.W.3    Gray, S.R.4    Luzio, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.