Protonation States of Methionine Aminopeptidase and Their Relevance for Inhibitor Binding and Catalytic Activity

Journal of Biological Chemistry

Volumn 278, Issue 48, 2003, Pages 47862-47867

  Klein, Christian D P ^a   Schiffmann, Rolf ^a   Folkers, Gerd ^b   Piana, Stefano ^c   Röthlisberger, Ursula ^c  

^a SAARLAND UNIVERSITY   (Germany)

^b ETH ZURICH   (Switzerland)

^c EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYST ACTIVITY; COMPUTER SIMULATION; ENZYMES; HYDROLYSIS; PH EFFECTS; SCREENING;

PROTONATION STATES;

BIOCHEMISTRY;

ANGIOGENESIS INHIBITOR; ANTIBIOTIC AGENT; FUMAGILLIN; METHIONYL AMINOPEPTIDASE; METHIONYL AMINOPEPTIDASE 2; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE COMPLEX; GEOMETRY; HYDROLYSIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS; SIMULATION;

AMINOPEPTIDASES; BINDING SITES; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANES; ENZYME INHIBITORS; ESCHERICHIA COLI; FATTY ACIDS, UNSATURATED; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; HYDROXIDES; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTONS; SESQUITERPENES; SOFTWARE; WATER;

EID: 0347481378     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305325200     Document Type: Article

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