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Volumn 45, Issue 2, 2006, Pages 129-138

Chondroprotective drugs in degenerative joint diseases

Author keywords

Chondroprotection; DMOADs; IL 1; Osteoarthritis; TNF

Indexed keywords

CHONDROITIN SULFATE; CHONDROPROTECTIVE AGENT; COLLAGENASE; CORTICOSTEROID; CYTOKINE; DIACETYLRHEIN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DOXYCYCLINE; GLUCOSAMINE; GROWTH FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; MATRIX METALLOPROTEINASE; MINOCYCLINE; NITRIC OXIDE; PIASCLEDINE; PLACEBO; POLYSACCHARIDE; PROSTAGLANDIN E2; RHEIN; SOMATOMEDIN; SOMATOMEDIN RECEPTOR; STROMELYSIN; TETRACYCLINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNINDEXED DRUG;

EID: 31544479592     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kei171     Document Type: Review
Times cited : (131)

References (145)
  • 1
    • 0033710649 scopus 로고    scopus 로고
    • Recommendations for the medical management of osteoarthritis of the hip and knee
    • 2000 update. ACR subcommittee on osteoarthritis guidelines
    • Altman RD, Hochberg MC, Moskowitz RW, Schnitzer TJ. Recommendations for the medical management of osteoarthritis of the hip and knee. 2000 update. ACR subcommittee on osteoarthritis guidelines. Arthritis Rheum 2000;43:1905-15.
    • (2000) Arthritis Rheum , vol.43 , pp. 1905-1915
    • Altman, R.D.1    Hochberg, M.C.2    Moskowitz, R.W.3    Schnitzer, T.J.4
  • 2
    • 0030773419 scopus 로고    scopus 로고
    • Chondrocyte cytokine and growth factor expression in murine osteoarthritis
    • Chambers MG, Bayliss MT, Mason RM. Chondrocyte cytokine and growth factor expression in murine osteoarthritis. Osteoarthritis Cart 1997;5:301-8.
    • (1997) Osteoarthritis Cart , vol.5 , pp. 301-308
    • Chambers, M.G.1    Bayliss, M.T.2    Mason, R.M.3
  • 3
    • 0032963536 scopus 로고    scopus 로고
    • Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage
    • Moos V, Fickert S, Muller B, Weber U, Sieper J. Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 1999;26:870-9.
    • (1999) J Rheumatol , vol.26 , pp. 870-879
    • Moos, V.1    Fickert, S.2    Muller, B.3    Weber, U.4    Sieper, J.5
  • 4
    • 0027500651 scopus 로고
    • Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: Studies in anatomically intact cartilage in vitro and in vivo
    • van Beuningen HM, van der Kraan PM, Arntz OJ, van den Berg WB. Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: Studies in anatomically intact cartilage in vitro and in vivo. Ann Rheum Dis 1993; 52:185-91.
    • (1993) Ann Rheum Dis , vol.52 , pp. 185-191
    • van Beuningen, H.M.1    van der Kraan, P.M.2    Arntz, O.J.3    van den Berg, W.B.4
  • 5
    • 0020319188 scopus 로고
    • Effect of insulin-like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture
    • Guenther HL, Guenther HE, Froesch ER, Fleisch H. Effect of insulin-like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture. Experientia 1982;38:979-81.
    • (1982) Experientia , vol.38 , pp. 979-981
    • Guenther, H.L.1    Guenther, H.E.2    Froesch, E.R.3    Fleisch, H.4
  • 6
    • 0023038743 scopus 로고
    • Stimulation of proteoglycan synthesis by serum and insulin-like growth factor-1 in cultured bovine articular cartilage
    • McQuillan DL, Handley CJ, Campbell MA, Bolis S, Milway VE, Herington AC. Stimulation of proteoglycan synthesis by serum and insulin-like growth factor-1 in cultured bovine articular cartilage. Biochem J 1986;240:423-30.
    • (1986) Biochem J , vol.240 , pp. 423-430
    • McQuillan, D.L.1    Handley, C.J.2    Campbell, M.A.3    Bolis, S.4    Milway, V.E.5    Herington, A.C.6
  • 7
    • 0024209843 scopus 로고
    • Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants
    • Luyten FP, Hascall VC, Nissley SP, Morales TI, Reddi AH. Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants. Arch Biochem Biophys 1988;267:416-25.
    • (1988) Arch Biochem Biophys , vol.267 , pp. 416-425
    • Luyten, F.P.1    Hascall, V.C.2    Nissley, S.P.3    Morales, T.I.4    Reddi, A.H.5
  • 8
    • 0026512898 scopus 로고
    • Effects of free and bound insulin-like growth factors on proteoglycan metabolism in articular cartilage explants
    • Tesch GH, Handley CJ, Cornell HJ, Herington AC. Effects of free and bound insulin-like growth factors on proteoglycan metabolism in articular cartilage explants. J Orthop Res 1992;10:14-22.
    • (1992) J Orthop Res , vol.10 , pp. 14-22
    • Tesch, G.H.1    Handley, C.J.2    Cornell, H.J.3    Herington, A.C.4
  • 9
    • 0029558871 scopus 로고
    • Standardization of nutrient media for isolated human articular chondrocytes in gelified agarose suspension culture
    • Verbruggen G, Malfait AM, Dewulf M, Broddelez C, Veys EM. Standardization of nutrient media for isolated human articular chondrocytes in gelified agarose suspension culture. Osteoarthritis Cart 1995;3:249-59.
    • (1995) Osteoarthritis Cart , vol.3 , pp. 249-259
    • Verbruggen, G.1    Malfait, A.M.2    Dewulf, M.3    Broddelez, C.4    Veys, E.M.5
  • 10
    • 0031574479 scopus 로고    scopus 로고
    • Synergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes
    • Yaeger PC, Masi TL, de Ortiz JL, Binette F, Tubo R, McPherson JM. Synergistic action of transforming growth factor-beta and insulin-like growth factor-I induces expression of type II collagen and aggrecan genes in adult human articular chondrocytes. Exp Cell Res 1997;237:318-25.
    • (1997) Exp Cell Res , vol.237 , pp. 318-325
    • Yaeger, P.C.1    Masi, T.L.2    de Ortiz, J.L.3    Binette, F.4    Tubo, R.5    McPherson, J.M.6
  • 11
    • 0029126199 scopus 로고
    • Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis
    • Verschure PJ, van Marle J, Joosten LA, van den Berg WB. Chondrocyte IGF-1 receptor expression and responsiveness to IGF-1 stimulation in mouse articular cartilage during various phases of experimentally induced arthritis. Ann Rheum Dis 1995;54:645-53.
    • (1995) Ann Rheum Dis , vol.54 , pp. 645-653
    • Verschure, P.J.1    van Marle, J.2    Joosten, L.A.3    van den Berg, W.B.4
  • 14
    • 0021257276 scopus 로고
    • The effect of synovial catabolin on cartilage synthetic activity
    • Dingle JT. The effect of synovial catabolin on cartilage synthetic activity. Connect Tiss Res 1984;12:277-86.
    • (1984) Connect Tiss Res , vol.12 , pp. 277-286
    • Dingle, J.T.1
  • 15
    • 0022383463 scopus 로고
    • Pig IL-1 (catabolin) induces resorption of cartilage proteoglycan and prevents synthesis of proteoglycan and collagen
    • Tyler JA, Saklatvala J. Pig IL-1 (catabolin) induces resorption of cartilage proteoglycan and prevents synthesis of proteoglycan and collagen. Br J Rheumatol 1985;24(Suppl. 1):150-5.
