-
1
-
-
0028266566
-
Aspects of the oridative metabolism of nicotine
-
Neurath, G. B. (1994) Aspects of the oridative metabolism of nicotine. Clin. Invest. 72, 190-195.
-
(1994)
Clin. Invest.
, vol.72
, pp. 190-195
-
-
Neurath, G.B.1
-
2
-
-
0027958225
-
Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
-
Benowitz, N. L., Jacob, P., III, Fong, I., and Gupta, S. (1994) Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J. Pharmacol. Exp. Ther. 268, 296-303.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.268
, pp. 296-303
-
-
Benowitz, N.L.1
Jacob P. III2
Fong, I.3
Gupta, S.4
-
3
-
-
0015935463
-
1′(5′) iminium ion
-
1′(5′) iminium ion. J. Biol. Chem. 248, 2796-2800.
-
(1973)
J. Biol. Chem.
, vol.248
, pp. 2796-2800
-
-
Murphy, P.J.1
-
5
-
-
0002368023
-
Nicotine metabolism by DNA expressed human cytochrome P-450
-
Flammang, A., Gelboin, H., Aoyama, T., Gonzalez, F., and McCoy, G. D. (1992) Nicotine metabolism by DNA expressed human cytochrome P-450. Biochem. Arch. 8, 1-8.
-
(1992)
Biochem. Arch.
, vol.8
, pp. 1-8
-
-
Flammang, A.1
Gelboin, H.2
Aoyama, T.3
Gonzalez, F.4
McCoy, G.D.5
-
6
-
-
0026702860
-
Metabolism of nicotine by human liver microsomes: Stereoselective formation of transnicotine N′-oxide
-
Cashman, J. R., Park, S. B., Yang, Z.-C., Wrighton, S. A., Jacob, P., III, and Benowitz, N. L. (1992) Metabolism of nicotine by human liver microsomes: stereoselective formation of transnicotine N′-oxide. Chem. Res. Toxicol. 5, 639-646.
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 639-646
-
-
Cashman, J.R.1
Park, S.B.2
Yang, Z.-C.3
Wrighton, S.A.4
Jacob P. III5
Benowitz, N.L.6
-
7
-
-
8044258385
-
Role of human cytochrome P4502A6 in C-oxidation of nicotine
-
Nakajima, M., Yamamoto, T., Nunoya, K.-I., Yokoi, T., Nagashima, K., Inoue, K., Funae, Y., Shimada, N., Kamataki, T., and Kuroiwa, Y. (1996) Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab. Dispos. 24, 1212-1217.
-
(1996)
Drug Metab. Dispos.
, vol.24
, pp. 1212-1217
-
-
Nakajima, M.1
Yamamoto, T.2
Nunoya, K.-I.3
Yokoi, T.4
Nagashima, K.5
Inoue, K.6
Funae, Y.7
Shimada, N.8
Kamataki, T.9
Kuroiwa, Y.10
-
8
-
-
0030885491
-
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
-
Messina, E. S., Tyndale, R. F., and Sellers, E. M. (1997) A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. J. Pharmacol. Exp. Ther. 282, 1608-1614.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.282
, pp. 1608-1614
-
-
Messina, E.S.1
Tyndale, R.F.2
Sellers, E.M.3
-
9
-
-
5544281923
-
Characterization of CYP 2A6 involved in 3′-hydroxylation of cotinine in human liver microsomes
-
Nakajima, M., Yamamoto, T., Nunoya, K.-I., Yokoi, T., Nagashima, K., Inoue, K., Funae, Y., Shimada, N., Kamataki, T., and Kuroiwa, Y. (1996) Characterization of CYP 2A6 involved in 3′-hydroxylation of cotinine in human liver microsomes. J. Pharmacol. Exp. Ther. 277, 1010-1015.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.277
, pp. 1010-1015
-
-
Nakajima, M.1
Yamamoto, T.2
Nunoya, K.-I.3
Yokoi, T.4
Nagashima, K.5
Inoue, K.6
Funae, Y.7
Shimada, N.8
Kamataki, T.9
Kuroiwa, Y.10
-
10
-
-
0025173114
-
Identification of cis-3′-hydroxycotinine as a urinary nicotine metabolite
-
Voncken, P., Rustemeier, K., and Schepers, G. (1990) Identification of cis-3′-hydroxycotinine as a urinary nicotine metabolite. Xenobiotica 20, 1353-1356.
