Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats

Chest

Volumn 119, Issue 2, 2001, Pages 554-561

  Miyata, M ^a   Ito, M ^a   Sasajima, T ^a   Ohira, H ^a   Kasukawa, R ^a  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

5 hydroxytryptamine; Interleukin 6; MCI 9042; Pulmonary hypertension; Serotonin; Serotonin receptor; Serotonin receptor antagonist; Thromboembolic pulmonary hypertension

Indexed keywords

1 [4 [(METHOXYPHENYL)ETHYL]PHENOXY] 3 (DIMETHYLAMINO) 2 PROPYL HYDROGEN SUCCINATE HYDROCHLORIDE; INTERLEUKIN 6; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INDUCED DISEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MITOGENICITY; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SEROTONIN BLOOD LEVEL; SMOOTH MUSCLE FIBER; THROMBOCYTE COUNT; THROMBOEMBOLISM; THROMBOSIS; VASCULAR SMOOTH MUSCLE;

EID: 0035116279     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.119.2.554     Document Type: Article

References (22)

1. Pulmonary arterial hypertension of chronic thrombo-embolic origin: 70 patients
2. Pulmonary hypertension in rats: 2. Role of interleukin-6
3. Platelet-vessel wall interactions in hemostasis: Implication of 5-hydroxytryptamine
4. Effect of serotonin, thromboxane A2, and specific receptor antagonists on vascular smooth muscle cell proliferation
5. Vascular smooth muscle cell hyper-responsiveness to growth factors in hypertension
6. MCI-9042, a new antiplatelet agent is a selective S2-serotonergic receptor antagonist
7. Changes in pulmonary structure and function induced by monocrotaline intoxication
8. Ventricular weight in cardiac hypertrophy
9. Determination of rat brain tissue catecholamines using liquid chromatography with electrochemical detection
10. Determination of serotonin plasma by liquid chromatography with electrochemical detection
11. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
12. 5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamme2A receptors on sympathetic efferent terminals
13. Development of monocrotaline-induced pulmonary hypertension is attenuated by a serotonin receptor antagonist
14. Mechanisms and pathology of monocrotaline pulmonary toxicity
15. Morphologic and ultrastructural evidence of interleukin-6 induced platelet activation
16. Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner
17. Serotonin stimulates megakaryocytopoiesis via the 5-HT2 receptor
18. Regulation of levels of 5-HT2A receptor mRNA
19. Adaptive regulation of central serotonin receptors linked to phosphoinositide hydrolysis
20. Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension
21. Association of interleukin 6 release from endothelial cells and pulmonary hypertension in SLE
22. Immunological analysis of pulmonary hypertension in connective tissue diseases