    • (1985) Br J Rheumatol , vol.24 , Issue.SUPPL. 1 , pp. 150-155
    • Tyler, J.A.1    Saklatvala, J.2
  • 17
    • 0023037402 scopus 로고
    • Identification of a common class of high affinity receptors for both types of interleukin-1 on connective tissue cells
    • Bird TA, Saklatvala J. Identification of a common class of high affinity receptors for both types of interleukin-1 on connective tissue cells. Nature 1986;324:263-6.
    • (1986) Nature , vol.324 , pp. 263-266
    • Bird, T.A.1    Saklatvala, J.2
  • 18
    • 0024521046 scopus 로고
    • Induction of interleukin-1 receptors on chondrocytes by fibroblast growth factor: A possible mechanism for modulation of interleukin-1 activity
    • Chandrasekhar S, Harvey AK. Induction of interleukin-1 receptors on chondrocytes by fibroblast growth factor: A possible mechanism for modulation of interleukin-1 activity. J Cell Physiol 1989;138: 236-46.
    • (1989) J Cell Physiol , vol.138 , pp. 236-246
    • Chandrasekhar, S.1    Harvey, A.K.2
  • 19
    • 0027181936 scopus 로고
    • Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4
    • Colotta F, Re F, Muzio M et al. Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4. Science 1993;261: 472-5.
    • (1993) Science , vol.261 , pp. 472-475
    • Colotta, F.1    Re, F.2    Muzio, M.3
  • 20
    • 0034704070 scopus 로고    scopus 로고
    • Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention
    • Attur MG, Dave M, Cipolletta C et al. Reversal of autocrine and paracrine effects of interleukin 1 (IL-1) in human arthritis by type II IL-1 decoy receptor. Potential for pharmacological intervention. J Biol Chem 2000;275:40307-15
    • (2000) J Biol Chem , vol.275 , pp. 40307-40315
    • Attur, M.G.1    Dave, M.2    Cipolletta, C.3
  • 21
    • 0038328889 scopus 로고    scopus 로고
    • Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage
    • Wang J, Elewaut D, Veys EM, Verbruggen G. Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage. Arthritis Rheum 2003;48:1281-91.
    • (2003) Arthritis Rheum , vol.48 , pp. 1281-12891
    • Wang, J.1    Elewaut, D.2    Veys, E.M.3    Verbruggen, G.4
  • 22
    • 0024338070 scopus 로고
    • Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines
    • Tyler JA. Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines. Biochem J 1989;260:543-8.
    • (1989) Biochem J , vol.260 , pp. 543-548
    • Tyler, J.A.1
  • 23
    • 0026538791 scopus 로고
    • Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage
    • Middleton JF, Tyler JA. Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage. Ann Rheum Dis 1992;51:440-7.
    • (1992) Ann Rheum Dis , vol.51 , pp. 440-447
    • Middleton, J.F.1    Tyler, J.A.2
  • 24
    • 0030064177 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage
    • Middleton J, Manthey A, Tyler J. Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage. J Histochem Cytochem 1996;44:133-41.
    • (1996) J Histochem Cytochem , vol.44 , pp. 133-141
    • Middleton, J.1    Manthey, A.2    Tyler, J.3
  • 25
    • 0029962656 scopus 로고    scopus 로고
    • Localization of insulin-like growth factor-1 receptor in human normal and osteoarthritic cartilage in relation to proteoglycan synthesis and content
    • Verschure PJ, Marle JV, Joosten LA, Helsen MM, Lafeber FP, Berg WB. Localization of insulin-like growth factor-1 receptor in human normal and osteoarthritic cartilage in relation to proteoglycan synthesis and content. Br J Rheumatol 1996;35:1044-55.
    • (1996) Br J Rheumatol , vol.35 , pp. 1044-1055
    • Verschure, P.J.1    Marle, J.V.2    Joosten, L.A.3    Helsen, M.M.4    Lafeber, F.P.5    Berg, W.B.6
  • 26
    • 0242606952 scopus 로고    scopus 로고
    • Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro
    • Wang J, Verdonk P, Elewaut D, Veys EM, Verbruggen G. Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro. Osteoarthritis Cart 2003;11:801-9.
    • (2003) Osteoarthritis Cart , vol.11 , pp. 801-809
    • Wang, J.1    Verdonk, P.2    Elewaut, D.3    Veys, E.M.4    Verbruggen, G.5
  • 27
    • 0034092320 scopus 로고    scopus 로고
    • Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis
    • Shlopov BV, Gumanovskaya ML, Hasty KA. Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis. Arthritis Rheum 2000;43:195-205.
    • (2000) Arthritis Rheum , vol.43 , pp. 195-205
    • Shlopov, B.V.1    Gumanovskaya, M.L.2    Hasty, K.A.3
  • 29
    • 0026736030 scopus 로고
    • Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium
    • Okada Y, Shinmei M, Tanaka O et al. Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest 1992;66:680-90.
    • (1992) Lab Invest , vol.66 , pp. 680-690
    • Okada, Y.1    Shinmei, M.2    Tanaka, O.3
  • 30
    • 0029100088 scopus 로고
    • Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1
    • Arner EC, Tortorella MD. Signal transduction through chondrocyte integrin receptors induces matrix metalloproteinase synthesis and synergizes with interleukin-1. Arthritis Rheum 1995;38:1304-14.
    • (1995) Arthritis Rheum , vol.38 , pp. 1304-1314
    • Arner, E.C.1    Tortorella, M.D.2
  • 31
    • 0031454425 scopus 로고    scopus 로고
    • Role of metalloproteases in the release of the IL-1 type II decoy receptor
    • Orlando S, Sironi M, Bianchi G et al. Role of metalloproteases in the release of the IL-1 type II decoy receptor. J Biol Chem 1997;272:31764-9.
    • (1997) J Biol Chem , vol.272 , pp. 31764-31769
    • Orlando, S.1    Sironi, M.2    Bianchi, G.3
  • 32
    • 0033105652 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of incompletely spliced transcripts
    • Penton-Rol G, Orlando S, Polentarutti N et al. Bacterial lipopolysaccharide causes rapid shedding, followed by inhibition of mRNA expression, of the IL-1 type II receptor, with concomitant up-regulation of the type I receptor and induction of incompletely spliced transcripts. J Immunol 1999;162:2931-8.
    • (1999) J Immunol , vol.162 , pp. 2931-2938
    • Penton-Rol, G.1    Orlando, S.2    Polentarutti, N.3
  • 35
    • 0034858555 scopus 로고    scopus 로고
    • Induction of apoptosis in chondrocytes by tumor necrosis factor-α
    • Aizawa T, Kon T, Einhorn TA, Gerstenfeld LC. Induction of apoptosis in chondrocytes by tumor necrosis factor-α. J Orthop Res 2001;19:785-96.
    • (2001) J Orthop Res , vol.19 , pp. 785-796
    • Aizawa, T.1    Kon, T.2    Einhorn, T.A.3    Gerstenfeld, L.C.4
  • 36
    • 0036033243 scopus 로고    scopus 로고
    • Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-α, inducible nitric oxide synthase, p53, c-myc, and bax-alpha, and suppression of bcl-2
    • Islam N, Haqqi TM, Jepsen KJ et al. Hydrostatic pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor necrosis factor-α, inducible nitric oxide synthase, p53, c-myc, and bax-alpha, and suppression of bcl-2. J Cell Biochem 2002;87:266-78.
    • (2002) J Cell Biochem , vol.87 , pp. 266-278
    • Islam, N.1    Haqqi, T.M.2    Jepsen, K.J.3
  • 37
    • 0032963536 scopus 로고    scopus 로고
    • Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage
    • Moos V, Fickert S, Muller B, Weber U, Sieper J. Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 1999;26:870-9.
