-
1
-
-
0032900953
-
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
-
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. 1999. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39: 361-398.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 361-398
-
-
Ambudkar, S.V.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Pastan, I.5
Gottesman, M.M.6
-
2
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano RL, Ling V. 1976. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152-162.
-
(1976)
Biochim Biophys Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
3
-
-
0029098340
-
Multidrug resistance and the role of P-glycoprotein knockout mice
-
Schinkel AH, Mol CA, Wagenaar E, van Deemter L, Smit JJ, Borst P. 1995. Multidrug resistance and the role of P-glycoprotein knockout mice. Eur J Cancer 31A:1295-1298.
-
(1995)
Eur J Cancer
, vol.31 A
, pp. 1295-1298
-
-
Schinkel, A.H.1
Mol, C.A.2
Wagenaar, E.3
Van Deemter, L.4
Smit, J.J.5
Borst, P.6
-
4
-
-
0027218689
-
Biochemistry of multidrug resistance mediated by the multidrug transporter
-
Gottesman MM, Pastan I. 1993. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62:385-427.
-
(1993)
Annu Rev Biochem
, vol.62
, pp. 385-427
-
-
Gottesman, M.M.1
Pastan, I.2
-
5
-
-
0035063261
-
P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir
-
Huisman MT, Smit JW, Wiltshire HR, Hoetelmans RM, Beijnen JH, Schinkel AH. 2001. P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir. Mol Pharmacol 59:806-813.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 806-813
-
-
Huisman, M.T.1
Smit, J.W.2
Wiltshire, H.R.3
Hoetelmans, R.M.4
Beijnen, J.H.5
Schinkel, A.H.6
-
6
-
-
0035703732
-
The roles of P-glycoprotein and MRP1 in the blood-brain and blood-cerebrospinal fluid barriers
-
Schinkel AH. 2001. The roles of P-glycoprotein and MRP1 in the blood-brain and blood-cerebrospinal fluid barriers. Adv Exp Med Biol 500:365-372.
-
(2001)
Adv Exp Med Biol
, vol.500
, pp. 365-372
-
-
Schinkel, A.H.1
-
7
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, Berns AJM, Borst P. 1994. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.10
Berns, A.J.M.11
Borst, P.12
-
8
-
-
0030782511
-
Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities
-
Shapiro AB, Ling V. 1997. Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities. Eur J Biochem 250:130-137.
-
(1997)
Eur J Biochem
, vol.250
, pp. 130-137
-
-
Shapiro, A.B.1
Ling, V.2
-
9
-
-
0033083015
-
Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone: Evidence for a third drug-binding site
-
Shapiro AB, Fox K, Lam P, Ling V. 1999. Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone: Evidence for a third drug-binding site. Eur J Biochem 259:841-850.
-
(1999)
Eur J Biochem
, vol.259
, pp. 841-850
-
-
Shapiro, A.B.1
Fox, K.2
Lam, P.3
Ling, V.4
-
10
-
-
0034739274
-
Two transport binding sites of P-glycoprotein are unequal yet contingent: Initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence
-
Wang EJ, Casciano CN, Clement RP, Johnson WW. 2000. Two transport binding sites of P-glycoprotein are unequal yet contingent: Initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence. Biochim Biophys Acta 1481: 63-74.
-
(2000)
Biochim Biophys Acta
, vol.1481
, pp. 63-74
-
-
Wang, E.J.1
Casciano, C.N.2
Clement, R.P.3
Johnson, W.W.4
-
11
-
-
0035976774
-
Active transport of fluorescent P-glycoprotein substrates: Evaluation as markers and interaction with inhibitors
-
Wang EJ, Casciano CN, Clement RP, Johnson WW. 2001. Active transport of fluorescent P-glycoprotein substrates: Evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun 289:580-585.
-
(2001)
Biochem Biophys Res Commun
, vol.289
, pp. 580-585
-
-
Wang, E.J.1
Casciano, C.N.2
Clement, R.P.3
Johnson, W.W.4
-
12
-
-
0034858151
-
Identification and localization of three photobinding sites of iodoarylazidoprazosin in hamster P-glycoprotein
-
Isenberg B, Thole H, Tummler B, Demmer A. 2001. Identification and localization of three photobinding sites of iodoarylazidoprazosin in hamster P-glycoprotein. Eur J Biochem 268:2629-2634.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2629-2634
-
-
Isenberg, B.1
Thole, H.2
Tummler, B.3
Demmer, A.4
-
13
-
-
0033610801
-
Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain
-
Bakos E, Evers R, Szakacs G, Tusnady GE, Welker E, Szabo K, de Haas M, van Deemter L, Borst P, Varadi A, Sarkadi B. 1998. Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. J Biol Chem 273:32167-32175.
