Crystal Structures of Staphylococcus aureus Methionine Aminopeptidase Complexed with Keto Heterocycle and Aminoketone Inhibitors Reveal the Formation of a Tetrahedral Intermediate

Journal of Medicinal Chemistry

Volumn 47, Issue 6, 2004, Pages 1325-1328

  Douangamath, Alice ^a   Dale, Glenn E ^a   D'Arcy, Allan ^a   Almstetter, Michael ^a,b   Eckl, Robert ^a,b   Frutos Hoener, Annabelle ^a   Henkel, Bernd ^a,b   Illgen, Katrin ^a,b   Nerdinger, Sven ^a,b   Schulz, Henk ^a   MacSweeney, Aengus ^a   Thormann, Michael ^a,b   Treml, Andreas ^a,b   Pierau, Sabine ^a   Wadman, Sjoerd ^a   Oefner, Christian ^a  

^a Morphochem AG Basel   (Switzerland)

^b Biovertis AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOKETONE; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; ENZYME INHIBITOR; HETEROCYCLIC COMPOUND; METHIONYL AMINOPEPTIDASE; METHIONYL AMINOPEPTIDASE INHIBITOR; UNCLASSIFIED DRUG; AMINE; AMINOPEPTIDASE; CYCLOPROPANE DERIVATIVE; KETONE; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENSITY; DRUG MECHANISM; DRUG TARGETING; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; HYDROLYSIS; MOLECULAR INTERACTION; NONHUMAN; PHASE TRANSITION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINES; AMINOPEPTIDASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; KETONES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; STAPHYLOCOCCUS AUREUS; THIAZOLES;

EID: 1542298116     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034188j     Document Type: Article

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