    • (1999) J Rheumatol , vol.26 , pp. 870-879
    • Moos, V.1    Fickert, S.2    Muller, B.3    Weber, U.4    Sieper, J.5
  • 38
    • 16344376594 scopus 로고    scopus 로고
    • Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads
    • Verdier MP, Seite S, Guntzer K, Pujol JP, Boumediene K. Immunohistochemical analysis of transforming growth factor beta isoforms and their receptors in human cartilage from normal and osteoarthritic femoral heads. Rheumatol Int 2005;25:118-24.
    • (2005) Rheumatol Int , vol.25 , pp. 118-124
    • Verdier, M.P.1    Seite, S.2    Guntzer, K.3    Pujol, J.P.4    Boumediene, K.5
  • 39
    • 18744385527 scopus 로고    scopus 로고
    • Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions
    • Tchetina EV, Squires G, Poole AR. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol 2005; 32:876-86.
    • (2005) J Rheumatol , vol.32 , pp. 876-886
    • Tchetina, E.V.1    Squires, G.2    Poole, A.R.3
  • 40
    • 0025808268 scopus 로고
    • Transforming growth factor-beta inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes
    • Harvey AK, Hrubey PS, Chandrasekhar S. Transforming growth factor-beta inhibition of interleukin-1 activity involves down-regulation of interleukin-1 receptors on chondrocytes. Exp Cell Res 1991;195:376-85.
    • (1991) Exp Cell Res , vol.195 , pp. 376-385
    • Harvey, A.K.1    Hrubey, P.S.2    Chandrasekhar, S.3
  • 41
    • 31544460312 scopus 로고
    • Intra-articular heparin therapy of genuine arthrosis deformans of the knee joint
    • Eylau O, Intra-articular heparin therapy of genuine arthrosis deformans of the knee joint. Med Klin 1959;54:145.
    • (1959) Med Klin , vol.54 , pp. 145
    • Eylau, O.1
  • 42
    • 31544455188 scopus 로고
    • On the pathogenesis and causal treatment of arthrosis of the knee joint
    • Eylau O. On the pathogenesis and causal treatment of arthrosis of the knee joint. Med Klin 1960;55:2367-70.
    • (1960) Med Klin , vol.55 , pp. 2367-2370
    • Eylau, O.1
  • 43
    • 0016912316 scopus 로고
    • Clinical chemical changes in the synovial fluid following intra-articular injection of a glycosaminoglycan polysulfate
    • Momburg M, Stuhlsatz HW, Vogeli H, Vojtisek O, Eylau O, Greiling H. Clinical chemical changes in the synovial fluid following intra-articular injection of a glycosaminoglycan polysulfate. Z Rheumatol 1976;35(Suppl. 4):389-90.
    • (1976) Z Rheumatol , vol.35 , Issue.SUPPL. 4 , pp. 389-390
    • Momburg, M.1    Stuhlsatz, H.W.2    Vogeli, H.3    Vojtisek, O.4    Eylau, O.5    Greiling, H.6
  • 44
    • 0015344125 scopus 로고
    • Synthesis of chondromucoprotein by chondrocytes in suspension culture
    • Nevo Z, Horwitz AL, Dorfman A. Synthesis of chondromucoprotein by chondrocytes in suspension culture. Dev Biol 1972;28:219-28.
    • (1972) Dev Biol , vol.28 , pp. 219-228
    • Nevo, Z.1    Horwitz, A.L.2    Dorfman, A.3
  • 45
    • 0015382619 scopus 로고
    • Stimulation of chondromucoprotein synthesis in chondrocytes by extracellular chondromucoprotein
    • Nevo Z, Dorfman A. Stimulation of chondromucoprotein synthesis in chondrocytes by extracellular chondromucoprotein. Proc Natl Acad Sci USA 1972;69:2069-72.
    • (1972) Proc Natl Acad Sci USA , vol.69 , pp. 2069-2072
    • Nevo, Z.1    Dorfman, A.2
  • 46
    • 0015738354 scopus 로고
    • Environmental enhancement of in vitro chondrogenesis
    • Kosher RA, Lash JW, Minor RR. Environmental enhancement of in vitro chondrogenesis. Dev Biol 1973;35:210-20.
    • (1973) Dev Biol , vol.35 , pp. 210-220
    • Kosher, R.A.1    Lash, J.W.2    Minor, R.R.3
  • 47
    • 0016702672 scopus 로고
    • Stimulation of chondroitin sulfate proteoglycan production of by chondrocytes in monolayer
    • Schwartz NB, Dorfman A. Stimulation of chondroitin sulfate proteoglycan production of by chondrocytes in monolayer. Conn Tiss Res 1975;3:115-22.
    • (1975) Conn Tiss Res , vol.3 , pp. 115-122
    • Schwartz, N.B.1    Dorfman, A.2
  • 48
    • 0017609643 scopus 로고
    • Influence of sulphated glycosaminoglycans upon proteoglycan metabolism of the synovial lining cells
    • Verbruggen G, Veys EM. Influence of sulphated glycosaminoglycans upon proteoglycan metabolism of the synovial lining cells. Acta Rheumatol 1977;1:75-92.
    • (1977) Acta Rheumatol , vol.1 , pp. 75-92
    • Verbruggen, G.1    Veys, E.M.2
  • 49
    • 0018577454 scopus 로고
    • Influence of an oversulphated heparinoid upon hyaluronate metabolism of the human synovial cell in vivo
    • Verbruggen G, Veys EM. Influence of an oversulphated heparinoid upon hyaluronate metabolism of the human synovial cell in vivo. J Rheumatol 1979;6:554-61.
    • (1979) J Rheumatol , vol.6 , pp. 554-561
    • Verbruggen, G.1    Veys, E.M.2
  • 50
    • 0020643746 scopus 로고
    • Experimental confirmation of the antiarthritic activity of glycosaminoglycan polysulfate
    • Kalbhen DA. Experimental confirmation of the antiarthritic activity of glycosaminoglycan polysulfate. Z Rheumatol 1983;42:178-84.
    • (1983) Z Rheumatol , vol.42 , pp. 178-184
    • Kalbhen, D.A.1
  • 51
    • 0022507107 scopus 로고
    • The effect of glycosaminoglycan polysulfuric acid ester on articular cartilage in experimental osteoarthritis: Effects on morphological variables of disease severity
    • Carreno MR, Muniz OE, Howell DS. The effect of glycosaminoglycan polysulfuric acid ester on articular cartilage in experimental osteoarthritis: Effects on morphological variables of disease severity. J Rheumatol 1986;13:490-7.
    • (1986) J Rheumatol , vol.13 , pp. 490-497
    • Carreno, M.R.1    Muniz, O.E.2    Howell, D.S.3
  • 52
    • 0023374062 scopus 로고
    • Effects of glycosaminoglycan polysulfate treatment on soundness, hyaluronic acid content of synovial fluid and proteoglycan aggregate in articular cartilage of lame boars
    • Brennan JJ, Aherne FX, Nakano T. Effects of glycosaminoglycan polysulfate treatment on soundness, hyaluronic acid content of synovial fluid and proteoglycan aggregate in articular cartilage of lame boars. Can J Vet Res 1987;51:394-8.
    • (1987) Can J Vet Res , vol.51 , pp. 394-398
    • Brennan, J.J.1    Aherne, F.X.2    Nakano, T.3
  • 53
    • 0031781252 scopus 로고    scopus 로고
    • Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit
    • Uebelhart D, Thonar EJ, Zhang J, Williams JM. Protective effect of exogenous chondroitin 4,6-sulfate in the acute degradation of articular cartilage in the rabbit. Osteoarthritis Cart 1998; 6(Suppl. A):6-13.
