A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism

Pigment Cell Research

Volumn 17, Issue 4, 2004, Pages 363-370

  Giménez, Estela ^a   Lavado, Alfonso ^a   Giraldo, Patricia ^a,c   Cozar, Patricia ^a   Jeffery, Glen ^b   Montoliu, Lluís ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

Albino; Doxycycline; Retinal pigment epithelium; Transgenic mice; Uncrossed chiasmatic pathway; Variegation

Indexed keywords

COMPLEMENTARY DNA; DOXYCYCLINE; MONOPHENOL MONOOXYGENASE; TETRACYCLINE; TRANSACTIVATOR PROTEIN;

ALBINISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE INDUCTION; GENE LOCUS; HETEROZYGOSITY; HOMOZYGOSITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OCULOCUTANEOUS ALBINISM; PIGMENT EPITHELIUM; PROMOTER REGION; RETINA; RETINA DEVELOPMENT; TRANSGENIC MOUSE; VISION; VISUAL SYSTEM;

ALBINISM, OCULOCUTANEOUS; ANIMALS; BASE SEQUENCE; DNA, COMPLEMENTARY; EYE; GENE EXPRESSION REGULATION; GENETIC VECTORS; HOMOZYGOTE; MELANINS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MOLECULAR SEQUENCE DATA; MONOPHENOL MONOOXYGENASE; OPTIC CHIASM; OPTIC NERVE NEOPLASMS; PLASMIDS; TETRACYCLINE; UP-REGULATION;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 3342920711     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0749.2004.00158.x     Document Type: Article

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