Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics

Biochemical Journal

Volumn 368, Issue 3, 2002, Pages 673-677

  Murray Stewart, Tracy ^a   Wang, Yanlin ^a   Devereux, Wendy ^a   Casero Jr , Robert A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Isoform; N1 acetylspermine; Polyamines; Spermidine; Spermine

Indexed keywords

AMINES; BIOCHEMISTRY; ENZYME KINETICS; METABOLISM; OXIDATION;

ISOENZYMES;

CLONING;

ISOENZYME; POLYAMINE OXIDASE;

ARTICLE; CATABOLISM; CELL LINE; CONTROLLED STUDY; EMBRYO; GENETIC CODE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN VARIANT;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE LIBRARY; HUMANS; KINETICS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYAMINES; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; SEQUENCE HOMOLOGY, AMINO ACID; SPERMIDINE; SPERMINE; SUBSTRATE SPECIFICITY; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0037115754     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021587     Document Type: Article

References (19)

1. Bergeron, R. J., Feng, Y., Weimar, W. R., McManis, J. S., Dimova, H., Porter, C., Raisler, B. and Phanstiel, O. (1997) A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics. J. Med. Chem. 40, 1475-1494
2. Casero, Jr, R. A. and Woster, P. M. (2001) Terminally alkylated polyamine analogues as chemotherapeutic agents. J. Med. Chem. 44, 1-26
3. 1-acetyltransferase - The turning point in polyamine metabolism. FASEB J. 7, 653-661
4. Seiler, N. (1995) Polyamine oxidase, properties and functions. Prog. Brain Res. 106, 333-344
5. Ha, H. C, Woster, P. M., Yager, J. D. and Casero, Jr, R. A. (1997) The role of polyamine catabolism in polyamine analogue-induced programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 94, 11557-11562
6. Wang, Y., Devereux, W., Woster, P. M., Stewart, T. M., Hacker, A. and Casero, Jr, R. A. (2001) Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. Cancer Res. 61, 5370-5373
7. Vujcic, S., Diegelman, P., Bacchi, C. J., Kramer, D. L. and Porter, C. W. (2002) Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem. J. 367, 665-575
8. 11-[(cycloheptyl)methyl]-4,8-diazaundecane (CHENSpm) by polyamine oxidase. Clin. Cancer Res. 8, 1241-1247
9. Suzuki, O., Matsumoto, T. and Katsumata, Y. (1984) Determination of polyamine oxidase activities in human tissues. Experientia 40, 838-839
10. Tavladoraki, P., Schinina, M. E., Cecconi, F., Di Agostino, S., Manera, F., Rea, G., Mariottini, P., Federico, R. and Angelini, R. (1998) Maize polyamine oxidase: Primary structure from protein and cDNA sequencing. FEBS Lett. 426, 62-56
11. Binda, C, Coda, A., Angelini, R., Federico, R., Ascenzi, P. and Mattevi, A. (1999) A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase. Structure Fold. Des. 7, 265-276
12. Chen, Y., Kramer, D. L., Diegelman, P., Vujcic, S. and Porter, C. W. (2001) Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells. Cancer Res. 61, 6437-6444
13. Wallace, H. M., Duthie, J., Evans, D. M., Lamond, S., Nicoll, K. M. and Heys, S. D. (2000) Alterations in polyamine catabolic enzymes in human breast cancer tissue. Clin. Cancer Res. 6, 3657-3661
14. Hartl, F. U. and Hayer-Hartl, M. (2002) Molecular chaperones in the cytosol: From nascent chain to folded protein. Science 295, 1852-1858
15. Cervelli, M., Cona, A., Angelini, R., Polticelli, F., Federico, R. and Mariottini, P. (2001) A barley polyamine oxidase isoform with distinct structural features and subcellular localization. Eur. J. Biochem. 268, 3816-3830
16. Federico, R., Alisi, C., Cona, A. and Angelini, R. (1988) Purification of polyamine oxidase from maize seedlings by immunoadsorbent column. Adv. Exp. Med. Biol. 250, 617-523
17. Van den Munckhof, R. J., Denyn, M., Tigchelaar-Gutter, W., Schipper, R. G., Verhofstad, A. A., Van Noorden, C. J. and Frederiks, W. M. (1995) In situ substrate specificity and ultrastructural localization of polyamine oxidase activity in unfixed rat tissues. J. Histochem. Cytochem. 43, 1155-1162
18. Nishikawa, M., Hagishita, T., Yurimoto, H., Kato, N., Sakai, Y. and Hatanaka, T. (2000) Primary structure and expression of peroxisomal acetylspermidine oxidase in the methylotrophic yeast Candida boidinii. FEBS Lett. 476, 150-154
19. Hotroyd, C. and Erdmann, R. (2001) Protein translocation machineries of peroxisomes. FEBS Lett. 501, 6-10