    • (1998) Osteoarthritis Cart , vol.6 , Issue.SUPPL. A , pp. 6-13
    • Uebelhart, D.1    Thonar, E.J.2    Zhang, J.3    Williams, J.M.4
  • 54
    • 0031781253 scopus 로고    scopus 로고
    • Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA
    • Verbruggen G, Goemaere S, Veys EM. Chondroitin sulfate: S/DMOAD (structure/disease modifying anti-osteoarthritis drug) in the treatment of finger joint OA. Osteoarthritis Cart 1998; 6(Suppl. A):37-8.
    • (1998) Osteoarthritis Cart , vol.6 , Issue.SUPPL. A , pp. 37-38
    • Verbruggen, G.1    Goemaere, S.2    Veys, E.M.3
  • 55
    • 0036068985 scopus 로고    scopus 로고
    • Systems to assess the progression of finger joint osteoarthritis and the effects of disease modifying osteoarthritis drugs
    • Verbruggen G, Goemaere S, Veys EM. Systems to assess the progression of finger joint osteoarthritis and the effects of disease modifying osteoarthritis drugs. Clin Rheumatol 2002;21:231-43.
    • (2002) Clin Rheumatol , vol.21 , pp. 231-243
    • Verbruggen, G.1    Goemaere, S.2    Veys, E.M.3
  • 56
    • 0031747132 scopus 로고    scopus 로고
    • Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: A pilot study
    • Uebelhart D, Thonar EJ, Delmas PD, Chantraine A, Vignon E. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: A pilot study. Osteoarthritis Cart 1998;6(Suppl. A): 39-46.
    • (1998) Osteoarthritis Cart , vol.6 , Issue.SUPPL. A , pp. 39-46
    • Uebelhart, D.1    Thonar, E.J.2    Delmas, P.D.3    Chantraine, A.4    Vignon, E.5
  • 57
    • 1842635731 scopus 로고    scopus 로고
    • Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: A one-year, randomized, double-blind, multicenter study versus placebo
    • Uebelhart D, Malaise M, Marcolongo R et al. Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: A one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthritis Cart 2004;12:269-76.
    • (2004) Osteoarthritis Cart , vol.12 , pp. 269-276
    • Uebelhart, D.1    Malaise, M.2    Marcolongo, R.3
  • 58
    • 14944363294 scopus 로고    scopus 로고
    • Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trial
    • Michel BA, Stucki G, Frey D et al. Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trial. Arthritis Rheum 2005;52:779-86.
    • (2005) Arthritis Rheum , vol.52 , pp. 779-786
    • Michel, B.A.1    Stucki, G.2    Frey, D.3
  • 59
    • 0026574141 scopus 로고
    • Intra-articular injection of pentosanpoly-sulphate results in increased hyaluronan molecular weight in joint fluid
    • Verbruggen G, Veys EM. Intra-articular injection of pentosanpoly-sulphate results in increased hyaluronan molecular weight in joint fluid. Clin Exp Rheumatol 1992;10:249-54.
    • (1992) Clin Exp Rheumatol , vol.10 , pp. 249-254
    • Verbruggen, G.1    Veys, E.M.2
  • 60
    • 0027248696 scopus 로고
    • Pentosan polysulphate and glycosaminoglycan polysulphate stimulate the synthesis of hyaluronan in vivo
    • Francis DJ, Hutadilok N, Kongtawelert P, Ghosh P. Pentosan polysulphate and glycosaminoglycan polysulphate stimulate the synthesis of hyaluronan in vivo. Rheumatol Int 1993;13:61-4.
    • (1993) Rheumatol Int , vol.13 , pp. 61-64
    • Francis, D.J.1    Hutadilok, N.2    Kongtawelert, P.3    Ghosh, P.4
  • 61
    • 0032811875 scopus 로고    scopus 로고
    • Influence of polysulfated polysaccharides on aggrecans synthesized by differentiated human articular chondrocytes
    • Verbruggen G, Cornelissen M, Elewaut D, Broddelez C, De Ridder L, Veys EM. Influence of polysulfated polysaccharides on aggrecans synthesized by differentiated human articular chondrocytes. J Rheumatol 1999;26:1663-71.
    • (1999) J Rheumatol , vol.26 , pp. 1663-1671
    • Verbruggen, G.1    Cornelissen, M.2    Elewaut, D.3    Broddelez, C.4    De Ridder, L.5    Veys, E.M.6
  • 62
    • 0037099486 scopus 로고    scopus 로고
    • Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes
    • Sadowski T, Steinmeyer J. Effects of polysulfated glycosaminoglycan and triamcinolone acetonid on the production of proteinases and their inhibitors by IL-1alpha treated articular chondrocytes. Biochem Pharmacol 2002;64:217-27.
    • (2002) Biochem Pharmacol , vol.64 , pp. 217-227
    • Sadowski, T.1    Steinmeyer, J.2
  • 63
    • 0036709492 scopus 로고    scopus 로고
    • Influence of polysulphated polysaccharides and hydrocortisone on the extracellular matrix metabolism of human articular chondrocytes in vitro
    • Wang L, Wang J, Almqvist KF, Veys EM, Verbruggen G. Influence of polysulphated polysaccharides and hydrocortisone on the extracellular matrix metabolism of human articular chondrocytes in vitro. Clin Exp Rheumatol 2002;20:669-76.
    • (2002) Clin Exp Rheumatol , vol.20 , pp. 669-676
    • Wang, L.1    Wang, J.2    Almqvist, K.F.3    Veys, E.M.4    Verbruggen, G.5
  • 64
    • 0036158517 scopus 로고    scopus 로고
    • Inducible nitric oxide expression in equine articular chondrocytes: Effects of antiinflammatory compounds
    • Tung JT, Venta PJ, Caron JP. Inducible nitric oxide expression in equine articular chondrocytes: Effects of antiinflammatory compounds. Osteoarthritis Cart 2002;10:5-12.
    • (2002) Osteoarthritis Cart , vol.10 , pp. 5-12
    • Tung, J.T.1    Venta, P.J.2    Caron, J.P.3
  • 66
    • 0020857195 scopus 로고
    • In vivo study of the distribution, affinity for cartilage and metabolism of glycosaminoglycan polysulphate (GAGPS, Arteparon)
    • Muller W, Panse P, Brand S, Staubli A. In vivo study of the distribution, affinity for cartilage and metabolism of glycosaminoglycan polysulphate (GAGPS, Arteparon). Z Rheumatol 1983;42:355-61.
    • (1983) Z Rheumatol , vol.42 , pp. 355-361
    • Muller, W.1    Panse, P.2    Brand, S.3    Staubli, A.4
  • 67
    • 0038344676 scopus 로고    scopus 로고
    • Oral absorption and bioavailability of ichthyic origin chondroitin sulfate in healthy male volunteers
    • Volpi N. Oral absorption and bioavailability of ichthyic origin chondroitin sulfate in healthy male volunteers. Osteoarthritis Cart 2003;11:433-41.
    • (2003) Osteoarthritis Cart , vol.11 , pp. 433-441
    • Volpi, N.1
  • 68
    • 0036793123 scopus 로고    scopus 로고
    • Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers
    • Volpi N. Oral bioavailability of chondroitin sulfate (Condrosulf) and its constituents in healthy male volunteers. Osteoarthritis Cart 2002;10:768-77.
    • (2002) Osteoarthritis Cart , vol.10 , pp. 768-777
    • Volpi, N.1
  • 69
    • 0043031287 scopus 로고    scopus 로고
    • Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes
    • Henrotin YE, Sanchez C, Deberg MA et al. Avocado/soybean unsaponifiables increase aggrecan synthesis and reduce catabolic and proinflammatory mediator production by human osteoarthritic chondrocytes. J Rheumatol 2003;30:1825-34.
