Effects of isolated isoflavonoids on lipids, lipoproteins, insulin sensitivity, and ghrelin in postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 7, 2004, Pages 3567-3572

  Nikander, Eini ^a,b   Tiitinen, Aila ^a   Laitinen, Kalevi ^a   Tikkanen, Matti ^a   Ylikorkala, Olavi ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b JORVI HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; GHRELIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; ISOFLAVONOID; LIPID; LIPOPROTEIN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; TRIACYLGLYCEROL;

ADULT; AGED; ANAMNESIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GLUCOSE TOLERANCE TEST; HORMONE METABOLISM; HUMAN; INSULIN SENSITIVITY; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; POSTMENOPAUSE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; ISOFLAVONES; LIPIDS; LIPOPROTEINS; LIPOPROTEINS, LDL; MIDDLE AGED; PEPTIDE HORMONES; POSTMENOPAUSE;

EID: 3242658417     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-032229     Document Type: Article

References (61)

1. Tikkanen MJ, Adlercreutz H 2000 Dietary soy-derived isoflavone phytoestrogens - could they have a role in coronary heart disease prevention? Biochem Pharmacol 60:1-5
2. Tham DM, Gardner CD, Haskell WL 1998 Clinical Review 97. Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence. J Clin Endocrinol Metab 83:2223-2235
3. Knight DC, Eden JA 1996 A review of the clinical effects of phytoestrogens. Obstet Gynecol 87:897-904
4. Kuiper GGJM, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson J-Å 1998 Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139:4252-4263
5. Murkies AL, Wilcox G, Davis SR 1998 Clinical review 92: Phytoestrogens. J Clin Endocrinol Metab 83:297-303
6. Godsland IF 2001 Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations: analysis of studies published from 1974-2000. Fertil Steril 75:898-915
7. Anderson JW, Johnstone BM, Cook-Newell ME 1995 Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333:276-282
8. Nestel PJ, Yamashita T, Sasahara T, Pomeroy S, Dart A, Komesaroff P, Owen A, Abbey M 1997 Soy isoflavones improve systemic arterial compliance but not plasma lipids in menopausal and perimenopausal women. Arterioscler Thromb Vasc Biol 17:3392-3398
9. Simons LA, von Konigsmark M, Simons J, Celermajer DS 2000 Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol 85:1297-1301
10. Teede HJ, Dalais FS, Kotsopoulos D, Liang Y-L, Davis S, McGrath BP 2001 Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab 86:3053-3060
11. Dewell A, Hollenbeck CB, Bruce B 2002 The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. J Clin Endocrinol Metab 87:118-121
12. Dalais FS, Ebeling PR, Kotsopoulos D, McGrath BP, Teede HJ 2003 The effects of soy protein containing isoflavones on lipids and indices of bone resorption in postmenopausal women Clin Endocrinol (Oxf) 58:704-709
13. Reaven G, Lithell H, Landsberg L 1996 Mechanisms of disease: hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N Engl J Med 334:374-381
14. McIntyre EA, Walker M 2002 Genetics of type 2 diabetes and insulin resistance: knowledge from human studies. Clin Endocrinol (Oxf) 57:303-311
15. Moller D, Flier J 1991 Insulin resistance - mechanisms, syndromes, and implications. N Engl J Med 325:938-948
16. Gaspard UJ, Gottal J-M, den Brule FA 1995 Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas 21:171-178
17. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
18. Schöfl C, Horn R, Schill T, Schlössler HW, Müller MJ, Brabant G 2002 Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 87:4607-4610
19. Toshinai K, Date Y, Murakami N, Shimada M, Mondai MS, Shimbara T, Guan J-L, Wang Q-P, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M 2003 Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 144:1506-1512
20. Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M, Ghigo E 2002 Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 440:235-254
21. Wagner JD, Cefalu WT, Anthony MS, Litwak KN, Zhang L, Clarkson TB 1997 Dietary soy protein and estrogen replacement therapy improve cardiovascular risk factors and decrease aortic cholesterol ester content in ovariectomized cynomolgus monkeys. Metabolism 46:698-705
22. Jayagopal V, Albertazzi P, Kilpatrick ES, Howarth EM, Jennings PE, Hepburn DA, Atkin SL 2002 Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 25:1709-1714
23. Duncan AM, Underhill KEW, Xu X, Lavelleur J, Phipps WR, Kurzer MS 1999 Modest hormonal effects of soy isoflavones in postmenopausal women. J Clin Endocrinol Metab 84:3479-3484
24. Nikander E, Kilkkinen A, Metsä-Heikkilä M, Adlercreutz H, Pietinen P, Tiitinen A, Ylikorkala O 2003 A randomized placebo-controlled cross-over trial with phytoestrogens in treatment of menopause in breast cancer patients. Obstet Gynecol 101:1213-1220
25. Setchell KDR, Brown NM, Lydeking-Olsen E 2002 The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 132:3577-3584
26. Ranta V, Oksanen H, Arrenbrecht S, Ylikorkala O 2002 National differences in lipid response to postmenopausal hormone replacement therapy. Maturitas 42:259-265
27. Wenger N, Grady D 1999 Postmenopausal hormone therapy, SERMs, and coronary heart disease in women. J Endocrinol Invest 22:616-624
28. Somekawa Y, Chiguchi M, Ishibashi T, Aso T 2001 Soy intake related to menopausal symptoms, serum lipids, and bone mineral density in postmenopausal Japanese women. Obstet Gynecol 97:109-115
29. Nikander E, Metsä-Heikkilä M, Ylikorkala O, Tiitinen A 2004 Effects of phytoestrogens on bone turnover in postmenopausal women with a history of breast cancer. J Clin Endocrinol Metab 89:1207-1212
