Metal-mediated inhibition of escherichia coli methionine aminopeptidase: Structure-activity relationships and development of a novel scoring function for metal-ligand interactions

Journal of Medicinal Chemistry

Volumn 49, Issue 2, 2006, Pages 511-522

  Schiffmann, Rolf ^a   Neugebauer, Alexander ^a   Klein, Christian D ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

(1H BENZIMIDAZOL 2 YL)THIAZOL 2 YL AMINE; 1 BENZYL 2 PYRIDIN 2 YL 1H BENZOIMIDAZOLE; 1 BENZYL 2 THIAZOL 4 YL 1H BENZOIMIDAZOLE; 1 METHYL 2 THIAZOL 4 YL 1H BENZOIMIDAZOLE; 1H BENZIMIDAZOL 2 YL THIOUREA; 2 (1H BENZOIMIDAZOL 2 YL)PHENOL; 2 (1H BENZOIMIDAZOL 2 YL)PYRIDIN 3 OL; 2 FURAN 2 YL 1H BENZOIMIDAZOLE; 2 PYRAZIN 2 YL 1H BENZOIMIDAZOLE; 2 PYRIDIN 2 YL 1H BENZOIMIDAZOLE; 2 PYRIDIN 3 YL 1H BENZOIMIDAZOLE; 2 THIOPHEN 2 YL 1H BENZOIMIDAZOLE; 5 METHYL 2 PYRIDIN 2 YL 1(3)H BENZOIMIDAZOLE; 5 METHYL 2 THIAZOL 4 YL 1(3)H BENZOIMIDAZOLE; 5 TERT BUTYL 2 THIAZOL 4 YL 1H BENZOIMIDAZOLE; 5,6 DIMETHYL 2 PYRIDIN 2 YL 1H BENZOIMIDAZOLE; 5,6 DIMETHYL 2 THIAZOL 4 YL 1H BENZOIMIDAZOLE; 6 (1H BENZOIMIDAZOL 2 YL)PYRIDIN 2 OL; ALBENDAZOLE; BENZIMIDAZOLE DERIVATIVE; CARBENDAZIM; COBALT; ENZYME INHIBITOR; FENBENDAZOLE; FUBERIDAZOLE; MEBENDAZOLE; METHIONYL AMINOPEPTIDASE INHIBITOR; THIABENDAZOLE DERIVATIVE; TIABENDAZOLE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; EVALUATION; IC 50; NONHUMAN; SCORING SYSTEM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINOPEPTIDASES; BINDING SITES; COBALT; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; LIGANDS; MANGANESE; METALS; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIABENDAZOLE;

EID: 31544473513     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050476z     Document Type: Article

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