Activation of Akt1 by human 5-hydroxytryptamine (Serotonin)1B receptors is sensitive to inhibitors of MEK

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 2, 2001, Pages 825-832

  Hsu, Eugenia H ^a   Lochan, Anthony C ^a   Cowen, Daniel S ^a,b  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; COMPLEMENTARY DNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE B; SEROTONIN 1B RECEPTOR;

ARTICLE; CELL SPECIFICITY; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANIMALS; ARABIDOPSIS PROTEINS; BUTADIENES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; IMMUNOBLOTTING; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT PROTEINS; POTASSIUM CHANNELS; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; TRANSFECTION;

EID: 0034920208     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
2. The catalytic subunit of phosphoinositide 3-kinase: Requirements for oncogenicity
3. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase
4. Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-1- and prosaptide-induced survival in Schwann cells
5. How MAP kinases are regulated
6. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase
7. 1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis
8. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt
9. Specificity and mechanism of action of some commonly used protein kinase inhibitors
10. Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the phosphatidylinositol 3-kinase, protein kinase B/Akt, and p70 S6 kinase signaling pathway
11. Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neurogenesis of the neuroblastoma cell line SH-SY5Y
12. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
13. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
14. ras independent pathway
15. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
16. α12/13 families of heterotrimeric G proteins
17. 1A receptor via a G protein βγ-subunit-initiated pathway
18. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
19. ras
20. 1B receptors in transfected BE(2)-C neuroblastoma cells is inhibited by RGS4
21. βγ subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor
22. Biphasic and synergistic activation of p44mapk (ERK-1) by growth factors: Correlation between late phase activation and mitogenicity
23. Involvement of JAK2, but not PI 3-kinase/Akt and MAP kinase pathways, in anti-apototic signals of GM-CSF in human eosinophils
24. Activation of Akt/protein kinase B by G-protein coupled receptors. A role for α and βγ subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinase γ
25. i2-mediated activation of the MAP kinase cascade
26. 1B receptors to activation of MAP kinase (ERK-2) and p70 S6 kinase signaling systems
27. G-protein-coupled receptors and Fcγreceptors mediate activation of Akt/protein kinase B in human phagocytes
28. βγ subunits stimulate phosphorylation of Shc adapter protein