The difluoromethylenephosphonothioic acid group as a phosphate surrogatefor obtaining PTP-1B inhibitors. Transformation of difluoromethylenephosphonicacids into difluoromethylenephosphonothioic acids

Arkivoc

Volumn 2003, Issue 8, 2003, Pages 256-266

  Murano, Tetsuo ^a   Takechi, Hiroaki ^a   Yuasa, Yoko ^a   Yokomatsu, Tsutomu ^a   Umesue, Ikuko ^b   Soeda, Shinji ^b   Shimeno, Hiroshi ^b   Shibuya, Shiroshi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

Bis (2 cyanoethyl) esters; Enzyme inhibitors; Phosphonothioic acids; Protein tyrosine phosphatases

Indexed keywords

[1,1' BIPHENYL] 3 YL(DIFLUORO)METHYLPHOSPHONIC ACID; [3 [BIS(METHYLSULFONYL)AMINO] 4 (2 PHENYLETHENYL)PHENYL]DIFLUOROMETHYLPHOSPHONIC ACID; BIS (2 CYANOETHYL)ESTER; DIFLUORO(2 NAPHTHYL)METHYLPHOSPHONOTHIOIC ACID; DIFLUOROMETHYLENEPHOSPHONIC ACID; ESTER DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; POTASSIUM [1,1' BIPHENYL] 3 YL(DIFLUORO)METHYLPHOSPHONOTHIOATE; POTASSIUM [3 [BIS(METHYLSULFONYL)AMINO] 4 (2 PHENYLETHENYL)PHENYL]DIFLUOROMETHYLPHOSPHONOTHIOATE; POTASSIUM DIFLUORO(2 NAPHTHYL)METHYLPHOSPHONOTHIOATE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG POTENCY; DRUG TRANSFORMATION; HYDROPHOBICITY;

EID: 3242717609     PISSN: 14246376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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