30. Andersson B, Mattsson L-Å, Hahn L, Mårin P, Lapidus L, Holm G, Bengtsson B-Å, Björntorp P 1997 Estrogen replacement therapy decreases hyperandrogenicity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 82:638-643
31. Brussaard HE, Gevers Leuven JA, Frolich M, Kluft C, Krans HM 1997 Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM. Diabetologia 40:843-849
32. Ballantyne CM 2003 Current and future aims of lipid-lowering therapy: changing paradigms and lessons from the Heart Protection Study on standards of efficacy and safety. Am J Cardiol 92:3K-9K
33. Nikander E, Metsä-Heikkilä M, Tiitinen A, Ylikorkala O 2003 Evidence of the lack of effect of phytoestrogen regimen on the levels of C-reactive protein, E-selectin and nitrate in postmenopausal women. J Clin Endocrinol Metab 88:5180-5185
34. Greenland P, Knoll MD, Stamler J, Neaton JD, Dyer AR, Garside DB, Wilson PW 2003 Major risk factors as antecedents of fatal and nonfatal coronary heart disease events. JAMA 290:891-897
35. Clarkson TB 2002 Soy, soy phytoestrogens and cardiovascular disease. J Nutr 132:5665-5695
36. Hodgson JM, Puddey IB, Beilin LJ, Mori TA, Croft KD 1998 Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 128:728-732
37. Lichenstein AH, Jalbert SM, Adlercreutz H, Goldin BR, Rasmussen H, Schaefer EJ, Ausman LM 2002 Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects. Arterioscler Thromb Vasc Biol 22:1852-1858
38. Uesugi T, Fukui Y, Yamori Y 2002 Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: a four-week study. J Am Coll Nutr 21:97-102
39. Clifton-Bligh PB, Baber RJ, Fulcher GR, Nery M-L, Moreton T 2001 The effect of isoflavones extracted from red clover (Rimostil) on lipid and bone metabolism. Menopause 8:259-265
40. Washburn S, Burke GL, Morgan T, Anthony M 1999 Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause 6:7-13
41. Wangen KE, Duncan AM, Xu J, Kurzer MS 2001 Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 73:225-231
42. Crouse JR, Morgan T, Terry JG, Ellis J, Vitolins M, Burke GL 1999 A randomized trial comparing the effect of casein with that of soy protein containing varying amounts of isoflavones on plasma concentrations of lipids and lipoproteins. Arch Intern Med 159:2070-2076
43. Merz-Demlow BE, Duncan AM, Wangen KE, Xia X, Carr TP, Phipps WR, Kurzer MS 2000 Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. Am J Clin Nutr 71:1462-1469
44. Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman Jr JW 1998 Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68(Suppl 6):1375S-1379S
45. Jenkins DJA, Kendall CWC, Jackson C-JC, Connelly PW, Parker T, Faulkner D, Vidgen E, Cunnane SC, Leiter LA, Josse RG 2002 Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr 76:365-372
46. Greaves KA, Parks JS, Williams JK, Wagner JD 1999 Intact dietary soy protein, but not adding an isoflavone-rich soy extract to casein, improves plasma lipids in ovariectomized cynomolgus monkeys. J Nutr 129:1585-1592
47. Mikkola TS, Anthony MS, Clarkson TB, St. Clair RW 2003 Serum cholesterol efflux potential is an independent predictor of coronary artery atherosclerosis. Atherosclerosis 170:31-38
48. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E, for the Heart and Estrogen/progestin Replacement Study (HERS) Research Group 1998 Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 280:605-613
49. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Hutchinson F, Stefanick ML, Jackson RD, Beresford SAA, Howard BV, Johnson KC, Kotchen JM, Ockene J. Writing Group for the Women's Health Initiative Investigators 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-333
50. Espeland MA, Hogan PE, Fineberg SF, Howard G, Schrott H, Waclawiw MA, Bush TL, for the PEPI Investigators 1998 Effect of postmenopausal hormone therapy on glucose and insulin concentrations. Diabetes Care 21:1589-1595
51. Brown MD, Korytkowski MT, Zmuda JM, McCole SD, Moore GE, Hagberg JM 2000 Insulin sensitivity in postmenopausal women. Diabetes Care 23:1731-1736
52. Ryan AS, Nicklas BJ, Bennan DM 2002 Hormone replacement therapy, insulin sensitivity, and abdominal obesity in postmenopausal women. Diabetes Care 25:127-133
53. DeFronzo R, Tobin J, Andres R 1979 Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
54. Bergman R 1989 Toward physiological understanding of glucose intolerance. Minimal model approach. Diabetes 38:1512-1527
55. Stern MP, Williams K, Haffner SM 2002 Identification of persons at high risk for type 2 diabetes mellitus: do we need the oral glucose tolerance test? Ann Intern Med 136:575-581
56. McNeely MJ, Boyko EJ, Leonetti DL, Kahn SE, Fujimoto WY 2003 Comparison of a clinical model, the oral glucose tolerance test, and fasting glucose for prediction of type 2 diabetes risk in Japanese Americans. Diabetes Care 26:758-763
57. Goodman-Gruen D, Kritz-Silverstein D 2001 Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 131:1202-1206
58. Cummings DE, Weigle DS, Frayo RS, Breed PA, Ma MK, Dellinger EP, Purnell JQ 2002 Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630
59. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML 2001 Circulating ghrelin levels are decreased in human obesity. Diabetes 50:707-709
60. Orio Jr F, Lucidi P, Palomba S, Tauchmanova L, Cascella T, Russo T, Zullo F, Colao A, Lombardi G, DeFeo P 2003 Circulating ghrelin concentrations in the polycystic ovary syndrome. J Clin Endocrinol Metab 88:942-945
61. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719