-
(1998)
J Biol Chem
, vol.273
, pp. 32167-32175
-
-
Bakos, E.1
Evers, R.2
Szakacs, G.3
Tusnady, G.E.4
Welker, E.5
Szabo, K.6
De Haas, M.7
Van Deemter, L.8
Borst, P.9
Varadi, A.10
Sarkadi, B.11
-
14
-
-
0032804327
-
Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor
-
Polli JW, Jarrett JL, Studenberg SD, Humphreys JE, Dennis SW, Brouwer KR, Woolley JL. 1999. Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor. Pharm Res 16:1206-1212.
-
(1999)
Pharm Res
, vol.16
, pp. 1206-1212
-
-
Polli, J.W.1
Jarrett, J.L.2
Studenberg, S.D.3
Humphreys, J.E.4
Dennis, S.W.5
Brouwer, K.R.6
Woolley, J.L.7
-
16
-
-
0033567425
-
Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells
-
Sharom FJ, Yu X, Lu P, Liu R, Chu JW, Szabo K, Muller M, Hose CD, Monks A, Varadi A, Seprodi J, Sarkadi B. 1999. Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells. Biochem Pharmacol 58:571-586.
-
(1999)
Biochem Pharmacol
, vol.58
, pp. 571-586
-
-
Sharom, F.J.1
Yu, X.2
Lu, P.3
Liu, R.4
Chu, J.W.5
Szabo, K.6
Muller, M.7
Hose, C.D.8
Monks, A.9
Varadi, A.10
Seprodi, J.11
Sarkadi, B.12
-
17
-
-
0034763005
-
Rational use of in vitro P-glycoprotein assays in drug discovery
-
Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS. 2001. Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther 299:620-628.
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 620-628
-
-
Polli, J.W.1
Wring, S.A.2
Humphreys, J.E.3
Huang, L.4
Morgan, J.B.5
Webster, L.O.6
Serabjit-Singh, C.S.7
-
18
-
-
0035923518
-
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein
-
Kondratov RV, Komarov PG, Becker Y, Ewenson A, Gudkov AV. 2001. Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. Proc Natl Acad Sci USA 98:14078-14083.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 14078-14083
-
-
Kondratov, R.V.1
Komarov, P.G.2
Becker, Y.3
Ewenson, A.4
Gudkov, A.V.5
-
19
-
-
0035313896
-
Screening for human ADME/Tox drug properties in drug discovery
-
Li AP. 2001. Screening for human ADME/Tox drug properties in drug discovery. Drug Discov Today 6: 357-366.
-
(2001)
Drug Discov Today
, vol.6
, pp. 357-366
-
-
Li, A.P.1
-
20
-
-
0003161252
-
Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers
-
Doyle A, Griffiths JB, Newell DJ, editors. New York: John Wiley & Sons
-
Gao J, Hugger ED, Beck-Westermeyer MS, Borchardt RT. 2000. Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers. In: Doyle A, Griffiths JB, Newell DJ, editors. Current protocols in pharmacology. New York: John Wiley & Sons, pp 1-23.
-
(2000)
Current Protocols in Pharmacology
, pp. 1-23
-
-
Gao, J.1
Hugger, E.D.2
Beck-Westermeyer, M.S.3
Borchardt, R.T.4
-
21
-
-
0036293772
-
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
-
Tang F, Horie K, Borchardt RT. 2002. Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res 19:766-772.
-
(2002)
Pharm Res
, vol.19
, pp. 766-772
-
-
Tang, F.1
Horie, K.2
Borchardt, R.T.3
-
22
-
-
0033060742
-
Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat
-
Letrent SP, Pollack GM, Brouwer KR, Brouwer KL. 1999. Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat. Drug Metab Dispos 27:827-834.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 827-834
-
-
Letrent, S.P.1
Pollack, G.M.2
Brouwer, K.R.3
Brouwer, K.L.4
-
23
-
-
0034782738
-
Detection of P-glycoprotein in cell lines and leukemic blasts: Failure of select monoclonal antibodies to detect clinically significant P-gp levels in primary cells
-
Taylor BJ, Olson DP, Ivy SP. 2001. Detection of P-glycoprotein in cell lines and leukemic blasts: Failure of select monoclonal antibodies to detect clinically significant P-gp levels in primary cells. Leuk Res 25:1127-1135.
-
(2001)
Leuk Res
, vol.25
, pp. 1127-1135
-
-
Taylor, B.J.1
Olson, D.P.2
Ivy, S.P.3
-
24
-
-
0032695270
-
Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR
-
de Bruin M, Miyake K, Litman T, Robey R, Bates SE. 1999. Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR. Cancer Lett 146:117-126.
-
(1999)
Cancer Lett
, vol.146
, pp. 117-126
-
-
De Bruin, M.1
Miyake, K.2
Litman, T.3
Robey, R.4
Bates, S.E.5
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