    • (2003) J Rheumatol , vol.30 , pp. 1825-1834
    • Henrotin, Y.E.1    Sanchez, C.2    Deberg, M.A.3
  • 70
    • 0035696713 scopus 로고    scopus 로고
    • Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (TIMP-1 and TIMP-2) secretion by human fibroblasts in culture
    • Kut-Lasserre C, Miller CC, Ejeil AL et al. Effect of avocado and soybean unsaponifiables on gelatinase A (MMP-2), stromelysin 1 (MMP-3), and tissue inhibitors of matrix metalloproteinase (TIMP-1 and TIMP-2) secretion by human fibroblasts in culture. J Periodontol 2001;72:1685-94.
    • (2001) J Periodontol , vol.72 , pp. 1685-1694
    • Kut-Lasserre, C.1    Miller, C.C.2    Ejeil, A.L.3
  • 71
    • 0031928319 scopus 로고    scopus 로고
    • The possible "chondroprotective" effect of the unsaponifiable constituents of avocado and soya in vivo
    • Khayyal MT, el-Ghazaly MA. The possible "chondroprotective" effect of the unsaponifiable constituents of avocado and soya in vivo. Drugs Exp Clin Res 1998;24:41-50.
    • (1998) Drugs Exp Clin Res , vol.24 , pp. 41-50
    • Khayyal, M.T.1    el-Ghazaly, M.A.2
  • 72
    • 0034533184 scopus 로고    scopus 로고
    • Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU)
    • Cake MA, Read RA, Guillou B, Ghosh P. Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU). Osteoarthritis Cart 2000;8:404-11.
    • (2000) Osteoarthritis Cart , vol.8 , pp. 404-411
    • Cake, M.A.1    Read, R.A.2    Guillou, B.3    Ghosh, P.4
  • 73
    • 0036167377 scopus 로고    scopus 로고
    • Structural effect of avocado/soybean unsaponifiables on joint space loss in osteoarthritis of the hip
    • Lequesne M, Maheu E, Cadet C, Dreiser RL. Structural effect of avocado/ soybean unsaponifiables on joint space loss in osteoarthritis of the hip. Arthritis Rheum 2002;47:50-8.
    • (2002) Arthritis Rheum , vol.47 , pp. 50-58
    • Lequesne, M.1    Maheu, E.2    Cadet, C.3    Dreiser, R.L.4
  • 74
    • 0026315787 scopus 로고
    • Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase
    • Yu LP Jr, Smith GN Jr, Hasty KA, Brandt KD. Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase. J Rheumatol 1991;18: 1450-2.
    • (1991) J Rheumatol , vol.18 , pp. 1450-1452
    • Yu Jr., L.P.1    Smith Jr., G.N.2    Hasty, K.A.3    Brandt, K.D.4
  • 75
    • 0032908329 scopus 로고    scopus 로고
    • Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes
    • Shlopov BV, Smith GN Jr, Cole AA, Hasty KA. Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes. Arthritis Rheum 1999;42:719-27.
    • (1999) Arthritis Rheum , vol.42 , pp. 719-727
    • Shlopov, B.V.1    Smith Jr., G.N.2    Cole, A.A.3    Hasty, K.A.4
  • 77
    • 0034889429 scopus 로고    scopus 로고
    • Tetracyclines inhibit nitrosothiol production by cytokine-stimulated osteoarthritic synovial cells
    • Borderie D, Hernvann A, Hilliquin P, Lemarchal H, Kahan A, Ekindjian OG. Tetracyclines inhibit nitrosothiol production by cytokine-stimulated osteoarthritic synovial cells. Inflamm Res 2001;50:409-14.
    • (2001) Inflamm Res , vol.50 , pp. 409-414
    • Borderie, D.1    Hernvann, A.2    Hilliquin, P.3    Lemarchal, H.4    Kahan, A.5    Ekindjian, O.G.6
  • 78
    • 0030450402 scopus 로고    scopus 로고
    • A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
    • Amin AR, Attur MG, Thakker GD et al. A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases. Proc Natl Acad Sci USA 1996;93:14014-9.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14014-14019
    • Amin, A.R.1    Attur, M.G.2    Thakker, G.D.3
  • 79
    • 2642649541 scopus 로고    scopus 로고
    • Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage
    • Smith GN Jr, Yu LP Jr, Brandt KD, Capello WN. Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage. J Rheumatol 1998;25:532-5.
    • (1998) J Rheumatol , vol.25 , pp. 532-535
    • Smith Jr., G.N.1    Yu Jr., L.P.2    Brandt, K.D.3    Capello, W.N.4
  • 80
    • 0035291207 scopus 로고    scopus 로고
    • The effects of doxycycline on nitric oxide and stromelysin production in dogs with cranial cruciate ligament rupture
    • Jauernig S, Schweighauser A, Reist M, Von Rechenberg B, Schawalder P, Spreng D. The effects of doxycycline on nitric oxide and stromelysin production in dogs with cranial cruciate ligament rupture. Vet Surg 2001;30:132-9.
    • (2001) Vet Surg , vol.30 , pp. 132-139
    • Jauernig, S.1    Schweighauser, A.2    Reist, M.3    Von Rechenberg, B.4    Schawalder, P.5    Spreng, D.6
  • 81
    • 0032200055 scopus 로고    scopus 로고
    • Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs
    • de Bri E, Lei W, Svensson O, Chowdhury M, Moak SA, Greenwald RA. Effect of an inhibitor of matrix metalloproteinases on spontaneous osteoarthritis in guinea pigs. Adv Dent Res 1998;12:82-5.
    • (1998) Adv Dent Res , vol.12 , pp. 82-85
    • de Bri, E.1    Lei, W.2    Svensson, O.3    Chowdhury, M.4    Moak, S.A.5    Greenwald, R.A.6
  • 83
    • 22244469120 scopus 로고    scopus 로고
    • Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo-controlled, double-blind trial
    • Brandt KD, Mazzuca SA, Katz BP et al. Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum 2005;52:2015-25.
    • (2005) Arthritis Rheum , vol.52 , pp. 2015-2025
    • Brandt, K.D.1    Mazzuca, S.A.2    Katz, B.P.3
  • 85
    • 0019076798 scopus 로고
    • A non-steroidal anti-inflammatory drug that stimulates prostaglandins release
    • Pomarelli P, Berti M, Gatti MT, Mosconi P. A non-steroidal anti-inflammatory drug that stimulates prostaglandins release. Farmaco Ed Sci 1980;35:836-42.
    • (1980) Farmaco Ed Sci , vol.35 , pp. 836-842
    • Pomarelli, P.1    Berti, M.2    Gatti, M.T.3    Mosconi, P.4
  • 86
    • 0031743216 scopus 로고    scopus 로고
    • Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes
    • Pelletier JP, Mineau F, Fernandes JC, Duval N, Martel-Pelletier J. Diacerhein and rhein reduce the interleukin 1beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. J Rheumatol 1998;25:2417-24.
    • (1998) J Rheumatol , vol.25 , pp. 2417-2424
    • Pelletier, J.P.1    Mineau, F.2    Fernandes, J.C.3    Duval, N.4    Martel-Pelletier, J.5
  • 87
    • 0035843764 scopus 로고    scopus 로고
    • Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis
    • Tamura T, Ohmori K. Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis. Eur J Pharmacol 2001;419:269-74.
    • (2001) Eur J Pharmacol , vol.419 , pp. 269-274
    • Tamura, T.1    Ohmori, K.2
  • 89
    • 0033568011 scopus 로고    scopus 로고
    • A novel mechanism of action of chemically modified tetracyclines: Inhibition of COX-2-mediated prostaglandin E2 production
    • Patel RN, Attur MG, Dave MN et al. A novel mechanism of action of chemically modified tetracyclines: Inhibition of COX-2-mediated prostaglandin E2 production. Immunology 1999;163:3459-67.