-
(1990)
Xenobiotica
, vol.20
, pp. 1353-1356
-
-
Voncken, P.1
Rustemeier, K.2
Schepers, G.3
-
12
-
-
0015319224
-
Structure of hydroxycotinine, a nicotine metabolite
-
Dagne, E., and Castagnoli, N. (1972) Structure of hydroxycotinine, a nicotine metabolite. J. Med. Chem. 15, 356-360.
-
(1972)
J. Med. Chem.
, vol.15
, pp. 356-360
-
-
Dagne, E.1
Castagnoli, N.2
-
13
-
-
0023104833
-
Trans-3′-Hydroxycotinine as a main metabolite in urine of smokers
-
Neurath, G. B., Dunger, M., Orth, D., and Pein, F. G. (1987) trans-3′-Hydroxycotinine as a main metabolite in urine of smokers. Int. Arch. Occup. Environ. Health 59, 199-201.
-
(1987)
Int. Arch. Occup. Environ. Health
, vol.59
, pp. 199-201
-
-
Neurath, G.B.1
Dunger, M.2
Orth, D.3
Pein, F.G.4
-
15
-
-
0016295831
-
Deuterium isotope effects in the in vivo metabolism of cotinine
-
Dagne, E., Gruenke, L., and Castagnoli, N. (1974) Deuterium isotope effects in the in vivo metabolism of cotinine. J. Med. Chem. 17, 1330-1333.
-
(1974)
J. Med. Chem.
, vol.17
, pp. 1330-1333
-
-
Dagne, E.1
Gruenke, L.2
Castagnoli, N.3
-
16
-
-
0015385918
-
Cotinine n-oxide, a new metabolite of nicotine
-
Dagne, E., and Castagnoli, N. (1972) Cotinine N-oxide, a new metabolite of nicotine. J. Med. Chem. 15, 840-841.
-
(1972)
J. Med. Chem.
, vol.15
, pp. 840-841
-
-
Dagne, E.1
Castagnoli, N.2
-
17
-
-
0001730452
-
Demethylation of cotinine in vivo
-
McKennis, H., Jr., Turnbull, L. B., Bowman, E. R., and Wada, E. (1959) Demethylation of cotinine in vivo. J. Am. Chem. Soc. 81, 3951-3954.
-
(1959)
J. Am. Chem. Soc.
, vol.81
, pp. 3951-3954
-
-
McKennis H., Jr.1
Turnbull, L.B.2
Bowman, E.R.3
Wada, E.4
-
18
-
-
0028174713
-
N-Hydroxymethylnorcotinine, a new primary in vitro metabolite of cotinine
-
Li, Y., and Gorrod, J. W. (1994) N-Hydroxymethylnorcotinine, a new primary in vitro metabolite of cotinine. Xenobiotica 24, 409-415.
-
(1994)
Xenobiotica
, vol.24
, pp. 409-415
-
-
Li, Y.1
Gorrod, J.W.2
-
19
-
-
0031419535
-
Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine α-hydroxylation in human liver microsomes
-
Patten, C. J., Smith, T. J., Tynes, R., Friesen, M., Lee, J., Yang, C. S., and Murphy, S. E. (1997) Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine α-hydroxylation in human liver microsomes. Carcinogenesis 18, 1623-1628.
-
(1997)
Carcinogenesis
, vol.18
, pp. 1623-1628
-
-
Patten, C.J.1
Smith, T.J.2
Tynes, R.3
Friesen, M.4
Lee, J.5
Yang, C.S.6
Murphy, S.E.7
-
20
-
-
0020464281
-
Simultaneous determination of nicotine and cotinine in plasma using capillary column gas chromatography with nitrogen sensitive detection
-
Curvall, M., Kazemi-Vala, E., and Enzell, C. (1982) Simultaneous determination of nicotine and cotinine in plasma using capillary column gas chromatography with nitrogen sensitive detection. J. Chromatogr. 232, 283-293.
-
(1982)
J. Chromatogr.
, vol.232
, pp. 283-293
-
-
Curvall, M.1
Kazemi-Vala, E.2
Enzell, C.3
-
21
-
-
0030248683
-
Kinetic analysis of activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes, and the effect of P450 specific chemical inhibitors on this activation in human liver microsomes
-
Patten, C. J., Smith, T. J., Murphy, S. E., Wang, M.-H., Lee, J., Tynes, R. E., Koch, P., and Yang, C. S. (1996) Kinetic analysis of activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes, and the effect of P450 specific chemical inhibitors on this activation in human liver microsomes. Arch. Biochem. Biophys. 333, 127-138.
