Immunostimulatory CpG-oligodeoxynucleotides (CpG-ODN) induce early hepatic injury, but provide a late window for protection against endotoxin-mediated liver damage

Journal of Hepatology

Volumn 44, Issue 3, 2006, Pages 576-585

  Slotta, Jan E ^a   Scheuer, Claudia ^a   Menger, Michael D ^a   Vollmar, Brigitte ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Inflammation; Lipopolysaccharide; Liver; Neutrophils; Rodent

Indexed keywords

CASPASE 3; CPG OLIGODEOXYNUCLEOTIDE; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL INTERACTION; CONTROLLED STUDY; DNA SEQUENCE; ENDOTHELIUM CELL; ESCHERICHIA COLI; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; KUPFFER CELL; LEUKOCYTE; LIVER INJURY; LIVER TOXICITY; MALE; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BLOTTING, WESTERN; CASPASE 3; CASPASES; DISEASE MODELS, ANIMAL; ENZYME PRECURSORS; ESCHERICHIA COLI; HEPATITIS; LIPOPOLYSACCHARIDES; LIVER FAILURE, ACUTE; MALE; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 4; TNF RECEPTOR-ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

EID: 32444450374     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.08.014     Document Type: Article

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