Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis

Clinical and Experimental Rheumatology

Volumn 22, Issue 3, 2004, Pages 293-299

  Nakamura, Hiroshi ^a   Shibakawa, Atsuyuki ^a   Tanaka, Michiaki ^a   Kato, Tomohiro ^a   Nishioka, Kusuki ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chondrocytes; COX 2; Glucosamine; MMP; NO; Osteoarthritis; PGE2; Synovial cells

Indexed keywords

AUTACOID; COLLAGENASE 3; CYCLOOXYGENASE 2; GLUCOSAMINE; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; STROMELYSIN;

ADULT; AGED; ARTICLE; CARTILAGE CELL; CELL CULTURE; CELL METABOLISM; CELL STIMULATION; CELL TYPE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; ENZYME SYNTHESIS; FEMUR NECK FRACTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; JOINT; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; QUANTITATIVE ANALYSIS; SUPERNATANT; SYNOVIOCYTE; TOTAL KNEE REPLACEMENT;

AGED; AGED, 80 AND OVER; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSAMINE; HUMANS; INTERLEUKIN-1; ISOENZYMES; MEMBRANE PROTEINS; METALLOPROTEASES; MIDDLE AGED; NITRIC OXIDE; OSTEOARTHRITIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYNOVIAL MEMBRANE;

EID: 2342638989     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. HUGENBERG ST, BRANDT KD, COLE CA: Effect of sodium salicylate, aspirin, and ibuprofen on enzymes required by the chondrocyte for synthesis of chondroitin sulfate. J Rheumatol 1993; 20: 2128-33.
2. Van de LOO FA, JOOSTEN LA, van LENT PL, ARNTZ OJ, van den BERG WB: IL-1/NO/ chondrocyte Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum 1995; 38: 164-72.
3. FARAHAT MN, YANNI G, POSTON R, PANAYI GS: Cytokine expression in synovial membranes of patients with rheumatoid athritis and osteoarthritis. Ann Rheum Dis 1993; 52: 870-5.
4. MOOS V, FICKERT S, MULLER B, WEBER U, SIEPER J: Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 1999; 26: 870-9.
5. KUMKUMIAN GK, LAFYATIS R, REMMERS EF, CASE JP, KIM SJ, WILDER RL: Platelet-derived growth factor and IL-1 interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. J Immunol 1989; 143: 833-7.
6. GUERNE PA, ZURAW BL, VAUGHAN JH, CARSON DA, LOTZ M: Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 1989; 83: 585-92.
7. STEFANOVIC-RACIC M, STADLER J, GEORGESCU HI, EVANS CH: Nitric oxide synthesis and its regulation by rabbit synoviocytes. J Rheumatol 1994; 21: 1892-8.
8. CAMPBELL IK, PICCOLI DS, HAMILTON JA: Stimulation of human chondrocyte prostaglandin E2 production by recombinant human interleukin-1 and tumour necrosis factor. Biochim Biophys Acta 1990; 1051: 310-8
9. STADLER J, STEFANOVIC-RACIC M, BILLIAR TR et al.: Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 1991; 147: 3915-20.
10. TETLOW LC, ADLAM DJ, WOOLLEY DE: Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes. Arthritis Rheum 2001; 44: 585-94.
11. BILLINGHURST RC, DAHLBERG L, IONESCU M et al.: Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J Clin Invest 1997; 99: 1534-45.
12. OKADA Y, SHINMEI M, TANAKA O et al.: Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest 1992; 66: 680-90.
13. FULKERSON JP, DAMIANO P: Effect of prostaglandin E2 on adult pig articular cartilage slices in culture. Clin Orthop 1983; 179: 266-9.
14. FERREIRA SH, NAKAMURA M, CASTRO MSA: Tbe hyperalgesic effects of prostacyclin and prostaglandin E2. Prostaglandins 1978; 16: 31-7.
15. HASHIMOTO S, TAKAHASHI K, AMIEL D, COUTTS RD, LOTZ M: Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis. Arthritis Rheum 1998; 41: 1266-74.
16. PELLETIER JP, JOVANOVIC DV, LASCAUCOMAN V et al.: Selective inhibition of inducible nitric oxide synthase reduces progression of experimental osteoarthritis in vivo: possible link with the reduction in chondrocyte apoptosis and caspase 3 level. Arthritis Rheum 2000; 43: 1290-9.
17. McALINDON TE, LaVALLEY MP, GULIN JP, FELSON DT: Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000; 283: 1469-75.
18. PIPERNO M, REBOUL P, HELLIO Le GRAVERAND MP et al.: Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage 2000; 8: 207-12.
19. BASSLEER C, ROVATI L, FRANCHIMONT P: Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage 1998; 6: 427-34.
20. GOUZE JN, BORDJI K, GULBERTI S et al.: Interleukin-1 beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Arthritis Rheum 2001; 44: 351-60.
21. SHIKHMAN AR, KUHN K, ALAAEDDINE N, LOTZ M: N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes. J Immunol 2001; 166: 5155-60.
22. DENIZOT F, LANG R: Rapid colorimetric assay for cell growth and survival. J Immunol Methods 1986; 89: 271-7.
23. GOLDRING MB: The role of the chondrocytes in osteoarthritis. Arthritis Rheum 2000; 43: 1916-26.
24. RIBBENS C, ANDRE B, KAYE O et al.: Synovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not. Rheumatology (Oxford) 2000; 39: 1357-65.
25. YOSHIHARA Y, NAKAMURA H, OBATA K et al.: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Ann Rheum Dis 2000; 59: 455-61.
26. ITO T, UZUKI M, SHIMAMURA T, SAWAI T: Dynamics of matrix metalloproteinase (MMP)-13 in the patients with rheumatoid arthritis. Ryumachi 2002; 42: 60-9.
27. MARTEL-PELLETIER J, MCCOLLUM R, Di-BATTISTA J et al.: The interleukin-1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function. Arthritis Rheum 1992; 35: 530-40.
28. HARDY MM, SEIBERT K, MANNING PT et al.: Cyclooxygenase 2-dependent prostaglandin E2 modulates cartilage proteoglycan degradation in human osteoarthritis explants. Arthritis Rheum 2002; 46: 1789-803.
29. ABRAMSON SB: The role of COX-2 produced by cartilage in arthritis. Osteoarthritis Cartilage 1999; 7: 380-1.
30. NAKAMURA H, NISHIOKA K: Effects of glucosamine/chondroitin supplement on osteoarthritis: Involvement of PGE2 and YKL-40. Jpn J Rheum Surg 2002, 21: 175-84.
31. LESLIE CC: Properties and regulation of cytosolic phopholipase A2. J Biol Chem 1997; 27: 16709-12.
32. JAKOBSSON P-J, THOREN S, MORGENSTERN R, SAMUELSSON B: Identification of human prostaglandin E synthase: a microsomal glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 1999; 96: 7220-5.
33. LARGO R, ALVAREZ-SORIA MA, DIEZ-ORTEGO I et al.: Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 2003; 11: 290-8.
34. DODGE GR, JIMENEZ SA: Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human ostcoarthritis articular chondrocytes. Osteoarthritis Cartilage 2003; 11: 424-32.
35. BYRON CR, ORTH MW, VENTA PJ et al.: Influence of glucosamine on matrix metalloproteinase expression and activity in lipopolysaccharide-stimulated equine chondrocytes. Am J Vet Res 2003; 64: 666-71.
36. de MATTEI M, PELLATI A, PASELLO M et al.: High doses of glucosamine-HCl have detrimental effects on bovine articular cartilage explants cultured in vitro. Osteoarthritis Cartilage 2002; 10: 816-25.