    • (1999) Immunology , vol.163 , pp. 3459-3467
    • Patel, R.N.1    Attur, M.G.2    Dave, M.N.3
  • 90
    • 0033136716 scopus 로고    scopus 로고
    • Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures
    • Yaron M, Shirazi I, Yaron I. Anti-interleukin-1 effects of diacerein and rhein in human osteoarthritic synovial tissue and cartilage cultures. Osteoarthritis Cart 1999;7:272-80.
    • (1999) Osteoarthritis Cart , vol.7 , pp. 272-280
    • Yaron, M.1    Shirazi, I.2    Yaron, I.3
  • 91
    • 0031945949 scopus 로고    scopus 로고
    • In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes
    • Martel-Pelletier J, Mineau F, Jolicoeur FC, Cloutier JM, Pelletier JP. In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes. J Rheumatol 1998;25:753-62.
    • (1998) J Rheumatol , vol.25 , pp. 753-762
    • Martel-Pelletier, J.1    Mineau, F.2    Jolicoeur, F.C.3    Cloutier, J.M.4    Pelletier, J.P.5
  • 93
    • 0036020052 scopus 로고    scopus 로고
    • Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha
    • Mendes AF, Caramona MM, de Carvalho AO, Lopes MC. Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha. Pharmacol Toxicol 2002;91:22-8.
    • (2002) Pharmacol Toxicol , vol.91 , pp. 22-28
    • Mendes, A.F.1    Caramona, M.M.2    de Carvalho, A.O.3    Lopes, M.C.4
  • 94
    • 0036701572 scopus 로고    scopus 로고
    • Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: Molecular and cellular aspects
    • Dozin B, Malpeli M, Camardella L, Cancedda R, Pietrangelo A. Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: Molecular and cellular aspects. Matrix Biol 2002;21:449-59.
    • (2002) Matrix Biol , vol.21 , pp. 449-459
    • Dozin, B.1    Malpeli, M.2    Camardella, L.3    Cancedda, R.4    Pietrangelo, A.5
  • 95
    • 0027622197 scopus 로고
    • Effect of diacerhein (ART 50) on the matrix synthesis and collagenase secretion by cultured joint chondrocytes in rabbits
    • Boittin N, Redini F, Loyau G, Pujol JP. Effect of diacerhein (ART 50) on the matrix synthesis and collagenase secretion by cultured joint chondrocytes in rabbits. Rev Rhum 1993;60:68S-76S.
    • (1993) Rev Rhum , vol.60
    • Boittin, N.1    Redini, F.2    Loyau, G.3    Pujol, J.P.4
  • 96
    • 0035027359 scopus 로고    scopus 로고
    • Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes
    • Tamura T, Kosaka N, Ishiwa J, Sato T, Nagase H, Ito A. Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes. Osteoarthritis Cart 2001;9:257-63.
    • (2001) Osteoarthritis Cart , vol.9 , pp. 257-263
    • Tamura, T.1    Kosaka, N.2    Ishiwa, J.3    Sato, T.4    Nagase, H.5    Ito, A.6
  • 97
    • 0035134180 scopus 로고    scopus 로고
    • Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes
    • Tamura T, Ohmori K. Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes. Jpn J Pharmacol 2001; 85:101-4.
    • (2001) Jpn J Pharmacol , vol.85 , pp. 101-104
    • Tamura, T.1    Ohmori, K.2
  • 98
    • 0033136710 scopus 로고    scopus 로고
    • Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1
    • Felisaz N, Boumediene K, Ghayor C et al. Stimulating effect of diacerein on TGF-beta1 and beta2 expression in articular chondrocytes cultured with and without interleukin-1. Osteoarthritis Cart 1999;7:255-64.
    • (1999) Osteoarthritis Cart , vol.7 , pp. 255-264
    • Felisaz, N.1    Boumediene, K.2    Ghayor, C.3
  • 99
    • 0027623389 scopus 로고
    • Diacetylrhein on a postcontusion model of experimental osteoarthritis in the rabbit
    • Mazieres B, Berdah L, Thiechart M, Viguier G. Diacetylrhein on a postcontusion model of experimental osteoarthritis in the rabbit. Rev Rhum 1993;60:77S-81S.
    • (1993) Rev Rhum , vol.60
    • Mazieres, B.1    Berdah, L.2    Thiechart, M.3    Viguier, G.4
  • 100
    • 0032722064 scopus 로고    scopus 로고
    • Effect of diacerein on spontaneous polyarthritis in male New Zealand black/KN mice
    • Tamura T, Ohmori K, Nakamura K. Effect of diacerein on spontaneous polyarthritis in male New Zealand black/KN mice. Osteoarthritis Cart 1999;7:533-8.
    • (1999) Osteoarthritis Cart , vol.7 , pp. 533-538
    • Tamura, T.1    Ohmori, K.2    Nakamura, K.3
  • 101
    • 0029963463 scopus 로고    scopus 로고
    • Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation
    • Carney SL. Effect of diacetyl rhein on the development of experimental osteoarthritis. A biochemical investigation. Osteoarthritis Cart 1996;4:251-61.
    • (1996) Osteoarthritis Cart , vol.4 , pp. 251-261
    • Carney, S.L.1
  • 103
    • 0345196596 scopus 로고    scopus 로고
    • Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis
    • Smith GN Jr, Myers SL, Brandt KD, Mickler EA, Albrecht ME. Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate-deficiency model of osteoarthritis. Arthritis Rheum 1999;42:545-54.
    • (1999) Arthritis Rheum , vol.42 , pp. 545-554
    • Smith Jr., G.N.1    Myers, S.L.2    Brandt, K.D.3    Mickler, E.A.4    Albrecht, M.E.5
  • 104
    • 0035157807 scopus 로고    scopus 로고
    • Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial
    • Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip. ECHODIAH Investigators Study Group
    • Dougados M, Nguyen M, Berdah L, Mazieres B, Lequesne M; ECHODIAH Investigators Study Group. Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. Evaluation of the Chondromodulating Effect of Diacerein in OA of the Hip. Arthritis Rheum 2001;44:2539-47.
    • (2001) Arthritis Rheum , vol.44 , pp. 2539-2547
    • Dougados, M.1    Nguyen, M.2    Berdah, L.3    Mazieres, B.4    Lequesne, M.5
  • 105
    • 9644281133 scopus 로고    scopus 로고
    • Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis
    • Pham T, Le Henanff A, Ravaud P, Dieppe P, Paolozzi L, Dougados M. Evaluation of the symptomatic and structural efficacy of a new hyaluronic acid compound, NRD101, in comparison with diacerein and placebo in a 1 year randomised controlled study in symptomatic knee osteoarthritis. Ann Rheum Dis 2004;63:1611-7.
    • (2004) Ann Rheum Dis , vol.63 , pp. 1611-1617
    • Pham, T.1    Le Henanff, A.2    Ravaud, P.3    Dieppe, P.4    Paolozzi, L.5    Dougados, M.6
  • 106
    • 0037116589 scopus 로고    scopus 로고
    • Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway
    • Gouze JN, Bianchi A, Becuwe P et al. Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kappa B pathway. FEBS Lett 2002;510:166-70.
    • (2002) FEBS Lett , vol.510 , pp. 166-170
    • Gouze, J.N.1    Bianchi, A.2    Becuwe, P.3
  • 107
    • 0035871802 scopus 로고    scopus 로고
    • N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes
    • Shikhman AR, Kuhn K, Alaaeddine N, Lotz M. N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes. J Immunol 2001;166:5155-60.
    • (2001) J Immunol , vol.166 , pp. 5155-5160
    • Shikhman, A.R.1    Kuhn, K.2    Alaaeddine, N.3    Lotz, M.4
  • 108
    • 0037385065 scopus 로고    scopus 로고
    • Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes
    • Largo R, Alvarez-Soria MA, Diez-Ortego I et al. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cart 2003;11:290-8.