-
(1996)
Arch. Biochem. Biophys.
, vol.333
, pp. 127-138
-
-
Patten, C.J.1
Smith, T.J.2
Murphy, S.E.3
Wang, M.-H.4
Lee, J.5
Tynes, R.E.6
Koch, P.7
Yang, C.S.8
-
22
-
-
0019473826
-
The tautomeric structures of 5-hydroxycotinine, a secondary mammalian metabolite of nicotine
-
Nguyen, T. L., Dagne, E., Gruenke, L., Bhargava, H., and Castagnoli, N. (1981) The tautomeric structures of 5-hydroxycotinine, a secondary mammalian metabolite of nicotine. J. Org. Chem. 46, 758-760.
-
(1981)
J. Org. Chem.
, vol.46
, pp. 758-760
-
-
Nguyen, T.L.1
Dagne, E.2
Gruenke, L.3
Bhargava, H.4
Castagnoli, N.5
-
23
-
-
0024239936
-
Species variation and stereoselectivity in the metabolism of nicotine enantiomers
-
Nwosu, C. G., and Crooks, P. A. (1988) Species variation and stereoselectivity in the metabolism of nicotine enantiomers. Xenobiotica 18, 1361-1372.
-
(1988)
Xenobiotica
, vol.18
, pp. 1361-1372
-
-
Nwosu, C.G.1
Crooks, P.A.2
-
24
-
-
0026781890
-
Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation
-
Pearce, R., Greenway, D., and Parkinson, A. (1992) Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Arch. Biochem. Biophys. 298, 211-225.
-
(1992)
Arch. Biochem. Biophys.
, vol.298
, pp. 211-225
-
-
Pearce, R.1
Greenway, D.2
Parkinson, A.3
-
25
-
-
0024507690
-
Identification of a novel P450 expressed in rat lung: CDNA cloning and sequence, chromosome mapping and induction by 3-methyl-cholanthrene
-
Kimura, S., Kozak, C. A., and Gonzalez, F. J. (1989) Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping and induction by 3-methyl-cholanthrene. Biochemistry 28, 3798-3803.
-
(1989)
Biochemistry
, vol.28
, pp. 3798-3803
-
-
Kimura, S.1
Kozak, C.A.2
Gonzalez, F.J.3
-
26
-
-
0344586488
-
Role of cytochrome P450 2A6 in cotinine metabolism in vitro and in vivo
-
Murphy, S. E., Johnson, L. M., Losey, L. M., Pullo, D. A., and Hatsukami, D. K. (1998) Role of cytochrome P450 2A6 in cotinine metabolism in vitro and in vivo. Proc. Am. Assoc. Cancer Res. 39, 488.
-
(1998)
Proc. Am. Assoc. Cancer Res.
, vol.39
, pp. 488
-
-
Murphy, S.E.1
Johnson, L.M.2
Losey, L.M.3
Pullo, D.A.4
Hatsukami, D.K.5
-
27
-
-
0345017449
-
Studies on the metabolic fate of (S)-nicotine and its pyrrolic analog β-nicotyrine
-
(Benowitz, N. L., Ed.) Oxford University Press, New York
-
Castagnoli, N., Jr., Liu, X., Shigenaga, M. K., Wardrop, R., and Castagnoli, K. (1998) Studies on the metabolic fate of (S)-nicotine and its pyrrolic analog β-nicotyrine. In Nicotine Safety and Toxicity (Benowitz, N. L., Ed.) pp 57-65, Oxford University Press, New York.
-
(1998)
Nicotine Safety and Toxicity
, pp. 57-65
-
-
Castagnoli N., Jr.1
Liu, X.2
Shigenaga, M.K.3
Wardrop, R.4
Castagnoli, K.5
-
28
-
-
0032565878
-
Nicotine metabolism defect reduces smoking
-
Pianezza, M. L., Sellers, E. M., and Tyndale, R. F. (1998) Nicotine metabolism defect reduces smoking. Nature 393, 750.
-
(1998)
Nature
, vol.393
, pp. 750
-
-
Pianezza, M.L.1
Sellers, E.M.2
Tyndale, R.F.3
-
29
-
-
0031831381
-
Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines
-
Hecht, S. S. (1998) Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem. Res. Toxicol. 11, 559-603.
-
(1998)
Chem. Res. Toxicol.
, vol.11
, pp. 559-603
-
-
Hecht, S.S.1
|