A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells

Genes and Development

Volumn 16, Issue 23, 2002, Pages 2991-3003

  Tsai, Robert Y L ^a   McKay, Ronald D G ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cell proliferation; GTP; Nucleolus; Nucleostemin; P53; Stem cell

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; MUTANT PROTEIN; NUCLEAR PROTEIN; NUCLEOSTEMIN; PROTEIN P53; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL; CANCER CELL CULTURE; CARCINOGENESIS; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL POPULATION; CELL PROLIFERATION; CELL TRANSFORMATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; EMBRYO CELL; IN VITRO STUDY; IN VIVO STUDY; MITOSIS; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; RAT; REGULATORY MECHANISM; STEM CELL;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CELL NUCLEOLUS; CENTRAL NERVOUS SYSTEM; CLONING, MOLECULAR; DOWN-REGULATION; MICE; MOLECULAR SEQUENCE DATA; NEOPLASMS; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; RATS; STEM CELLS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA;

EID: 0036894648     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.55671     Document Type: Article

References (27)

1. Blander, G., Kipnis, J., Leal, J.F., Yu, C.E., Schellenberg, G.D., and Oren, M. 1999. Physical and functional interaction between p53 and the Werner's syndrome protein. J. Biol. Chem. 274: 29463-29469.
2. Drayton, S. and Peters, G. 2002. Immortalisation and transformation revisited. Curr. Opin. Genet. Dev. 12: 98-104.
3. Du, Y.C. and Stillman, B. 2002. Yph1p, an ORC-interacting protein: Potential links between cell proliferation control, DNA replication, and ribosome biogenesis. Cell 109: 835-848.
4. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
5. Geschwind, D.H., Ou, J., Easterday, M.C., Dougherty, J.D., Jackson, R.L., Chen, Z., Antoine, H., Terskikh, A., Weissman, I.L., Nelson, S.F., et al. 2001. A genetic analysis of neural progenitor differentiation. Neuron 29: 325-339.
6. Hay, B.A., Maile, R., and Rubin, G.M. 1997. P element insertion-dependent gene activation in the Drosophila eye. Proc. Natl. Acad. Sci. 94: 5195-5200.
7. Ivanova, N.B., Dimos, J.T., Schaniel, C., Hackney, J.A., Moore, K.A., and Lemischka, I.R. 2002. A stem cell molecular signature. Science 298: 601-604.
8. Johe, K.K., Hazel, T.G., Muller, T., Dugich-Djordjevic, M.M., and McKay, R.D. 1996. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes & Dev. 10: 3129-3140.
9. Kamijo, T., Zindy, F., Roussel, M.F., Quelle, D.E., Downing, J.R., Ashmun, R.A., Grosveld, G., and Sherr, C.J. 1997. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649-659.
10. Kamijo, T., Weber, J.D., Zambetti, G., Zindy, F., Roussel, M.F., and Sherr, C.J. 1998. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc. Natl. Acad. Sci. 95: 8292-8297.
11. LaBonne, C. and Bronner-Fraser, M. 1998. Induction and patterning of the neural crest, a stem cell-like precursor population. J. Neurobiol. 36: 175-189.
12. Lendahl, U., Zimmerman, L.B., and McKay, R.D. 1990. CNS stem cells express a new class of intermediate filament protein. Cell 60: 585-595.
13. Michael, D. and Oren, M. 2002. The p53 and Mdm2 families in cancer. Curr. Opin. Genet. Dev. 12: 53-59.
14. Mizushima, S. and Nagata, S. 1990. pEF-BOS: A powerful mammalian expression vector. Nucleic Acids Res. 18: 5322.
15. Phillips, R.L., Ernst, R.E., Brunk, B., Ivanova, N., Mahan, M.A., Deanehan, J.K., Moore, K.A., Overton, G.C., and Lemischka, I.R. 2000. The genetic program of hematopoietic stem cells. Science 288: 1635-1640.
16. Ramalho-Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R.C., and Melton, D.A. 2002. "Stemness": Transcriptional profiling of embryonic and adult stem cells. Science 298: 597-600.
17. Reynolds, B.A. and Weiss, S. 1992. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255: 1707-1710.
18. Spillare, E.A., Robles, A.I., Wang, X.W., Shen, J.C., Yu, C.E., Schellenberg, G.D., and Harris, C.C. 1999. p53-mediated apoptosis is attenuated in Werner syndrome cells. Genes & Dev. 13: 1355-1360.
19. Srinivasan, A., Roth, K.A., Sayers, R.O., Shindler, K.S., Wong, A.M., Fritz, L.C., and Tomaselli, K.J. 1998. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system. Cell Death Differ. 5: 1004-1016.
20. Tao, W. and Levine, A.J. 1999. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc. Natl. Acad. Sci. 96: 6937-6941.
21. 2/M transition by p53. Oncogene 20: 1803-1815.
22. Terskikh, A.V., Easterday, M.C., Li, L., Hood, L., Kornblum, H.I., Geschwind, D.H., and Weissman, I.L. 2001. From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs. Proc. Natl. Acad. Sci. 98: 7934-7949.
23. Tsai, R.Y. and McKay, R.D. 2000. Cell contact regulates fate choice by cortical stem cells. J. Neurosci. 20: 3725-3735.
24. Tyner, S.D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415: 45-53.
25. Van Doren, M., Broihier, H.T., Moore, L.A., and Lehmann, R. 1998. HMG-CoA reductase guides migrating primordial germ cells. Nature 396: 466-469.
26. Yang, X.W., Wynder, C., Doughty, M.L., and Heintz, N. 1999. BAC-mediated gene-dosage analysis reveals a role for Ziprol (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Nat. Genet. 22: 327-335.
27. Zhang, Y., Xiong, Y., and Yarbrough, W.G. 1998. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92: 725-734.