    • (2003) Osteoarthritis Cart , vol.11 , pp. 290-298
    • Largo, R.1    Alvarez-Soria, M.A.2    Diez-Ortego, I.3
  • 109
    • 0034111377 scopus 로고    scopus 로고
    • Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro
    • Piperno M, Reboul P, Hellio Le Graverand MP et al. Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro. Osteoarthritis Cart 2000;8:207-12.
    • (2000) Osteoarthritis Cart , vol.8 , pp. 207-212
    • Piperno, M.1    Reboul, P.2    Hellio Le Graverand, M.P.3
  • 110
    • 2342638989 scopus 로고    scopus 로고
    • Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis
    • Nakamura H, Shibakawa A, Tanaka M, Kato T, Nishioka K. Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis. Clin Exp Rheumatol 2004; 22:293-9.
    • (2004) Clin Exp Rheumatol , vol.22 , pp. 293-299
    • Nakamura, H.1    Shibakawa, A.2    Tanaka, M.3    Kato, T.4    Nishioka, K.5
  • 111
    • 0034745403 scopus 로고    scopus 로고
    • Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: Influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes
    • Gouze JN, Bordji K, Gulberti S et al. Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: Influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Arthritis Rheum 2001;44:351-60.
    • (2001) Arthritis Rheum , vol.44 , pp. 351-360
    • Gouze, J.N.1    Bordji, K.2    Gulberti, S.3
  • 114
    • 0036701569 scopus 로고    scopus 로고
    • Effects of anti-arthritis preparations on gene expression and enzyme activity of cyclooxygenase-2 in cultured equine chondrocytes
    • Tung JT, Venta PJ, Eberhart SW, Yuzbasiyan-Gurkan V, Alexander L, Caron JP. Effects of anti-arthritis preparations on gene expression and enzyme activity of cyclooxygenase-2 in cultured equine chondrocytes. Am J Vet Res 2002;63:1134-9.
    • (2002) Am J Vet Res , vol.63 , pp. 1134-1139
    • Tung, J.T.1    Venta, P.J.2    Eberhart, S.W.3    Yuzbasiyan-Gurkan, V.4    Alexander, L.5    Caron, J.P.6
  • 115
    • 0038344684 scopus 로고    scopus 로고
    • Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes
    • Dodge GR, Jimenez SA. Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cart 2003;11:424-32.
    • (2003) Osteoarthritis Cart , vol.11 , pp. 424-432
    • Dodge, G.R.1    Jimenez, S.A.2
  • 116
    • 0032189902 scopus 로고    scopus 로고
    • Chondrocyte-mediated catabolism of aggrecan: Aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine
    • Sandy JD, Gamett D, Thompson V, Verscharen C. Chondrocyte-mediated catabolism of aggrecan: Aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine. Biochem J 1998;335:59-66.
    • (1998) Biochem J , vol.335 , pp. 59-66
    • Sandy, J.D.1    Gamett, D.2    Thompson, V.3    Verscharen, C.4
  • 117
    • 0034141981 scopus 로고    scopus 로고
    • Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage
    • Patwari P, Kurz B, Sandy JD, Grodzinsky AJ. Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage. Arch Biochem Biophys 2000;374:79-85.
    • (2000) Arch Biochem Biophys , vol.374 , pp. 79-85
    • Patwari, P.1    Kurz, B.2    Sandy, J.D.3    Grodzinsky, A.J.4
  • 118
    • 0036793172 scopus 로고    scopus 로고
    • High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro
    • de Mattei M, Pellati A, Pasello M et al. High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. Osteoarthritis Cart 2002;10:816-25.
    • (2002) Osteoarthritis Cart , vol.10 , pp. 816-825
    • de Mattei, M.1    Pellati, A.2    Pasello, M.3
  • 119
    • 17244378123 scopus 로고    scopus 로고
    • Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis
    • Tiraloche G, Girard C, Chouinard L et al. Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum 2005;52:1118-28.
    • (2005) Arthritis Rheum , vol.52 , pp. 1118-1128
    • Tiraloche, G.1    Girard, C.2    Chouinard, L.3
  • 120
    • 19944427322 scopus 로고    scopus 로고
    • Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis
    • Shikhman AR, Amiel D, D'Lima D et al. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis 2005;64:89-94.
    • (2005) Ann Rheum Dis , vol.64 , pp. 89-94
    • Shikhman, A.R.1    Amiel, D.2    D'Lima, D.3
  • 121
    • 0035956653 scopus 로고    scopus 로고
    • Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomised, placebo-controlled clinical trial
    • Reginster JY, Deroisy R, Rovati LC et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomised, placebo-controlled clinical trial. Lancet 2001;357:251-6.
    • (2001) Lancet , vol.357 , pp. 251-256
    • Reginster, J.Y.1    Deroisy, R.2    Rovati, L.C.3
  • 122
    • 0037078298 scopus 로고    scopus 로고
    • Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study
    • Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G, Rovati LC. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23.
    • (2002) Arch Intern Med , vol.162 , pp. 2113-2123
    • Pavelka, K.1    Gatterova, J.2    Olejarova, M.3    Machacek, S.4    Giacovelli, G.5    Rovati, L.C.6
  • 123
    • 0023574619 scopus 로고
    • Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells
    • Knudsen PJ, Dinarello CA, Strom TB. Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J Immunol 1987;139:4129-34.
    • (1987) J Immunol , vol.139 , pp. 4129-4134
    • Knudsen, P.J.1    Dinarello, C.A.2    Strom, T.B.3
  • 124
    • 0000693107 scopus 로고
    • Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA
    • Lee SW, Tsou AP, Chan H et al. Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA. Proc Natl Acad Sci USA 1988;85:1204-8.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1204-1208
    • Lee, S.W.1    Tsou, A.P.2    Chan, H.3
  • 125
    • 0024474390 scopus 로고
    • In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage
    • Pelletier JP, Cloutier JM, Martel-Pelletier J. In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage. J Rheumatol 1989;16:646-55.
    • (1989) J Rheumatol , vol.16 , pp. 646-655
    • Pelletier, J.P.1    Cloutier, J.M.2    Martel-Pelletier, J.3
  • 126
    • 0019486308 scopus 로고
    • Effects of cortisol on cell proliferation and proteoglycan synthesis and degradation in cartilage zones of the calf costochondral growth plate in vitro with and without rat plasma somatomedin activity
    • Hill DJ. Effects of cortisol on cell proliferation and proteoglycan synthesis and degradation in cartilage zones of the calf costochondral growth plate in vitro with and without rat plasma somatomedin activity. J Endocrinol 1981;88:425-35.
    • (1981) J Endocrinol , vol.88 , pp. 425-435
    • Hill, D.J.1
  • 127
    • 0024149890 scopus 로고
    • Hydrocortisone stimulation of proliferation and glycosaminoglycan synthesis in rabbit craniofacial chondrocytes in vitro
    • Takigawa M, Takano T, Nakagawa K, Sakuda M, Suzuki F. Hydrocortisone stimulation of proliferation and glycosaminoglycan synthesis in rabbit craniofacial chondrocytes in vitro. Arch Oral Bio1 1988;33:893-9.
    • (1988) Arch Oral Biol , vol.33 , pp. 893-899
    • Takigawa, M.1    Takano, T.2    Nakagawa, K.3    Sakuda, M.4    Suzuki, F.5
  • 128
    • 0019792987 scopus 로고
    • Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic synovium in vitro: Effects of hydrocortisone and indomethacin
    • McGuire MB, Murphy M, Reynolds JJ, Russell RGG. Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic synovium in vitro: Effects of hydrocortisone and indomethacin. Clin Biol 1981;61:703-10.
