Cytosine-phosphate-guanine (CpG) motifs are sensitizing agents for lipopolysaccharide in toxic shock model

Intensive Care Medicine

Volumn 28, Issue 9, 2002, Pages 1340-1347

  Cornélie, Sylvie ^a   Wiel, Eric ^b   Lund, Niels ^c   Lebuffe, Gilles ^b   Vendeville, Catherine ^a   Riveau, Gilles ^a   Vallet, Benoît ^b   Ban, Elisabeth ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Cytosine phosphate guanine (CpG) oligodeoxynucleotide; D galactosamine; Lipopolysaccharide (LPS); Septic shock; Tumor necrosis factor

Indexed keywords

BACTERIAL DNA; BACTERIUM LIPOPOLYSACCHARIDE; CYTOSINE PHOSPHATE GUANINE OLIGODEOXYNUCLEOTIDE; GALACTOSAMINE; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE DERIVATIVE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; LETHAL DOSE; LIVER; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; SENSITIZATION; SEPTIC SHOCK; TRANSCRIPTION REGULATION;

EID: 0036037736     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-002-1418-z     Document Type: Article

References (50)

1. Immune effects and mechanisms of action of CpG motifs
2. Macrophage activation by immunostimulatory DNA
3. The role of immunostimulatory CpG-DNA in septic shock
4. Further studies of infectious DNA extracted from mycobacteriophages
5. A synthetic single-stranded DNA, poly(dG,dC), induces interferon-alpha/beta and -gamma, augments natural killer activity and suppresses tumor growth
6. Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors
7. DNA from bacteria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth
8. CpG motifs in bacterial DNA trigger direct B-cell activation
9. Non-methylated CpG-rich islands at the human alpha-globin locus: Implications for evolution of the alpha-globin pseudogene
10. Patterns of DNA methylation - Evolutionary vestiges of foreign DNA inactivation as a host defense mechanism. A proposal
11. Over- and under-representation of short oligodeoxynucleotides in DNA sequences
12. The immunologic properties of DNA
13. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock
14. Macrophages ingest and are activated by bacterial DNA
15. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
16. Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12
17. Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
18. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
19. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon gamma
20. Enhanced murine macrophage TNF receptor shedding by cytosine-guanine sequences in oligode-oxynucleotides
21. Cutting edge: Bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages
22. Bacterial DNA causes septic shock
23. Galactosamine-induced sensitization to the lethal effects of endotoxin
24. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
25. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models
26. Tumor necrosis factor-alpha: Molecular-biological aspects mini-review
27. CpG DNA and LPS induce distinct patterns of activation in human monocytes
28. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
29. The regulation of tumor necrosis factor-alpha production in murine mast cells: Pentoxifylline or dexamethasone inhibits IgE-dependent production of TNF-alpha by distinct mechanisms
30. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays
31. Innate immunity: The virtues of a non-clonal system recognition
32. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the LPS gene product
33. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
34. MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4
35. A toll-like receptor recognizes bacterial DNA
36. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
37. Endotoxin signal transduction in macrophages
38. Rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
39. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
40. Bacterial DNA and lipopolysaccharide induce synergistic production of TNF-alpha through a post-transcriptional mechanism
41. B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor-α gene in primary macrophages
42. Enhancers and transcriptional factors controlling the inducibility of the tumor necrosis factor-α promoter in primary macrophages
43. Priming of human monocytes for enhanced lipopolysaccharide responses: Expression of alpha interferon, interferon regulatory factors and tumor necrosis factor
44. IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and mRNA stability
45. Post-transcriptional regulation of pro-inflammatory gene expression
46. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha
47. The 3′ untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR
48. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
49. Pentoxifylline
50. Interleukin 12, interferon gamma and tumor necrosis factor alpha are the key cytokines of the generalized Shwartzman reaction