Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1

American Journal of Respiratory Cell and Molecular Biology

Volumn 34, Issue 2, 2006, Pages 182-191

  Liu, Yinglin ^a   Fanburg, Barry L ^a  

^a TUFTS MEDICAL CENTER   (United States)

Author keywords

Mammalian target of rapamycin; p70 ribosomal S6 kinase; Phosphatidylinositol 3 kinase; Pulmonary hypertension; Serine threonine protein kinase; Serotonin; Smooth muscle cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 (3 DIMETHYLAMINOPROPYL) 4 HYDROXY N [4 (4 PYRIDINYL)PHENYL]BENZAMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 8 [4 (5 AMINO 2,4 DIMETHOXYBENZOYL)BUTYL] 1,3,8 TRIAZASPIRO[4.5]DECANE 2,4 DIONE; ACETYLCYSTEINE; ANTIOXIDANT; DIPHENYLIODONIUM SALT; GINKGO BILOBA EXTRACT; KETANSERIN; MAMMALIAN TARGET OF RAPAMYCIN; MIANSERIN; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NL 71 101; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO KINASE; S6 KINASE; S6 KINASE 1; SB 215505; SEROTONIN; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SMALL INTERFERING RNA; TIRON; UNCLASSIFIED DRUG; UNINDEXED DRUG; WORTMANNIN;

ANIMAL CELL; ARTERY MUSCLE; ARTICLE; CELL PROLIFERATION; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; MITOGENICITY; NONHUMAN; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIOXIDANTS; CATTLE; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYMES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE, SMOOTH, VASCULAR; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; REACTIVE OXYGEN SPECIES; RECEPTOR, SEROTONIN, 5-HT2A; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SEROTONIN;

ANIMALIA; GINKGO (GENUS); GINKGO BILOBA; MAMMALIA;

EID: 32044456989     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2005-0163OC     Document Type: Article

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