    • (1981) Clin Biol , vol.61 , pp. 703-710
    • McGuire, M.B.1    Murphy, M.2    Reynolds, J.J.3    Russell, R.G.G.4
  • 129
    • 0022337498 scopus 로고
    • Cartilage degradation by neutral proteoglycanases in experimental osteoarthritis. Suppression by steroids
    • Pelletier JP, Martel-Pelletier J. Cartilage degradation by neutral proteoglycanases in experimental osteoarthritis. Suppression by steroids. Arthritis Rheum 1985;28:1393-401.
    • (1985) Arthritis Rheum , vol.28 , pp. 1393-1401
    • Pelletier, J.P.1    Martel-Pelletier, J.2
  • 131
    • 0023220884 scopus 로고
    • Proteoglycan-degrading acid metalloproteinase activity in human osteoarthritic cartilage, and the effects of intraarticular steroid injections
    • Pelletier JP, Martel-Pelletier J, Cloutier JM, Woessner JF Jr. Proteoglycan-degrading acid metalloproteinase activity in human osteoarthritic cartilage, and the effects of intraarticular steroid injections. Arthritis Rheum 1987;30:541-8.
    • (1987) Arthritis Rheum , vol.30 , pp. 541-548
    • Pelletier, J.P.1    Martel-Pelletier, J.2    Cloutier, J.M.3    Woessner Jr., J.F.4
  • 132
    • 0028258012 scopus 로고
    • Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis
    • Pelletier JP, Mineau F, Raynauld JP, Woessner JF, Gunja-Smith Z, Martel-Pelletier J. Intraarticular injections with methylprednisolone acetate reduce osteoarthritic lesions in parallel with chondrocyte stromelysin synthesis in experimental osteoarthritis. Arthritis Rheum 1994;37:414-23.
    • (1994) Arthritis Rheum , vol.37 , pp. 414-423
    • Pelletier, J.P.1    Mineau, F.2    Raynauld, J.P.3    Woessner, J.F.4    Gunja-Smith, Z.5    Martel-Pelletier, J.6
  • 133
    • 0025870007 scopus 로고
    • Interactions between steroid hormones and insulin-like growth factor-I in rabbit chondrocytes
    • Itagane Y, Inada H, Fujita K, Isshiki G. Interactions between steroid hormones and insulin-like growth factor-I in rabbit chondrocytes. Endocrinology 1991;128:1419-24.
    • (1991) Endocrinology , vol.128 , pp. 1419-1424
    • Itagane, Y.1    Inada, H.2    Fujita, K.3    Isshiki, G.4
  • 134
    • 0027369999 scopus 로고
    • Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I
    • Van der Kraan PM, Vitters EL, Postma NS, Verbunt J, van den Berg WB. Maintenance of the synthesis of large proteoglycans in anatomically intact murine articular cartilage by steroids and insulin-like growth factor I. Ann Rheum Dis 1993; 52:734-41.
    • (1993) Ann Rheum Dis , vol.52 , pp. 734-741
    • Van der Kraan, P.M.1    Vitters, E.L.2    Postma, N.S.3    Verbunt, J.4    van den Berg, W.B.5
  • 135
    • 0035146263 scopus 로고    scopus 로고
    • In vitro redifferentiation of culture-expanded rabbit and human auricular chondrocytes for cartilage reconstruction
    • Van Osch GJ, van der Veen SW, Verwoerd-Verhoef HL. In vitro redifferentiation of culture-expanded rabbit and human auricular chondrocytes for cartilage reconstruction. Plast Reconstr Surg 2001;107:433-40.
    • (2001) Plast Reconstr Surg , vol.107 , pp. 433-440
    • Van Osch, G.J.1    van der Veen, S.W.2    Verwoerd-Verhoef, H.L.3
  • 136
    • 0020563101 scopus 로고
    • A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically
    • Colombo C, Butler M, Hickman L, Selwyn M, Chart J, Steinetz B. A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically. Arthritis Rheum 1983;26:1132-9.
    • (1983) Arthritis Rheum , vol.26 , pp. 1132-1139
    • Colombo, C.1    Butler, M.2    Hickman, L.3    Selwyn, M.4    Chart, J.5    Steinetz, B.6
  • 137
    • 0021028108 scopus 로고
    • A new model of osteoarthritis in rabbits. III. Evaluation of anti-osteoarthritic effects of selected drugs administered intraarticularly
    • Butler M, Colombo C, Hickman L et al. A new model of osteoarthritis in rabbits. III. Evaluation of anti-osteoarthritic effects of selected drugs administered intraarticularly. Arthritis Rheum 1983;26:1380-6.
    • (1983) Arthritis Rheum , vol.26 , pp. 1380-1386
    • Butler, M.1    Colombo, C.2    Hickman, L.3
  • 138
    • 0022347939 scopus 로고
    • Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage
    • Williams JM, Brandt KD. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum 1985;28: 1267-74.
    • (1985) Arthritis Rheum , vol.28 , pp. 1267-1274
    • Williams, J.M.1    Brandt, K.D.2
  • 139
    • 0024555663 scopus 로고
    • Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis
    • Pelletier JP, Martel-Pelletier J. Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis. Arthritis Rheum 1989;32:181-93.
    • (1989) Arthritis Rheum , vol.32 , pp. 181-193
    • Pelletier, J.P.1    Martel-Pelletier, J.2
  • 140
    • 0346690025 scopus 로고    scopus 로고
    • Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism
    • Wang J, Elewaut D, Hoffman I, Veys EM, Verbruggen G. Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism. Ann Rheum Dis 2004;63:61-6.
    • (2004) Ann Rheum Dis , vol.63 , pp. 61-66
    • Wang, J.1    Elewaut, D.2    Hoffman, I.3    Veys, E.M.4    Verbruggen, G.5
  • 141
    • 0024314554 scopus 로고
    • Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
    • Brennan FM, Chantry D, Jackson A, Maini R, Feldmann M. Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 1989; 2:244-7.
    • (1989) Lancet , vol.2 , pp. 244-247
    • Brennan, F.M.1    Chantry, D.2    Jackson, A.3    Maini, R.4    Feldmann, M.5
  • 142
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
    • Lipsky PE, van der Heijde DM, St Clair EW et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 2000;343: 1594-602.
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    van der Heijde, D.M.2    St. Clair, E.W.3
  • 143
    • 17244364098 scopus 로고    scopus 로고
    • Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: A detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study
    • ATTRACT Study Group
    • Smolen JS, Han C, Bala M et al.; ATTRACT Study Group. Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: A detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with concomitant therapy study. Arthritis Rheum 2005;52:1020-30.
    • (2005) Arthritis Rheum , vol.52 , pp. 1020-1030
    • Smolen, J.S.1    Han, C.2    Bala, M.3
  • 144
    • 0036183028 scopus 로고    scopus 로고
    • Repeated infusions of infliximab, a chimeric anti-TNFalpha monoclonal antibody, in patients with active spondyloarthropathy: One year follow up
    • Kruithof E, Van den Bosch F, Baeten D et al. Repeated infusions of infliximab, a chimeric anti-TNFalpha monoclonal antibody, in patients with active spondyloarthropathy: One year follow up. Ann Rheum Dis 2002;61:207-12.
    • (2002) Ann Rheum Dis , vol.61 , pp. 207-212
    • Kruithof, E.1    Van den Bosch, F.2    Baeten, D.3
  • 145
    • 0030041071 scopus 로고    scopus 로고
    • Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints
    • Verbruggen G, Veys EM. Numerical scoring systems for the anatomic evolution of osteoarthritis of the finger joints. Arthritis Rheum 1996;39:308-20.
    • (1996) Arthritis Rheum , vol.39 , pp. 308-320
    • Verbruggen, G.1    Veys, E.M.2


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